-
1
-
-
0035313153
-
Advances in Escherichia coli production of therapeutic proteins
-
Schwartz, J. R. Advances in Escherichia coli production of therapeutic proteins. Curr. Opin. Biotechnol. 12, 195-201 (2001).
-
(2001)
Curr. Opin. Biotechnol.
, vol.12
, pp. 195-201
-
-
Schwartz, J.R.1
-
2
-
-
0035313635
-
Industrial choices for protein production by large-scale cell culture
-
Chu, L. & Robinson, D. K. Industrial choices for protein production by large-scale cell culture. Curr. Opin. Biotechnol. 12, 180-187 (2001).
-
(2001)
Curr. Opin. Biotechnol.
, vol.12
, pp. 180-187
-
-
Chu, L.1
Robinson, D.K.2
-
3
-
-
0033672657
-
Transgenic animal bioreactors
-
Houdebaine, L. M. Transgenic animal bioreactors. Transgenic Res. 9, 305-320 (2000).
-
(2000)
Transgenic Res.
, vol.9
, pp. 305-320
-
-
Houdebaine, L.M.1
-
4
-
-
0033667765
-
Molecular farming of pharmaceutical proteins
-
Fischer, R. & Emans, N. Molecular farming of pharmaceutical proteins. Transgenic Res. 9, 279-299 (2000).
-
(2000)
Transgenic Res.
, vol.9
, pp. 279-299
-
-
Fischer, R.1
Emans, N.2
-
5
-
-
0035477961
-
Transgenic plants as protein factories
-
Giddings, G. Transgenic plants as protein factories. Curr. Opin. Biotechnol. 12, 450-454 (2001)
-
(2001)
Curr. Opin. Biotechnol.
, vol.12
, pp. 450-454
-
-
Giddings, G.1
-
6
-
-
0001081886
-
The expression of a nopaline synthase human growth hormone chimaeric gene in transformed tobacco and sunflower callus tissue
-
Barta, A. et al. The expression of a nopaline synthase human growth hormone chimaeric gene in transformed tobacco and sunflower callus tissue. Plant Mol. Biol. 6, 347-357 (1986).
-
(1986)
Plant Mol. Biol.
, vol.6
, pp. 347-357
-
-
Barta, A.1
-
7
-
-
0024959945
-
Production of antibodies in transgenic plants
-
Hiatt, A., Cafferkey, R. & Bowdish, K. Production of antibodies in transgenic plants. Nature 342, 76-78 (1989).
-
(1989)
Nature
, vol.342
, pp. 76-78
-
-
Hiatt, A.1
Cafferkey, R.2
Bowdish, K.3
-
8
-
-
0027048769
-
Expression of hepatitis B surface antigen in transgenic plants
-
Mason, H. S., Lam, D. M. K. & Arntzen, C. J. Expression of hepatitis B surface antigen in transgenic plants. Proc. Natl Acad. Sci. USA 89, 11745-11749 (1992)
-
(1992)
Proc. Natl Acad. Sci. USA
, vol.89
, pp. 11745-11749
-
-
Mason, H.S.1
Lam, D.M.K.2
Arntzen, C.J.3
-
9
-
-
0028944992
-
Immunogenicity of transgenic plant-derived hepatitis B surface antigen
-
Thanavala, Y., Yang, Y.-F., Lyons, P., Mason, H. S. & Arntzen, C. J. Immunogenicity of transgenic plant-derived hepatitis B surface antigen. Proc. Natl Acad. Sci USA 92, 3358-3361 (1995).
-
(1995)
Proc. Natl Acad. Sci USA
, vol.92
, pp. 3358-3361
-
-
Thanavala, Y.1
Yang, Y.-F.2
Lyons, P.3
Mason, H.S.4
Arntzen, C.J.5
-
10
-
-
0141644652
-
Criteria for high-level expression of a fungal laccase gene in transgenic maize
-
Hood, E. E. et al. Criteria for high-level expression of a fungal laccase gene in transgenic maize. Plant Biotechnol. J. 1, 129-140 (2003).
-
(2003)
Plant Biotechnol. J.
, vol.1
, pp. 129-140
-
-
Hood, E.E.1
-
11
-
-
0000217415
-
Commercial production of avidin from transgenic maize: Characterization of transformant, production, processing, extraction and purification
-
Hood, E. E. et al. Commercial production of avidin from transgenic maize: characterization of transformant, production, processing, extraction and purification. Mol. Breeding 3, 291-306 (1997).
-
(1997)
Mol. Breeding
, vol.3
, pp. 291-306
-
-
Hood, E.E.1
-
12
-
-
0031194819
-
Expression of the human milk protein β-casein in transgenic potato plants
-
Chong, D. K. X. et al. Expression of the human milk protein β-casein in transgenic potato plants. Transgenic Res. 6, 289-296 (1997).
-
(1997)
Transgenic Res.
, vol.6
, pp. 289-296
-
-
Chong, D.K.X.1
-
13
-
-
0034598976
-
Triple helix assembly and processing of human collagen produced in transgenic tobacco plants
-
Ruggiero, F. et al. Triple helix assembly and processing of human collagen produced in transgenic tobacco plants. FEBS Lett. 469, 132-136 (2000).
-
(2000)
FEBS Lett.
, vol.469
, pp. 132-136
-
-
Ruggiero, F.1
-
14
-
-
0034016818
-
High-yield production of a human therapeutic protein in tobacco chloroplasts
-
Staub, J. M. et al. High-yield production of a human therapeutic protein in tobacco chloroplasts. Nature Biotechnol. 18, 333-338 (2000). This report shows that the secreted human protein somatotropin is soluble and biologically active when expressed in tobacco chloroplasts and has correctly formed disulphide bonds.
-
(2000)
Nature Biotechnol.
, vol.18
, pp. 333-338
-
-
Staub, J.M.1
-
15
-
-
85169106486
-
A chloroplast transgenic approach to hyper-express and purify human serum albumin, a protein highly susceptible to proteolytic degradation
-
Fernandez-San Millan, A., Mingo-Castel, A., Miller, M. & Daniell, H. A chloroplast transgenic approach to hyper-express and purify human serum albumin, a protein highly susceptible to proteolytic degradation. Plant Biotechnol 1, 77-79 (2003).
