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Volumn 595, Issue 24, 2017, Pages 7275-7309

The role of declining adaptive homeostasis in ageing

Author keywords

caloric restriction; cold shock; emotional stress; exercise induced adaptation; heat shock; hypoxia; immune response; Lon protease; mechanical stress; Nrf2 Keap1; osmotic stress; oxidative stress; proteasome; stress response

Indexed keywords

COLD SHOCK PROTEIN; GLUCOSE REGULATED PROTEIN 78; GLUCOSE REGULATED PROTEIN 94; HEAT SHOCK TRANSCRIPTION FACTOR 1; HYPOXIA INDUCIBLE FACTOR 1; KELCH LIKE ECH ASSOCIATED PROTEIN 1; SIRTUIN; TRANSCRIPTION FACTOR NRF2;

EID: 85034792651     PISSN: 00223751     EISSN: 14697793     Source Type: Journal    
DOI: 10.1113/JP275072     Document Type: Review
Times cited : (149)

References (414)
  • 1
    • 0037247359 scopus 로고    scopus 로고
    • Plasticity of skeletal muscle mitochondria in response to contractile activity
    • Adhihetty PJ, Irrcher I, Joseph AM, Ljubicic V & Hood DA (2003). Plasticity of skeletal muscle mitochondria in response to contractile activity. Exp Physiol 88, 99–107.
    • (2003) Exp Physiol , vol.88 , pp. 99-107
    • Adhihetty, P.J.1    Irrcher, I.2    Joseph, A.M.3    Ljubicic, V.4    Hood, D.A.5
  • 2
    • 0033543566 scopus 로고    scopus 로고
    • Nrf2, a Cap'n’Collar transcription factor, regulates induction of the heme oxygenase-1 gene
    • Alam J, Stewart D, Touchard C, Boinapally S, Choi AM & Cook JL (1999). Nrf2, a Cap'n’Collar transcription factor, regulates induction of the heme oxygenase-1 gene. J Biol Chem 274, 26071–26078.
    • (1999) J Biol Chem , vol.274 , pp. 26071-26078
    • Alam, J.1    Stewart, D.2    Touchard, C.3    Boinapally, S.4    Choi, A.M.5    Cook, J.L.6
  • 3
    • 0028302033 scopus 로고
    • GPD1, which encodes glycerol-3-phosphate dehydrogenase, is essential for growth under osmotic stress in Saccharomyces cerevisiae, and its expression is regulated by the high-osmolarity glycerol response pathway
    • Albertyn J, Hohmann S, Thevelein JM & Prior BA (1994). GPD1, which encodes glycerol-3-phosphate dehydrogenase, is essential for growth under osmotic stress in Saccharomyces cerevisiae, and its expression is regulated by the high-osmolarity glycerol response pathway. Mol Cell Biol 14, 4135–4144.
    • (1994) Mol Cell Biol , vol.14 , pp. 4135-4144
    • Albertyn, J.1    Hohmann, S.2    Thevelein, J.M.3    Prior, B.A.4
  • 4
    • 33646066296 scopus 로고    scopus 로고
    • The cold-shock response in cultured mammalian cells: Harnessing the response for the improvement of recombinant protein production
    • Al-Fageeh MB, Marchant RJ, Carden MJ & Smales CM (2006). The cold-shock response in cultured mammalian cells: Harnessing the response for the improvement of recombinant protein production. Biotechnol Bioeng 93, 829–835.
    • (2006) Biotechnol Bioeng , vol.93 , pp. 829-835
    • Al-Fageeh, M.B.1    Marchant, R.J.2    Carden, M.J.3    Smales, C.M.4
  • 8
    • 84929484253 scopus 로고    scopus 로고
    • Candidate genes that affect aging through protein homeostasis
    • In, ed., Atzmon PG, Springer New York, New York
    • Argon Y & Gidalevitz T (2015). Candidate genes that affect aging through protein homeostasis. In Longevity Genes: A Blueprint for Aging, ed. Atzmon PG, pp. 45–72. Springer New York, New York.
    • (2015) Longevity Genes: A Blueprint for Aging , pp. 45-72
    • Argon, Y.1    Gidalevitz, T.2
  • 9
    • 79251519000 scopus 로고    scopus 로고
    • In vivo estimation of the contribution of elastin and collagen to the mechanical properties in the human abdominal aorta: effect of age and sex
    • Åstrand H, Stålhand J, Karlsson J, Karlsson M, Sonesson B & Länne T (2011). In vivo estimation of the contribution of elastin and collagen to the mechanical properties in the human abdominal aorta: effect of age and sex. J Appl Physiol 110, 176–187.
    • (2011) J Appl Physiol , vol.110 , pp. 176-187
    • Åstrand, H.1    Stålhand, J.2    Karlsson, J.3    Karlsson, M.4    Sonesson, B.5    Länne, T.6
  • 10
    • 4444378251 scopus 로고    scopus 로고
    • Hormesis” – an inappropriate extrapolation from the specific to the universal
    • Axelrod D, Burns K, Davis D & Von Larebeke N (2004). “Hormesis” – an inappropriate extrapolation from the specific to the universal. Int J Occup Environ Health 10, 335–339.
    • (2004) Int J Occup Environ Health , vol.10 , pp. 335-339
    • Axelrod, D.1    Burns, K.2    Davis, D.3    Von Larebeke, N.4
  • 11
    • 0033369476 scopus 로고    scopus 로고
    • Mitochondrial oxygen radical generation and leak: sites of production in states 4 and 3, organ specificity, and relation to aging and longevity
    • Barja G (1999). Mitochondrial oxygen radical generation and leak: sites of production in states 4 and 3, organ specificity, and relation to aging and longevity. J Bioenerg Biomembr 31, 347–366.
    • (1999) J Bioenerg Biomembr , vol.31 , pp. 347-366
    • Barja, G.1
  • 12
    • 4544322045 scopus 로고    scopus 로고
    • Free radicals and aging
    • Barja G (2004). Free radicals and aging. Trends Neurosci 27, 595–600.
    • (2004) Trends Neurosci , vol.27 , pp. 595-600
    • Barja, G.1
  • 15
    • 84929842908 scopus 로고    scopus 로고
    • Hypoxic preconditioning of mesenchymal stromal cells induces metabolic changes, enhances survival, and promotes cell retention in vivo
    • Beegle J, Lakatos K, Kalomoiris S, Stewart H, Isseroff RR, Nolta JA & Fierro FA (2015). Hypoxic preconditioning of mesenchymal stromal cells induces metabolic changes, enhances survival, and promotes cell retention in vivo. Stem Cells 33, 1818–1828.
    • (2015) Stem Cells , vol.33 , pp. 1818-1828
    • Beegle, J.1    Lakatos, K.2    Kalomoiris, S.3    Stewart, H.4    Isseroff, R.R.5    Nolta, J.A.6    Fierro, F.A.7
  • 17
    • 70349266064 scopus 로고    scopus 로고
    • Collapse of proteostasis represents an early molecular event in Caenorhabditis elegans aging
    • Ben-Zvi A, Miller EA & Morimoto RI (2009). Collapse of proteostasis represents an early molecular event in Caenorhabditis elegans aging. Proc Natl Acad Sci USA 106, 14914–14919.
    • (2009) Proc Natl Acad Sci USA , vol.106 , pp. 14914-14919
    • Ben-Zvi, A.1    Miller, E.A.2    Morimoto, R.I.3
  • 19
    • 84948799393 scopus 로고    scopus 로고
    • LON is the master protease that protects against protein aggregation in human mitochondria through direct degradation of misfolded proteins
    • Bezawork-Geleta A, Brodie EJ, Dougan DA & Truscott KN (2015). LON is the master protease that protects against protein aggregation in human mitochondria through direct degradation of misfolded proteins. Sci Rep 5, 17397.
    • (2015) Sci Rep , vol.5 , pp. 17397
    • Bezawork-Geleta, A.1    Brodie, E.J.2    Dougan, D.A.3    Truscott, K.N.4
  • 20
    • 12344286371 scopus 로고    scopus 로고
    • Time course of molecular responses of human skeletal muscle to acute bouts of resistance exercise
    • Bickel CS, Slade J, Mahoney E, Haddad F, Dudley GA & Adams GR (2005). Time course of molecular responses of human skeletal muscle to acute bouts of resistance exercise. J Appl Physiol (1985) 98, 482–488.
    • (2005) J Appl Physiol (1985) , vol.98 , pp. 482-488
    • Bickel, C.S.1    Slade, J.2    Mahoney, E.3    Haddad, F.4    Dudley, G.A.5    Adams, G.R.6
  • 22
    • 83755206847 scopus 로고    scopus 로고
    • Hormesis does not make sense except in the light of TOR-driven aging
    • Blagosklonny MV (2011). Hormesis does not make sense except in the light of TOR-driven aging. Aging (Albany NY) 3, 1051–1062.
    • (2011) Aging (Albany NY) , vol.3 , pp. 1051-1062
    • Blagosklonny, M.V.1
  • 23
    • 84923392191 scopus 로고    scopus 로고
    • Oxidative stress components explored in anoxic and hypoxic global gene expression data
    • In, Springer
    • Blokhina OB, Törönen P & Fagerstedt KV (2014). Oxidative stress components explored in anoxic and hypoxic global gene expression data. In Low-Oxygen Stress in Plants, pp. 19–39. Springer.
    • (2014) Low-Oxygen Stress in Plants , pp. 19-39
    • Blokhina, O.B.1    Törönen, P.2    Fagerstedt, K.V.3
  • 24
    • 80052210886 scopus 로고    scopus 로고
    • The ageing cardiovascular system
    • Bolton E & Rajkumar C (2011). The ageing cardiovascular system. Rev Clin Gerontol 21, 99–109.
    • (2011) Rev Clin Gerontol , vol.21 , pp. 99-109
    • Bolton, E.1    Rajkumar, C.2
  • 26
    • 37349115260 scopus 로고    scopus 로고
    • Effects of aging and hypoxia-inducible factor-1 activity on angiogenic cell mobilization and recovery of perfusion after limb ischemia
    • Bosch-Marce M, Okuyama H, Wesley JB, Sarkar K, Kimura H, Liu YV, Zhang H, Strazza M, Rey S & Savino L (2007). Effects of aging and hypoxia-inducible factor-1 activity on angiogenic cell mobilization and recovery of perfusion after limb ischemia. Circ Res 101, 1310–1318.
    • (2007) Circ Res , vol.101 , pp. 1310-1318
    • Bosch-Marce, M.1    Okuyama, H.2    Wesley, J.B.3    Sarkar, K.4    Kimura, H.5    Liu, Y.V.6    Zhang, H.7    Strazza, M.8    Rey, S.9    Savino, L.10
  • 27
    • 84979231413 scopus 로고    scopus 로고
    • Mitochondrial Lon protease in human disease and aging: Including an etiologic classification of Lon-related diseases and disorders
    • Bota DA & Davies KJA (2016). Mitochondrial Lon protease in human disease and aging: Including an etiologic classification of Lon-related diseases and disorders. Free Radic Biol Med 100, 188–198.
    • (2016) Free Radic Biol Med , vol.100 , pp. 188-198
    • Bota, D.A.1    Davies, K.J.A.2
  • 28
    • 84960091385 scopus 로고    scopus 로고
    • Nrf2 silencing to inhibit proteolytic defense induced by hyperthermia in HT22 cells
    • Bozaykut P, Ozer NK & Karademir B (2016). Nrf2 silencing to inhibit proteolytic defense induced by hyperthermia in HT22 cells. Redox Biol 8, 323–332.
    • (2016) Redox Biol , vol.8 , pp. 323-332
    • Bozaykut, P.1    Ozer, N.K.2    Karademir, B.3
  • 31
    • 0031961688 scopus 로고    scopus 로고
    • Regulation of translational initiation during cellular responses to stress
    • Brostrom CO & Brostrom MA (1998). Regulation of translational initiation during cellular responses to stress. Prog Nucleic Acid Res Mol Biol 58, 79–125.
    • (1998) Prog Nucleic Acid Res Mol Biol , vol.58 , pp. 79-125
    • Brostrom, C.O.1    Brostrom, M.A.2
  • 32
    • 84866544628 scopus 로고    scopus 로고
    • The endoplasmic reticulum stress response in aging and age-related diseases
    • Brown MK & Naidoo N (2012). The endoplasmic reticulum stress response in aging and age-related diseases. Front Physiol 3, 263.
    • (2012) Front Physiol , vol.3 , pp. 263
    • Brown, M.K.1    Naidoo, N.2
  • 34
    • 10244280511 scopus 로고    scopus 로고
    • The maturing of hormesis as a credible dose-response model
    • Calabrese EJ (2003). The maturing of hormesis as a credible dose-response model. Nonlinearity Biol Toxico Med 1, 319–343.
    • (2003) Nonlinearity Biol Toxico Med , vol.1 , pp. 319-343
    • Calabrese, E.J.1
  • 35
    • 11144337431 scopus 로고    scopus 로고
    • Hormesis: a revolution in toxicology, risk assessment and medicine
    • Calabrese EJ (2004). Hormesis: a revolution in toxicology, risk assessment and medicine. EMBO Rep 5, S37–S40.
    • (2004) EMBO Rep , vol.5 , pp. S37-S40
    • Calabrese, E.J.1
  • 36
    • 22544476468 scopus 로고    scopus 로고
    • Paradigm lost, paradigm found: the re-emergence of hormesis as a fundamental dose response model in the toxicological sciences
    • Calabrese EJ (2005). Paradigm lost, paradigm found: the re-emergence of hormesis as a fundamental dose response model in the toxicological sciences. Environ Pollut 138, 378–411.
    • (2005) Environ Pollut , vol.138 , pp. 378-411
    • Calabrese, E.J.1
  • 37
    • 0037434705 scopus 로고    scopus 로고
    • Toxicology rethinks its central belief
    • Calabrese EJ & Baldwin LA (2003). Toxicology rethinks its central belief. Nature 421, 691–692.
    • (2003) Nature , vol.421 , pp. 691-692
    • Calabrese, E.J.1    Baldwin, L.A.2
  • 40
    • 0028155756 scopus 로고
    • Adaptation of muscle glucose transport with caloric restriction in adult, middle-aged, and old rats
    • Cartee G, Kietzke E & Briggs-Tung C (1994). Adaptation of muscle glucose transport with caloric restriction in adult, middle-aged, and old rats. Am J Physiol Regul Integr Comp Physiol 266, R1443–R1447.
    • (1994) Am J Physiol Regul Integr Comp Physiol , vol.266 , pp. R1443-R1447
    • Cartee, G.1    Kietzke, E.2    Briggs-Tung, C.3
  • 42
    • 84879391795 scopus 로고    scopus 로고
    • SIRT1 mediates central circadian control in the SCN by a mechanism that decays with aging
    • Chang H-C & Guarente L (2013). SIRT1 mediates central circadian control in the SCN by a mechanism that decays with aging. Cell 153, 1448–1460.
    • (2013) Cell , vol.153 , pp. 1448-1460
    • Chang, H.-C.1    Guarente, L.2
  • 44
    • 34250774463 scopus 로고    scopus 로고
    • Role of endothelial shear stress in the natural history of coronary atherosclerosis and vascular remodeling: molecular, cellular, and vascular behavior
    • Chatzizisis YS, Coskun AU, Jonas M, Edelman ER, Feldman CL & Stone PH (2007). Role of endothelial shear stress in the natural history of coronary atherosclerosis and vascular remodeling: molecular, cellular, and vascular behavior. J Am Coll Cardiol 49, 2379–2393.
    • (2007) J Am Coll Cardiol , vol.49 , pp. 2379-2393
    • Chatzizisis, Y.S.1    Coskun, A.U.2    Jonas, M.3    Edelman, E.R.4    Feldman, C.L.5    Stone, P.H.6
  • 46
    • 79957979314 scopus 로고    scopus 로고
    • Tumour suppressor SIRT3 deacetylates and activates manganese superoxide dismutase to scavenge ROS
    • Chen Y, Zhang J, Lin Y, Lei Q, Guan KL, Zhao S & Xiong Y (2011). Tumour suppressor SIRT3 deacetylates and activates manganese superoxide dismutase to scavenge ROS. EMBO Rep 12, 534–541.
    • (2011) EMBO Rep , vol.12 , pp. 534-541
    • Chen, Y.1    Zhang, J.2    Lin, Y.3    Lei, Q.4    Guan, K.L.5    Zhao, S.6    Xiong, Y.7
  • 48
    • 57349200362 scopus 로고    scopus 로고
    • Genome-wide RNAi screen and in vivo protein aggregation reporters identify degradation of damaged proteins as an essential hypertonic stress response
    • Choe KP & Strange K (2008). Genome-wide RNAi screen and in vivo protein aggregation reporters identify degradation of damaged proteins as an essential hypertonic stress response. Am J Physiol Cell Physiol 295, C1488–C1498.
    • (2008) Am J Physiol Cell Physiol , vol.295 , pp. C1488-C1498
    • Choe, K.P.1    Strange, K.2
  • 49
    • 84897683362 scopus 로고    scopus 로고
    • Aging: It's SIRTainly possible to restore mitochondrial dysfunction
    • Christian Brooke E & Shadel Gerald S (2014). Aging: It's SIRTainly possible to restore mitochondrial dysfunction. Curr Biol 24, R206–R208.
    • (2014) Curr Biol , vol.24 , pp. R206-R208
    • Christian Brooke, E.1    Shadel Gerald, S.2
  • 53
    • 0034036567 scopus 로고    scopus 로고
    • Hypoxia regulates gene expression of alveolar epithelial transport proteins
    • Clerici C & Matthay MA (2000). Hypoxia regulates gene expression of alveolar epithelial transport proteins. J Appl Physiol 88, 1890–1896.
    • (2000) J Appl Physiol , vol.88 , pp. 1890-1896
    • Clerici, C.1    Matthay, M.A.2
  • 56
    • 35348831738 scopus 로고    scopus 로고
    • Psychological stress and disease
    • Cohen S, Janicki-Deverts D & Miller GE (2007). Psychological stress and disease. JAMA 298, 1685–1687.
    • (2007) JAMA , vol.298 , pp. 1685-1687
    • Cohen, S.1    Janicki-Deverts, D.2    Miller, G.E.3
  • 57
    • 73649113518 scopus 로고    scopus 로고
    • Temporal expression of heat shock genes during cold stress and recovery from chill coma in adult Drosophila melanogaster
    • Colinet H, Lee SF & Hoffmann A (2010). Temporal expression of heat shock genes during cold stress and recovery from chill coma in adult Drosophila melanogaster. FEBS J 277, 174–185.
