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1
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0032903183
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Chimeric plant virus particles administered nasally or orally induce systemic and mucosal immune responses in mice
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This study demonstrates efficacy of chimeric virus particles in inducing immune responses after three different delivery formats
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Brennan F, Bellaby T, Helliwell S, Jones T, Kamstrup S, Dalsgaard K, Flock J, Hamilton W: Chimeric plant virus particles administered nasally or orally induce systemic and mucosal immune responses in mice. J Virol 1999, 73:930-938. This study demonstrates efficacy of chimeric virus particles in inducing immune responses after three different delivery formats.
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J Virol
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Brennan, F.1
Bellaby, T.2
Helliwell, S.3
Jones, T.4
Kamstrup, S.5
Dalsgaard, K.6
Flock, J.7
Hamilton, W.8
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2
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0032921502
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Pseudomonas aeruginosa outermembrane protein F epitopes are highly immunogenic in mice when expressed on a plant virus
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Brennan F, Jones T, Gilleland L, Bellaby T, Xu F, North P, Thompson A, Staczek J, Lin T, JOhnson J et al.: Pseudomonas aeruginosa outermembrane protein F epitopes are highly immunogenic in mice when expressed on a plant virus. Microbiol 1999, 145:211-220.
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Microbiol
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Brennan, F.1
Jones, T.2
Gilleland, L.3
Bellaby, T.4
Xu, F.5
North, P.6
Thompson, A.7
Staczek, J.8
Lin, T.9
Johnson, J.10
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3
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0030891738
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Plant- derived vaccine protects target animals against a viral disease
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Dalsgaard K, Uttenthal A, Jones T, Xu F, Merryweather A, Hamilton W, Langeveld J, Boshuizen R, Kamstrup S, Lomonossoff P et al.: Plant- derivedderived vaccine protects target animals against a viral disease. Nat Biotechnol 1997, 15:248-252.
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Nat Biotechnol
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Dalsgaard, K.1
Uttenthal, A.2
Jones, T.3
Xu, F.4
Merryweather, A.5
Hamilton, W.6
Langeveld, J.7
Boshuizen, R.8
Kamstrup, S.9
Lomonossoff, P.10
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4
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0032478127
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Immunization against rabies with plant-derived antigen
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Modelska A, BIetzschold B, Sleysh N, Fu Z, Steplewski K, Hooper D, Koprowski H, Yusibov V: Immunization against rabies with plant- derived antigen. Proc Natl Acad Sci USA 1998, 95:2481-2485.
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Proc Natl Acad Sci USA
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Modelska, A.1
Bietzschold, B.2
Sleysh, N.3
Fu, Z.4
Steplewski, K.5
Hooper, D.6
Koprowski, H.7
Yusibov, V.8
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5
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0031790556
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A humanized monoclonal antibody produced in transgenic plants for immunoprotection of the vagina against genital herpes
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A soybean-derived humanized monoclonal antibody protected mice from genital herpes when applied topically to the vagina
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Zeitlin L, Olmsted S, Moench T, Co M, Martinell B, Paradkar V, Russell D, Queen C, Cone R, Whaley K: A humanized monoclonal antibody produced in transgenic plants for immunoprotection of the vagina against genital herpes. Nat Biotechnol 1998, 16:1361-1364. A soybean-derived humanized monoclonal antibody protected mice from genital herpes when applied topically to the vagina.
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Nat Biotechnol
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Zeitlin, L.1
Olmsted, S.2
Moench, T.3
Co, M.4
Martinell, B.5
Paradkar, V.6
Russell, D.7
Queen, C.8
Cone, R.9
Whaley, K.10
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6
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0024959945
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Production of antibodies in transgenic plants
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Hiatt A, Cafferkey R, Bowdish K: Production of antibodies in transgenic plants. Nature 1989, 342:76-78.
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Nature
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Hiatt, A.1
Cafferkey, R.2
Bowdish, K.3
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7
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0032168897
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Compartment specific accumulation of recombinant immunoglobulins in plant cells: An essential tool for antibody production and immunomodulation of physiological functions and pathogen activity
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Conrad U, Fiedler U: Compartment specific accumulation of recombinant immunoglobulins in plant cells: An essential tool for antibody production and immunomodulation of physiological functions and pathogen activity. Plant Mol Biol 1998, 38:101-109.
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Plant Mol Biol
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Conrad, U.1
Fiedler, U.2
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8
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0032103446
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Depicker: Accumulation patterns of IgG antibodies and F-ab fragments in transgenic Arabidopsis thaliana plants
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De Wilde C, De RYcke R, Beeckman T, De Neve M, Montagu MV, Engler G, Depicker: Accumulation patterns of IgG antibodies and F-ab fragments in transgenic Arabidopsis thaliana plants. Plant Cell Physiol 1998, 39:639-646.