-
(2003)
Plant Biotechnol
, vol.1
, pp. 77-79
-
-
Fernandez-San Millan, A.1
Mingo-Castel, A.2
Miller, M.3
Daniell, H.4
-
16
-
-
0141533545
-
-
Oil bodies and associated proteins as affinity matrices. US Patent 6,509,453 (2003)
-
Moloney, M., Boothe, J. & Van Rooijen, G. Oil bodies and associated proteins as affinity matrices. US Patent 6,509,453 (2003).
-
-
-
Moloney, M.1
Boothe, J.2
Van Rooijen, G.3
-
17
-
-
0035313152
-
Therapeutic antibody expression technology
-
Chadd, H. E. & Chamow, S. M. Therapeutic antibody expression technology. Curr. Opin. Biotechnol. 12, 188-194 (2001).
-
(2001)
Curr. Opin. Biotechnol.
, vol.12
, pp. 188-194
-
-
Chadd, H.E.1
Chamow, S.M.2
-
18
-
-
0029035201
-
Generation and assembly of secretory antibodies in plants
-
Ma, J. K. et al. Generation and assembly of secretory antibodies in plants. Science 268, 716-719 (1995). This study shows for the first time that secretory antibodies, with 10 polypeptide chains that represent the products of four genes, can be assembled correctly in transgenic plants. Two rounds of crossing, which involved four singly-transgenic lines, were required to stack all four transgenes in the same plant.
-
(1995)
Science
, vol.268
, pp. 716-719
-
-
Ma, J.K.1
-
19
-
-
0033758177
-
Production of hepatitis B surface antigen in transgenic plants for oral immunization
-
Richter, L. J., Thanavala, Y., Arntzen, C. J. & Mason, H. S. Production of hepatitis B surface antigen in transgenic plants for oral immunization. Nature Biotechnol. 18, 1167-1171 (2000).
-
(2000)
Nature Biotechnol.
, vol.18
, pp. 1167-1171
-
-
Richter, L.J.1
Thanavala, Y.2
Arntzen, C.J.3
Mason, H.S.4
-
20
-
-
0032863164
-
A plant-derived edible vaccine against hepatitis B virus
-
Kapusta, J. et al. A plant-derived edible vaccine against hepatitis B virus. FASEB J. 13, 1796-1799 (1999).
-
(1999)
FASEB J.
, vol.13
, pp. 1796-1799
-
-
Kapusta, J.1
-
21
-
-
0031863854
-
Immunogenicity in humans of a recombinant bacterial-antigen delivered in a transgenic potato
-
Tacket, C. O. et al. Immunogenicity in humans of a recombinant bacterial-antigen delivered in a transgenic potato. Nature Med. 4, 607-609 (1998).
-
(1998)
Nature Med.
, vol.4
, pp. 607-609
-
-
Tacket, C.O.1
-
22
-
-
0013651896
-
Human immune responses to a novel Norwalk virus vaccine delivered in transgenic potatoes
-
Tacket, C. O. et al. Human immune responses to a novel Norwalk virus vaccine delivered in transgenic potatoes. J. Infect. Dis. 182, 302-305 (2000).
-
(2000)
J. Infect. Dis.
, vol.182
, pp. 302-305
-
-
Tacket, C.O.1
-
23
-
-
0034030703
-
Expression of full-length bioactive antimicrobial human lactoferrin in potato plants
-
Chong, D. K. X. & Langridge, W. H. R. Expression of full-length bioactive antimicrobial human lactoferrin in potato plants. Transgenic Res. 9, 71-78 (2000).
-
(2000)
Transgenic Res.
, vol.9
, pp. 71-78
-
-
Chong, D.K.X.1
Langridge, W.H.R.2
-
24
-
-
0030447028
-
Expression of an environmentally friendly synthetic protein-based polymer in transgenic tobacco plants
-
Zhang, X. Urry, D. W. & Daniell, H. Expression of an environmentally friendly synthetic protein-based polymer in transgenic tobacco plants. Plant Cell Reps. 16, 174-179 (1996)
-
(1996)
Plant Cell Reps.
, vol.16
, pp. 174-179
-
-
Zhang, X.1
Urry, D.W.2
Daniell, H.3
-
25
-
-
0033984413
-
Stable expression of a biodegradable protein-based polymer in stable tobacco chloroplasts
-
Guda, C., Lee, S. B. & Daniell, H. Stable expression of a biodegradable protein-based polymer in stable tobacco chloroplasts. Plant Cell Reps. 19, 257-262 (2000).
-
(2000)
Plant Cell Reps.
, vol.19
, pp. 257-262
-
-
Guda, C.1
Lee, S.B.2
Daniell, H.3
-
26
-
-
0037181489
-
Hydroxylated human homotrimeric collagen I in Agrobacterium tumefaciens-mediated transient expression and in transgenic tobacco plant
-
Merle, C. et al. Hydroxylated human homotrimeric collagen I in Agrobacterium tumefaciens-mediated transient expression and in transgenic tobacco plant. FEBS Lett. 515, 114-118 (2002).
-
(2002)
FEBS Lett.
, vol.515
, pp. 114-118
-
-
Merle, C.1
-
27
-
-
0035007556
-
Production of spider silk proteins in tobacco and potato
-
Scheller, J., Guhrs, K. H., Grosse, F. & Conrad, U. Production of spider silk proteins in tobacco and potato Nature Biotechnol. 19, 573-577 (2001).
-
(2001)
Nature Biotechnol.
, vol.19
, pp. 573-577
-
-
Scheller, J.1
Guhrs, K.H.2
Grosse, F.3
Conrad, U.4
-
28
-
-
0021919918
-
Identification of DNA sequences required for activity of the cauliflower mosaic virus 35S promoter
-
O'Dell, J. T., Nagy, F. & Chua, N. H. Identification of DNA sequences required for activity of the cauliflower mosaic virus 35S promoter. Nature 313, 810-812 (1985).
