Immunogenicity in humans of an edible vaccine for hepatitis B

Proceedings of the National Academy of Sciences of the United States of America

Volumn 102, Issue 9, 2005, Pages 3378-3382

  Thanavala, Yasmin ^a   Mahoney, Martin ^a   Pal, Sribani ^a,c   Scott, Adrienne ^a,d   Richter, Liz ^b,e   Natarajan, Nachimuthu ^a   Goodwin, Patti ^a   Arntzen, Charles J ^b,f   Mason, Hugh S ^b,f  

^a ROSWELL PARK CANCER INSTITUTE   (United States)

^b United States Department of Agriculture Agricultural Research Service and Boyce Thompson Institute for Plant Research   (United States)

^c LERNER RESEARCH INSTITUTE   (United States)

^d PFIZER INC   (United States)

^e LEXICON PHARMACEUTICALS INC   (United States)

^f ARIZONA STATE UNIVERSITY   (United States)

Author keywords

Mucosal immune response; Oral vaccine; Surface antigen; Transgenic plant

Indexed keywords

HEPATITIS B SURFACE ANTIGEN; IMMUNOLOGICAL ADJUVANT;

ADULT; ANTIBODY BLOOD LEVEL; ARTICLE; BLOOD SAMPLING; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; FEMALE; HEALTH CARE PERSONNEL; HEPATITIS B; HUMAN; IMMUNE RESPONSE; IMMUNOGENICITY; IMMUNOPROPHYLAXIS; INGESTION; MAJOR CLINICAL STUDY; MALE; POTATO; PREVENTIVE HEALTH SERVICE; PRIORITY JOURNAL; SAFETY; STOMACH PH; TRANSGENIC PLANT; VACCINATION;

ADMINISTRATION, ORAL; DOUBLE-BLIND METHOD; HEPATITIS B ANTIBODIES; HEPATITIS B SURFACE ANTIGENS; HEPATITIS B VACCINES; HUMANS; PLANTS, GENETICALLY MODIFIED;

EID: 14744274482     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.0409899102     Document Type: Article

References (26)

1. Kane, M. (1995) Vaccine 13, S47-S49.
2. Coleman, P. J., McQuillan, G. J., Moyer, L. A., Lambert, S. B. & Margois, H. S. (1998) J. Infect. Dis. 178, 954-959.
3. McQuillan, G. M., Coleman, P. J., Kruszon-Moran, D., Moyer, L. A., Lambert, S. B. & Margolis, H. S. (1999) Am. J. Public Health 89, 14-18.
4. Bloom, B. R. & Widdus, R. (1998) Nat. Med. 4, Suppl., 480-484.
5. Haq, T. A., Mason, H. S., Clements, J. D. & Arntzen, C. J. (1995) Science 268, 714-716.
6. Mason, H. S., Ball, J. M., Shi, J. J., Jiang, X., Estes, M. K. & Arntzen, C. J. (1996) Proc. Natl. Acad. Sci. USA 93, 5335-5340.
7. Mason, H. S., Haq, T. A., Clements, J. D. & Arntzen, C. J. (1998) Vaccine 16, 1336-1343.
8. Tacket, C. O., Mason, H. S., Losonsky, G., Clements, J. D., Levine, M. M. & Arntzen, C. J. (1998) Nat. Med. 4, 607-609.
9. Tacket, C., Mason, H. S., Losonsky, G., Estes, M. K., Levine, M. M. & Arntzen, C. J. (2000) J. Infect. Dis. 182, 302-305.
10. Tacket, C. O., Pasetti, M. F., Edelman, R., Howard, J. A. & Streatfield, S. (2004) Vaccine 22, 4385-4389.
11. Thanavala, Y., Yang, Y.-F., Lyons, P., Mason, H. S. & Arntzen, C. J. (1995) Proc. Natl. Acad. Sci. USA 92, 3358-3361.
12. Kong, Q., Richter, L., Yang, Y. F., Arntzen, C. J., Mason, H. S. & Thanavala, Y. (2001) Proc. Natl. Acad. Sci. USA 98, 11539-11544.
13. Mason, H. S., Lam, D. M. K. & Arntzen, C. J. (1992) Proc. Natl. Acad. Sci. USA 89, 11745-11749.
14. Richter, L. J., Thanavala, Y., Arntzen, C. J. & Mason, H. S. (2000) Nat. Biotechnol. 18, 1167-1171.
15. Smith, M., Richter, L., Arntzen, C., Shuler, M. & Mason, H. (2003) Vaccine 21, 4011-4021.
16. Hollander, M. & Wolfe, D. (1973) in Nonparametric Statistical Methods, eds. Bradley, R. A., Hunter, J. S., Kendall, D. G. & Watson, G. S. (Wiley, New York), pp. 114-137.
17. Argesti, A. (1996) in An Introduction to Categorical Data Analysis, eds. Barnett, V., Bradley, R. A., Fisher, N., Hunter, J. S., Kadane, J. B., Kendall, D. G., Scott, D. W., Smith, A. F. M., Teugels, J. L. & Watson, G. (Wiley, New York), pp. 39-44.
18. Stevens, C. E., Alter, H. J., Taylor, P. E., Zang, E. A., Harley, E. J. & Szmuness, W. (1984) N. Engl. J. Med. 311, 496-501.
19. Weber, D. J., Rutala, W. A., Samsa, G. P., Santimaw, J. E. & Lemon, S. M. (1985) J. Am. Med. Assoc. 254, 3187-3189.
20. Goldwater, P. N. (1997) Vaccine 15, 353-356.
21. Jilg, W. (1998) Vaccine 16, Suppl., S65-S68.
22. Barash, C., Conn, M. I., DiMarino, A. J., Jr., Marzano, J. & Allen, M. L. (1999) Arch. Intern. Med. 159, 1481-1483.
23. Jilg, W., Schmidt, M., Deinhardt, F. & Zachova, R. (1984) Lancet 2 (8400), 458.
24. Tacket, C. O., Losonsky, G., Lubeck, M. D., Davis, A. R., Mizutani, S., Horwith, G., Hung, P., Edelman, R. & Levine, M. M. (1992) Vaccine 10, 673-676.
25. Henry, S. H., Bosch, F. X., Troxell., T. C. & Bolger, P. M. (1999) Science 286, 2453-2454.
26. Chang, M.-H., Chen, C.-J., Lai, M.-S., Hsu, H.-S., Wu, T.-C., Kong, M.-S., Liang, D.-C., Shau, W.-Y. & Chen, D.-S. (1997) N. Engl. J. Med. 336, 1855-1859.