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Volumn 6, Issue 2, 1996, Pages 176-182

Use of macromolecular assemblies as expression systems for peptides and synthetic vaccines

Author keywords

[No Author keywords available]

Indexed keywords

RECOMBINANT PROTEIN; SYNTHETIC PEPTIDE; VACCINE;

EID: 0029921999     PISSN: 0959440X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0959-440X(96)80072-8     Document Type: Article
Times cited : (69)

References (66)
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    • Benito A, Mateu MG, Villaverde A: Improved mimicry of a foot and mouth disease virus antigenic site by a viral peptide displayed on β-galactosidase surface. Biotechnology 1995, 13:801-804. The antigenicity of several recombinant E. coli β-galactosidases displaying the immunodominant epitope from FMDV in different sites on the enzyme surface was studied. For each site, the inserted peptide showed a different specificity with a set of anti-FMDV monoclonal antibodies directed against the epitope. The results indicate that the precise way a sequence is presented on the surface of a macromolecule can dramatically influence its immunological properties.
    • (1995) Biotechnology , vol.13 , pp. 801-804
    • Benito, A.1    Mateu, M.G.2    Villaverde, A.3


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