Chimeric plant virus particles administered nasally or orally induce systemic and mucosal immune responses in mice

Journal of Virology

Volumn 73, Issue 2, 1999, Pages 930-938

  Brennan, Frank R ^a   Bellaby, Trevor ^a   Helliwell, Sharon M ^a   Jones, Tim D ^a   Kamstrup, Søren ^b   Dalsgaard, Kristian ^b   Flock, Jan Ingmar ^c   Hamilton, William D O ^a  

^a Axis Genetics plc   (United Kingdom)

^b TECHNICAL UNIVERSITY OF DENMARK   (Denmark)

^c KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

BINDING PROTEIN; DNA VACCINE; FIBRONECTIN; IMMUNOGLOBULIN G; IMMUNOGLOBULIN G2A; IMMUNOGLOBULIN G2B; ISCOM; VIRUS VACCINE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTIBODY TITER; ARTICLE; CHIMERA; CONTROLLED STUDY; FEMALE; HELPER CELL; MOSAIC VIRUS; MOUSE; NONHUMAN; PLANT VIRUS; PRIORITY JOURNAL; STAPHYLOCOCCUS AUREUS; T LYMPHOCYTE; VACCINE PRODUCTION; VIRUS PARTICLE; VIRUS RECOMBINANT;

EID: 0032903183     PISSN: 0022538X     EISSN: None     Source Type: Journal    
DOI: 10.1128/jvi.73.2.930-938.1999     Document Type: Article

References (52)

