Foods as production and delivery vehicles for human vaccines

Journal of the American College of Nutrition

Volumn 21, Issue , 2002, Pages 212S-217S

  Korban, Schuyler S ^a   Krasnyanski, Sergei F ^a   Buetow, Dennis E ^b  

^a UNIVERSITY OF ILLINOIS AT URBANA CHAMPAIGN   (United States)

^b UNIVERSITY OF ILLINOIS AT URBANA CHAMPAIGN   (United States)

Author keywords

Food crops; Oral edible vaccines; Plant based vaccines; Transgenic plants

Indexed keywords

VACCINE; DRUG VEHICLE;

BIOSYNTHESIS; FOOD; HUMAN; IMMUNOLOGY; INFECTION CONTROL; METHODOLOGY; REVIEW; TRANSGENIC PLANT; ANTIBIOTIC RESISTANCE; BACTERIAL STRAIN; CONFERENCE PAPER; DRUG DELIVERY SYSTEM; GENETIC ENGINEERING; GENETICALLY MODIFIED CROP; IMMUNOGENICITY; INFECTION; VACCINATION;

COMMUNICABLE DISEASE CONTROL; FOOD; HUMANS; PLANTS, GENETICALLY MODIFIED; VACCINES; HUMAN; SUPPORT, NON-U.S. GOV'T; SUPPORT, U.S. GOV'T, NON-P.H.S.;

EID: 0036016077     PISSN: 07315724     EISSN: 15411087     Source Type: Journal    
DOI: 10.1080/07315724.2002.10719268     Document Type: Article

References (26)

1. Scheibner V: Vaccinations 100 Years of Orthodox Research. Santa Fe: New Altantean Press, 1993.
2. Buetow DE, Korban SS: Transgenic plants producing viral and bacterial antigens. AgBiotechnet. CAB Intl., Oxon, UK, www.AgBiotechnet.com, Vol. 2, April, ABN 045, 2000.
3. Giddings G, Allison G, Brooks D, Carter A: Transgenic plants as factories for biopharmaceuticals. Nat Biotech 18:1151-1155, 2000.
4. Daniell H, Streatfield J, Wycoff K: Medical molecular farming: production of antibodies, biopharmaceuticals and edible vaccines in plants. Trends Plant Sci 6:219-226, 2001.
5. Richter L, Kipp PB: Transgenic plants as edible vaccines. Curr Topics Microbiol Immunol 240:159-176, 1999.
6. Mason HS, Lam DMK, Arntzen CJ: Expression of hepatitis B surface antigen in transgenic plants. Proc Natl Acad Sci USA 89:11745-11749, 1992.
7. Thanavala Y, Fang Y-F, Lyons P, Mason HS, Arntzen D: Immunogenecity of transgenic plant-derived hepatitis B surface antigen. Proc Natl Acad Sci USA 92, 3358-3361, 1995.
8. Haq TA, Mason HS, Clements JD, Arntzen CJ: Oral immunization with a recombinant bacterial antigen produced in transgenic plants. Science 268:714-716, 1995.
9. Arakawa T, Chong DKX, Langridge WHR: Efficacy of a food plant-based oral cholera toxin B subunit vaccine. Nat Biotech 16:292-297, 1998.
10. Mason HS, Haq TA, Clements JD, Arntzen CJ: Edible vaccine protects mice against Escherichia coli heat-labile enterotoxin (LT): potatoes expressing a synthetic LT-B gene. Vaccine 16:1336-1343, 1998.
11. Tacket CO, Mason HS, Losonsky G, Clements JD, Levine MM, Arntzen CJ: Immunogenicity in humans of a recombinant bacterial antigen delivered in a transgenic potato. Nat Med 4: 607-609, 1998.
12. Mason HS, Ball JM, Shi JJ, Jiang X, Estes MK, Arntzen CJ: Expression of Norwalk virus capsid protein in transgenic tobacco and potato and its oral immunogenicity in mice. Proc Natl Acad Sci USA 93:5335-5340, 1996.
13. Tacket CO, Mason HS, Losonsky G, Estes MK, Levine MM, Arntzen CJ: Human immune responses to a novel Norwalk virus vaccine delivered in transgenic potatoes. J Infect Dis 182:302-305, 2000.
14. Yu J, Langridge WHR: A plant-based multicomponent vaccine protects mice from enteric diseases. Nat Biotech 19:548-552, 2001.
15. Kapusta J, Modelska A, Figlerowicz M, Pniewski T, Letellier M, Lisowa O, Yusibov V, Koprowski H, Plucienniczak A, Legocki AN: A plant-derived vaccine against hepatitis B virus. FASEB J 13:1796-1799, 1999.
16. Zeitlin L, Olmsted SS, Moench TR, Co MS, Martinell BJ, Paradkar VM, Russell DR, Queen C, Cone RA, Whaley KJ: A humanized monoclonal antibody produced in transgenic plants for immunoprotection of the vagina against genital herpes. Nat Biotech 16: 1361-1364, 1998.
17. Streatfield SJ, Jilka JM, Hood EE, Turner DD, Bailey MR, Mayor JM, Woodard SL, Beifuss KK, Horn ME, Delaney DE, Tizard IR, Howard JA: Plant-based vaccines: unique advantages. Vaccine 19:2742-2748, 2001.
18. Stöger E, Vaquero C, Torres E, Sack M, Nicholson L, Drossard J, Williams S, Keen D, Perrin Y, Christou P, Fischer R: Cereal crops as viable production and storage systems for pharmaceutical scFv antibodies. Plant Mol Biol 42:583-590, 2000.
19. Mor TS, Sternfeld M, Soreq H, Arntzen CJ, Mason HS: Expression of recombinant human acetylcholinesterase in transgenic tomato plants. Biotech Bioeng 75:259-266, 2001.
20. Darville T, Yamauchi T: Respiratory syncytial virus. Pediat Rev 19:55-61, 1998.
21. Prober CG, Wang EEL: Reducing the morbidity of lower respiratory tract infections caused by respiratory syncytial virus: still no answer. Pediatrics 99:472-475, 1997.
22. Falsey AR, Walsh EE: Relationship of serum antibody to risk of respiratory syncytial virus infection in elderly adults. J Infec Dis 177:463-466, 1998.
23. Tristram DA, Welliver RC: A vaccine for RSV: Is it possible? Contemp Pediat 13:47-63, 1996.
24. Sandhu JS, Osadjan MD, Krasnyanski SF, Domier LL, Korban SS, Buetow DE: Enhanced expression of the human respiratory syncytial virus-F gene in apple leaf protoplasts. Plant Cell Rep 18: 394-397, 1999.
25. Sandhu JS, Krasnyanski SF, Domier LL, Korban SS, Osadjan MD, Buetow DE: Oral immunization of mice with transgenic tomato fruit expressing respiratory syncytial virus-F protein induces a systemic immune response. Transgenic Res 9:127-135, 2000.
26. Chargelegue D, Obergon P, Drake PMW: Transgenic plants for vaccine production: expectations and limitations. Trends Plant Sci 6:495-496, 2001.