-
(1985)
Nature
, vol.313
, pp. 810-812
-
-
O'Dell, J.T.1
Nagy, F.2
Chua, N.H.3
-
29
-
-
0001354961
-
Expression of a soybean β-conclycinin gene under the control of the cauliflower mosaic virus 35S and 19S promoters in transformed petunia tissues
-
Lawton, M. A. et al. Expression of a soybean β-conclycinin gene under the control of the cauliflower mosaic virus 35S and 19S promoters in transformed petunia tissues. Plant Mol. Biol. 9, 315-324 (1987).
-
(1987)
Plant Mol. Biol.
, vol.9
, pp. 315-324
-
-
Lawton, M.A.1
-
30
-
-
0023236892
-
Duplication of CaMV- 35S promoter sequences creates a strong enhancer for plant genes
-
Kay, R., Chan, A. Daly, M. & McPherson, J. Duplication of CaMV-35S promoter sequences creates a strong enhancer for plant genes. Science 236, 1299-1302 (1987).
-
(1987)
Science
, vol.236
, pp. 1299-1302
-
-
Kay, R.1
Chan, A.2
Daly, M.3
McPherson, J.4
-
31
-
-
0030138945
-
Ubiquitin promoter-based vectors for high-level expression of selectable and/or screenable marker genes in monocotyledonous plants
-
Christensen, A. H. & Quail, P. H. Ubiquitin promoter-based vectors for high-level expression of selectable and/or screenable marker genes in monocotyledonous plants. Transgenic Res. 5, 213-218 (1996).
-
(1996)
Transgenic Res.
, vol.5
, pp. 213-218
-
-
Christensen, A.H.1
Quail, P.H.2
-
32
-
-
0030066414
-
Intron-mediated enhancement of gene expression in maize (Zea mays L.) and bluegrass (Poa pratensis L.)
-
Vain, P., Finer, K. R., Engler, D. E., Pratt, R. C. & Flner, J. J. Intron-mediated enhancement of gene expression in maize (Zea mays L.) and bluegrass (Poa pratensis L.). Plant Cell Rep. 15, 489-494 (1996).
-
(1996)
Plant Cell Rep.
, vol.15
, pp. 489-494
-
-
Vain, P.1
Finer, K.R.2
Engler, D.E.3
Pratt, R.C.4
Flner, J.J.5
-
33
-
-
0342748410
-
Cereal crops as viable production and storage systems for pharmaceutical scFv antibodies
-
Stoger E. et al. Cereal crops as viable production and storage systems for pharmaceutical scFv antibodies. Plant Mol. Biol. 42, 583-590 (2000).
-
(2000)
Plant Mol. Biol.
, vol.42
, pp. 583-590
-
-
Stoger, E.1
-
34
-
-
0031711457
-
Potato tubers as a biofactory for recombinant antibodies
-
Artsaenko, O., Kettig, B., Fiedler, U., Conrad, U. & Düring K. Potato tubers as a biofactory for recombinant antibodies. Mol. Breeding 4, 313-319 (1998).
-
(1998)
Mol. Breeding
, vol.4
, pp. 313-319
-
-
Artsaenko, O.1
Kettig, B.2
Fiedler, U.3
Conrad, U.4
Düring, K.5
-
35
-
-
0037394628
-
Chemically regulated gene expression in plants
-
Padidam, M. Chemically regulated gene expression in plants. Curr. Opin. Plant Biol. 6, 169-177 (2003).
-
(2003)
Curr. Opin. Plant Biol.
, vol.6
, pp. 169-177
-
-
Padidam, M.1
-
36
-
-
0013057023
-
Chemical-inducible, ecdysone receptor-based gene expression system for plants
-
Padidam, M., Gore, M., Lu, D. L. & Smirnova, O. Chemical-inducible, ecdysone receptor-based gene expression system for plants. Transgenic Res. 12, 101-109 (2003).
-
(2003)
Transgenic Res.
, vol.12
, pp. 101-109
-
-
Padidam, M.1
Gore, M.2
Lu, D.L.3
Smirnova, O.4
-
37
-
-
0032952346
-
Transgenic plants for therapeutic proteins: Linking upstream and downstream technologies
-
Cramer C. L., Boothe, J. G. & Oishi, K. K. Transgenic plants for therapeutic proteins: linking upstream and downstream technologies. Curr. Top. Microbiol. Immunol. 240, 95-118 (1999).
-
(1999)
Curr. Top. Microbiol. Immunol.
, vol.240
, pp. 95-118
-
-
Cramer, C.L.1
Boothe, J.G.2
Oishi, K.K.3
-
38
-
-
0033178118
-
Apoplastic and cytosolic expression of full-size antibodies and antibody fragments in Nicotiana tabacum
-
Schillberg, S., Zimmermann, S., Voss, A. & Fischer, R. Apoplastic and cytosolic expression of full-size antibodies and antibody fragments in Nicotiana tabacum. Transgenic Res. 8, 255-263 (1999). This paper compares the stability of identical scFv antibodies that are targeted to different compartments, and shows that the secretory pathway is generally much more suitable for antibody accumulation than the cytosol.
-
(1999)
Transgenic Res.
, vol.8
, pp. 255-263
-
-
Schillberg, S.1
Zimmermann, S.2
Voss, A.3
Fischer, R.4
-
39
-
-
0002440028
-
High-level accumulation of single-chain variable fragments in the cytosol of transgenic Petunia hybrida
-
De Jaeger, G. et al. High-level accumulation of single-chain variable fragments in the cytosol of transgenic Petunia hybrida. Eur. J. Biochem. 259, 1-10 (1998).
-
(1998)
Eur. J. Biochem.
, vol.259
, pp. 1-10
-
-
De Jaeger, G.1
-
40
-
-
0037205497
-
Formation of disulfide bridges by a single-chain Fv antibody in the reducing ectopic environment of the plant cytosol
-
Schouten, A., Rossien, J., Bakker, J. & Schots, A. Formation of disulfide bridges by a single-chain Fv antibody in the reducing ectopic environment of the plant cytosol. J. Biol Chem 277, 19339-19345 (2002).