    • (2010) FEBS J , vol.277 , pp. 174-185
    • Colinet, H.1    Lee, S.F.2    Hoffmann, A.3
  • 63
    • 84964621692 scopus 로고    scopus 로고
    • Adaptive homeostasis
    • Davies KJA (2016). Adaptive homeostasis. Mol Aspects Med 49, 1–7.
    • (2016) Mol Aspects Med , vol.49 , pp. 1-7
    • Davies, K.J.A.1
  • 66
    • 0020494533 scopus 로고
    • Ubisemiquinone radicals in liver: implications for a mitochondrial Q cycle in vivo
    • Davies KJA & Hochstein P (1982). Ubisemiquinone radicals in liver: implications for a mitochondrial Q cycle in vivo. Biochem Biophys Res Commun 107, 1292–1299.
    • (1982) Biochem Biophys Res Commun , vol.107 , pp. 1292-1299
    • Davies, K.J.A.1    Hochstein, P.2
  • 67
    • 0242691880 scopus 로고
    • Muscle mitochondrial bioenergetics, oxygen supply, and work capacity during dietary iron deficiency and repletion
    • Davies KJA, Maguire J, Brooks G, Dallman P & Packer L (1982a). Muscle mitochondrial bioenergetics, oxygen supply, and work capacity during dietary iron deficiency and repletion. Am J Physiol Endocrinol Metab 242, E418–E427.
    • (1982) Am J Physiol Endocrinol Metab , vol.242 , pp. E418-E427
    • Davies, K.J.A.1    Maguire, J.2    Brooks, G.3    Dallman, P.4    Packer, L.5
  • 68
    • 0019404223 scopus 로고
    • Biochemical adaptation of mitochondria, muscle, and whole-animal respiration to endurance training
    • Davies KJA, Packer L & Brooks GA (1981). Biochemical adaptation of mitochondria, muscle, and whole-animal respiration to endurance training. Arch Biochem Biophys 209, 539–554.
    • (1981) Arch Biochem Biophys , vol.209 , pp. 539-554
    • Davies, K.J.A.1    Packer, L.2    Brooks, G.A.3
  • 71
    • 75649146988 scopus 로고    scopus 로고
    • The role of systemic inflammation in age-related muscle weakness and wasting
    • Degens H (2010). The role of systemic inflammation in age-related muscle weakness and wasting. Scand J Med Sci Sports 20, 28–38.
    • (2010) Scand J Med Sci Sports , vol.20 , pp. 28-38
    • Degens, H.1
  • 72
    • 0036626120 scopus 로고    scopus 로고
    • The 78 kDa glucose-regulated protein (GRP78/BIP) is expressed on the cell membrane, is released into cell culture medium and is also present in human peripheral circulation
    • Delpino A & Castelli M (2002). The 78 kDa glucose-regulated protein (GRP78/BIP) is expressed on the cell membrane, is released into cell culture medium and is also present in human peripheral circulation. Biosci Rep 22, 407–420.
    • (2002) Biosci Rep , vol.22 , pp. 407-420
    • Delpino, A.1    Castelli, M.2
  • 73
    • 33750023633 scopus 로고    scopus 로고
    • Akt and FOXO dysregulation contribute to infection-induced wasting in Drosophila
    • Dionne MS, Pham LN, Shirasu-Hiza M & Schneider DS (2006). Akt and FOXO dysregulation contribute to infection-induced wasting in Drosophila. Curr Biol 16, 1977–1985.
    • (2006) Curr Biol , vol.16 , pp. 1977-1985
    • Dionne, M.S.1    Pham, L.N.2    Shirasu-Hiza, M.3    Schneider, D.S.4
  • 74
    • 27944497333 scopus 로고    scopus 로고
    • Tissue cells feel and respond to the stiffness of their substrate
    • Discher DE, Janmey P & Wang Y-l (2005). Tissue cells feel and respond to the stiffness of their substrate. Science (New York, NY) 310, 1139–1143.
    • (2005) Science (New York, NY) , vol.310 , pp. 1139-1143
    • Discher, D.E.1    Janmey, P.2    Wang, Y.-L.3
  • 75
    • 57749095081 scopus 로고    scopus 로고
    • Against the oxidative damage theory of aging: superoxide dismutases protect against oxidative stress but have little or no effect on life span in Caenorhabditis elegans
    • Doonan R, McElwee JJ, Matthijssens F, Walker GA, Houthoofd K, Back P, Matscheski A, Vanfleteren JR & Gems D (2008). Against the oxidative damage theory of aging: superoxide dismutases protect against oxidative stress but have little or no effect on life span in Caenorhabditis elegans. Genes Dev 22, 3236–3241.
    • (2008) Genes Dev , vol.22 , pp. 3236-3241
    • Doonan, R.1    McElwee, J.J.2    Matthijssens, F.3    Walker, G.A.4    Houthoofd, K.5    Back, P.6    Matscheski, A.7    Vanfleteren, J.R.8    Gems, D.9
  • 76
    • 57749089433 scopus 로고    scopus 로고
    • 2 dysregulation induce premature aging
    • 2 dysregulation induce premature aging? Physiology 23, 333–349.
    • (2008) Physiology , vol.23 , pp. 333-349
    • Douglas, R.M.1    Haddad, G.G.2
  • 77
    • 13844309577 scopus 로고    scopus 로고
    • Cold stress-induced protein Rbm3 binds 60S ribosomal subunits, alters microRNA levels, and enhances global protein synthesis
    • Dresios J, Aschrafi A, Owens GC, Vanderklish PW, Edelman GM & Mauro VP (2005). Cold stress-induced protein Rbm3 binds 60S ribosomal subunits, alters microRNA levels, and enhances global protein synthesis. Proc Natl Acad Sci USA 102, 1865–1870.
    • (2005) Proc Natl Acad Sci USA , vol.102 , pp. 1865-1870
    • Dresios, J.1    Aschrafi, A.2    Owens, G.C.3    Vanderklish, P.W.4    Edelman, G.M.5    Mauro, V.P.6
  • 78
    • 68849110235 scopus 로고    scopus 로고
    • Reduction of oxidative stress, amyloid deposition, and memory deficit by manganese superoxide dismutase overexpression in a transgenic mouse model of Alzheimer's disease
    • Dumont M, Wille E, Stack C, Calingasan NY, Beal MF & Lin MT (2009). Reduction of oxidative stress, amyloid deposition, and memory deficit by manganese superoxide dismutase overexpression in a transgenic mouse model of Alzheimer's disease. FASEB J 23, 2459–2466.
    • (2009) FASEB J , vol.23 , pp. 2459-2466
    • Dumont, M.1    Wille, E.2    Stack, C.3    Calingasan, N.Y.4    Beal, M.F.5    Lin, M.T.6
  • 79
    • 84872899284 scopus 로고    scopus 로고
    • FOXOs: signalling integrators for homeostasis maintenance
    • Eijkelenboom A & Burgering BM (2013). FOXOs: signalling integrators for homeostasis maintenance. Nat Rev Mol Cell Biol 14, 83–97.
    • (2013) Nat Rev Mol Cell Biol , vol.14 , pp. 83-97
    • Eijkelenboom, A.1    Burgering, B.M.2
  • 80
    • 39149104320 scopus 로고    scopus 로고
    • The role for endoplasmic reticulum stress in diabetes mellitus
    • Eizirik DL, Cardozo AK & Cnop M (2007). The role for endoplasmic reticulum stress in diabetes mellitus. Endocr Rev 29, 42–61.
    • (2007) Endocr Rev , vol.29 , pp. 42-61
    • Eizirik, D.L.1    Cardozo, A.K.2    Cnop, M.3
  • 81
    • 33747152561 scopus 로고    scopus 로고
    • Matrix elasticity directs stem cell lineage specification
    • Engler AJ, Sen S, Sweeney HL & Discher DE (2006). Matrix elasticity directs stem cell lineage specification. Cell 126, 677–689.
    • (2006) Cell , vol.126 , pp. 677-689
    • Engler, A.J.1    Sen, S.2    Sweeney, H.L.3    Discher, D.E.4
  • 82
    • 66449104770 scopus 로고    scopus 로고
    • Regulator of calcineurin (RCAN1-1L) is deficient in Huntington disease and protective against mutant huntingtin toxicity in vitro
    • Ermak G, Hench KJ, Chang KT, Sachdev S & Davies KJA (2009). Regulator of calcineurin (RCAN1-1L) is deficient in Huntington disease and protective against mutant huntingtin toxicity in vitro. J Biol Chem 284, 11845–11853.
    • (2009) J Biol Chem , vol.284 , pp. 11845-11853
    • Ermak, G.1    Hench, K.J.2    Chang, K.T.3    Sachdev, S.4    Davies, K.J.A.5
  • 83
    • 80053928996 scopus 로고    scopus 로고
    • Do RCAN1 proteins link chronic stress with neurodegeneration
    • Ermak G, Pritchard MA, Dronjak S, Niu B & Davies KJA (2011). Do RCAN1 proteins link chronic stress with neurodegeneration? FASEB J 25, 3306–3311.
    • (2011) FASEB J , vol.25 , pp. 3306-3311
    • Ermak, G.1    Pritchard, M.A.2    Dronjak, S.3    Niu, B.4    Davies, K.J.A.5
  • 85
    • 0025190717 scopus 로고
    • Decreased expression of heat shock protein 70 mRNA and protein after heat treatment in cells of aged rats
    • Fargnoli J, Kunisada T, Fornace AJ, Schneider EL & Holbrook NJ (1990). Decreased expression of heat shock protein 70 mRNA and protein after heat treatment in cells of aged rats. Proc Natl Acad Sci US A 87, 846–850.
    • (1990) Proc Natl Acad Sci US A , vol.87 , pp. 846-850
    • Fargnoli, J.1    Kunisada, T.2    Fornace, A.J.3    Schneider, E.L.4    Holbrook, N.J.5
  • 86
    • 79955142004 scopus 로고    scopus 로고
    • Sarcopenia: an undiagnosed condition in older adults. Current consensus definition: prevalence, etiology, and consequences. International working group on sarcopenia
    • Fielding RA, Vellas B, Evans WJ, Bhasin S, Morley JE, Newman AB, van Kan GA, Andrieu S, Bauer J & Breuille D (2011). Sarcopenia: an undiagnosed condition in older adults. Current consensus definition: prevalence, etiology, and consequences. International working group on sarcopenia. J Am Med Dir Assoc 12, 249–256.
    • (2011) J Am Med Dir Assoc , vol.12 , pp. 249-256
    • Fielding, R.A.1    Vellas, B.2    Evans, W.J.3    Bhasin, S.4    Morley, J.E.5    Newman, A.B.6    van Kan, G.A.7    Andrieu, S.8    Bauer, J.9    Breuille, D.10
  • 88
    • 0015937026 scopus 로고
    • Body temperatures in the elderly: a national study of physiological, social, and environmental conditions
    • Fox R, Woodward PM, Exton-Smith A, Green M, Donnison D & Wicks M (1973). Body temperatures in the elderly: a national study of physiological, social, and environmental conditions. Br Med J 1, 200–206.
    • (1973) Br Med J , vol.1 , pp. 200-206
    • Fox, R.1    Woodward, P.M.2    Exton-Smith, A.3    Green, M.4    Donnison, D.5    Wicks, M.6
  • 90
    • 84900988267 scopus 로고    scopus 로고
    • Chronic inflammation (inflammaging) and its potential contribution to age-associated diseases
    • Franceschi C & Campisi J (2014). Chronic inflammation (inflammaging) and its potential contribution to age-associated diseases. J Gerontol A Biol Sci Med Sci 69, S4–S9.
    • (2014) J Gerontol A Biol Sci Med Sci , vol.69 , pp. S4-S9
    • Franceschi, C.1    Campisi, J.2
  • 93
    • 0032748767 scopus 로고    scopus 로고
    • The function of hypoxia-inducible factor 1 (HIF-1) is impaired in senescent mice
    • Frenkel-Denkberg G, Gershon D & Levy AP (1999). The function of hypoxia-inducible factor 1 (HIF-1) is impaired in senescent mice. FEBS Lett 462, 341–344.
    • (1999) FEBS Lett , vol.462 , pp. 341-344
    • Frenkel-Denkberg, G.1    Gershon, D.2    Levy, A.P.3
  • 95
    • 0033222848 scopus 로고    scopus 로고
    • Cold shock response in mammalian cells
    • Fujita J (1999). Cold shock response in mammalian cells. J Mol Microbiol Biotechnol 1, 243–255.
    • (1999) J Mol Microbiol Biotechnol , vol.1 , pp. 243-255
    • Fujita, J.1
  • 96
    • 33947724515 scopus 로고    scopus 로고
    • HIF-1 regulates cytochrome oxidase subunits to optimize efficiency of respiration in hypoxic cells
    • Fukuda R, Zhang H, Kim J-w, Shimoda L, Dang CV & Semenza GL (2007). HIF-1 regulates cytochrome oxidase subunits to optimize efficiency of respiration in hypoxic cells. Cell 129, 111–122.
    • (2007) Cell , vol.129 , pp. 111-122
    • Fukuda, R.1    Zhang, H.2    Kim, J.-W.3    Shimoda, L.4    Dang, C.V.5    Semenza, G.L.6
  • 97
    • 39649110574 scopus 로고    scopus 로고
    • Stress-response hormesis and aging:“that which does not kill us makes us stronger
    • Gems D & Partridge L (2008). Stress-response hormesis and aging:“that which does not kill us makes us stronger”. Cell Metab 7, 200–203.
    • (2008) Cell Metab , vol.7 , pp. 200-203
    • Gems, D.1    Partridge, L.2
  • 100
  • 101
    • 33750523632 scopus 로고    scopus 로고
    • NF-κB activation by reactive oxygen species: fifteen years later
    • Gloire G, Legrand-Poels S & Piette J (2006). NF-κB activation by reactive oxygen species: fifteen years later. Biochem Pharmacol 72, 1493–1505.
    • (2006) Biochem Pharmacol , vol.72 , pp. 1493-1505
    • Gloire, G.1    Legrand-Poels, S.2    Piette, J.3
  • 102
    • 0023856662 scopus 로고
    • Human adaptation to repeated cold immersions
    • Golden FS & Tipton MJ (1988). Human adaptation to repeated cold immersions. J Physiol 396, 349–363.
    • (1988) J Physiol , vol.396 , pp. 349-363
    • Golden, F.S.1    Tipton, M.J.2
  • 103
    • 84875261848 scopus 로고    scopus 로고
    • Cold-related mortality due to cardiovascular diseases, respiratory diseases and cancer: a case-crossover study
    • Gómez-Acebo I, Llorca J & Dierssen T (2013). Cold-related mortality due to cardiovascular diseases, respiratory diseases and cancer: a case-crossover study. Public Health 127, 252–258.
    • (2013) Public Health , vol.127 , pp. 252-258
    • Gómez-Acebo, I.1    Llorca, J.2    Dierssen, T.3
  • 104
    • 84930941319 scopus 로고    scopus 로고
    • Redox modulation of mitochondriogenesis in exercise. Does antioxidant supplementation blunt the benefits of exercise training
    • Gomez-Cabrera MC, Salvador-Pascual A, Cabo H, Ferrando B & Viña J (2015). Redox modulation of mitochondriogenesis in exercise. Does antioxidant supplementation blunt the benefits of exercise training? Free Radic Biol Med 86, 37–46.
    • (2015) Free Radic Biol Med , vol.86 , pp. 37-46
    • Gomez-Cabrera, M.C.1    Salvador-Pascual, A.2    Cabo, H.3    Ferrando, B.4    Viña, J.5
  • 105
    • 23844540597 scopus 로고    scopus 로고
    • Decreasing xanthine oxidase-mediated oxidative stress prevents useful cellular adaptations to exercise in rats
    • Gomez-Cabrera MC, Borrás C, Pallardó FV, Sastre J, Ji LL & Viña J (2005). Decreasing xanthine oxidase-mediated oxidative stress prevents useful cellular adaptations to exercise in rats. J Physiol 567, 113–120.
    • (2005) J Physiol , vol.567 , pp. 113-120
    • Gomez-Cabrera, M.C.1    Borrás, C.2    Pallardó, F.V.3    Sastre, J.4    Ji, L.L.5    Viña, J.6
  • 106
    • 0032504634 scopus 로고    scopus 로고
    • Cooling and rewarming-induced IL-8 expression in human bronchial epithelial cells through p38 MAP kinase-dependent pathway
    • Gon Y, Hashimoto S, Matsumoto K, Nakayama T, Takeshita I & Horie T (1998). Cooling and rewarming-induced IL-8 expression in human bronchial epithelial cells through p38 MAP kinase-dependent pathway. Biochem Biophys Res Commun 249, 156–160.
    • (1998) Biochem Biophys Res Commun , vol.249 , pp. 156-160
    • Gon, Y.1    Hashimoto, S.2    Matsumoto, K.3    Nakayama, T.4    Takeshita, I.5    Horie, T.6
  • 107
    • 2342457055 scopus 로고    scopus 로고
    • Induction, modification and accumulation of HSP70s in the rat liver after acute exercise: early and late responses
    • González B & Manso R (2004). Induction, modification and accumulation of HSP70s in the rat liver after acute exercise: early and late responses. J Physiol 556, 369–385.
    • (2004) J Physiol , vol.556 , pp. 369-385
    • González, B.1    Manso, R.2
  • 108
    • 36148992160 scopus 로고    scopus 로고
    • Hormetic effects of regular exercise in aging: correlation with oxidative stress
    • Goto S, Naito H, Kaneko T, Chung HY & Radak Z (2007). Hormetic effects of regular exercise in aging: correlation with oxidative stress. Appl Physiol Nutr Metab 32, 948–953.
    • (2007) Appl Physiol Nutr Metab , vol.32 , pp. 948-953
    • Goto, S.1    Naito, H.2    Kaneko, T.3    Chung, H.Y.4    Radak, Z.5
  • 110
    • 0016502213 scopus 로고
    • Role of the hypothalamus in the regulation of food and water intake
    • Grossman SP (1975). Role of the hypothalamus in the regulation of food and water intake. Psychol Rev 82, 200.