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Plant Cell Physiol
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De Wilde, C.1
De Rycke, R.2
Beeckman, T.3
De Neve, M.4
Montagu, M.V.5
Engler, G.6
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9
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0029035201
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Generation and assembly of secretory antibodies in plants
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Ma J, Hiatt A, Hein M, Vine N, Wang F, Stabila P, Van Dolleweerd C, Mostov K, Lehner T: Generation and assembly of secretory antibodies in plants. Science 1995, 268:716-719.
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Ma, J.1
Hiatt, A.2
Hein, M.3
Vine, N.4
Wang, F.5
Stabila, P.6
Van Dolleweerd, C.7
Mostov, K.8
Lehner, T.9
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10
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0003266615
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EPIcyte produces antibodies in plants
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February: 15
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Potera C: Epicyte produces antibodies in plants. Gen Eng News 1999, February: 15.
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(1999)
Gen Eng News
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Potera, C.1
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11
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0031732939
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Expression and assembly of a full- length monoclonal antibody in plants using a plant virus vector
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Verch T, Yusibov V, Koprowski H: Expression and assembly of a full- lengthlength monoclonal antibody in plants using a plant virus vector. J Immunol Methods 1998, 220:69-75.
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J Immunol Methods
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Verch, T.1
Yusibov, V.2
Koprowski, H.3
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12
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0000217415
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Commercial production of avidin from transgenic maize: Characterization of transformant, production, processing, extraction and purification
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Hood E, Witcher D, Maddock S, Meyer T, Baszczynski C, Bailey M, Flynn P, Register J, Marshall L, Bond D et al.: Commercial production of avidin from transgenic maize: Characterization of transformant, production, processing, extraction and purification. Mol Breed 1997, 3:291-306.
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Mol Breed
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Hood, E.1
Witcher, D.2
Maddock, S.3
Meyer, T.4
Baszczynski, C.5
Bailey, M.6
Flynn, P.7
Register, J.8
Marshall, L.9
Bond, D.10
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13
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0011977387
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Commercial production of β-glucuronidase (GUS): A model system for the production of proteins in plants
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Witcher D, Hood E, Peterson D, Bailey M, Bond D, Kusnadi A, Evangelista R, Nikolov Z, Wooge C, Mehigh R et al.: commercial production of β-glucuronidase (GUS): A model system for the production of proteins in plants. Mol Breed 1998, 4:301-312.
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Mol Breed
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Witcher, D.1
Hood, E.2
Peterson, D.3
Bailey, M.4
Bond, D.5
Kusnadi, A.6
Evangelista, R.7
Nikolov, Z.8
Wooge, C.9
Mehigh, R.10
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14
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0033280755
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Molecular farming of industrial proteins from transgenic maize
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Edited by Shahidi F, Kolodziejczyk P, Whitaker J, Lopez Munguia A, Fuller G. Plenum Publishing Corp.; This chapter summarizes all aspects of production of the first two products marketed from transgenic maize - transformation, biochemistry, genetics, scale-up, processing, and purification
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Hood E, Kusnadi A, Nikolov Z, Howard J: Molecular farming of industrial proteins from transgenic maize. In Chemicals Via Higher Plant Bioengineering. Edited by Shahidi F, Kolodziejczyk P, Whitaker J, Lopez Munguia A, Fuller G. Plenum Publishing Corp.; 1999:127-148. This chapter summarizes all aspects of production of the first two products marketed from transgenic maize - transformation, biochemistry, genetics, scale-up, processing, and purification.
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(1999)
Chemicals Via Higher Plant Bioengineering
, pp. 127-148
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Hood, E.1
Kusnadi, A.2
Nikolov, Z.3
Howard, J.4
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15
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0031555505
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Production of recombinant proteins in transgenic plants: Practical considerations
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Kusnadi A, Nikolov Z, Howard J: Production of recombinant proteins in transgenic plants: Practical considerations. Biotechnol Bioeng 1997, 56:473-484.
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Biotechnol Bioeng
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Kusnadi, A.1
Nikolov, Z.2
Howard, J.3
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16
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85030366466
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Accumulation of thermostable endo-1,4-β-D-glucanase in the apoplast of Arabidopsis thaliana
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in press. A cell-wall degrading enzyme, endo-1,4-β-D-glucanase, was expressed at 25% of total soluble protein in Arabidopis. This thermophilic enzyme was not active at normal growth temperatures and did not degrade plant tissues with which it was in direct contact
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Ziegler M, Thomas S, Danna K: Accumulation of thermostable endo-1,4-β-D-glucanase in the apoplast of Arabidopsis thaliana. Mol Breed 1999, in press. A cell-wall degrading enzyme, endo-1,4-β-D-glucanase, was expressed at 25% of total soluble protein in Arabidopis. This thermophilic enzyme was not active at normal growth temperatures and did not degrade plant tissues with which it was in direct contact.