-
(2002)
J. Biol Chem.
, vol.277
, pp. 19339-19345
-
-
Schouten, A.1
Rossien, J.2
Bakker, J.3
Schots, A.4
-
41
-
-
0032168897
-
Compartment-specific accumulation of recombinant immunoglobulins in plant cells: An essential tool for antibody production and immunomodulation of physiological functions and pathogen activity
-
Conrad, U. & Fiedler, U. Compartment-specific accumulation of recombinant immunoglobulins in plant cells: an essential tool for antibody production and immunomodulation of physiological functions and pathogen activity. Plant Mol. Biol. 38, 101-109 (1998).
-
(1998)
Plant Mol. Biol.
, vol.38
, pp. 101-109
-
-
Conrad, U.1
Fiedler, U.2
-
43
-
-
0032573210
-
A viral suppressor of gene silencing in plants
-
Anandalakshmi, R. et al. A viral suppressor of gene silencing in plants. Proc. Natl Acad. Sci. USA 95, 13079-13084 (1998).
-
(1998)
Proc. Natl Acad. Sci. USA
, vol.95
, pp. 13079-13084
-
-
Anandalakshmi, R.1
-
44
-
-
0037337257
-
Agrobacterium-mediated plant transformation: The biology behind the "gene-jockeying" tool
-
Gelvin, S. B. Agrobacterium-mediated plant transformation: the biology behind the "gene-jockeying" tool. Microbiol. Mol. Biol. Rev. 67, 16-23 (2003).
-
(2003)
Microbiol. Mol. Biol. Rev.
, vol.67
, pp. 16-23
-
-
Gelvin, S.B.1
-
45
-
-
0013187276
-
Re-engineering plant gene targeting
-
Britt, A. B. & May, G. D. Re-engineering plant gene targeting. Trends Plant Sci. 8, 90-95 (2003).
-
(2003)
Trends Plant Sci.
, vol.8
, pp. 90-95
-
-
Britt, A.B.1
May, G.D.2
-
46
-
-
0141644651
-
The current status of plant transformation technologies
-
Veluthambi, K., Gupta, A. K. & Sharma, A. The current status of plant transformation technologies. Curr. Sci. India 84, 368-380 (2003).
-
(2003)
Curr. Sci. India
, vol.84
, pp. 368-380
-
-
Veluthambi, K.1
Gupta, A.K.2
Sharma, A.3
-
47
-
-
0030440711
-
Transformation technology
-
Christou, P. Transformation technology. Trends Plant Sci. 1, 423-431 (1996).
-
(1996)
Trends Plant Sci.
, vol.1
, pp. 423-431
-
-
Christou, P.1
-
48
-
-
0036369625
-
-
(ed. Setlow, J. K.) (Kluwer-Plenum, New York)
-
Twyman, R. M., Stoger, E., Kohli, A. & Christou, P. in Genetic Engineering: Principles and Practice Vol. 24 (ed. Setlow, J. K.) 107-136 (Kluwer-Plenum, New York, 2002).
-
(2002)
Genetic Engineering: Principles and Practice
, vol.24
, pp. 107-136
-
-
Twyman, R.M.1
Stoger, E.2
Kohli, A.3
Christou, P.4
-
49
-
-
0001559166
-
On defining T-DNA
-
Martineau, B., Voelker, T. A. & Sanders, V. A. On defining T-DNA. Plant Cell 6, 1032-1033 (1994).
-
(1994)
Plant Cell
, vol.6
, pp. 1032-1033
-
-
Martineau, B.1
Voelker, T.A.2
Sanders, V.A.3
-
50
-
-
0033197809
-
A simple method to enrich an Agrobacterium-transformed population for plants containing only T-DNA sequences
-
Hanson, B. et al. A simple method to enrich an Agrobacterium-transformed population for plants containing only T-DNA sequences. Plant J. 19, 727-734 (1999).
-
(1999)
Plant J.
, vol.19
, pp. 727-734
-
-
Hanson, B.1
-
51
-
-
0034112666
-
Linear transgene constructs lacking vector backbone sequences generate low-copy-number transgenic plants with simple integration patterns
-
Fu, X. et al. Linear transgene constructs lacking vector backbone sequences generate low-copy-number transgenic plants with simple integration patterns. Transgenic Res. 9, 11-19 (2000).
-
(2000)
Transgenic Res.
, vol.9
, pp. 11-19
-
-
Fu, X.1
-
52
-
-
0034570433
-
N-glycosylation of recombinant pharmaceutical glycoproteins produced in transgenic plants: Towards humanisation of plant N-glycans
-
Lerouge, P., Bardor, M., Pagny, S., Gomord, V. & Faye, L. N-glycosylation of recombinant pharmaceutical glycoproteins produced in transgenic plants: towards humanisation of plant N-glycans. Curr. Pharmaceutical Biotech. 1, 347-354 (2000).
-
(2000)
Curr. Pharmaceutical Biotech.
, vol.1
, pp. 347-354
-
-
Lerouge, P.1
Bardor, M.2
Pagny, S.3
Gomord, V.4
Faye, L.5
-
53
-
-
0038581900
-
Immunoreactivity in mammals of two typical plant glyco-epitopes: Core α(1,3)-fucose and core xylose
-
Bardor, M. et al. Immunoreactivity in mammals of two typical plant glyco-epitopes: core α(1,3)-fucose and core xylose. Glycobiology 13, 427-434 (2003).
-
(2003)
Glycobiology
, vol.13
, pp. 427-434
-
-
Bardor, M.1
-
54
-
-
0033805614
-
A murine monoclonal antibody produced in transgenic plants with plant-specific glycans is not immunogenic in mice
-
Chargelegue, D., Vine, N. D., van Dolleweerd, C. J., Drake, P. M. & Ma, J. K. A murine monoclonal antibody produced in transgenic plants with plant-specific glycans is not immunogenic in mice. Transgenic Res. 9, 187-194 (2000). The first published paper that discusses the immunogenicity of a plant-derived glycosylated recombinant protein.
-
(2000)
Transgenic Res.
, vol.9
, pp. 187-194
-
-
Chargelegue, D.1
Vine, N.D.2
Van Dolleweerd, C.J.3
Drake, P.M.4
Ma, J.K.5
-
55
-
-
0004055174
-
-
(eds Ernst, B., Hart, G. W. & Sanay, P.) (Wiley, New York)
-
Warner, T. G. in Carbohydrates in Chemistry and Biology (eds Ernst, B., Hart, G. W. & Sanay, P.) 1043-1064 (Wiley, New York, 2000).