    • (1975) Psychol Rev , vol.82 , pp. 200
    • Grossman, S.P.1
  • 111
    • 70449596545 scopus 로고    scopus 로고
    • Simultaneous tracking of movement and gene expression in multiple Drosophila melanogaster flies using GFP and DsRED fluorescent reporter transgenes
    • Grover D, Yang J, Ford D, Tavaré S & Tower J (2009). Simultaneous tracking of movement and gene expression in multiple Drosophila melanogaster flies using GFP and DsRED fluorescent reporter transgenes. BMC Res Notes 2, 58.
    • (2009) BMC Res Notes , vol.2 , pp. 58
    • Grover, D.1    Yang, J.2    Ford, D.3    Tavaré, S.4    Tower, J.5
  • 112
  • 113
    • 0029984892 scopus 로고    scopus 로고
    • Degradation of oxidized proteins in K562 human hematopoietic cells by proteasome
    • Grune T, Reinheckel T & Davies KJA (1996). Degradation of oxidized proteins in K562 human hematopoietic cells by proteasome. J Biol Chem 271, 15504–15509.
    • (1996) J Biol Chem , vol.271 , pp. 15504-15509
    • Grune, T.1    Reinheckel, T.2    Davies, K.J.A.3
  • 116
    • 0025978583 scopus 로고
    • Influence of coronary collateral vessels on myocardial infarct size in humans. Results of phase I thrombolysis in myocardial infarction (TIMI) trial. The TIMI Investigators
    • Habib G, Heibig J, Forman S, Brown B, Roberts R, Terrin M & Bolli R (1991). Influence of coronary collateral vessels on myocardial infarct size in humans. Results of phase I thrombolysis in myocardial infarction (TIMI) trial. The TIMI Investigators. Circulation 83, 739–746.
    • (1991) Circulation , vol.83 , pp. 739-746
    • Habib, G.1    Heibig, J.2    Forman, S.3    Brown, B.4    Roberts, R.5    Terrin, M.6    Bolli, R.7
  • 118
    • 77949887506 scopus 로고    scopus 로고
    • Mammalian sirtuins: biological insights and disease relevance
    • Haigis MC & Sinclair DA (2010). Mammalian sirtuins: biological insights and disease relevance. Annu Rev Pathol Mechanical Disease 5, 253–295.
    • (2010) Annu Rev Pathol Mechanical Disease , vol.5 , pp. 253-295
    • Haigis, M.C.1    Sinclair, D.A.2
  • 119
    • 78649350746 scopus 로고    scopus 로고
    • The aging stress response
    • Haigis MC & Yankner BA (2010). The aging stress response. Mol Cell 40, 333–344.
    • (2010) Mol Cell , vol.40 , pp. 333-344
    • Haigis, M.C.1    Yankner, B.A.2
  • 120
    • 0027936755 scopus 로고
    • A MAP kinase targeted by endotoxin and hyperosmolarity in mammalian cells
    • Han J, Lee J, Bibbs L & Ulevitch R (1994). A MAP kinase targeted by endotoxin and hyperosmolarity in mammalian cells. Science 265, 808–811.
    • (1994) Science , vol.265 , pp. 808-811
    • Han, J.1    Lee, J.2    Bibbs, L.3    Ulevitch, R.4
  • 121
    • 84900800420 scopus 로고    scopus 로고
    • AMPK: regulating energy balance at the cellular and whole body levels
    • Hardie DG & Ashford ML (2014). AMPK: regulating energy balance at the cellular and whole body levels. Physiology 29, 99–107.
    • (2014) Physiology , vol.29 , pp. 99-107
    • Hardie, D.G.1    Ashford, M.L.2
  • 122
    • 77049308856 scopus 로고
    • Aging: a theory based on free radical and radiation chemistry
    • Harman D (1955). Aging: a theory based on free radical and radiation chemistry. J Gerontol 11, 298–300.
    • (1955) J Gerontol , vol.11 , pp. 298-300
    • Harman, D.1
  • 123
    • 84887431711 scopus 로고    scopus 로고
    • Brown and beige fat: development, function and therapeutic potential
    • Harms M & Seale P (2013). Brown and beige fat: development, function and therapeutic potential. Nat Med 19, 1252–1263.
    • (2013) Nat Med , vol.19 , pp. 1252-1263
    • Harms, M.1    Seale, P.2
  • 124
    • 84863782263 scopus 로고    scopus 로고
    • Osmotic stress induced oxidative damage: possible mechanism of cataract formation in diabetes
    • Hashim Z & Zarina S (2012). Osmotic stress induced oxidative damage: possible mechanism of cataract formation in diabetes. J Diabetes Complications 26, 275–279.
    • (2012) J Diabetes Complications , vol.26 , pp. 275-279
    • Hashim, Z.1    Zarina, S.2
  • 125
    • 84924126477 scopus 로고    scopus 로고
    • A first line of stress defense: small heat shock proteins and their function in protein homeostasis
    • Haslbeck M & Vierling E (2015). A first line of stress defense: small heat shock proteins and their function in protein homeostasis. J Mol Biol 427, 1537–1548.
    • (2015) J Mol Biol , vol.427 , pp. 1537-1548
    • Haslbeck, M.1    Vierling, E.2
  • 126
    • 33745658629 scopus 로고    scopus 로고
    • Activation of the HOG pathway upon cold stress in Saccharomyces cerevisiae
    • Hayashi M & Maeda T (2006). Activation of the HOG pathway upon cold stress in Saccharomyces cerevisiae. J Biochem (Tokyo) 139, 797–803.
    • (2006) J Biochem (Tokyo) , vol.139 , pp. 797-803
    • Hayashi, M.1    Maeda, T.2
  • 127
    • 0033956744 scopus 로고    scopus 로고
    • The Nrf2 transcription factor contributes both to the basal expression of glutathione S-transferases in mouse liver and to their induction by the chemopreventive synthetic antioxidants, butylated hydroxyanisole and ethoxyquin
    • Hayes J, Chanas S, Henderson C, McMahon M, Sun C, Moffat G, Wolf C & Yamamoto M (2000). The Nrf2 transcription factor contributes both to the basal expression of glutathione S-transferases in mouse liver and to their induction by the chemopreventive synthetic antioxidants, butylated hydroxyanisole and ethoxyquin. Biochem Soc Trans 28, 33–41.
    • (2000) Biochem Soc Trans , vol.28 , pp. 33-41
    • Hayes, J.1    Chanas, S.2    Henderson, C.3    McMahon, M.4    Sun, C.5    Moffat, G.6    Wolf, C.7    Yamamoto, M.8
  • 128
    • 33645526333 scopus 로고    scopus 로고
    • Effect of 6-month calorie restriction on biomarkers of longevity, metabolic adaptation, and oxidative stress in overweight individuals: A randomized controlled trial
    • Heilbronn LK, de Jonge L, Frisard MI et al. (2006). Effect of 6-month calorie restriction on biomarkers of longevity, metabolic adaptation, and oxidative stress in overweight individuals: A randomized controlled trial. JAMA 295, 1539–1548.
    • (2006) JAMA , vol.295 , pp. 1539-1548
    • Heilbronn, L.K.1    de Jonge, L.2    Frisard, M.I.3
  • 129
    • 0031792920 scopus 로고    scopus 로고
    • Reactive oxygen species and oxidative DNA damage
    • Hemnani T & Parihar M (1998). Reactive oxygen species and oxidative DNA damage. Indian J Physiol Pharmacol 42, 440–452.
    • (1998) Indian J Physiol Pharmacol , vol.42 , pp. 440-452
    • Hemnani, T.1    Parihar, M.2
  • 130
    • 0028198372 scopus 로고
    • Localization of the gene encoding human BiP/GRP78, the endoplasmic reticulum cognate of the HSP70 family, to chromosome 9q34
    • Hendershot LM, Valentine VA, Lee AS, Morris SW & Shapiro DN (1994). Localization of the gene encoding human BiP/GRP78, the endoplasmic reticulum cognate of the HSP70 family, to chromosome 9q34. Genomics 20, 281–284.
    • (1994) Genomics , vol.20 , pp. 281-284
    • Hendershot, L.M.1    Valentine, V.A.2    Lee, A.S.3    Morris, S.W.4    Shapiro, D.N.5
  • 131
    • 84856111924 scopus 로고    scopus 로고
    • The unfolded protein response: controlling cell fate decisions under ER stress and beyond
    • Hetz C (2012). The unfolded protein response: controlling cell fate decisions under ER stress and beyond. Nat Rev Mol Cell Biol 13, 89–102.
    • (2012) Nat Rev Mol Cell Biol , vol.13 , pp. 89-102
    • Hetz, C.1
  • 132
    • 79958192153 scopus 로고    scopus 로고
    • The Hog1 mitogen-activated protein kinase mediates a hypoxic response in Saccharomyces cerevisiae
    • Hickman MJ, Spatt D & Winston F (2011). The Hog1 mitogen-activated protein kinase mediates a hypoxic response in Saccharomyces cerevisiae. Genetics 188, 325–338.
    • (2011) Genetics , vol.188 , pp. 325-338
    • Hickman, M.J.1    Spatt, D.2    Winston, F.3
  • 133
    • 0029838640 scopus 로고    scopus 로고
    • ER degradation of a misfolded luminal protein by the cytosolic ubiquitin-proteasome pathway
    • Hiller MM, Finger A, Schweiger M & Wolf DH (1996). ER degradation of a misfolded luminal protein by the cytosolic ubiquitin-proteasome pathway. Science (New York, NY) 273, 1725–1728.
    • (1996) Science (New York, NY) , vol.273 , pp. 1725-1728
    • Hiller, M.M.1    Finger, A.2    Schweiger, M.3    Wolf, D.H.4
  • 135
    • 0036282743 scopus 로고    scopus 로고
    • Osmotic stress signaling and osmoadaptation in yeasts
    • Hohmann S (2002). Osmotic stress signaling and osmoadaptation in yeasts. Microbiol Mol Biol Rev 66, 300–372.
    • (2002) Microbiol Mol Biol Rev , vol.66 , pp. 300-372
    • Hohmann, S.1
  • 136
    • 84901316606 scopus 로고    scopus 로고
    • Cellular mechanisms and physiological consequences of redox-dependent signalling
    • Holmstrom K & Finkel T (2014). Cellular mechanisms and physiological consequences of redox-dependent signalling. Nat Rev Mol Cell Biol 15, 411–421.
    • (2014) Nat Rev Mol Cell Biol , vol.15 , pp. 411-421
    • Holmstrom, K.1    Finkel, T.2
  • 137
    • 84892884397 scopus 로고    scopus 로고
    • Effects of prolonged and maintenance strength training on force production, walking, and balance in aging women and men
    • Holviala J, Häkkinen A, Alen M, Sallinen J, Kraemer W & Häkkinen K (2014). Effects of prolonged and maintenance strength training on force production, walking, and balance in aging women and men. Scandinavian J Med Sci Sports 24, 224–233.
    • (2014) Scandinavian J Med Sci Sports , vol.24 , pp. 224-233
    • Holviala, J.1    Häkkinen, A.2    Alen, M.3    Sallinen, J.4    Kraemer, W.5    Häkkinen, K.6
  • 138
    • 0038686802 scopus 로고    scopus 로고
    • Yeast gene expression during growth at low temperature
    • Homma T, Iwahashi H & Komatsu Y (2003). Yeast gene expression during growth at low temperature. Cryobiology 46, 230–237.
    • (2003) Cryobiology , vol.46 , pp. 230-237
    • Homma, T.1    Iwahashi, H.2    Komatsu, Y.3
  • 141
    • 84938723264 scopus 로고    scopus 로고
    • Health effects of intermittent fasting: hormesis or harm? A systematic review
    • Horne BD, Muhlestein JB & Anderson JL (2015). Health effects of intermittent fasting: hormesis or harm? A systematic review. Am J Clin Nutr 102, 464–470.
    • (2015) Am J Clin Nutr , vol.102 , pp. 464-470
    • Horne, B.D.1    Muhlestein, J.B.2    Anderson, J.L.3
  • 142
    • 0038701745 scopus 로고    scopus 로고
    • Regulation of aging and age-related disease by DAF-16 and heat-shock factor
    • Hsu A-L, Murphy CT & Kenyon C (2003). Regulation of aging and age-related disease by DAF-16 and heat-shock factor. Science (New York, NY) 300, 1142–1145.
    • (2003) Science (New York, NY) , vol.300 , pp. 1142-1145
    • Hsu, A.-L.1    Murphy, C.T.2    Kenyon, C.3
  • 143
    • 33847149663 scopus 로고    scopus 로고
    • Reduced eIF2alpha phosphorylation and increased proapoptotic proteins in aging
    • Hussain SG & Ramaiah KV (2007). Reduced eIF2alpha phosphorylation and increased proapoptotic proteins in aging. Biochem Biophys Res Commun 355, 365–370.
    • (2007) Biochem Biophys Res Commun , vol.355 , pp. 365-370
    • Hussain, S.G.1    Ramaiah, K.V.2
  • 144
    • 63149089930 scopus 로고    scopus 로고
    • The NAD World: a new systemic regulatory network for metabolism and aging – Sirt1, systemic NAD biosynthesis, and their importance
    • Imai S-i (2009). The NAD World: a new systemic regulatory network for metabolism and aging – Sirt1, systemic NAD biosynthesis, and their importance. Cell Biochem Biophys 53, 65–74.
    • (2009) Cell Biochem Biophys , vol.53 , pp. 65-74
    • Imai, S.-I.1
  • 145
    • 84923349090 scopus 로고    scopus 로고
    • Calorie restriction mimetics: can you have your cake and eat it, too
    • Ingram DK & Roth GS (2015). Calorie restriction mimetics: can you have your cake and eat it, too? Ageing Res Rev 20, 46–62.
    • (2015) Ageing Res Rev , vol.20 , pp. 46-62
    • Ingram, D.K.1    Roth, G.S.2
  • 147
    • 0025500122 scopus 로고
    • Hypothalamic-pituitary-adrenal activity in aged, cognitively impaired and cognitively unimpaired rats
    • Issa AM, Rowe W, Gauthier S & Meaney MJ (1990). Hypothalamic-pituitary-adrenal activity in aged, cognitively impaired and cognitively unimpaired rats. J Neurosci 10, 3247–3254.
    • (1990) J Neurosci , vol.10 , pp. 3247-3254
    • Issa, A.M.1    Rowe, W.2    Gauthier, S.3    Meaney, M.J.4
  • 148
    • 12444257799 scopus 로고    scopus 로고
    • Keap1 regulates both cytoplasmic-nuclear shuttling and degradation of Nrf2 in response to electrophiles
    • Itoh K, Wakabayashi N, Katoh Y, Ishii T, O'Connor T & Yamamoto M (2003). Keap1 regulates both cytoplasmic-nuclear shuttling and degradation of Nrf2 in response to electrophiles. Genes Cells 8, 379–391.
    • (2003) Genes Cells , vol.8 , pp. 379-391
    • Itoh, K.1    Wakabayashi, N.2    Katoh, Y.3    Ishii, T.4    O'Connor, T.5    Yamamoto, M.6
  • 150
    • 84925441813 scopus 로고    scopus 로고
    • Control of adaptive immunity by the innate immune system
    • Iwasaki A & Medzhitov R (2015). Control of adaptive immunity by the innate immune system. Nat Immunol 16, 343–353.
    • (2015) Nat Immunol , vol.16 , pp. 343-353
    • Iwasaki, A.1    Medzhitov, R.2
  • 153
    • 0033927851 scopus 로고    scopus 로고
    • Skeletal muscle mass and distribution in 468 men and women aged 18–88 yr
    • Janssen I, Heymsfield SB, Wang Z & Ross R (2000). Skeletal muscle mass and distribution in 468 men and women aged 18–88 yr. J Appl Physiol 89, 81–88.
    • (2000) J Appl Physiol , vol.89 , pp. 81-88
    • Janssen, I.1    Heymsfield, S.B.2    Wang, Z.3    Ross, R.4
  • 155
    • 84991702090 scopus 로고    scopus 로고
    • Cortisol dysregulation: the bidirectional link between stress, depression, and type 2 diabetes mellitus
    • Joseph JJ & Golden SH (2016). Cortisol dysregulation: the bidirectional link between stress, depression, and type 2 diabetes mellitus. Ann N Y Acad Sci 1391, 20–34.
    • (2016) Ann N Y Acad Sci , vol.1391 , pp. 20-34
    • Joseph, J.J.1    Golden, S.H.2
  • 156
    • 33646058316 scopus 로고    scopus 로고
    • Intracellular distribution of oxidized proteins and proteasome in HT22 cells during oxidative stress
    • Jung T, Engels M, Kaiser B, Poppek D & Grune T (2006). Intracellular distribution of oxidized proteins and proteasome in HT22 cells during oxidative stress. Free Radic Biol Med 40, 1303–1312.
    • (2006) Free Radic Biol Med , vol.40 , pp. 1303-1312
    • Jung, T.1    Engels, M.2    Kaiser, B.3    Poppek, D.4    Grune, T.5
  • 157
    • 0347361625 scopus 로고    scopus 로고
    • Satellite cells and myonuclei in young and elderly women and men
    • Kadi F, Charifi N, Denis C & Lexell J (2004). Satellite cells and myonuclei in young and elderly women and men. Muscle Nerve 29, 120–127.
    • (2004) Muscle Nerve , vol.29 , pp. 120-127
    • Kadi, F.1    Charifi, N.2    Denis, C.3    Lexell, J.4
  • 158
    • 0036840502 scopus 로고    scopus 로고
    • High osmolarity extends life span in Saccharomyces cerevisiae by a mechanism related to calorie restriction
    • Kaeberlein M, Andalis AA, Fink GR & Guarente L (2002). High osmolarity extends life span in Saccharomyces cerevisiae by a mechanism related to calorie restriction. Mol Cell Biol 22, 8056–8066.
    • (2002) Mol Cell Biol , vol.22 , pp. 8056-8066
    • Kaeberlein, M.1    Andalis, A.A.2    Fink, G.R.3    Guarente, L.4
  • 159
    • 19344374925 scopus 로고    scopus 로고
    • Sir2-independent life span extension by calorie restriction in yeast
    • Kaeberlein M, Kirkland KT, Fields S & Kennedy BK (2004). Sir2-independent life span extension by calorie restriction in yeast. PLoS Biol 2, e296.
