A plant signal peptide-hepatitis B surface antigen fusion protein with enhanced stability and immunogenicity expressed in plant cells

Proceedings of the National Academy of Sciences of the United States of America

Volumn 100, Issue 5, 2003, Pages 2209-2214

  Sojikul, Punchapat ^a,b   Buehner, Norene ^b   Mason, Hugh S ^b,c  

^a Department of Obstetrics Gynecology   (United States)

^b United States Department of Agriculture Agricultural Research Service and Boyce Thompson Institute for Plant Research   (United States)

^c ARIZONA STATE UNIVERSITY   (United States)

Author keywords

Tobacco NT 1 cell; Transgenic plants; Vaccine

Indexed keywords

HEPATITIS B SURFACE ANTIGEN; HYBRID PROTEIN; PROTEIN VSP ALPHA S; PROTEIN VSP ALPHA S HEPATITIS B SURFACE ANTIGEN; PROTEIN VSPA; UNCLASSIFIED DRUG; VEGETABLE PROTEIN;

ANIMAL EXPERIMENT; ANTIGEN EXPRESSION; ARTICLE; DISULFIDE BOND; DRUG DESIGN; DRUG STABILITY; DRUG TARGETING; ENDOPLASMIC RETICULUM; GENETIC CODE; HEPATITIS B; HEPATITIS B VIRUS; HUMAN; HUMAN CELL; IMMUNOGENICITY; LIVER CELL; NONHUMAN; NUCLEOTIDE SEQUENCE; PLANT CELL; PRIORITY JOURNAL; PROTEIN STABILITY; SOYBEAN; TRANSGENIC PLANT; VACCINATION; VACCINE PRODUCTION;

AMINO ACID MOTIFS; AMINO ACID SEQUENCE; ANIMALS; CENTRIFUGATION, DENSITY GRADIENT; ELECTROPORATION; ENDOPLASMIC RETICULUM; ENZYME-LINKED IMMUNOSORBENT ASSAY; GENETIC TECHNIQUES; HEPATITIS B ANTIGENS; MICE; MICE, INBRED BALB C; MOLECULAR SEQUENCE DATA; PEPTIDES; PLANT PROTEINS; PLANTS, GENETICALLY MODIFIED; PLASMIDS; PRECIPITIN TESTS; RECOMBINANT FUSION PROTEINS; SOYBEANS; SUCROSE; TEMPERATURE; TIME FACTORS; TOBACCO;

ANIMALIA; DNA VIRUSES; GLYCINE MAX; HEPATITIS B VIRUS; NICOTIANA TABACUM; VIBRIO PHAGE NT-1;

EID: 0037418173     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.0438037100     Document Type: Article

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