-
(2000)
Carbohydrates in Chemistry and Biology
, pp. 1043-1064
-
-
Warner, T.G.1
-
56
-
-
0037157167
-
Efficient chemoenzymatic synthesis of O-linked sialyl oligosaccharides
-
Blixt, O., Allin, K., Pereira, L., Datta, A. & Paulson, J. C. Efficient chemoenzymatic synthesis of O-linked sialyl oligosaccharides. J. Am. Chem. Soc. 124, 5739-5746 (2002).
-
(2002)
J. Am. Chem. Soc.
, vol.124
, pp. 5739-5746
-
-
Blixt, O.1
Allin, K.2
Pereira, L.3
Datta, A.4
Paulson, J.C.5
-
57
-
-
0035956939
-
Galactose-extended glycans of antibodies produced by transgenic plants
-
Bakker, H. et al. Galactose-extended glycans of antibodies produced by transgenic plants. Proc Natl Acad. Sci. USA 98, 2899-2904 (2001). In this study, a transgenic tobacco line that expressed the heavy and light chains of a murine antibody was crossed with a line that expressed human β-1,4-galactosyltransferase. The progeny produced antibodies ∼30% of which had partially galactosylated N-glycans, which provided a useful approach for the 'humanization' of plant glycans.
-
(2001)
Proc Natl Acad. Sci. USA
, vol.98
, pp. 2899-2904
-
-
Bakker, H.1
-
58
-
-
0034050074
-
Species-specific variation in glycosylation of IgG: Evidence for the species-specific sialylation and branch-specific galactosylation and importance for engineering recombinant glycoprotein therapeutics
-
Raju, T. S., Briggs, J., Borge, S. M. & Jones, A. J. S. Species-specific variation in glycosylation of IgG: evidence for the species-specific sialylation and branch-specific galactosylation and importance for engineering recombinant glycoprotein therapeutics. Glycobiology 10, 477-486 (2000). In this study, cell-specific glycosylation of immunoglobulins was studied by mass spectrometry and capillary electrophoresis/laser-induced fluorescence in 13 different animal systems. The glycan patterns were found to be unique in different species, which indicated that some might be more suitable than others for the production of human therapeutic proteins. The same might apply to plant systems, which were not considered in this paper.
-
(2000)
Glycobiology
, vol.10
, pp. 477-486
-
-
Raju, T.S.1
Briggs, J.2
Borge, S.M.3
Jones, A.J.S.4
-
59
-
-
0032916112
-
Production of recombinant proteins in plant root exudates
-
Borisjuk, N. V. et al. Production of recombinant proteins in plant root exudates. Nature Biotechnol. 17, 466-469 (1999).
-
(1999)
Nature Biotechnol.
, vol.17
, pp. 466-469
-
-
Borisjuk, N.V.1
-
60
-
-
0033729827
-
Production of recombinant proteins in tobacco guttation fluid
-
Komarnytsky, S., Borisjuk, N. V., Borisjuk, L. G., Alam, M. Z. & Raskin, I. Production of recombinant proteins in tobacco guttation fluid. Plant Physiol. 124, 927-933 (2000).
-
(2000)
Plant Physiol.
, vol.124
, pp. 927-933
-
-
Komarnytsky, S.1
Borisjuk, N.V.2
Borisjuk, L.G.3
Alam, M.Z.4
Raskin, I.5
-
61
-
-
0037703161
-
Rhizosecretion of a monoclonal antibody protein complex from transgenic tobacco roots
-
Drake, P. M. W. et al. Rhizosecretion of a monoclonal antibody protein complex from transgenic tobacco roots. Plant Mol. Biol. 52, 233-241 (2003).
-
(2003)
Plant Mol. Biol.
, vol.52
, pp. 233-241
-
-
Drake, P.M.W.1
-
62
-
-
0036008774
-
Engineering the plastid genome of higher plants
-
Maliga, P. Engineering the plastid genome of higher plants. Curr. Opin. Plant Biol. 5, 164-17212002).
-
(2002)
Curr. Opin. Plant Biol.
, vol.5
, pp. 164-1721
-
-
Maliga, P.1
-
63
-
-
0036481848
-
Milestones in chloroplast genetic engineering: An environmentally friendly era in biotechnology
-
Daniell, H., Khan, M. S. & Allison, L. Milestones in chloroplast genetic engineering: an environmentally friendly era in biotechnology. Trends Plant Sci. 7, 84-91 (2002).
-
(2002)
Trends Plant Sci.
, vol.7
, pp. 84-91
-
-
Daniell, H.1
Khan, M.S.2
Allison, L.3
-
64
-
-
0037440739
-
Expression of tetanus toxin fragment C in tobacco chloroplasts
-
Tregoning, J. S. et al. Expression of tetanus toxin fragment C in tobacco chloroplasts. Nucleic Acids Res. 31, 1174-1179 (2003).
-
(2003)
Nucleic Acids Res.
, vol.31
, pp. 1174-1179
-
-
Tregoning, J.S.1
-
65
-
-
0035979785
-
Expression of the native cholera B toxin subunit gene and assembly as functional oligomers in transgenic tobacco chloroplasts
-
Daniell, H., Lee, S. B., Panchal, T. & Wiebe, P. O. Expression of the native cholera B toxin subunit gene and assembly as functional oligomers in transgenic tobacco chloroplasts J. Mol. Biol. 311, 1001-1009 (2001).
-
(2001)
J. Mol. Biol.
, vol.311
, pp. 1001-1009
-
-
Daniell, H.1
Lee, S.B.2
Panchal, T.3
Wiebe, P.O.4
-
66
-
-
0032852381
-
Fluorescent antibiotic resistance marker for tracking plastid transformation in higher plants
-
Khan, M. S. & Maliga, P. Fluorescent antibiotic resistance marker for tracking plastid transformation in higher plants. Nature Biotechnol. 17, 910-915 (1999).
-
(1999)
Nature Biotechnol.