    • (2004) PLoS Biol , vol.2
    • Kaeberlein, M.1    Kirkland, K.T.2    Fields, S.3    Kennedy, B.K.4
  • 160
    • 0033214237 scopus 로고    scopus 로고
    • The SIR2/3/4 complex and SIR2 alone promote longevity in Saccharomyces cerevisiae by two different mechanisms
    • Kaeberlein M, McVey M & Guarente L (1999). The SIR2/3/4 complex and SIR2 alone promote longevity in Saccharomyces cerevisiae by two different mechanisms. Genes Dev 13, 2570–2580.
    • (1999) Genes Dev , vol.13 , pp. 2570-2580
    • Kaeberlein, M.1    McVey, M.2    Guarente, L.3
  • 161
    • 0242335698 scopus 로고    scopus 로고
    • Sipping from a poisoned chalice
    • Kaiser J (2003). Sipping from a poisoned chalice. Science (New York, NY) 302, 376–379.
    • (2003) Science (New York, NY) , vol.302 , pp. 376-379
    • Kaiser, J.1
  • 162
    • 66449137379 scopus 로고    scopus 로고
    • GRP78 expression inhibits insulin and ER stress-induced SREBP-1c activation and reduces hepatic steatosis in mice
    • Kammoun HL, Chabanon H, Hainault I, Luquet S, Magnan C, Koike T, Ferré P & Foufelle F (2009). GRP78 expression inhibits insulin and ER stress-induced SREBP-1c activation and reduces hepatic steatosis in mice. J Clin Invest 119, 1201–1215.
    • (2009) J Clin Invest , vol.119 , pp. 1201-1215
    • Kammoun, H.L.1    Chabanon, H.2    Hainault, I.3    Luquet, S.4    Magnan, C.5    Koike, T.6    Ferré, P.7    Foufelle, F.8
  • 163
    • 84884547174 scopus 로고    scopus 로고
    • Exercise training attenuates aging-associated mitochondrial dysfunction in rat skeletal muscle: role of PGC-1α
    • Kang C, Chung E, Diffee G & Ji LL (2013). Exercise training attenuates aging-associated mitochondrial dysfunction in rat skeletal muscle: role of PGC-1α. Exp Gerontol 48, 1343–1350.
    • (2013) Exp Gerontol , vol.48 , pp. 1343-1350
    • Kang, C.1    Chung, E.2    Diffee, G.3    Ji, L.L.4
  • 164
    • 84878785993 scopus 로고    scopus 로고
    • The Keap1-Nrf2 pathway: Mechanisms of activation and dysregulation in cancer
    • Kansanen E, Kuosmanen SM, Leinonen H & Levonen A-L (2013). The Keap1-Nrf2 pathway: Mechanisms of activation and dysregulation in cancer. Redox Biol 1, 45–49.
    • (2013) Redox Biol , vol.1 , pp. 45-49
    • Kansanen, E.1    Kuosmanen, S.M.2    Leinonen, H.3    Levonen, A.-L.4
  • 166
    • 0035151514 scopus 로고    scopus 로고
    • Low external pH induces HOG1-dependent changes in the organization of the Saccharomyces cerevisiae cell wall
    • Kapteyn J, Ter Riet B, Vink E, Blad S, De Nobel H, Van Den Ende H & Klis F (2001). Low external pH induces HOG1-dependent changes in the organization of the Saccharomyces cerevisiae cell wall. Mol Microbiol 39, 469–480.
    • (2001) Mol Microbiol , vol.39 , pp. 469-480
    • Kapteyn, J.1    Ter Riet, B.2    Vink, E.3    Blad, S.4    De Nobel, H.5    Van Den Ende, H.6    Klis, F.7
  • 167
    • 34548495323 scopus 로고    scopus 로고
    • The mitochondrial transcription factor TFAM coordinates the assembly of multiple DNA molecules into nucleoid-like structures
    • Kaufman BA, Durisic N, Mativetsky JM, Costantino S, Hancock MA, Grutter P & Shoubridge EA (2007). The mitochondrial transcription factor TFAM coordinates the assembly of multiple DNA molecules into nucleoid-like structures. Mol Biol Cell 18, 3225–3236.
    • (2007) Mol Biol Cell , vol.18 , pp. 3225-3236
    • Kaufman, B.A.1    Durisic, N.2    Mativetsky, J.M.3    Costantino, S.4    Hancock, M.A.5    Grutter, P.6    Shoubridge, E.A.7
  • 168
    • 77951260924 scopus 로고    scopus 로고
    • The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors
    • Kawai T & Akira S (2010). The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors. Nat Immunol 11, 373–384.
    • (2010) Nat Immunol , vol.11 , pp. 373-384
    • Kawai, T.1    Akira, S.2
  • 170
    • 84925272779 scopus 로고    scopus 로고
    • Stress and type 2 diabetes: a review of how stress contributes to the development of type 2 diabetes
    • Kelly SJ & Ismail M (2015). Stress and type 2 diabetes: a review of how stress contributes to the development of type 2 diabetes. Annu Rev Public Health 36, 441–462.
    • (2015) Annu Rev Public Health , vol.36 , pp. 441-462
    • Kelly, S.J.1    Ismail, M.2
  • 171
    • 84940476834 scopus 로고    scopus 로고
    • Insulin resistance, glucose intolerance and diabetes mellitus in obstructive sleep apnoea
    • Kent BD, McNicholas WT & Ryan S (2015). Insulin resistance, glucose intolerance and diabetes mellitus in obstructive sleep apnoea. J Thoracic Disease 7, 1343–1357.
    • (2015) J Thoracic Disease , vol.7 , pp. 1343-1357
    • Kent, B.D.1    McNicholas, W.T.2    Ryan, S.3
  • 172
    • 0036803832 scopus 로고    scopus 로고
    • Depression and immune function: central pathways to morbidity and mortality
    • Kiecolt-Glaser JK & Glaser R (2002). Depression and immune function: central pathways to morbidity and mortality. J Psychosom Res 53, 873–876.
    • (2002) J Psychosom Res , vol.53 , pp. 873-876
    • Kiecolt-Glaser, J.K.1    Glaser, R.2
  • 173
    • 0036860192 scopus 로고    scopus 로고
    • Modulation of redox-sensitive transcription factors by calorie restriction during aging
    • Kim HJ, Jung KJ, Yu BP, Cho CG, Choi JS & Chung HY (2002). Modulation of redox-sensitive transcription factors by calorie restriction during aging. Mech Ageing Dev 123, 1589–1595.
    • (2002) Mech Ageing Dev , vol.123 , pp. 1589-1595
    • Kim, H.J.1    Jung, K.J.2    Yu, B.P.3    Cho, C.G.4    Choi, J.S.5    Chung, H.Y.6
  • 174
    • 77955279350 scopus 로고    scopus 로고
    • A protective role of nuclear factor-erythroid 2-related factor-2 (Nrf2) in inflammatory disorders
    • Kim J, Cha Y-N & Surh Y-J (2010). A protective role of nuclear factor-erythroid 2-related factor-2 (Nrf2) in inflammatory disorders. Mutat Res/Fund Mol Mech Mutagenesis 690, 12–23.
    • (2010) Mutat Res/Fund Mol Mech Mutagenesis , vol.690 , pp. 12-23
    • Kim, J.1    Cha, Y.-N.2    Surh, Y.-J.3
  • 175
    • 3543008924 scopus 로고    scopus 로고
    • Oxidative stress sensor Keap1 functions as an adaptor for Cul3-based E3 ligase to regulate proteasomal degradation of Nrf2
    • Kobayashi A, Kang M-I, Okawa H, Ohtsuji M, Zenke Y, Chiba T, Igarashi K & Yamamoto M (2004). Oxidative stress sensor Keap1 functions as an adaptor for Cul3-based E3 ligase to regulate proteasomal degradation of Nrf2. Mol Cell Biol 24, 7130–7139.
    • (2004) Mol Cell Biol , vol.24 , pp. 7130-7139
    • Kobayashi, A.1    Kang, M.-I.2    Okawa, H.3    Ohtsuji, M.4    Zenke, Y.5    Chiba, T.6    Igarashi, K.7    Yamamoto, M.8
  • 176
    • 79251498807 scopus 로고    scopus 로고
    • Protein homeostasis and aging: The importance of exquisite quality control
    • Koga H, Kaushik S & Cuervo AM (2011). Protein homeostasis and aging: The importance of exquisite quality control. Ageing Res Rev 10, 205–215.
    • (2011) Ageing Res Rev , vol.10 , pp. 205-215
    • Koga, H.1    Kaushik, S.2    Cuervo, A.M.3
  • 177
    • 84898974238 scopus 로고    scopus 로고
    • Markers of human skeletal muscle mitochondrial biogenesis and quality control: effects of age and aerobic exercise training
    • Konopka AR, Suer MK, Wolff CA & Harber MP (2013). Markers of human skeletal muscle mitochondrial biogenesis and quality control: effects of age and aerobic exercise training. J Gerontol A Biol Sci Med Sci 69, 371–378.
    • (2013) J Gerontol A Biol Sci Med Sci , vol.69 , pp. 371-378
    • Konopka, A.R.1    Suer, M.K.2    Wolff, C.A.3    Harber, M.P.4
  • 178
    • 34447632877 scopus 로고    scopus 로고
    • Exercise, MAPK, and NF-κB signaling in skeletal muscle
    • Kramer HF & Goodyear LJ (2007). Exercise, MAPK, and NF-κB signaling in skeletal muscle. J Appl Physiol 103, 388–395.
    • (2007) J Appl Physiol , vol.103 , pp. 388-395
    • Kramer, H.F.1    Goodyear, L.J.2
  • 180
    • 0034538217 scopus 로고    scopus 로고
    • Increased hsp22 RNA levels in Drosophila lines genetically selected for increased longevity
    • Kurapati R, Passananti HB, Rose MR & Tower J (2000). Increased hsp22 RNA levels in Drosophila lines genetically selected for increased longevity. J Gerontol A Biol Sci Med Sci 55, B552–B559.
    • (2000) J Gerontol A Biol Sci Med Sci , vol.55 , pp. B552-B559
    • Kurapati, R.1    Passananti, H.B.2    Rose, M.R.3    Tower, J.4
  • 181
    • 84885211241 scopus 로고    scopus 로고
    • Role of reactive oxygen species-mediated signaling in aging
    • Labunskyy VM & Gladyshev VN (2013). Role of reactive oxygen species-mediated signaling in aging. Antioxid Redox Signal 19, 1362–1372.
    • (2013) Antioxid Redox Signal , vol.19 , pp. 1362-1372
    • Labunskyy, V.M.1    Gladyshev, V.N.2
  • 183
  • 184
    • 12144264839 scopus 로고    scopus 로고
    • Transcriptional targets of DAF-16 insulin signaling pathway protect C. elegans from extreme hypertonic stress
    • Lamitina ST & Strange K (2005). Transcriptional targets of DAF-16 insulin signaling pathway protect C. elegans from extreme hypertonic stress. Am J Physiol Cell Physiol 288, C467–C474.
    • (2005) Am J Physiol Cell Physiol , vol.288 , pp. C467-C474
    • Lamitina, S.T.1    Strange, K.2
  • 185
    • 33747083190 scopus 로고    scopus 로고
    • Genome-wide RNAi screening identifies protein damage as a regulator of osmoprotective gene expression
    • Lamitina T, Huang CG & Strange K (2006). Genome-wide RNAi screening identifies protein damage as a regulator of osmoprotective gene expression. Proc Natl Acad Sci USA 103, 12173–12178.
    • (2006) Proc Natl Acad Sci USA , vol.103 , pp. 12173-12178
    • Lamitina, T.1    Huang, C.G.2    Strange, K.3
  • 187
    • 0019790481 scopus 로고
    • Brain aging correlates: retardation by hormonal-pharmacological treatments
    • Landfield PW, Baskin RK & Pitler TA (1981). Brain aging correlates: retardation by hormonal-pharmacological treatments. Science (New York, NY) 214, 581–584.
    • (1981) Science (New York, NY) , vol.214 , pp. 581-584
    • Landfield, P.W.1    Baskin, R.K.2    Pitler, T.A.3
  • 188
    • 0018263702 scopus 로고
    • Hippocampal aging and adrenocorticoids: quantitative correlations
    • Landfield PW, Waymire JC & Lynch G (1978). Hippocampal aging and adrenocorticoids: quantitative correlations. Science (New York, NY) 202, 1098–1102.
    • (1978) Science (New York, NY) , vol.202 , pp. 1098-1102
    • Landfield, P.W.1    Waymire, J.C.2    Lynch, G.3
  • 189
    • 84872530990 scopus 로고    scopus 로고
    • Gene expression changes in response to aging compared to heat stress, oxidative stress and ionizing radiation in Drosophila melanogaster
    • Landis G, Shen J & Tower J (2012). Gene expression changes in response to aging compared to heat stress, oxidative stress and ionizing radiation in Drosophila melanogaster. Aging (Albany NY) 4, 768–789.
    • (2012) Aging (Albany NY) , vol.4 , pp. 768-789
    • Landis, G.1    Shen, J.2    Tower, J.3
  • 191
    • 0038354488 scopus 로고    scopus 로고
    • Sleep-disordered breathing in heart failure: characteristics and implications
    • Lanfranchi PA & Somers VK (2003). Sleep-disordered breathing in heart failure: characteristics and implications. Respir Physiol Neurobiol 136, 153–165.
    • (2003) Respir Physiol Neurobiol , vol.136 , pp. 153-165
    • Lanfranchi, P.A.1    Somers, V.K.2
  • 192
    • 0034253463 scopus 로고    scopus 로고
    • Role of redox-regulated transcription factors in inflammation, aging and age-related diseases
    • Lavrovsky Y, Chatterjee B, Clark R & Roy A (2000). Role of redox-regulated transcription factors in inflammation, aging and age-related diseases. Exp Gerontol 35, 521–532.
    • (2000) Exp Gerontol , vol.35 , pp. 521-532
    • Lavrovsky, Y.1    Chatterjee, B.2    Clark, R.3    Roy, A.4
  • 193
    • 34447332207 scopus 로고    scopus 로고
    • Hormetic effects of repeated exposures to cold at young age on longevity, aging and resistance to heat or cold shocks in Drosophila melanogaster
    • Le Bourg É (2007). Hormetic effects of repeated exposures to cold at young age on longevity, aging and resistance to heat or cold shocks in Drosophila melanogaster. Biogerontology 8, 431–444.
    • (2007) Biogerontology , vol.8 , pp. 431-444
    • Le Bourg, É.1
  • 194
    • 0028946316 scopus 로고
    • Demonstration that polyol accumulation is responsible for diabetic cataract by the use of transgenic mice expressing the aldose reductase gene in the lens
    • Lee A, Chung SK & Chung S (1995). Demonstration that polyol accumulation is responsible for diabetic cataract by the use of transgenic mice expressing the aldose reductase gene in the lens. Proc Natl Acad Sci USA 92, 2780–2784.
    • (1995) Proc Natl Acad Sci USA , vol.92 , pp. 2780-2784
    • Lee, A.1    Chung, S.K.2    Chung, S.3
  • 195
    • 84897036337 scopus 로고    scopus 로고
    • Glucose-regulated proteins in cancer: molecular mechanisms and therapeutic potential
    • Lee AS (2014). Glucose-regulated proteins in cancer: molecular mechanisms and therapeutic potential. Nat Rev Cancer 14, 263–276.
    • (2014) Nat Rev Cancer , vol.14 , pp. 263-276
    • Lee, A.S.1
  • 196
    • 0032958288 scopus 로고    scopus 로고
    • Contributions of polyol pathway to oxidative stress in diabetic cataract
    • Lee AY & Chung SS (1999). Contributions of polyol pathway to oxidative stress in diabetic cataract. FASEB J 13, 23–30.
    • (1999) FASEB J , vol.13 , pp. 23-30
    • Lee, A.Y.1    Chung, S.S.2
  • 199
    • 77953485026 scopus 로고    scopus 로고
    • Induction of the unfolded protein response and cell death pathway in Alzheimer's disease, but not in aged Tg2576 mice
    • Lee JH, Won SM, Suh J, Son SJ, Moon GJ, Park UJ & Gwag BJ (2010). Induction of the unfolded protein response and cell death pathway in Alzheimer's disease, but not in aged Tg2576 mice. Experiment Mol Med 42, 386–394.
    • (2010) Experiment Mol Med , vol.42 , pp. 386-394
    • Lee, J.H.1    Won, S.M.2    Suh, J.3    Son, S.J.4    Moon, G.J.5    Park, U.J.6    Gwag, B.J.7
  • 201
    • 0030020630 scopus 로고    scopus 로고
    • Sudden cardiac death triggered by an earthquake
    • Leor J, Poole WK & Kloner RA (1996). Sudden cardiac death triggered by an earthquake. N Engl J Med 334, 413–419.
    • (1996) N Engl J Med , vol.334 , pp. 413-419
    • Leor, J.1    Poole, W.K.2    Kloner, R.A.3
  • 202
    • 0025612373 scopus 로고
    • Prognostic implications of echocardiographically determined left ventricular mass in the Framingham Heart Study
    • Levy D, Garrison RJ, Savage DD, Kannel WB & Castelli WP (1990). Prognostic implications of echocardiographically determined left ventricular mass in the Framingham Heart Study. N Engl J Med 322, 1561–1566.
    • (1990) N Engl J Med , vol.322 , pp. 1561-1566
    • Levy, D.1    Garrison, R.J.2    Savage, D.D.3    Kannel, W.B.4    Castelli, W.P.5
  • 204
    • 33744468523 scopus 로고    scopus 로고
    • Exercise and hormesis: activation of cellular antioxidant signaling pathways
    • Li J, Gomez-Cabrera M & Vina J (2006). Exercise and hormesis: activation of cellular antioxidant signaling pathways. Ann NY Acad Sci 1067, 425–435.
    • (2006) Ann NY Acad Sci , vol.1067 , pp. 425-435
    • Li, J.1    Gomez-Cabrera, M.2    Vina, J.3
  • 205
    • 33646171070 scopus 로고    scopus 로고
    • Stress induction of GRP78/BiP and its role in cancer
    • Li J & Lee AS (2006). Stress induction of GRP78/BiP and its role in cancer. Curr Mol Med 6, 45–54.