1. Adams, S. E., K. M. Dawson, K. Gulli, S. M. Kingsman, and A. J. Kingsman. 1987. The expression of hybrid HIV:ty virus-like particles in yeast. Nature 329:68-70.
2. Almeida, A. J., and H. O. Alpar. 1996. Nasal delivery of vaccines. J. Drug Targeting 3:455-467.
3. Alving, C. R. 1993. Lipopolysaccharide, lipid A, and liposomes containing lipid A as immunologie adjuvants. Immunobiology 187:430-446.
4. Ball, J. M., M. E. Hardy, R. L. Atmar, M. E. Conner, and M. E. Estes. 1998. Oral immunization with recombinant Norwalk virus-like particles induces a systemic and mucosal immune response in mice. J. Virol. 72:1345-1353.
5. 4a.Brennan, F. R., et al. Unpublished observations.
6. 4b.Brennan, F. R., et al. Submitted for publication.
7. Brennan, F. R., J. J. Oliver, and G. D. Baird. 1994. Differences in the immune responses of mice and sheep to an aromatic-dependent mutant of Salmonella typhimurium. J. Med. Microbiol. 40:11-19.
8. Bukawa, H., K.-I. Sekigawa, K. Hamajima, J. Fukushima, Y. Yamada, H. Kiyono, and K. Okuda. 1995. Neutralization of HIV-1 by secretory IgA induced by oral immunization with a new macromolecular multicomponent peptide vaccine candidate. Nat. Med. 1:681-685.
9. Ciborowski, P., J.-I. Flock, and T. Wadstrom. 1992. Immunological response to a Staphylococcus aureus fibronectin-binding protein. J. Med. Microbiol. 37:376-381.
10. Cox, J. C., and A. R. Coulter. 1997. Adjuvants - a classification and review of their modes of action. Vaccine 15:248-256.
11. Dalsgaard, K., K. Lovgren, and D. E. S. Steward-Tull. 1995. Immune-stimulating complexes with QuilA, p. 129-143. In D. E. S. Stewart-Tull (ed.), The theory and practical application of adjuvants. John Wiley & Sons, Ltd., London, United Kingdom.
12. Dalsgaard, K., A. Uttenthal, T. D. Jones, F. Xu, A. M. Merryweather, W. D. O. Hamilton, J. P. Langeveld, R. S. Boshuizen, S. Kamstrup, G. P. Lomonossof, C. Porta, C. Vela, J. I. Casal, R H. Meloen, and P. B. Rodgers. 1997. Plant-derived vaccine protects target animals against a viral disease. Nat. Biotechnol. 15:248-252.
13. Dessens, J. T., and G. P. Lomonossoff. 1993. Cauliflower mosaic virus 35S promoter-controlled DNA copies of cowpea mosaic virus RNAs are infectious on plants. J. Gen. Virol. 74:889-892.
14. Elson, C. O., and M. T. Dertzbaugh. 1994. Mucosal adjuvants, p. 391-402. In P. L. Ogra, J. Mestecky, M. E. Lamm, W. Strober, J. R. McGhee, and J. Bienenstock (ed.), Handbook of mucosal immunology. Academic Press, Inc., New York, N.Y.
15. 12a.Elstrom. J., et al. Submitted for publication.
16. Everest, P., P. Griffiths, and G. Dougan. 1995. Live Salmonella vaccines as a route towards oral immunization. Biologicals 23:119-124.
17. Flock, J.-I., G. Froman, K. Jonsson, B. Guss, C. Signas, B. Nilsson, G. Raucci, M. Hook, T. Wadstrom, and M. Lindberg. 1987. Cloning and expression of the gene for a fibronectin-binding protein of Staphylococcus aureus. EMBO J. 6:2351-2357.
18. Gilleland, H. E., Jr., L. B. Gilleland, J. Staczek, R. N. Harty, A. Garcia-Sastre, O. G. Engelhardt, and P. Palese. 1997. Chimeric influenza viruses incorporating epitopes of outer membrane protein F as vaccine against pulmonary infection with Pseudomonas aeruginosa. Behring Inst. Mitt. 98: 291-301.
19. Gupka, R. K., and G. R. Siber. 1995. Adjuvants for human vaccines - current status, problems and future prospects. Vaccine 13:1263-1276.
20. Hathaway, L. J., C. D. Partidos, P. Vohra, and M. W. Steward. 1995. Induction of systemic immune responses to measles virus synthetic peptides administered intranasally. Vaccine 13:1495-1500.
21. Hocart, M. J., J. S. Mackenzie, and G. A. Stewart. 1989. The IgG subclass response to influenza virus haemagglutinin in the mouse: effect of route of inoculation. J. Gen. Virol. 70:809-818.
22. Hsu, S.-C., E. B. Schadeck, A. Delmas, M. Shaw, and M. W. Steward. 1996. Linkage of a fusion peptide to a CTL epitope from the nucleoprotein of measles virus enables incorporation into ISCOMS and induction of CTL responses following intranasal immunization. Vaccine 14:1159-1166.
23. Kensil, C. R. 1996. Saponins as vaccine adjuvants. Crit. Rev. Ther. Drug Carrier Syst. 13:1-55.
24. Kipps, T. J., J. Parnham, J. Punt, and L. A. Herzemberg. 1985. Importance of immunoglobulin isotype in human antibody-dependent, cell-mediated cytotoxicity directed by murine monoclonal antibodies. J. Exp. Med. 161:1-17.
25. Klaus, G. G. B., M. B. Pepys, K. Kitajina, and B. A. Asconas. 1979. Activation of mouse complement by different classes of mouse antibody. J. Immunol. 38:687-695.
26. Kleanthous, H., G. A. Myers, K. M. Georgakopoulos, T. J. Tibbitts, J. W. Ingrassia, H. L. Gray, R. Ding, Z.-Z. Zhang, W. Lei, R Nichols, C. K. Lee, T. H. Ermak, and T. P. Monath. 1998. Rectal and intranasal immunizations with recombinant urease induce distinct local and serum immune responses in mice and protect against Helicobacter pylori infection. Infect. Immun. 66: 2879-2886.
27. Klinman, D. M., M. Takeno, M. Ichino, M. Gu, G. Yamshchikov, G. Mor, and J. Conover. 1997. DNA vaccines: safety and efficacy issues. Springer Semin. Immunopathol. 19:245-256.
28. Lehner, T., L. A. Bergmeier, C. Panagiotidi, L. Tao, R. Brookes, L. S. Klavinskis, P. Walker, J. Walker, R G. Ward, L. Hussain, A. J. H. Gearing, and S. E. Adams. 1992. Induction of mucosal and systemic immunity to a recombinant simian immunodeficiency viral protein. Science 25:1365-1369.