, vol.17
, pp. 910-915
-
-
Khan, M.S.1
Maliga, P.2
-
67
-
-
0032846881
-
Towards molecular farming in the future: Using plant-cell-suspension cultures as bioreactors
-
Fischer, R., Emans, N., Schuster, F., Hellwig, S. & Drossard, J. Towards molecular farming in the future: using plant-cell-suspension cultures as bioreactors. Biotechnol. Appl. Biochem. 30, 109-112 (1999).
-
(1999)
Biotechnol. Appl. Biochem.
, vol.30
, pp. 109-112
-
-
Fischer, R.1
Emans, N.2
Schuster, F.3
Hellwig, S.4
Drossard, J.5
-
68
-
-
0036355659
-
Practical considerations for pharmaceutical antibody production in different crop systems
-
Stöger, E. et al. Practical considerations for pharmaceutical antibody production in different crop systems. Mol. Breeding 9, 149-158 (2002). This paper considers in detail the factors that should be evaluated when choosing a crop system for the production of pharmaceutical proteins. The same scFv is expressed in many species to compare intrinsic yields, and features such as storage, distribution and biosafety are discussed, as well as economic factors.
-
(2002)
Mol. Breeding
, vol.9
, pp. 149-158
-
-
Stöger, E.1
-
69
-
-
0011977387
-
Commercial production of β-glucuronidase (GUS): A model system for the procluction of proteins in plants
-
Witcher, D. et al. Commercial production of β-glucuronidase (GUS): a model system for the procluction of proteins in plants. Mol. Breeding 4, 301-312 (1998).
-
(1998)
Mol. Breeding
, vol.4
, pp. 301-312
-
-
Witcher, D.1
-
70
-
-
0036901079
-
Monoclonal antibody manufacturing in transgenic plants - Myths and realities
-
Hood, E. E., Woodard, S. L. & Horn, M. E. Monoclonal antibody manufacturing in transgenic plants - myths and realities. Curr. Opin. Biotechnol. 13, 630-635 (2002).
-
(2002)
Curr. Opin. Biotechnol.
, vol.13
, pp. 630-635
-
-
Hood, E.E.1
Woodard, S.L.2
Horn, M.E.3
-
71
-
-
0037070490
-
From green plants to industnal enzymes
-
Hood, E. E. From green plants to industnal enzymes. Enzyme Microbial. Technol. 30, 279-283 (2002).
-
(2002)
Enzyme Microbial. Technol.
, vol.30
, pp. 279-283
-
-
Hood, E.E.1
-
72
-
-
0031790556
-
A humanized monoclonal antibody produced in transgenic plants for immunoprotection of the vagina against genital herpes
-
Zeitlin, L. et al. A humanized monoclonal antibody produced in transgenic plants for immunoprotection of the vagina against genital herpes. Nature Biotechnol. 16, 1361-1364 (1998).
-
(1998)
Nature Biotechnol.
, vol.16
, pp. 1361-1364
-
-
Zeitlin, L.1
-
73
-
-
0033587793
-
Production of a diagnostic monoclonal antibody in perennial alfalfa plants
-
Khoudi, H. et al. Production of a diagnostic monoclonal antibody in perennial alfalfa plants. Biotechnol Bioeng 64, 135-143 (1999).
-
(1999)
Biotechnol. Bioeng
, vol.64
, pp. 135-143
-
-
Khoudi, H.1
-
74
-
-
0033772176
-
Transgenic pea seeds as bioreactors for the production of a single-chain Fv fragment (scFV) antibody used in cancer diagnosis and therapy
-
Perrin, Y. et al. Transgenic pea seeds as bioreactors for the production of a single-chain Fv fragment (scFV) antibody used in cancer diagnosis and therapy. Mol. Breeding 6, 345-352 (2000).
-
(2000)
Mol. Breeding
, vol.6
, pp. 345-352
-
-
Perrin, Y.1
-
75
-
-
0036383059
-
Expression of antibodies and Fab fragments in transgenic potato plants: A case study for bulk production in crop plants
-
De Wilde, C., Peeters, K., Jacobs, A. Peck, I. & Depicker, A. Expression of antibodies and Fab fragments in transgenic potato plants: a case study for bulk production in crop plants. Mol. Breeding 9, 2871-282 (2002).
-
(2002)
Mol. Breeding
, vol.9
, pp. 2871-2282
-
-
De Wilde, C.1
Peeters, K.2
Jacobs, A.3
Peck, I.4
Depicker, A.5
-
76
-
-
0036342361
-
Biopharming the Simpli-RED™ HIV diagnostic reagent in barley, potato and tobacco
-
Schunmann, P. H. D., Coia, G. & Waterhouse, P. M. Biopharming the Simpli-RED™ HIV diagnostic reagent in barley, potato and tobacco. Mol. Breeding 9, 113-121 (2002).
-
(2002)
Mol. Breeding
, vol.9
, pp. 113-121
-
-
Schunmann, P.H.D.1
Coia, G.2
Waterhouse, P.M.3
-
77
-
-
0028863460
-
Expression of the rabies virus glycoprotein in transgenic tomatoes
-
McGarvey, P. B. et al. Expression of the rabies virus glycoprotein in transgenic tomatoes. Biotechnology 13, 1484-1487 (1995)
-
(1995)
Biotechnology
, vol.13
, pp. 1484-1487
-
-
McGarvey, P.B.1
-
78
-
-
0037472387
-
Vaccine antigen production in transgenic plants: Strategies gene constructs and perspectives
-
Sala, F. et al. Vaccine antigen production in transgenic plants: strategies, gene constructs and perspectives Vaccine 21, 803-808 (2003)
-
(2003)
Vaccine
, vol.21
, pp. 803-808
-
-
Sala, F.1
-
80
-
-
0035984713
-
Excision of selectable marker genes from transgenic plants
-
Hare, P. D. & Chua, N.-H. Excision of selectable marker genes from transgenic plants. Nature Biotechnol. 20, 575-579 (2002).
-
(2002)
Nature Biotechnol.
, vol.20
, pp. 575-579
-
-
Hare, P.D.1
Chua, N.-H.2
-
81
-
-
0036537227
-
Marker-free transformation: Increasing transformation frequency by the use of regeneration-promoting genes
-
Zuo, J. R., Niu, Q. W., Ikeda, Y. & Chua, N. H. Marker-free transformation: increasing transformation frequency by the use of regeneration-promoting genes. Curr. Opin. Biotechnol. 13, 173-180 (2002).