    • (2006) Curr Mol Med , vol.6 , pp. 45-54
    • Li, J.1    Lee, A.S.2
  • 206
    • 35548952832 scopus 로고    scopus 로고
    • Effect of deficiency in SREBP cleavage-activating protein on lipid metabolism during intermittent hypoxia
    • Li J, Nanayakkara A, Jun J, Savransky V & Polotsky VY (2007a). Effect of deficiency in SREBP cleavage-activating protein on lipid metabolism during intermittent hypoxia. Physiol Genomics 31, 273–280.
    • (2007) Physiol Genomics , vol.31 , pp. 273-280
    • Li, J.1    Nanayakkara, A.2    Jun, J.3    Savransky, V.4    Polotsky, V.Y.5
  • 207
    • 33846882824 scopus 로고    scopus 로고
    • Hyperlipidemia and lipid peroxidation are dependent on the severity of chronic intermittent hypoxia
    • Li J, Savransky V, Nanayakkara A, Smith PL, O'Donnell CP & Polotsky VY (2007b). Hyperlipidemia and lipid peroxidation are dependent on the severity of chronic intermittent hypoxia. J Appl Physiol 102, 557–563.
    • (2007) J Appl Physiol , vol.102 , pp. 557-563
    • Li, J.1    Savransky, V.2    Nanayakkara, A.3    Smith, P.L.4    O'Donnell, C.P.5    Polotsky, V.Y.6
  • 209
    • 0034703217 scopus 로고    scopus 로고
    • Requirement of NAD and SIR2 for life-span extension by calorie restriction in Saccharomyces cerevisiae
    • Lin SJ, Defossez PA & Guarente L (2000). Requirement of NAD and SIR2 for life-span extension by calorie restriction in Saccharomyces cerevisiae. Science (New York, NY) 289, 2126–2128.
    • (2000) Science (New York, NY) , vol.289 , pp. 2126-2128
    • Lin, S.J.1    Defossez, P.A.2    Guarente, L.3
  • 210
    • 0347128279 scopus 로고    scopus 로고
    • Calorie restriction extends yeast life span by lowering the level of NADH
    • Lin S-J, Ford E, Haigis M, Liszt G & Guarente L (2004). Calorie restriction extends yeast life span by lowering the level of NADH. Genes Dev 18, 12–16.
    • (2004) Genes Dev , vol.18 , pp. 12-16
    • Lin, S.-J.1    Ford, E.2    Haigis, M.3    Liszt, G.4    Guarente, L.5
  • 211
    • 84980317068 scopus 로고    scopus 로고
    • HIF-1 regulates insect lifespan extension by inhibiting c-Myc-TFAM signaling and mitochondrial biogenesis
    • Lin X-W, Tang L, Yang J & Xu W-H (2016). HIF-1 regulates insect lifespan extension by inhibiting c-Myc-TFAM signaling and mitochondrial biogenesis. Biochim Biophy Acta 1863, 2594–2603.
    • (2016) Biochim Biophy Acta , vol.1863 , pp. 2594-2603
    • Lin, X.-W.1    Tang, L.2    Yang, J.3    Xu, W.-H.4
  • 212
    • 0028232785 scopus 로고
    • Transient cold shock induces the heat shock response upon recovery at 37 degrees C in human cells
    • Liu AY, Bian H, Huang LE & Lee YK (1994). Transient cold shock induces the heat shock response upon recovery at 37 degrees C in human cells. J Biol Chem 269, 14768–14775.
    • (1994) J Biol Chem , vol.269 , pp. 14768-14775
    • Liu, A.Y.1    Bian, H.2    Huang, L.E.3    Lee, Y.K.4
  • 214
    • 35648972666 scopus 로고    scopus 로고
    • Time course of proteolytic, cytokine, and myostatin gene expression after acute exercise in human skeletal muscle
    • Louis E, Raue U, Yang Y, Jemiolo B & Trappe S (2007). Time course of proteolytic, cytokine, and myostatin gene expression after acute exercise in human skeletal muscle. J Appl Physiol 103, 1744–1751.
    • (2007) J Appl Physiol , vol.103 , pp. 1744-1751
    • Louis, E.1    Raue, U.2    Yang, Y.3    Jemiolo, B.4    Trappe, S.5
  • 215
    • 33846026712 scopus 로고    scopus 로고
    • Obesity induces a phenotypic switch in adipose tissue macrophage polarization
    • Lumeng CN, Bodzin JL & Saltiel AR (2007). Obesity induces a phenotypic switch in adipose tissue macrophage polarization. J Clin Invest 117, 175–184.
    • (2007) J Clin Invest , vol.117 , pp. 175-184
    • Lumeng, C.N.1    Bodzin, J.L.2    Saltiel, A.R.3
  • 217
    • 84896507427 scopus 로고    scopus 로고
    • Association between hypoxia and perinatal arterial ischemic stroke: a meta-analysis
    • Luo L, Chen D, Qu Y, Wu J, Li X & Mu D (2014). Association between hypoxia and perinatal arterial ischemic stroke: a meta-analysis. PLoS One 9, e90106.
    • (2014) PLoS One , vol.9
    • Luo, L.1    Chen, D.2    Qu, Y.3    Wu, J.4    Li, X.5    Mu, D.6
  • 218
    • 0030886976 scopus 로고    scopus 로고
    • Compromised mitochondrial function leads to increased cytosolic calcium and to activation of MAP kinases
    • Luo Y, Bond JD & Ingram VM (1997). Compromised mitochondrial function leads to increased cytosolic calcium and to activation of MAP kinases. Proc Natl Acad Sci 94, 9705–9710.
    • (1997) Proc Natl Acad Sci , vol.94 , pp. 9705-9710
    • Luo, Y.1    Bond, J.D.2    Ingram, V.M.3
  • 219
    • 84891624189 scopus 로고    scopus 로고
    • Predicting changes in posttraumatic growth and subjective well-being among breast cancer survivors: the role of social support and stress
    • McDonough MH, Sabiston CM & Wrosch C (2014). Predicting changes in posttraumatic growth and subjective well-being among breast cancer survivors: the role of social support and stress. Psycho-Oncology 23, 114–120.
    • (2014) Psycho-Oncology , vol.23 , pp. 114-120
    • McDonough, M.H.1    Sabiston, C.M.2    Wrosch, C.3
  • 220
    • 17444413709 scopus 로고    scopus 로고
    • Glucocorticoids, depression, and mood disorders: structural remodeling in the brain
    • McEwen BS (2005). Glucocorticoids, depression, and mood disorders: structural remodeling in the brain. Metabolism 54, 20–23.
    • (2005) Metabolism , vol.54 , pp. 20-23
    • McEwen, B.S.1
  • 222
    • 20444415033 scopus 로고    scopus 로고
    • Oxidative stress in atherogenesis and arterial thrombosis: the disconnect between cellular studies and clinical outcomes
    • Madamanchi NR, Hakim Z & Runge M (2005). Oxidative stress in atherogenesis and arterial thrombosis: the disconnect between cellular studies and clinical outcomes. J Thromb Haemost 3, 254–267.
    • (2005) J Thromb Haemost , vol.3 , pp. 254-267
    • Madamanchi, N.R.1    Hakim, Z.2    Runge, M.3
  • 224
    • 0020058971 scopus 로고
    • Effects of dietary iron deficiency on iron-sulfur proteins and bioenergetic functions of skeletal muscle mitochondria
    • Maguire JJ, Davies KJA, Dallman PR & Packer L (1982). Effects of dietary iron deficiency on iron-sulfur proteins and bioenergetic functions of skeletal muscle mitochondria. Biochim Biophys Acta 679, 210–220.
    • (1982) Biochim Biophys Acta , vol.679 , pp. 210-220
    • Maguire, J.J.1    Davies, K.J.A.2    Dallman, P.R.3    Packer, L.4
  • 225
    • 84962393627 scopus 로고    scopus 로고
    • Mammalian heat shock response and mechanisms underlying its genome-wide transcriptional regulation
    • Mahat DB, Salamanca HH, Duarte FM, Danko CG & Lis JT (2016). Mammalian heat shock response and mechanisms underlying its genome-wide transcriptional regulation. Mol Cell 62, 63–78.
    • (2016) Mol Cell , vol.62 , pp. 63-78
    • Mahat, D.B.1    Salamanca, H.H.2    Duarte, F.M.3    Danko, C.G.4    Lis, J.T.5
  • 226
    • 24644478044 scopus 로고    scopus 로고
    • Analysis of global mRNA expression in human skeletal muscle during recovery from endurance exercise
    • Mahoney DJ, Parise G, Melov S, Safdar A & Tarnopolsky MA (2005). Analysis of global mRNA expression in human skeletal muscle during recovery from endurance exercise. Faseb j 19, 1498–1500.
    • (2005) Faseb j , vol.19 , pp. 1498-1500
    • Mahoney, D.J.1    Parise, G.2    Melov, S.3    Safdar, A.4    Tarnopolsky, M.A.5
  • 227
    • 78650920491 scopus 로고    scopus 로고
    • Sugar-sweetened beverages and risk of metabolic syndrome and type 2 diabetes a meta-analysis
    • Malik VS, Popkin BM, Bray GA, Després J-P, Willett WC & Hu FB (2010). Sugar-sweetened beverages and risk of metabolic syndrome and type 2 diabetes a meta-analysis. Diabetes Care 33, 2477–2483.
    • (2010) Diabetes Care , vol.33 , pp. 2477-2483
    • Malik, V.S.1    Popkin, B.M.2    Bray, G.A.3    Després, J.-P.4    Willett, W.C.5    Hu, F.B.6
  • 228
    • 84898883354 scopus 로고    scopus 로고
    • Sleep apnea and 20-year follow-up for all-cause mortality, stroke, and cancer incidence and mortality in the Busselton Health Study cohort
    • Marshall NS, Wong K, Cullen S, Knuiman MW & Grunstein RR (2014). Sleep apnea and 20-year follow-up for all-cause mortality, stroke, and cancer incidence and mortality in the Busselton Health Study cohort. J Clin Sleep Med 10, 355–362.
    • (2014) J Clin Sleep Med , vol.10 , pp. 355-362
    • Marshall, N.S.1    Wong, K.2    Cullen, S.3    Knuiman, M.W.4    Grunstein, R.R.5
  • 230
    • 33748540014 scopus 로고    scopus 로고
    • Caloric restriction and intermittent fasting: two potential diets for successful brain aging
    • Martin B, Mattson MP & Maudsley S (2006). Caloric restriction and intermittent fasting: two potential diets for successful brain aging. Ageing Res Rev 5, 332–353.
    • (2006) Ageing Res Rev , vol.5 , pp. 332-353
    • Martin, B.1    Mattson, M.P.2    Maudsley, S.3
  • 231
    • 85037992643 scopus 로고    scopus 로고
    • The role of hormesis in life extension by dietary restriction
    • In, Karger Publishers
    • Masoro E (2006). The role of hormesis in life extension by dietary restriction. In Mechanisms of Dietary Restriction in Aging and Disease, pp. 1–17. Karger Publishers.
    • (2006) Mechanisms of Dietary Restriction in Aging and Disease , pp. 1-17
    • Masoro, E.1
  • 233
    • 77953508725 scopus 로고    scopus 로고
    • Adiponectin: a key player in obesity related disorders
    • Matsuzawa Y (2010). Adiponectin: a key player in obesity related disorders. Curr Pharm Des 16, 1896–1901.
    • (2010) Curr Pharm Des , vol.16 , pp. 1896-1901
    • Matsuzawa, Y.1
  • 235
    • 37749036931 scopus 로고    scopus 로고
    • Hormesis defined
    • Mattson MP (2008). Hormesis defined. Ageing Res Rev 7, 1–7.
    • (2008) Ageing Res Rev , vol.7 , pp. 1-7
    • Mattson, M.P.1
  • 236
    • 84855550444 scopus 로고    scopus 로고
    • Hormesis: what it is and why it matters
    • In, Springer
    • Mattson MP & Calabrese EJ (2010). Hormesis: what it is and why it matters. In Hormesis, pp. 1–13. Springer.
    • (2010) Hormesis , pp. 1-13
    • Mattson, M.P.1    Calabrese, E.J.2
  • 237
    • 85016907350 scopus 로고    scopus 로고
    • Impact of intermittent fasting on health and disease processes
    • Mattson MP, Longo VD & Harvie M (2016). Impact of intermittent fasting on health and disease processes. Ageing Res Rev.
    • (2016) Ageing Res Rev
    • Mattson, M.P.1    Longo, V.D.2    Harvie, M.3
  • 238
    • 47949099098 scopus 로고    scopus 로고
    • Origin and physiological roles of inflammation
    • Medzhitov R (2008). Origin and physiological roles of inflammation. Nature 454, 428–435.
    • (2008) Nature , vol.454 , pp. 428-435
    • Medzhitov, R.1
  • 240
    • 84949662264 scopus 로고    scopus 로고
    • Mitohormesis in exercise training
    • Merry TL & Ristow M (2016). Mitohormesis in exercise training. Free Radic Biol Med 98, 123–130.
    • (2016) Free Radic Biol Med , vol.98 , pp. 123-130
    • Merry, T.L.1    Ristow, M.2
  • 241
    • 0035032219 scopus 로고    scopus 로고
    • Hypoxia extends the life span of vascular smooth muscle cells through telomerase activation
    • Minamino T, Mitsialis S & Kourembanas S (2001). Hypoxia extends the life span of vascular smooth muscle cells through telomerase activation. Mol Cell Biol 21, 3336–3342.
    • (2001) Mol Cell Biol , vol.21 , pp. 3336-3342
    • Minamino, T.1    Mitsialis, S.2    Kourembanas, S.3
  • 242
    • 0037438869 scopus 로고    scopus 로고
    • Ectopic expression of catalase in Drosophila mitochondria increases stress resistance but not longevity
    • Mockett RJ, Bayne A-CV, Kwong LK, Orr WC & Sohal RS (2003). Ectopic expression of catalase in Drosophila mitochondria increases stress resistance but not longevity. Free Radic Biol Med 34, 207–217.
    • (2003) Free Radic Biol Med , vol.34 , pp. 207-217
    • Mockett, R.J.1    Bayne, A.-C.V.2    Kwong, L.K.3    Orr, W.C.4    Sohal, R.S.5
  • 243
    • 44849094781 scopus 로고    scopus 로고
    • Proteotoxic stress and inducible chaperone networks in neurodegenerative disease and aging
    • Morimoto RI (2008). Proteotoxic stress and inducible chaperone networks in neurodegenerative disease and aging. Genes Dev 22, 1427–1438.
    • (2008) Genes Dev , vol.22 , pp. 1427-1438
    • Morimoto, R.I.1
  • 244
    • 6344286028 scopus 로고    scopus 로고
    • Decreased lifespan in the absence of expression of the mitochondrial small heat shock protein Hsp22 in Drosophila
    • Morrow G, Battistini S, Zhang P & Tanguay RM (2004). Decreased lifespan in the absence of expression of the mitochondrial small heat shock protein Hsp22 in Drosophila. J Biol Chem 279, 43382–43385.
    • (2004) J Biol Chem , vol.279 , pp. 43382-43385
    • Morrow, G.1    Battistini, S.2    Zhang, P.3    Tanguay, R.M.4
  • 248
    • 80052317552 scopus 로고    scopus 로고
    • Hypoxia triggers AMPK activation through reactive oxygen species-mediated activation of calcium release-activated calcium channels
    • Mungai PT, Waypa GB, Jairaman A, Prakriya M, Dokic D, Ball MK & Schumacker PT (2011). Hypoxia triggers AMPK activation through reactive oxygen species-mediated activation of calcium release-activated calcium channels. Mol Cell Biol 31, 3531–3545.
    • (2011) Mol Cell Biol , vol.31 , pp. 3531-3545
    • Mungai, P.T.1    Waypa, G.B.2    Jairaman, A.3    Prakriya, M.4    Dokic, D.5    Ball, M.K.6    Schumacker, P.T.7
  • 249
    • 0042203536 scopus 로고    scopus 로고
    • Multiplex stress resistance in cells from long-lived dwarf mice
    • Murakami S, Salmon A & Miller RA (2003). Multiplex stress resistance in cells from long-lived dwarf mice. FASEB J 17, 1565–1566.
    • (2003) FASEB J , vol.17 , pp. 1565-1566
    • Murakami, S.1    Salmon, A.2    Miller, R.A.3
  • 250
    • 84880720466 scopus 로고    scopus 로고
    • Effects of mild cold shock (25°C) followed by warming up at 37°C on the cellular stress response
    • Neutelings T, Lambert CA, Nusgens BV & Colige AC (2013). Effects of mild cold shock (25°C) followed by warming up at 37°C on the cellular stress response. PLoS One 8, e69687.
    • (2013) PLoS One , vol.8
    • Neutelings, T.1    Lambert, C.A.2    Nusgens, B.V.3    Colige, A.C.4
  • 251
    • 63049095076 scopus 로고    scopus 로고
    • Mitochondrial Lon protease is a human stress protein
    • Ngo JK & Davies KJA (2009). Mitochondrial Lon protease is a human stress protein. Free Radic Biol Med 46, 1042–1048.
    • (2009) Free Radic Biol Med , vol.46 , pp. 1042-1048
    • Ngo, J.K.1    Davies, K.J.A.2
  • 252
    • 80054933045 scopus 로고    scopus 로고
    • Impairment of lon-induced protection against the accumulation of oxidized proteins in senescent wi-38 fibroblasts
    • Ngo JK, Pomatto LC, Bota DA, Koop AL & Davies KJA (2011). Impairment of lon-induced protection against the accumulation of oxidized proteins in senescent wi-38 fibroblasts. J Gerontol A Biol Sci Med Sci 66, 1178–1185.
    • (2011) J Gerontol A Biol Sci Med Sci , vol.66 , pp. 1178-1185
    • Ngo, J.K.1    Pomatto, L.C.2    Bota, D.A.3    Koop, A.L.4    Davies, K.J.A.5
  • 253
    • 84878771657 scopus 로고    scopus 로고
    • Upregulation of the mitochondrial Lon Protease allows adaptation to acute oxidative stress but dysregulation is associated with chronic stress, disease, and aging
    • Ngo JK, Pomatto LC & Davies KJA (2013). Upregulation of the mitochondrial Lon Protease allows adaptation to acute oxidative stress but dysregulation is associated with chronic stress, disease, and aging. Redox Biol 1, 258–264.