29. Lin, T., C. Porta, G. Lomonossoff, and J. E. Johnson. 1996 Structure-based design of peptide presentation on a viral surface: the crystal structure of a plant/animal virus chimera at 2.8 Å resolution. Folding Design 1:179-187.
30. Lovgren, K., H. Kaberg, and B. Morein. 1990. An experimental influenza subunit vaccine (ISCOM): induction of protective immunity to challenge infection in mice after intranasal or subcutaneous administration. Clin. Exp. Immunol. 82:435-440.
31. McLain, L., C. Porta, G. P. Lomonossoff, Z. Durrani, and N. J. Dimmock. 1995. Human immunodeficiency virus type 1 neutralizing antibodies raised to a gp41 peptide expressed on the surface of a plant virus. AIDS Res. Hum. Retroviruses 11:327-334.
32. McLain, L., Z. Durrani, L. A. Wisniewski, C. Porta, G. P. Lomonossoff, and N. J. Dimmock. 1996. Stimulation of neutralizing antibodies to human immunodeficiency virus type 1 in three strains of mice immunized with a 22-mer amino acid peptide expressed on the surface of a plant virus. Vaccine 14:799-810.
33. Modelska, A., B. Dietzschold, N. Sleysh, Z. F. Fu, K. Steplewsk, D. C. Hooper, H. Koprowski, and Y. Yusibov. 1998. Immunization against rabies with plant-derived antigen. Proc. Natl. Acad. Sci. USA 95:2481-2485.
34. Montgomery, D. L., J. J. Donnelly. J. W. Shiver, M. A. Liu, and J. B. Ulmer. 1994. Protein expression in vivo by injection of polynucleotides. Curr. Opin. Biotechnol. 5:505-510.
35. O'Neal, C. M., S. E. Crawford, M. K. Estes, and M. E. Conner. 1997. Rotavinis virus-like particles administered mucosally induce protective immunity. J. Virol. 71:8707-8717.
36. Partidos, C. D., P. Vohra, and M. W. Steward. 1996. Induction of measles virus-specific cytotoxic T-cell responses after intranasal immunization with synthetic peptides. Immunology 87:179-185.
37. Porta, C., V. E. Spall, J. E. Loveland, J. E. Johnson, P. J. Barker, and G. P. Lomonossoff. 1994. Development of cowpea mosaic virus as a high-yielding system for the presentation of foreign peptides. Virology 202:949-955.
38. Reed, R. C., V. Louis-Wileman, E. V. Cosmai, S. Fang, D. L. Jue, R. M. Wohlhueter, R. L. Hunter, and A. A. Lal. 1997. Multiple antigen constructs (MACs): induction of sterile immunity against sporozoite stage of rodent malaria parasites, Plasmodium berghei and Plasmodium yoelii. Vaccine 15: 482-488.
39. Resnick. D. A., A. D. Smith, S. C. Geister, A. Zhang, A. Arnold, and G. F. Arnold. 1995. Chimeras from a human rhinovirus 14-human immunodeficiency virus type 1 (HIV-1) V3 loop seroprevalence library induce neutralizing responses against HIV-1. J. Virol. 69:2406-2411.
40. Richards, C. M., T. J. Hill, and N. A. Williams. 1997. Enhancement of the immune response to non-replicating herpes simplex virus type-1 preparations by mucosal administration in the presence of cholera toxin. Vaccine 15: 1065-1069.
41. Rudin, A., E.-L. Johansson, C. Berquist, and J. Holmgren. 1998 Differential kinetics and distribution of antibodies in serum and nasal and vaginal secretions after nasal and oral vaccination of humans. Infect. Immun. 66:3390-3396.
42. Russell, M. W., Z. Moldoveanu, P. L. White, G. G. Sibert, J. Mestecky, and S. M. Michalek. 1996. Salivary, nasal, genital and systemic antibody responses in monkeys immunized intranasally with a bacterial protein antigen and the cholera toxin B subunit. Infect. Immun. 64:1272-1283.
43. Rose, C. S. P., and D. J. Evans. 1991. Poliovirus antigen chimeras. Trends Biotechnol. 9:415-421.
44. Schennings, T., A. Heimdahl, K. Caster, and J.-I. Flock. 1993. Immunization with fibronectin binding protein from Staphylococcus aureus protects against experimental endocarditis in rats. Microb. Pathog. 15:227-236.
45. Signas, C., G. Raueci, K. Jonsson, P.-E. Lindgren, G. M. Anantharamaiiah, M. Hook, and M. Lindgren. 1989. Nucleotide sequence of the gene for a fibronectin-binding protein from Staphylococcus aureus: use of this peptide sequence in the synthesis of biologically active peptides. Proc. Natl. Acad. Sci. USA 86:699-703.
46. Staats, H. F., R. J. Jackson, M. Marinaro, I. Takahashi, H. Kiyono, and J. K. McGhee. 1994. Mucosal immunity to infection with implications for vaccine development. Curr. Opin. Immunol. 6:572-583.
47. Staats, H. F., W. G. Nichols, and T. J. Palker. 1996. Mucosal immunity to HIV-1-systemic and vaginal antibody-responses after intranasal immunization with trie HIV-1 C4/V3 peptide T1SP10 MN (A). J. Immunol. 157: 462-472.
48. Sutter, G., and B. Moss. 1992. Non-replicating vaccinia vector efficiently expresses recombinant genes. Proc. Natl. Acad. Sci. USA 89:10847-10851.
49. Usha, R., J. Rohll, V. E. Spall, M. Shanks, A. J. Maule, J. E. Johnson, and G. P. Lomonossoff. 1993. Expression of an animal virus antigenic site on the surface of a plant virus particle. Virology 197:366-374.
50. van Kammen, A., and C. P. de Jager. 1978. Cowpea mosaic virus. CMI descriptions of plant viruses, no. 197. Commonwealth Mycological Institute, Kew, Richmond, Surrey. United Kingdom.
51. van Pinxteren, L. A., I. Campbell, C. J. Clarke, D. R. Snodgrass, and M. G. Bruce. 1997. A single oral dose of inactivated rotavirus and ISCOM matrices induces partial protection in lambs. Biochem. Soc. Trans. 25:3405.
52. Vlacha, V., E. N. Forman, D. Miron, and G. Peter. 1996. Recurrent thromhocytopenic purpura after repeated measles-mumps-rubella vaccination. Pediatrics 97:738-739.