-
(2002)
Curr. Opin. Biotechnol.
, vol.13
, pp. 173-180
-
-
Zuo, J.R.1
Niu, Q.W.2
Ikeda, Y.3
Chua, N.H.4
-
83
-
-
0036307494
-
In situ transfer of antibiotic resistance genes from transgenic (transplastomic) tobacco plants to bacteria
-
Kay, E., Vogel, T. M., Bertolla, F., Nalin, R. & Simonet, P. In situ transfer of antibiotic resistance genes from transgenic (transplastomic) tobacco plants to bacteria. Appl. Environ. Microbiol. 68, 3345-3351 (2002).
-
(2002)
Appl. Environ. Microbiol.
, vol.68
, pp. 3345-3351
-
-
Kay, E.1
Vogel, T.M.2
Bertolla, F.3
Nalin, R.4
Simonet, P.5
-
85
-
-
0042750509
-
Product differentiation alternatives: Identity preservation, segregation and traceability
-
Smyth, S & Phillips, R. W. B. Product differentiation alternatives: identity preservation, segregation and traceability. AgBioForum 5, 30-42 (2002).
-
(2002)
AgBioForum
, vol.5
, pp. 30-42
-
-
Smyth, S.1
Phillips, R.W.B.2
-
86
-
-
0037362471
-
Molecular farming of recombinant antibodies in plants
-
Schillberg, S., Fischer, R. & Emans, N. Molecular farming of recombinant antibodies in plants. Cell. Mol. Life Sci. 60, 433-445 (2003). This is a comprehensive discussion of the technical issues concerning the production of antibodies in plants, which is treated in much more detail than is possible in the present review.
-
(2003)
Cell. Mol. Life Sci.
, vol.60
, pp. 433-445
-
-
Schillberg, S.1
Fischer, R.2
Emans, N.3
-
87
-
-
0036535775
-
Plantibodies: Applications, advantages and bottlenecks
-
Stoger, E., Sack, M., Fischer, R. & Christou, P. Plantibodies: applications, advantages and bottlenecks. Curr. Opin. Biotechnol. 13, 161-166 (2002).
-
(2002)
Curr. Opin. Biotechnol.
, vol.13
, pp. 161-166
-
-
Stoger, E.1
Sack, M.2
Fischer, R.3
Christou, P.4
-
88
-
-
0033582277
-
Rapid production of specific vaccines for lymphoma by expression of the tumor-derived single-chain Fv epitopes in tobacco plants
-
McCormick, A. A. et al. Rapid production of specific vaccines for lymphoma by expression of the tumor-derived single-chain Fv epitopes in tobacco plants. Proc. Natl Acad. Sci. USA 96, 703-708 (1999).
-
(1999)
Proc. Natl Acad. Sci. USA
, vol.96
, pp. 703-708
-
-
McCormick, A.A.1
-
89
-
-
0034825803
-
Production of secretory IgA antibodies in plants
-
Larrick, J. W., Yu, L., Naftzger, C., Jaiswat, S. & Wycoff, K. Production of secretory IgA antibodies in plants. Biomolecular Eng. 18, 87-94 (2001). This paper presents a useful summary of recent advances in the plant-based production of secretory IgAs with a discussion of purification methods and production costs.
-
(2001)
Biomolecular Eng.
, vol.18
, pp. 87-94
-
-
Larrick, J.W.1
Yu, L.2
Naftzger, C.3
Jaiswat, S.4
Wycoff, K.5
-
90
-
-
0031835622
-
Characterization of a recombinant plant monoclonal secretory antibody and preventive immunotherapy in humans
-
Ma, J. K. et al. Characterization of a recombinant plant monoclonal secretory antibody and preventive immunotherapy in humans. Nature Med. 4, 601-605 (1998).
-
(1998)
Nature Med.
, vol.4
, pp. 601-605
-
-
Ma, J.K.1
-
91
-
-
0036515168
-
A carcinoembryonic antigen-specific diabody produced in tobacco
-
Vaquero, C. et al. A carcinoembryonic antigen-specific diabody produced in tobacco. FASEB J. 16, 408-410 (2002).
-
(2002)
FASEB J.
, vol.16
, pp. 408-410
-
-
Vaquero, C.1
-
92
-
-
0035988504
-
Efficacy of plant-produced recombinant antibodies against HCG
-
Kathuria, S. et al. Efficacy of plant-produced recombinant antibodies against HCG. Human Reproduction 17, 2054-2061 (2002).
-
(2002)
Human Reproduction
, vol.17
, pp. 2054-2061
-
-
Kathuria, S.1
-
93
-
-
0031081649
-
Plants as bioreactors for pharmaceuticals: Regulatory considerations
-
Miele, L. Plants as bioreactors for pharmaceuticals: regulatory considerations. Trends Biotechnol. 15, 45-50 (1997).
-
(1997)
Trends Biotechnol.
, vol.15
, pp. 45-50
-
-
Miele, L.1
-
94
-
-
0038769415
-
-
(eds Hood, E. E. & Howard, J.) (Kluwer Academic, New York
-
Emlay, D. in Plants as Factories for Protein Production (eds Hood, E. E. & Howard, J.) 175-180 (Kluwer Academic, New York, 2002).
-
(2002)
Plants as Factories for Protein Production
, pp. 175-180
-
-
Emlay, D.1
-
96
-
-
0141533544
-
-
(ed. Lo, B. K. C.) (Humana Press Inc., New Jersey. in the press)
-
Stoger, E., Schillberg, S., Twyman, R. M., Fischer, R. & Christou, P. in Methods in Molecular Biology. Antibody Engineering. Protocols and Methods 2nd edn (ed. Lo, B. K. C.) (Humana Press Inc., New Jersey. in the press).
-
Methods in Molecular Biology. Antibody Engineering. Protocols and Methods 2nd Edn
-
-
Stoger, E.1
Schillberg, S.2
Twyman, R.M.3
Fischer, R.4
Christou, P.5
-
97
-
-
0033779268
-
Plasma membrane display of anti-viral single chain Fv fragments confers resistance to tobacco mosaic virus
-
Schillberg, S., Zimmermann, S., Findlay, K. & Fischer, R. Plasma membrane display of anti-viral single chain Fv fragments confers resistance to tobacco mosaic virus. Mol. Breeding 6, 317-326 (2000).