    • (2013) Redox Biol , vol.1 , pp. 258-264
    • Ngo, J.K.1    Pomatto, L.C.2    Davies, K.J.A.3
  • 254
    • 69949170481 scopus 로고    scopus 로고
    • Regulation of PERK signaling and leukemic cell survival by a novel cytosolic isoform of the UPR regulator GRP78/BiP
    • Ni M, Zhou H, Wey S, Baumeister P & Lee AS (2009). Regulation of PERK signaling and leukemic cell survival by a novel cytosolic isoform of the UPR regulator GRP78/BiP. PLoS One 4, e6868.
    • (2009) PLoS One , vol.4
    • Ni, M.1    Zhou, H.2    Wey, S.3    Baumeister, P.4    Lee, A.S.5
  • 255
    • 5444240961 scopus 로고    scopus 로고
    • Contribution of NAD (P) H: quinone oxidoreductase 1 to protection against carcinogenesis, and regulation of its gene by the Nrf2 basic-region leucine zipper and the arylhydrocarbon receptor basic helix-loop-helix transcription factors
    • Nioi P & Hayes JD (2004). Contribution of NAD (P) H: quinone oxidoreductase 1 to protection against carcinogenesis, and regulation of its gene by the Nrf2 basic-region leucine zipper and the arylhydrocarbon receptor basic helix-loop-helix transcription factors. Mutat Res/Fund Mol Mech Mutagenesis 555, 149–171.
    • (2004) Mutat Res/Fund Mol Mech Mutagenesis , vol.555 , pp. 149-171
    • Nioi, P.1    Hayes, J.D.2
  • 257
    • 47249158198 scopus 로고    scopus 로고
    • Insulin-like growth factor-I protects cells from ER stress-induced apoptosis via enhancement of the adaptive capacity of endoplasmic reticulum
    • Novosyadlyy R, Kurshan N, Lann D, Vijayakumar A, Yakar S & LeRoith D (2008). Insulin-like growth factor-I protects cells from ER stress-induced apoptosis via enhancement of the adaptive capacity of endoplasmic reticulum. Cell Death Differ 15, 1304–1317.
    • (2008) Cell Death Differ , vol.15 , pp. 1304-1317
    • Novosyadlyy, R.1    Kurshan, N.2    Lann, D.3    Vijayakumar, A.4    Yakar, S.5    LeRoith, D.6
  • 260
    • 84872166765 scopus 로고    scopus 로고
    • Pleiotropic actions of insulin resistance and inflammation in metabolic homeostasis
    • Odegaard JI & Chawla A (2013). Pleiotropic actions of insulin resistance and inflammation in metabolic homeostasis. Science (New York, NY) 339, 172–177.
    • (2013) Science (New York, NY) , vol.339 , pp. 172-177
    • Odegaard, J.I.1    Chawla, A.2
  • 261
    • 70449519969 scopus 로고    scopus 로고
    • Contribution of hypoxia to Alzheimer's disease: is HIF-1alpha a mediator of neurodegeneration
    • Ogunshola OO & Antoniou X (2009). Contribution of hypoxia to Alzheimer's disease: is HIF-1alpha a mediator of neurodegeneration? Cell Mol Life Sci 66, 3555–3563.
    • (2009) Cell Mol Life Sci , vol.66 , pp. 3555-3563
    • Ogunshola, O.O.1    Antoniou, X.2
  • 262
    • 0036713724 scopus 로고    scopus 로고
    • Distinct roles of activating transcription factor 6 (ATF6) and double-stranded RNA-activated protein kinase-like endoplasmic reticulum kinase (PERK) in transcription during the mammalian unfolded protein response
    • Okada T, Yoshida H, Akazawa R, Negishi M & Kazutoshi M (2002). Distinct roles of activating transcription factor 6 (ATF6) and double-stranded RNA-activated protein kinase-like endoplasmic reticulum kinase (PERK) in transcription during the mammalian unfolded protein response. Biochem J 366, 585–594.
    • (2002) Biochem J , vol.366 , pp. 585-594
    • Okada, T.1    Yoshida, H.2    Akazawa, R.3    Negishi, M.4    Kazutoshi, M.5
  • 264
    • 84869083501 scopus 로고    scopus 로고
    • Enhanced age-related cataract in copper-zinc superoxide dismutase null mice
    • Olofsson EM, Marklund SL & Behndig A (2012). Enhanced age-related cataract in copper-zinc superoxide dismutase null mice. Clin Experiment Ophthalmol 40, 813–820.
    • (2012) Clin Experiment Ophthalmol , vol.40 , pp. 813-820
    • Olofsson, E.M.1    Marklund, S.L.2    Behndig, A.3
  • 266
    • 80053629048 scopus 로고    scopus 로고
    • Molecular and structural antioxidant defenses against oxidative stress in animals
    • Pamplona R & Costantini D (2011). Molecular and structural antioxidant defenses against oxidative stress in animals. Am J Physiol Regul Integr Comp Physiol 301, R843–R863.
    • (2011) Am J Physiol Regul Integr Comp Physiol , vol.301 , pp. R843-R863
    • Pamplona, R.1    Costantini, D.2
  • 267
    • 84910075230 scopus 로고    scopus 로고
    • Can sleep apnea cause Alzheimer's disease
    • Pan W & Kastin AJ (2014). Can sleep apnea cause Alzheimer's disease? Neurosci Biobehav Rev 47, 656–669.
    • (2014) Neurosci Biobehav Rev , vol.47 , pp. 656-669
    • Pan, W.1    Kastin, A.J.2
  • 268
    • 0021154216 scopus 로고
    • A Drosophila RNA polymerase II transcription factor binds to the regulatory site of an hsp 70 gene
    • Parker CS & Topol J (1984). A Drosophila RNA polymerase II transcription factor binds to the regulatory site of an hsp 70 gene. Cell 37, 273–283.
    • (1984) Cell , vol.37 , pp. 273-283
    • Parker, C.S.1    Topol, J.2
  • 275
    • 84862736551 scopus 로고    scopus 로고
    • Degradation of damaged proteins-the main function of the 20S proteasome
    • Pickering AM & Davies KJA (2012a). Degradation of damaged proteins-the main function of the 20S proteasome. Prog Mol Biol Transl Sci 109, 227–248.
    • (2012) Prog Mol Biol Transl Sci , vol.109 , pp. 227-248
    • Pickering, A.M.1    Davies, K.J.A.2
  • 276
    • 84861869794 scopus 로고    scopus 로고
    • Differential roles of proteasome and immunoproteasome regulators Pa28αβ, Pa28γ and Pa200 in the degradation of oxidized proteins
    • Pickering AM & Davies KJA (2012b). Differential roles of proteasome and immunoproteasome regulators Pa28αβ, Pa28γ and Pa200 in the degradation of oxidized proteins. Arch Biochem Biophys 523, 181–190.
    • (2012) Arch Biochem Biophys , vol.523 , pp. 181-190
    • Pickering, A.M.1    Davies, K.J.A.2
  • 277
    • 84929011938 scopus 로고    scopus 로고
    • Lifespan of mice and primates correlates with immunoproteasome expression
    • Pickering AM, Lehr M & Miller RA (2015). Lifespan of mice and primates correlates with immunoproteasome expression. J Clin Invest 125, 2059–2068.
    • (2015) J Clin Invest , vol.125 , pp. 2059-2068
    • Pickering, A.M.1    Lehr, M.2    Miller, R.A.3
  • 278
    • 84858972249 scopus 로고    scopus 로고
    • Nrf2-dependent induction of proteasome and Pa28αβ regulator are required for adaptation to oxidative stress
    • Pickering AM, Linder RA, Zhang H, Forman HJ & Davies KJA (2012). Nrf2-dependent induction of proteasome and Pa28αβ regulator are required for adaptation to oxidative stress. J Biol Chem 287, 10021–10031.
    • (2012) J Biol Chem , vol.287 , pp. 10021-10031
    • Pickering, A.M.1    Linder, R.A.2    Zhang, H.3    Forman, H.J.4    Davies, K.J.A.5
  • 279
    • 84873417130 scopus 로고    scopus 로고
    • A conserved role for the 20S proteasome and Nrf2 transcription factor in oxidative stress adaptation in mammals, Caenorhabditis elegans and Drosophila melanogaster
    • Pickering AM, Staab TA, Tower J, Sieburth D & Davies KJA (2013a). A conserved role for the 20S proteasome and Nrf2 transcription factor in oxidative stress adaptation in mammals, Caenorhabditis elegans and Drosophila melanogaster. J Exp Biol 216, 543–553.
    • (2013) J Exp Biol , vol.216 , pp. 543-553
    • Pickering, A.M.1    Staab, T.A.2    Tower, J.3    Sieburth, D.4    Davies, K.J.A.5
  • 281
    • 0028186967 scopus 로고
    • Endurance exercise in aging humans: effects on energy metabolism
    • Poehlman ET, Arciero PJ & Goran MI (1993). Endurance exercise in aging humans: effects on energy metabolism. Exerc Sport Sci Rev 22, 251–284.
    • (1993) Exerc Sport Sci Rev , vol.22 , pp. 251-284
    • Poehlman, E.T.1    Arciero, P.J.2    Goran, M.I.3
  • 283
    • 85055564814 scopus 로고    scopus 로고
    • The peroxisomal Lon protease LonP2 in aging and disease: functions and comparisons with mitochondrial Lon protease LonP1
    • Pomatto LC, Raynes R & Davies KJA (2016b). The peroxisomal Lon protease LonP2 in aging and disease: functions and comparisons with mitochondrial Lon protease LonP1. Biol Rev 92, 739–753.
    • (2016) Biol Rev , vol.92 , pp. 739-753
    • Pomatto, L.C.1    Raynes, R.2    Davies, K.J.A.3
  • 284
    • 85033401645 scopus 로고    scopus 로고
    • Sexual dimorphism and aging differentially regulate adaptive homeostasis
    • (in press;
    • Pomatto LCD, Tower J & Davies KJA (2017a). Sexual dimorphism and aging differentially regulate adaptive homeostasis. J Gerontol A Biol Sci Med Sci (in press; https://doi.org/10.1093/gerona/glx083).
    • (2017) J Gerontol A Biol Sci Med Sci
    • Pomatto, L.C.D.1    Tower, J.2    Davies, K.J.A.3
  • 285
    • 85018942373 scopus 로고    scopus 로고
    • The age-and sex-specific decline of the 20s proteasome and the Nrf2/CncC signal transduction pathway in adaption and resistance to oxidative stress in Drosophila melanogaster
    • Pomatto LC, Wong S, Carney C, Shen B, Tower J & Davies KJA (2017b). The age-and sex-specific decline of the 20s proteasome and the Nrf2/CncC signal transduction pathway in adaption and resistance to oxidative stress in Drosophila melanogaster. Aging (Albany NY) 9, 1153-1185.
    • (2017) Aging (Albany NY) , vol.9 , pp. 1153-1185
    • Pomatto, L.C.1    Wong, S.2    Carney, C.3    Shen, B.4    Tower, J.5    Davies, K.J.A.6
  • 286
    • 33750706551 scopus 로고    scopus 로고
    • Expression of stress response protein Grp78 is associated with the development of castration-resistant prostate cancer
    • Pootrakul L, Datar RH, Shi S-R, Cai J, Hawes D, Groshen SG, Lee AS & Cote RJ (2006). Expression of stress response protein Grp78 is associated with the development of castration-resistant prostate cancer. Clin Cancer Res 12, 5987–5993.
    • (2006) Clin Cancer Res , vol.12 , pp. 5987-5993
    • Pootrakul, L.1    Datar, R.H.2    Shi, S.-R.3    Cai, J.4    Hawes, D.5    Groshen, S.G.6    Lee, A.S.7    Cote, R.J.8
  • 287
    • 33644639061 scopus 로고    scopus 로고
    • Proteasomal defense of oxidative protein modifications
    • Poppek D & Grune T (2006). Proteasomal defense of oxidative protein modifications. Antioxid Redox Signal 8, 173–184.
    • (2006) Antioxid Redox Signal , vol.8 , pp. 173-184
    • Poppek, D.1    Grune, T.2
  • 288
    • 74049129489 scopus 로고    scopus 로고
    • Reactive oxygen species are signalling molecules for skeletal muscle adaptation
    • Powers SK, Duarte J, Kavazis AN & Talbert EE (2010). Reactive oxygen species are signalling molecules for skeletal muscle adaptation. Exp Physiol 95, 1–9.
    • (2010) Exp Physiol , vol.95 , pp. 1-9
    • Powers, S.K.1    Duarte, J.2    Kavazis, A.N.3    Talbert, E.E.4
  • 289
    • 0020323482 scopus 로고
    • Oral and environmental temperatures in a Scottish urban geriatric population
    • Primrose W & Smith L (1982). Oral and environmental temperatures in a Scottish urban geriatric population. J Clin Exp Gerontol 42, 151–165.
    • (1982) J Clin Exp Gerontol , vol.42 , pp. 151-165
    • Primrose, W.1    Smith, L.2
  • 290
    • 84979248341 scopus 로고    scopus 로고
    • External induction of heat shock stimulates the immune response and longevity of Caenorhabditis elegans towards pathogen exposure
    • Prithika U, Deepa V & Balamurugan K (2016). External induction of heat shock stimulates the immune response and longevity of Caenorhabditis elegans towards pathogen exposure. Innate Immunity 22, 466–478.
    • (2016) Innate Immunity , vol.22 , pp. 466-478
    • Prithika, U.1    Deepa, V.2    Balamurugan, K.3
  • 291
    • 35448967382 scopus 로고    scopus 로고
    • The unfolded protein response regulator GRP78/BiP as a novel target for increasing chemosensitivity in malignant gliomas
    • Pyrko P, Schönthal AH, Hofman FM, Chen TC & Lee AS (2007). The unfolded protein response regulator GRP78/BiP as a novel target for increasing chemosensitivity in malignant gliomas. Cancer Res 67, 9809–9816.
    • (2007) Cancer Res , vol.67 , pp. 9809-9816
    • Pyrko, P.1    Schönthal, A.H.2    Hofman, F.M.3    Chen, T.C.4    Lee, A.S.5
  • 292
    • 0036452555 scopus 로고    scopus 로고
    • Exercise training decreases DNA damage and increases DNA repair and resistance against oxidative stress of proteins in aged rat skeletal muscle
    • Radák Z, Naito H, Kaneko T, Tahara S, Nakamoto H, Takahashi R, Cardozo-Pelaez F & Goto S (2002). Exercise training decreases DNA damage and increases DNA repair and resistance against oxidative stress of proteins in aged rat skeletal muscle. Pflügers Archiv 445, 273–278.
    • (2002) Pflügers Archiv , vol.445 , pp. 273-278
    • Radák, Z.1    Naito, H.2    Kaneko, T.3    Tahara, S.4    Nakamoto, H.5    Takahashi, R.6    Cardozo-Pelaez, F.7    Goto, S.8
  • 293
    • 38349112898 scopus 로고    scopus 로고
    • Age-associated loss of Sirt1-mediated enhancement of glucose-stimulated insulin secretion in beta cell-specific Sirt1-overexpressing (BESTO) mice
    • Ramsey KM, Mills KF, Satoh A & Imai Si (2008). Age-associated loss of Sirt1-mediated enhancement of glucose-stimulated insulin secretion in beta cell-specific Sirt1-overexpressing (BESTO) mice. Aging Cell 7, 78–88.
    • (2008) Aging Cell , vol.7 , pp. 78-88
    • Ramsey, K.M.1    Mills, K.F.2    Satoh, A.3    Imai, S.4
  • 294
    • 0035869234 scopus 로고    scopus 로고
    • Increased glucocorticoid production and altered cortisol metabolism in women with mild to moderate Alzheimer's disease
    • Rasmuson S, Andrew R, Näsman B, Seckl JR, Walker BR & Olsson T (2001). Increased glucocorticoid production and altered cortisol metabolism in women with mild to moderate Alzheimer's disease. Biol Psychiatry 49, 547–552.
    • (2001) Biol Psychiatry , vol.49 , pp. 547-552
    • Rasmuson, S.1    Andrew, R.2    Näsman, B.3    Seckl, J.R.4    Walker, B.R.5    Olsson, T.6
  • 296
    • 84857116578 scopus 로고    scopus 로고
    • Reactive oxygen species (ROS) homeostasis and redox regulation in cellular signaling
    • Ray PD, Huang B-W & Tsuji Y (2012). Reactive oxygen species (ROS) homeostasis and redox regulation in cellular signaling. Cell Signal 24, 981–990.
    • (2012) Cell Signal , vol.24 , pp. 981-990
    • Ray, P.D.1    Huang, B.-W.2    Tsuji, Y.3
  • 298
    • 84975159148 scopus 로고    scopus 로고
    • Degradation of oxidized proteins by the proteasome: Distinguishing between the 20S, 26S, and immunoproteasome proteolytic pathways
    • Raynes R, Pomatto LC & Davies KJA (2016b). Degradation of oxidized proteins by the proteasome: Distinguishing between the 20S, 26S, and immunoproteasome proteolytic pathways. Mol Aspects Med 50, 41–55.
    • (2016) Mol Aspects Med , vol.50 , pp. 41-55
    • Raynes, R.1    Pomatto, L.C.2    Davies, K.J.A.3
  • 299
    • 84982103066 scopus 로고    scopus 로고
    • The molecular chaperone Hsp70 promotes the proteolytic removal of oxidatively damaged proteins by the proteasome
    • Reeg S, Jung T, Castro JP, Davies KJA, Henze A & Grune T (2016). The molecular chaperone Hsp70 promotes the proteolytic removal of oxidatively damaged proteins by the proteasome. Free Radic Biol Med 99, 153–166.
    • (2016) Free Radic Biol Med , vol.99 , pp. 153-166
    • Reeg, S.1    Jung, T.2    Castro, J.P.3    Davies, K.J.A.4    Henze, A.5    Grune, T.6
  • 300
    • 84855218925 scopus 로고    scopus 로고
    • Skeletal muscle power: a critical determinant of physical functioning in older adults
    • Reid KF & Fielding RA (2012). Skeletal muscle power: a critical determinant of physical functioning in older adults. Exerc Sport Sci Rev 40, 4–12.
    • (2012) Exerc Sport Sci Rev , vol.40 , pp. 4-12
    • Reid, K.F.1    Fielding, R.A.2
  • 303
    • 0037421839 scopus 로고    scopus 로고
    • Chemiosmotic coupling: the cost of living
    • Rich P (2003). Chemiosmotic coupling: the cost of living. Nature 421, 583–583.