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(1999)
Mol Breed
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Ziegler, M.1
Thomas, S.2
Danna, K.3
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17
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0000450509
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Plant seed oil-bodies as an immobilization matrix for a recombinant xylanase from the rumen fungus Neocallimastix patriciarum
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Liu J, Selinger B, Cheng K, Beauchemin K, MOloney M: Plant seed oil-bodies as an immobilization matrix for a recombinant xylanase from the rumen fungus Neocallimastix patriciarum. Mol Breed 1997, 3:463-470.
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Mol Breed
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Liu, J.1
Selinger, B.2
Cheng, K.3
Beauchemin, K.4
Moloney, M.5
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18
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0031281621
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Expression of cholera toxin B subunit oligomers in transgenic potato plants
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Arakawa T, Chong D, Merritt J, Langridge W: Expression of cholera toxin B subunit oligomers in transgenic potato plants. Trans Res 1997, 6:403-413.
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Trans Res
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Arakawa, T.1
Chong, D.2
Merritt, J.3
Langridge, W.4
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19
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0031935290
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Efficacy of a food plant-based oral cholera toxin B subunit vaccine
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Arakawa T, Chong D, Langridge W: Efficacy of a food plant-based oral cholera toxin B subunit vaccine. Nat Biotechnol 1998, 16:292-297.
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Nat Biotechnol
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Arakawa, T.1
Chong, D.2
Langridge, W.3
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20
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0031863854
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Immunogenicity in humans of a recombinant bacterial antigen delivered in a transgenic potato
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Tacket C, Mason H, Losonsky G, Clement J, Levine M, Arntzen C: Immunogenicity in humans of a recombinant bacterial antigen delivered in a transgenic potato. Nat Med 1998, 4:607-609.
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Nat Med
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Tacket, C.1
Mason, H.2
Losonsky, G.3
Clement, J.4
Levine, M.5
Arntzen, C.6
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21
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0029584041
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Structural requirements of oleosin domains for subcellular targeting to the oilbody
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Rooijen V, MOloney M: Structural requirements of oleosin domains for subcellular targeting to the oilbody. Plant Physiol 1995, 109:1353-1361.
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Plant Physiol
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Rooijen, V.1
Moloney, M.2
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22
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0031908631
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Production and purification of two recombinant proteins from transgenic corn
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Key issues in stability and fractionation are addressed in relation to avidin and GUS, the first two commercially sold proteins from transgenic plants
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Kusnadi A, Hood E, Witcher D, Howard J, Nikolov Z: Production and purification of two recombinant proteins from transgenic corn. Biotechnol Prog 1998, 14:149-155. Key issues in stability and fractionation are addressed in relation to avidin and GUS, the first two commercially sold proteins from transgenic plants.
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(1998)
Biotechnol Prog
, vol.14
, pp. 149-155
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Kusnadi, A.1
Hood, E.2
Witcher, D.3
Howard, J.4
Nikolov, Z.5
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23
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0032487368
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Processing of transgenic corn seed and its effect on the recovery of recombinant β-glucuronidase
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A complete paradigm is developed for processing, extraction and purification of an enzyme from transgenic maize
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Kusnadi A, Evangelista R, Hood E, Howard J, Nikolov Z: Processing of transgenic corn seed and its effect on the recovery of recombinant β-glucuronidase. Biotechnol Bioeng 1998, 60:44-52. A complete paradigm is developed for processing, extraction and purification of an enzyme from transgenic maize.
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Biotechnol Bioeng
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Kusnadi, A.1
Evangelista, R.2
Hood, E.3
Howard, J.4
Nikolov, Z.5
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24
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0032146489
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Edible vaccine protects mice against Escherichia coli heat-labile enterotoxin (LT): Potatoes expressing a synthetic LT-B gene
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Mason H, Haq T, Clements J, Arntzen C: Edible vaccine protects mice against Escherichia coli heat-labile enterotoxin (LT): Potatoes expressing a synthetic LT-B gene. Vaccine 1998, 16:1336-1343.
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Vaccine
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Mason, H.1
Haq, T.2
Clements, J.3
Arntzen, C.4
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25
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0031835622
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Characterization of a recombinant plant monoclonal secretory antibody and preventive immunotherapy in human
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This study describes the first human clinical trial in which a protein from a transgenic plant was effective in disease prevention. A monoclonal anti- body was applied topically to teeth and prevented colonization by Streptococcus mutans
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Ma K, Hikmat B, Wycoff K, Vine N, Chargelegue D, Yu L, Hein M, Lehner T: Characterization of a recombinant plant monoclonal secretory antibody and preventive immunotherapy in human. Nat Med 1998, 4:601-606. This study describes the first human clinical trial in which a protein from a transgenic plant was effective in disease prevention. A monoclonal anti- body was applied topically to teeth and prevented colonization by Streptococcus mutans.
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(1998)
Nat Med
, vol.4
, pp. 601-606
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Ma, K.1
Hikmat, B.2
Wycoff, K.3
Vine, N.4
Chargelegue, D.5
Yu, L.6
Hein, M.7
Lehner, T.8
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