-
(2000)
Mol. Breeding
, vol.6
, pp. 317-326
-
-
Schillberg, S.1
Zimmermann, S.2
Findlay, K.3
Fischer, R.4
-
98
-
-
0025271471
-
Production of correctly processed human serum albumin in transgenic plants
-
Sijmons, P. C. et al. Production of correctly processed human serum albumin in transgenic plants. Biotechnology 8, 217-221 (1990).
-
(1990)
Biotechnology
, vol.8
, pp. 217-221
-
-
Sijmons, P.C.1
-
99
-
-
0006878489
-
Expression of human α-interferon in plants
-
Zhu, Z. et al. Expression of human α-interferon in plants. Virology 172, 213-222 (1994).
-
(1994)
Virology
, vol.172
, pp. 213-222
-
-
Zhu, Z.1
-
100
-
-
0029257224
-
Characterisation of a human glycoprotein (erythropoetin) produced in cultured tobacco cells
-
Matsumoto, S., Ikura, K, Ueda, M. & Sasaki, R. Characterisation of a human glycoprotein (erythropoetin) produced in cultured tobacco cells. Plant Mol. Biol. 27, 1163-1172 (1995).
-
(1995)
Plant Mol. Biol.
, vol.27
, pp. 1163-1172
-
-
Matsumoto, S.1
Ikura, K.2
Ueda, M.3
Sasaki, R.4
-
101
-
-
2442495347
-
-
(ed Vasil, I.) (Kluwer Academic, Dordrecht. The Netherlands)
-
Delaney, D. et al. in Plant Biotechnology: 2002 and Beyond. Proceedings of the 10th IAPTC&B Congress, Orlando, Florida. (ed Vasil, I.) 393-394 (Kluwer Academic, Dordrecht. The Netherlands, 2002).
-
(2002)
Plant Biotechnology: 2002 and Beyond. Proceedings of the 10th IAPTC&B Congress, Orlando, Florida
, pp. 393-394
-
-
Delaney, D.1
-
102
-
-
0033498455
-
Rice cell culture as an alternative production system for functional diagnostic and therapeutic antibodies
-
Torres, E. et al. Rice cell culture as an alternative production system for functional diagnostic and therapeutic antibodies. Transgenic Res. 8, 441-449 (1999).
-
(1999)
Transgenic Res.
, vol.8
, pp. 441-449
-
-
Torres, E.1
-
103
-
-
0032695258
-
Production of functional human α1-antitrypsin by plant cell culture
-
Terashima, M. et al. Production of functional human α1-antitrypsin by plant cell culture. Appl. Microbiol. Biotechnol. 52, 516-523 (1999).
-
(1999)
Appl. Microbiol. Biotechnol.
, vol.52
, pp. 516-523
-
-
Terashima, M.1
-
104
-
-
0025477259
-
Synthesis and self-assembly of a functional monoclonal antibody in transgenic Nicotiana tabacum
-
Düring, K., Hippe, S., Kreuzaler, F. & Schell, J. Synthesis and self-assembly of a functional monoclonal antibody in transgenic Nicotiana tabacum. Plant Mol. Biol. 15, 281-293 (1990).
-
(1990)
Plant Mol. Biol.
, vol.15
, pp. 281-293
-
-
Düring, K.1
Hippe, S.2
Kreuzaler, F.3
Schell, J.4
-
105
-
-
0029035201
-
Generation and assembly of secretory antibodies in plants
-
Ma, J. K.-C. et al. Generation and assembly of secretory antibodies in plants. Science 268, 716-719 (1995).
-
(1995)
Science
, vol.268
, pp. 716-719
-
-
Ma, J.K.-C.1
-
106
-
-
0031239836
-
Expression and characterization of bryodin 1 and a bryodin 1-based single-chain immunotoxin from tobacco cell culture
-
Francisco, J. A. et al. Expression and characterization of bryodin 1 and a bryodin 1-based single-chain immunotoxin from tobacco cell culture. Bioconjug. Chem. 8, 708-713 (1997).
-
(1997)
Bioconjug. Chem.
, vol.8
, pp. 708-713
-
-
Francisco, J.A.1
-
107
-
-
0037457888
-
Expression and assembly of a fully active antibody in algae
-
Mayfield, S. P. et al. Expression and assembly of a fully active antibody in algae. Proc. Natl Acad. Sci. USA 100, 438-442 (2003).
-
(2003)
Proc. Natl Acad. Sci. USA
, vol.100
, pp. 438-442
-
-
Mayfield, S.P.1
-
108
-
-
0035925713
-
Plant-based vaccines: Unique advantages
-
Streatfield, S. J. et al. Plant-based vaccines: unique advantages. Vaccine 19, 2742-2748 (2001).
-
(2001)
Vaccine
, vol.19
, pp. 2742-2748
-
-
Streatfield, S.J.1
-
109
-
-
0030791484
-
Transgenic plants expressing autoantigens fed to mice to induce oral immune tolerance
-
Ma, S. W. et al. Transgenic plants expressing autoantigens fed to mice to induce oral immune tolerance. Nature Med. 3, 793-796 (1997).
-
(1997)
Nature Med.
, vol.3
, pp. 793-796
-
-
Ma, S.W.1
-
110
-
-
0035018196
-
A plant-based multicomponent vaccine protects mice from enteric diseases
-
Yu, J. & Langridge, W. H. A plant-based multicomponent vaccine protects mice from enteric diseases. Nature Biotechnol. 19, 548-552 (2001).
-
(2001)
Nature Biotechnol.
, vol.19
, pp. 548-552
-
-
Yu, J.1
Langridge, W.H.2
-
111
-
-
0037073630
-
Delivery of subunit vaccines in maize seed
-
Lamphear, B. J. et al. Delivery of subunit vaccines in maize seed. J. Control Release 83, 169-180 (2002).
-
(2002)
J. Control Release
, vol.83
, pp. 169-180
-
-
Lamphear, B.J.1
|