    • (2003) Nature , vol.421 , pp. 583
    • Rich, P.1
  • 305
    • 61449106744 scopus 로고    scopus 로고
    • AMPK and the biochemistry of exercise: implications for human health and disease
    • Richter EA & Ruderman NB (2009). AMPK and the biochemistry of exercise: implications for human health and disease. Biochem J 418, 261–275.
    • (2009) Biochem J , vol.418 , pp. 261-275
    • Richter, E.A.1    Ruderman, N.B.2
  • 306
    • 0034703017 scopus 로고    scopus 로고
    • Age-dependent defect in vascular endothelial growth factor expression is associated with reduced hypoxia-inducible factor 1 activity
    • Rivard A, Berthou-Soulie L, Principe N, Kearney M, Curry C, Branellec D, Semenza GL & Isner JM (2000). Age-dependent defect in vascular endothelial growth factor expression is associated with reduced hypoxia-inducible factor 1 activity. J Biol Chem 275, 29643–29647.
    • (2000) J Biol Chem , vol.275 , pp. 29643-29647
    • Rivard, A.1    Berthou-Soulie, L.2    Principe, N.3    Kearney, M.4    Curry, C.5    Branellec, D.6    Semenza, G.L.7    Isner, J.M.8
  • 307
    • 14544282413 scopus 로고    scopus 로고
    • Nutrient control of gluconeogenesis through PGC-1α/SIRT1 deacetylase complex
    • Rodgers J, Lerin C, Haas W, Gygi S, Spiegelman B & Puigserver P (2005). Nutrient control of gluconeogenesis through PGC-1α/SIRT1 deacetylase complex. Nature 434, 113–118.
    • (2005) Nature , vol.434 , pp. 113-118
    • Rodgers, J.1    Lerin, C.2    Haas, W.3    Gygi, S.4    Spiegelman, B.5    Puigserver, P.6
  • 308
    • 34547906123 scopus 로고    scopus 로고
    • Fasting-dependent glucose and lipid metabolic response through hepatic sirtuin 1
    • Rodgers JT & Puigserver P (2007). Fasting-dependent glucose and lipid metabolic response through hepatic sirtuin 1. Proc Natl Acad Sci USA 104, 12861–12866.
    • (2007) Proc Natl Acad Sci USA , vol.104 , pp. 12861-12866
    • Rodgers, J.T.1    Puigserver, P.2
  • 309
    • 84924705776 scopus 로고    scopus 로고
    • Organic extracts from African dust storms stimulate oxidative stress and induce inflammatory responses in human lung cells through Nrf2 but not NF-κB
    • Rodríguez-Cotto RI, Ortiz-Martínez MG & Jiménez-Vélez BD (2015). Organic extracts from African dust storms stimulate oxidative stress and induce inflammatory responses in human lung cells through Nrf2 but not NF-κB. Environ Toxicol Pharmacol 39, 845–856.
    • (2015) Environ Toxicol Pharmacol , vol.39 , pp. 845-856
    • Rodríguez-Cotto, R.I.1    Ortiz-Martínez, M.G.2    Jiménez-Vélez, B.D.3
  • 311
    • 8644224064 scopus 로고    scopus 로고
    • Sir2 mediates longevity in the fly through a pathway related to calorie restriction
    • Rogina B & Helfand SL (2004a). Sir2 mediates longevity in the fly through a pathway related to calorie restriction. Proc Natl Acad Sci USA 101, 15998–16003.
    • (2004) Proc Natl Acad Sci USA , vol.101 , pp. 15998-16003
    • Rogina, B.1    Helfand, S.L.2
  • 312
    • 8644224064 scopus 로고    scopus 로고
    • Sir2 mediates longevity in the fly through a pathway related to calorie restriction
    • Rogina B & Helfand SL (2004b). Sir2 mediates longevity in the fly through a pathway related to calorie restriction. Proc Natl Acad Sci USA 101, 15998–16003.
    • (2004) Proc Natl Acad Sci USA , vol.101 , pp. 15998-16003
    • Rogina, B.1    Helfand, S.L.2
  • 313
    • 18744416824 scopus 로고    scopus 로고
    • Longevity regulation by Drosophila Rpd3 deacetylase and caloric restriction
    • Rogina B, Helfand SL & Frankel S (2002). Longevity regulation by Drosophila Rpd3 deacetylase and caloric restriction. Science (New York, NY) 298, 1745–1745.
    • (2002) Science (New York, NY) , vol.298 , pp. 1745
    • Rogina, B.1    Helfand, S.L.2    Frankel, S.3
  • 314
    • 84898472912 scopus 로고    scopus 로고
    • Stimulation of systemic low-grade inflammation by psychosocial stress
    • Rohleder N (2014). Stimulation of systemic low-grade inflammation by psychosocial stress. Psychosom Med 76, 181–189.
    • (2014) Psychosom Med , vol.76 , pp. 181-189
    • Rohleder, N.1
  • 317
    • 84875968253 scopus 로고    scopus 로고
    • Surveillance-activated defenses block the ROS–induced mitochondrial unfolded protein response
    • Runkel ED, Liu S, Baumeister R & Schulze E (2013). Surveillance-activated defenses block the ROS–induced mitochondrial unfolded protein response. PLoS Genet 9, e1003346.
    • (2013) PLoS Genet , vol.9
    • Runkel, E.D.1    Liu, S.2    Baumeister, R.3    Schulze, E.4
  • 318
    • 0034123657 scopus 로고    scopus 로고
    • Mechanical stress-induced cardiac hypertrophy: mechanisms and signal transduction pathways
    • Ruwhof C & van der Laarse A (2000). Mechanical stress-induced cardiac hypertrophy: mechanisms and signal transduction pathways. Cardiovasc Res 47, 23–37.
    • (2000) Cardiovasc Res , vol.47 , pp. 23-37
    • Ruwhof, C.1    van der Laarse, A.2
  • 319
    • 84867162776 scopus 로고    scopus 로고
    • Response to hyperosmotic stress
    • Saito H & Posas F (2012). Response to hyperosmotic stress. Genetics 192, 289–318.
    • (2012) Genetics , vol.192 , pp. 289-318
    • Saito, H.1    Posas, F.2
  • 320
    • 0025913239 scopus 로고
    • HSP70 and other possible heat shock or oxidative stress proteins are induced in skeletal muscle, heart, and liver during exercise
    • Salo DC, Donovan CM & Davies KJA (1991). HSP70 and other possible heat shock or oxidative stress proteins are induced in skeletal muscle, heart, and liver during exercise. Free Radic Biol Med 11, 239–246.
    • (1991) Free Radic Biol Med , vol.11 , pp. 239-246
    • Salo, D.C.1    Donovan, C.M.2    Davies, K.J.A.3
  • 321
    • 79961210978 scopus 로고    scopus 로고
    • Higher levels of heat shock proteins in longer-lived mammals and birds
    • Salway KD, Gallagher EJ, Page MM & Stuart JA (2011). Higher levels of heat shock proteins in longer-lived mammals and birds. Mech Ageing Dev 132, 287–297.
    • (2011) Mech Ageing Dev , vol.132 , pp. 287-297
    • Salway, K.D.1    Gallagher, E.J.2    Page, M.M.3    Stuart, J.A.4
  • 322
    • 84883461858 scopus 로고    scopus 로고
    • Regulation of longevity and oxidative stress by nutritional interventions: role of methionine restriction
    • Sanchez-Roman I & Barja G (2013). Regulation of longevity and oxidative stress by nutritional interventions: role of methionine restriction. Exp Gerontol 48, 1030–1042.
    • (2013) Exp Gerontol , vol.48 , pp. 1030-1042
    • Sanchez-Roman, I.1    Barja, G.2
  • 324
    • 33745970444 scopus 로고    scopus 로고
    • Methionine restriction decreases mitochondrial oxygen radical generation and leak as well as oxidative damage to mitochondrial DNA and proteins
    • Sanz A, Caro P, Ayala V, Portero-Otin M, Pamplona R & Barja G (2006). Methionine restriction decreases mitochondrial oxygen radical generation and leak as well as oxidative damage to mitochondrial DNA and proteins. FASEB J 20, 1064–1073.
    • (2006) FASEB J , vol.20 , pp. 1064-1073
    • Sanz, A.1    Caro, P.2    Ayala, V.3    Portero-Otin, M.4    Pamplona, R.5    Barja, G.6
  • 325
    • 33745384267 scopus 로고    scopus 로고
    • Molecular mechanisms of aging-associated inflammation
    • Sarkar D & Fisher PB (2006). Molecular mechanisms of aging-associated inflammation. Cancer Lett 236, 13–23.
    • (2006) Cancer Lett , vol.236 , pp. 13-23
    • Sarkar, D.1    Fisher, P.B.2
  • 326
    • 33645011201 scopus 로고    scopus 로고
    • Nuclear control of respiratory gene expression in mammalian cells
    • Scarpulla RC (2006). Nuclear control of respiratory gene expression in mammalian cells. J Cell Biochem 97(4), 673–683.
    • (2006) J Cell Biochem , vol.97 , Issue.4 , pp. 673-683
    • Scarpulla, R.C.1
  • 327
    • 40949165265 scopus 로고    scopus 로고
    • The future of obesity: new drugs versus lifestyle interventions
    • Scheen AJ (2008). The future of obesity: new drugs versus lifestyle interventions. Expert Opin Investig Drugs 17, 263–267.
    • (2008) Expert Opin Investig Drugs , vol.17 , pp. 263-267
    • Scheen, A.J.1
  • 328
    • 33747356154 scopus 로고    scopus 로고
    • Adipose tissue from lipid storage compartment to endocrine organ
    • Scherer PE (2006). Adipose tissue from lipid storage compartment to endocrine organ. Diabetes 55, 1537–1545.
    • (2006) Diabetes , vol.55 , pp. 1537-1545
    • Scherer, P.E.1
  • 329
    • 84901052694 scopus 로고    scopus 로고
    • ROS function in redox signaling and oxidative stress
    • Schieber M & Chandel NS (2014). ROS function in redox signaling and oxidative stress. Curr Biol 24, R453–R462.
    • (2014) Curr Biol , vol.24 , pp. R453-R462
    • Schieber, M.1    Chandel, N.S.2
  • 330
    • 0025739254 scopus 로고
    • Reactive oxygen intermediates as apparently widely used messengers in the activation of the NF-kappa B transcription factor and HIV-1
    • Schreck R, Rieber P & Baeuerle PA (1991). Reactive oxygen intermediates as apparently widely used messengers in the activation of the NF-kappa B transcription factor and HIV-1. EMBO J 10, 2247.
    • (1991) EMBO J , vol.10 , pp. 2247
    • Schreck, R.1    Rieber, P.2    Baeuerle, P.A.3
  • 331
    • 0028106363 scopus 로고
    • The HOG pathway controls osmotic regulation of transcription via the stress response element (STRE) of the Saccharomyces cerevisiae CTT1 gene
    • Schüller C, Brewster J, Alexander M, Gustin M & Ruis H (1994). The HOG pathway controls osmotic regulation of transcription via the stress response element (STRE) of the Saccharomyces cerevisiae CTT1 gene. EMBO J 13, 4382–4389.
    • (1994) EMBO J , vol.13 , pp. 4382-4389
    • Schüller, C.1    Brewster, J.2    Alexander, M.3    Gustin, M.4    Ruis, H.5
  • 332
    • 84890100613 scopus 로고    scopus 로고
    • The human coronary collateral circulation: development and clinical importance
    • Seiler C, Stoller M, Pitt B & Meier P (2013). The human coronary collateral circulation: development and clinical importance. Eur Heart J 34, 2674–2682.
    • (2013) Eur Heart J , vol.34 , pp. 2674-2682
    • Seiler, C.1    Stoller, M.2    Pitt, B.3    Meier, P.4
  • 333
    • 0037098875 scopus 로고    scopus 로고
    • The consequences of acute cold exposure on protein oxidation and proteasome activity in short-tailed field voles, Microtus agrestis
    • Selman C, Grune T, Stolzing A, Jakstadt M, McLaren JS & Speakman JR (2002). The consequences of acute cold exposure on protein oxidation and proteasome activity in short-tailed field voles, Microtus agrestis. Free Radic Biol Med 33, 259–265.
    • (2002) Free Radic Biol Med , vol.33 , pp. 259-265
    • Selman, C.1    Grune, T.2    Stolzing, A.3    Jakstadt, M.4    McLaren, J.S.5    Speakman, J.R.6
  • 334
    • 84966541244 scopus 로고
    • Homeostasis and heterostasis
    • In, Springer
    • Selye H (1975). Homeostasis and heterostasis. In Trauma, pp. 25–29. Springer.
    • (1975) Trauma , pp. 25-29
    • Selye, H.1
  • 335
    • 0034006016 scopus 로고    scopus 로고
    • HIF-1: mediator of physiological and pathophysiological responses to hypoxia
    • Semenza GL (2000). HIF-1: mediator of physiological and pathophysiological responses to hypoxia. J Appl Physiol 88, 1474–1480.
    • (2000) J Appl Physiol , vol.88 , pp. 1474-1480
    • Semenza, G.L.1
  • 336
    • 34347227058 scopus 로고    scopus 로고
    • Oxygen-dependent regulation of mitochondrial respiration by hypoxia-inducible factor 1
    • Semenza GL (2007). Oxygen-dependent regulation of mitochondrial respiration by hypoxia-inducible factor 1. Biochem J 405, 1–9.
    • (2007) Biochem J , vol.405 , pp. 1-9
    • Semenza, G.L.1
  • 337
    • 76349095132 scopus 로고    scopus 로고
    • Defining the role of hypoxia-inducible factor 1 in cancer biology and therapeutics
    • Semenza GL (2010a). Defining the role of hypoxia-inducible factor 1 in cancer biology and therapeutics. Oncogene 29, 625–634.
    • (2010) Oncogene , vol.29 , pp. 625-634
    • Semenza, G.L.1
  • 338
    • 77950901310 scopus 로고    scopus 로고
    • Vascular responses to hypoxia and ischemia
    • Semenza GL (2010b). Vascular responses to hypoxia and ischemia. Arterioscler Thromb Vasc Biol 30, 648–652.
    • (2010) Arterioscler Thromb Vasc Biol , vol.30 , pp. 648-652
    • Semenza, G.L.1
  • 339
    • 84883501150 scopus 로고    scopus 로고
    • HIF-1 mediates metabolic responses to intratumoral hypoxia and oncogenic mutations
    • Semenza GL (2013). HIF-1 mediates metabolic responses to intratumoral hypoxia and oncogenic mutations. J Clin Invest 123, 3664–3671.
    • (2013) J Clin Invest , vol.123 , pp. 3664-3671
    • Semenza, G.L.1
  • 340
    • 0030460724 scopus 로고    scopus 로고
    • Hypoxia response elements in the aldolase A, enolase 1, and lactate dehydrogenase A gene promoters contain essential binding sites for hypoxia-inducible factor 1
    • Semenza GL, Jiang BH, Leung SW, Passantino R, Concordet JP, Maire P & Giallongo A (1996). Hypoxia response elements in the aldolase A, enolase 1, and lactate dehydrogenase A gene promoters contain essential binding sites for hypoxia-inducible factor 1. J Biol Chem 271, 32529–32537.
    • (1996) J Biol Chem , vol.271 , pp. 32529-32537
    • Semenza, G.L.1    Jiang, B.H.2    Leung, S.W.3    Passantino, R.4    Concordet, J.P.5    Maire, P.6    Giallongo, A.7
  • 341
    • 84938075260 scopus 로고    scopus 로고
    • Obstructive sleep apnea in patients with congenital long QT syndrome: implications for increased risk of sudden cardiac death
    • Shamsuzzaman AS, Somers VK, Knilans TK, Ackerman MJ, Wang Y & Amin RS (2015). Obstructive sleep apnea in patients with congenital long QT syndrome: implications for increased risk of sudden cardiac death. Sleep 38, 1113–1139.
    • (2015) Sleep , vol.38 , pp. 1113-1139
    • Shamsuzzaman, A.S.1    Somers, V.K.2    Knilans, T.K.3    Ackerman, M.J.4    Wang, Y.5    Amin, R.S.6
  • 342
    • 8644264053 scopus 로고    scopus 로고
    • MAP kinases and the adaptive response to hypertonicity: functional preservation from yeast to mammals
    • Sheikh-Hamad D & Gustin MC (2004). MAP kinases and the adaptive response to hypertonicity: functional preservation from yeast to mammals. Am J Physiol Ren Physiol 287, F1102–F1110.
    • (2004) Am J Physiol Ren Physiol , vol.287 , pp. F1102-F1110
    • Sheikh-Hamad, D.1    Gustin, M.C.2
  • 343
    • 0036591853 scopus 로고    scopus 로고
    • Protein turnover by the proteasome in aging and disease 1, 2
    • Shringarpure R & Davies KJA (2002). Protein turnover by the proteasome in aging and disease 1, 2. Free Radic Biol Med 32, 1084–1089.
    • (2002) Free Radic Biol Med , vol.32 , pp. 1084-1089
    • Shringarpure, R.1    Davies, K.J.A.2
  • 344
    • 0034798361 scopus 로고    scopus 로고
    • Protein oxidation and 20S proteasome-dependent proteolysis in mammalian cells
    • Shringarpure R, Grune T & Davies KJA (2001). Protein oxidation and 20S proteasome-dependent proteolysis in mammalian cells. Cell Mol Life Sci 58, 1442–1450.
    • (2001) Cell Mol Life Sci , vol.58 , pp. 1442-1450
    • Shringarpure, R.1    Grune, T.2    Davies, K.J.A.3
  • 346
    • 0033674181 scopus 로고    scopus 로고
    • Protein oxidation and degradation during cellular senescence of human BJ fibroblasts: part II – aging of nondividing cells
    • Sitte N, Merker K, Von Zglinicki T, Davies KJA & Grune T (2000b). Protein oxidation and degradation during cellular senescence of human BJ fibroblasts: part II – aging of nondividing cells. FASEB J 14, 2503–2510.
    • (2000) FASEB J , vol.14 , pp. 2503-2510
    • Sitte, N.1    Merker, K.2    Von Zglinicki, T.3    Davies, K.J.A.4    Grune, T.5
  • 347
    • 0034117954 scopus 로고    scopus 로고
    • Protein oxidation and degradation during proliferative senescence of human MRC-5 fibroblasts
    • Sitte N, Merker K, von Zglinicki T & Grune T (2000c). Protein oxidation and degradation during proliferative senescence of human MRC-5 fibroblasts. Free Radic Biol Med 28, 701–708.
    • (2000) Free Radic Biol Med , vol.28 , pp. 701-708
    • Sitte, N.1    Merker, K.2    von Zglinicki, T.3    Grune, T.4
  • 348
    • 0033673408 scopus 로고    scopus 로고
    • Protein oxidation and degradation during cellular senescence of human BJ fibroblasts: part I – effects of proliferative senescence
    • Sitte N, Merker K, Von Zglinicki T, Grune T & Davies KJA (2000d). Protein oxidation and degradation during cellular senescence of human BJ fibroblasts: part I – effects of proliferative senescence. FASEB J 14, 2495–2502.
    • (2000) FASEB J , vol.14 , pp. 2495-2502
    • Sitte, N.1    Merker, K.2    Von Zglinicki, T.3    Grune, T.4    Davies, K.J.A.5
  • 349
    • 34548615053 scopus 로고    scopus 로고
    • Calorie restriction extends the chronological lifespan of Saccharomyces cerevisiae independently of the Sirtuins
    • Smith DL Jr, McClure JM, Matecic M & Smith JS (2007). Calorie restriction extends the chronological lifespan of Saccharomyces cerevisiae independently of the Sirtuins. Aging Cell 6, 649–662.
    • (2007) Aging Cell , vol.6 , pp. 649-662
    • Smith, D.L.1    McClure, J.M.2    Matecic, M.3    Smith, J.S.4
  • 350
    • 0000853087 scopus 로고
    • Prolongation of the life of Drosophila subobscura by a brief exposure of adults to a high temperature
    • Smith JM (1958). Prolongation of the life of Drosophila subobscura by a brief exposure of adults to a high temperature. Nature 181, 496–497.
    • (1958) Nature , vol.181 , pp. 496-497
    • Smith, J.M.1
  • 351
    • 84958047436 scopus 로고    scopus 로고
    • Tau as the converging protein between chronic stress and Alzheimer's disease synaptic pathology
    • Sotiropoulos I & Sousa N (2015). Tau as the converging protein between chronic stress and Alzheimer's disease synaptic pathology. Neurodegener Dis 16, 22–25.
    • (2015) Neurodegener Dis , vol.16 , pp. 22-25
    • Sotiropoulos, I.1    Sousa, N.2
  • 352
    • 0000000661 scopus 로고
    • Effects of extract of western red-cedar heartwood on certain wood-decaying fungi in culture
    • Southam CM & Ehrlich J (1943). Effects of extract of western red-cedar heartwood on certain wood-decaying fungi in culture. Phytopathology 33, 517–524.
    • (1943) Phytopathology , vol.33 , pp. 517-524
    • Southam, C.M.1    Ehrlich, J.2
  • 354
    • 77950601859 scopus 로고    scopus 로고
    • gp96, an endoplasmic reticulum master chaperone for integrins and Toll-like receptors, selectively regulates early T and B lymphopoiesis
    • Staron M, Yang Y, Liu B, Li J, Shen Y, Zuniga-Pflucker JC, Aguila HL, Goldschneider I & Li Z (2010). gp96, an endoplasmic reticulum master chaperone for integrins and Toll-like receptors, selectively regulates early T and B lymphopoiesis. Blood 115, 2380–2390.
    • (2010) Blood , vol.115 , pp. 2380-2390
    • Staron, M.1    Yang, Y.2    Liu, B.3    Li, J.4    Shen, Y.5    Zuniga-Pflucker, J.C.6    Aguila, H.L.7    Goldschneider, I.8    Li, Z.9
  • 355
    • 56949107487 scopus 로고    scopus 로고
    • Emotional triggering of cardiac events
    • Steptoe A & Brydon L (2009). Emotional triggering of cardiac events. Neurosci Biobehav Rev 33, 63–70.
    • (2009) Neurosci Biobehav Rev , vol.33 , pp. 63-70
    • Steptoe, A.1    Brydon, L.2
  • 356
    • 84875428130 scopus 로고    scopus 로고
    • Stress and cardiovascular disease: an update on current knowledge
    • Steptoe A & Kivimäki M (2013). Stress and cardiovascular disease: an update on current knowledge. Annu Rev Public Health 34, 337–354.
    • (2013) Annu Rev Public Health , vol.34 , pp. 337-354
    • Steptoe, A.1    Kivimäki, M.2
  • 357
    • 80053916176 scopus 로고    scopus 로고
    • Metabolic regulation of hematopoietic stem cells in the hypoxic niche
    • Suda T, Takubo K & Semenza GL (2011). Metabolic regulation of hematopoietic stem cells in the hypoxic niche. Cell Stem Cell 9, 298–310.
    • (2011) Cell Stem Cell , vol.9 , pp. 298-310
    • Suda, T.1    Takubo, K.2    Semenza, G.L.3
  • 358
    • 80051666038 scopus 로고    scopus 로고
    • Reactive oxygen species in cardiovascular disease
    • Sugamura K & Keaney JF (2011). Reactive oxygen species in cardiovascular disease. Free Radic Biol Med 51, 978–992.
    • (2011) Free Radic Biol Med , vol.51 , pp. 978-992
    • Sugamura, K.1    Keaney, J.F.2
  • 359
    • 33646762480 scopus 로고    scopus 로고
    • Localization of GRP78 to mitochondria under the unfolded protein response
    • Sun F-C, Wei S, Li C-W, Chang Y-S, Chao C-C & Lai Y-K (2006). Localization of GRP78 to mitochondria under the unfolded protein response. Biochem J 396, 31–39.
    • (2006) Biochem J , vol.396 , pp. 31-39
    • Sun, F.-C.1    Wei, S.2    Li, C.-W.3    Chang, Y.-S.4    Chao, C.-C.5    Lai, Y.-K.6
  • 360
    • 0035989388 scopus 로고    scopus 로고
    • Induced overexpression of mitochondrial Mn-superoxide dismutase extends the life span of adult Drosophila melanogaster
    • Sun J, Folk D, Bradley TJ & Tower J (2002). Induced overexpression of mitochondrial Mn-superoxide dismutase extends the life span of adult Drosophila melanogaster. Genetics 161, 661–672.
    • (2002) Genetics , vol.161 , pp. 661-672
    • Sun, J.1    Folk, D.2    Bradley, T.J.3    Tower, J.4
  • 361
    • 3042711537 scopus 로고    scopus 로고
    • Linking gene expression to function: metabolic flexibility in the normal and diseased heart
    • Taegtmeyer H, Golfman L, Sharma S, Razeghi P & Arsdall M (2004). Linking gene expression to function: metabolic flexibility in the normal and diseased heart. Ann N Y Acad Sci 1015, 202–213.
    • (2004) Ann N Y Acad Sci , vol.1015 , pp. 202-213
    • Taegtmeyer, H.1    Golfman, L.2    Sharma, S.3    Razeghi, P.4    Arsdall, M.5
  • 363
    • 0023890443 scopus 로고
    • Human gene encoding the 78,000-dalton glucose-regulated protein and its pseudogene: structure, conservation, and regulation
    • Ting J & Lee AS (1988). Human gene encoding the 78,000-dalton glucose-regulated protein and its pseudogene: structure, conservation, and regulation. DNA 7, 275–286.
    • (1988) DNA , vol.7 , pp. 275-286
    • Ting, J.1    Lee, A.S.2
  • 364
    • 0035826271 scopus 로고    scopus 로고
    • Increased dosage of a sir-2 gene extends lifespan in Caenorhabditis elegans
    • Tissenbaum HA & Guarente L (2001). Increased dosage of a sir-2 gene extends lifespan in Caenorhabditis elegans. Nature 410, 227–230.
    • (2001) Nature , vol.410 , pp. 227-230
    • Tissenbaum, H.A.1    Guarente, L.2
  • 365
    • 8644277006 scopus 로고    scopus 로고
    • Reactive oxygen species in vascular biology: implications in hypertension
    • Touyz R & Schiffrin E (2004). Reactive oxygen species in vascular biology: implications in hypertension. Histochem Cell Biol 122, 339–352.
    • (2004) Histochem Cell Biol , vol.122 , pp. 339-352
    • Touyz, R.1    Schiffrin, E.2
  • 366
    • 79954633863 scopus 로고    scopus 로고
    • Heat shock proteins and Drosophila aging
    • Tower J (2011). Heat shock proteins and Drosophila aging. Exp Gerontol 46, 355–362.
    • (2011) Exp Gerontol , vol.46 , pp. 355-362
    • Tower, J.1
  • 367
    • 0030969868 scopus 로고    scopus 로고
    • Superoxide production by the mitochondrial respiratory chain
    • Turrens JF (1997). Superoxide production by the mitochondrial respiratory chain. Biosci Rep 17, 3–8.
    • (1997) Biosci Rep , vol.17 , pp. 3-8
    • Turrens, J.F.1
  • 368
    • 84855830535 scopus 로고    scopus 로고
    • Glycation-altered proteolysis as a pathobiologic mechanism that links dietary glycemic index, aging, and age-related disease (in nondiabetics)
    • Uchiki T, Weikel KA, Jiao W, Shang F, Caceres A, Pawlak D, Handa JT, Brownlee M, Nagaraj R & Taylor A (2012). Glycation-altered proteolysis as a pathobiologic mechanism that links dietary glycemic index, aging, and age-related disease (in nondiabetics). Aging Cell 11, 1–13.
    • (2012) Aging Cell , vol.11 , pp. 1-13
    • Uchiki, T.1    Weikel, K.A.2    Jiao, W.3    Shang, F.4    Caceres, A.5    Pawlak, D.6    Handa, J.T.7    Brownlee, M.8    Nagaraj, R.9    Taylor, A.10
  • 369
    • 0036088450 scopus 로고    scopus 로고
    • Invited review: molecular adaptations in mammalian hibernators: unique adaptations or generalized responses
    • Van Breukelen F & Martin SL (2002). Invited review: molecular adaptations in mammalian hibernators: unique adaptations or generalized responses? J Appl Physiol 92, 2640–2647.
    • (2002) J Appl Physiol , vol.92 , pp. 2640-2647
    • Van Breukelen, F.1    Martin, S.L.2
  • 375
    • 0036266110 scopus 로고    scopus 로고
    • Attenuated HSP70 response in skeletal muscle of aged rats following contractile activity
    • Vasilaki A, Jackson MJ & McArdle A (2002). Attenuated HSP70 response in skeletal muscle of aged rats following contractile activity. Muscle Nerve 25, 902–905.
    • (2002) Muscle Nerve , vol.25 , pp. 902-905
    • Vasilaki, A.1    Jackson, M.J.2    McArdle, A.3
  • 376
    • 33750161128 scopus 로고    scopus 로고
    • Adaptive responses of mouse skeletal muscle to contractile activity: the effect of age
    • Vasilaki A, McArdle F, Iwanejko L & McArdle A (2006). Adaptive responses of mouse skeletal muscle to contractile activity: the effect of age. Mech Ageing Dev 127, 830–839.
    • (2006) Mech Ageing Dev , vol.127 , pp. 830-839
    • Vasilaki, A.1    McArdle, F.2    Iwanejko, L.3    McArdle, A.4
  • 377
    • 64849110613 scopus 로고    scopus 로고
    • Skeletal muscle hypertrophy following resistance training is accompanied by a fiber type-specific increase in satellite cell content in elderly men
    • Verdijk LB, Gleeson BG, Jonkers RAM, Meijer K, Savelberg HHCM, Dendale P & van Loon LJC (2009). Skeletal muscle hypertrophy following resistance training is accompanied by a fiber type-specific increase in satellite cell content in elderly men. J Gerontol A 64A, 332–339.
    • (2009) J Gerontol A , vol.64A , pp. 332-339
    • Verdijk, L.B.1    Gleeson, B.G.2    Jonkers, R.A.M.3    Meijer, K.4    Savelberg, H.H.C.M.5    Dendale, P.6    van Loon, L.J.C.7
  • 382
    • 34447626095 scopus 로고    scopus 로고
    • SIRT2 deacetylates FOXO3a in response to oxidative stress and caloric restriction
    • Wang F, Nguyen M, Qin F & Tong Q (2007). SIRT2 deacetylates FOXO3a in response to oxidative stress and caloric restriction. Aging Cell 6, 505–514.
    • (2007) Aging Cell , vol.6 , pp. 505-514
    • Wang, F.1    Nguyen, M.2    Qin, F.3    Tong, Q.4
  • 383
    • 84863667325 scopus 로고    scopus 로고
    • Aging and atherosclerosis: mechanisms, functional consequences, and potential therapeutics for cellular senescence
    • Wang JC & Bennett M (2012). Aging and atherosclerosis: mechanisms, functional consequences, and potential therapeutics for cellular senescence. Circ Res 111, 245–259.
    • (2012) Circ Res , vol.111 , pp. 245-259
    • Wang, J.C.1    Bennett, M.2
  • 385
    • 78649980437 scopus 로고    scopus 로고
    • Regulation of the 26S proteasome complex during oxidative stress
    • Wang X, Yen J, Kaiser P & Huang L (2010). Regulation of the 26S proteasome complex during oxidative stress. Sci Signal 3, ra88.
    • (2010) Sci Signal , vol.3 , pp. ra88
    • Wang, X.1    Yen, J.2    Kaiser, P.3    Huang, L.4
  • 386
    • 33746245679 scopus 로고    scopus 로고
    • C. elegans 14-3-3 proteins regulate life span and interact with SIR-2.1 and DAF-16/FOXO
    • Wang Y, Oh SW, Deplancke B, Luo J, Walhout AJ & Tissenbaum HA (2006). C. elegans 14-3-3 proteins regulate life span and interact with SIR-2.1 and DAF-16/FOXO. Mech Ageing Dev 127, 741–747.
    • (2006) Mech Ageing Dev , vol.127 , pp. 741-747
    • Wang, Y.1    Oh, S.W.2    Deplancke, B.3    Luo, J.4    Walhout, A.J.5    Tissenbaum, H.A.6
  • 387
    • 0027225154 scopus 로고
    • In vitro degradation of mitochondrial proteins by ATP-dependent protease in bovine adrenal cortex
    • Watabe S, Hara T, Kohno H, Hiroi T, Yago N & Nakazawa T (1993). In vitro degradation of mitochondrial proteins by ATP-dependent protease in bovine adrenal cortex. J Biochem (Tokyo) 113, 672–676.
    • (1993) J Biochem (Tokyo) , vol.113 , pp. 672-676
    • Watabe, S.1    Hara, T.2    Kohno, H.3    Hiroi, T.4    Yago, N.5    Nakazawa, T.6
  • 389
    • 0035098360 scopus 로고    scopus 로고
    • Microarray profiling of gene expression in aging and its alteration by caloric restriction in mice
    • Weindruch R, Kayo T, Lee C-K & Prolla TA (2001). Microarray profiling of gene expression in aging and its alteration by caloric restriction in mice. J Nutr 131, 918S–923S.
    • (2001) J Nutr , vol.131 , pp. 918S-923S
    • Weindruch, R.1    Kayo, T.2    Lee, C.-K.3    Prolla, T.A.4
  • 390
    • 0020044308 scopus 로고
    • Dietary restriction in mice beginning at 1 year of age: effect on life-span and spontaneous cancer incidence
    • Weindruch R & Walford RL (1982). Dietary restriction in mice beginning at 1 year of age: effect on life-span and spontaneous cancer incidence. Science (New York, NY) 215, 1415–1418.
    • (1982) Science (New York, NY) , vol.215 , pp. 1415-1418
    • Weindruch, R.1    Walford, R.L.2
  • 392
    • 73949099327 scopus 로고    scopus 로고
    • Increased muscle PGC-1α expression protects from sarcopenia and metabolic disease during aging
    • Wenz T, Rossi SG, Rotundo RL, Spiegelman BM & Moraes CT (2009). Increased muscle PGC-1α expression protects from sarcopenia and metabolic disease during aging. Proc Natl Acad Sci USA 106, 20405–20410.
    • (2009) Proc Natl Acad Sci USA , vol.106 , pp. 20405-20410
    • Wenz, T.1    Rossi, S.G.2    Rotundo, R.L.3    Spiegelman, B.M.4    Moraes, C.T.5
  • 393
    • 0028826029 scopus 로고
    • Muscle-specific expression of Drosophila hsp70 in response to aging and oxidative stress
    • Wheeler JC, Bieschke ET & Tower J (1995). Muscle-specific expression of Drosophila hsp70 in response to aging and oxidative stress. Proc Natl Acad Sci USA 92, 10408–10412.
    • (1995) Proc Natl Acad Sci USA , vol.92 , pp. 10408-10412
    • Wheeler, J.C.1    Bieschke, E.T.2    Tower, J.3
  • 394
    • 0028904871 scopus 로고
    • Transient adaptation to oxidative stress in mammalian cells
    • Wiese AG, Pacifici RE & Davies KJA (1995). Transient adaptation to oxidative stress in mammalian cells. Arch Biochem Biophys 318, 231–240.
    • (1995) Arch Biochem Biophys , vol.318 , pp. 231-240
    • Wiese, A.G.1    Pacifici, R.E.2    Davies, K.J.A.3
  • 395
    • 0036548318 scopus 로고    scopus 로고
    • Heat stress activates the yeast high-osmolarity glycerol mitogen-activated protein kinase pathway, and protein tyrosine phosphatases are essential under heat stress
    • Winkler A, Arkind C, Mattison CP, Burkholder A, Knoche K & Ota I (2002). Heat stress activates the yeast high-osmolarity glycerol mitogen-activated protein kinase pathway, and protein tyrosine phosphatases are essential under heat stress. Eukaryotic Cell 1, 163–173.
    • (2002) Eukaryotic Cell , vol.1 , pp. 163-173
    • Winkler, A.1    Arkind, C.2    Mattison, C.P.3    Burkholder, A.4    Knoche, K.5    Ota, I.6
  • 399
    • 0030722269 scopus 로고    scopus 로고
    • Effect of chronic hypoxia on glucose transporters in heart and skeletal muscle of immature and adult rats
    • Xia Y, Warshaw JB & Haddad GG (1997). Effect of chronic hypoxia on glucose transporters in heart and skeletal muscle of immature and adult rats. Am J Physiol Regul Integr Comp Physiol 273, R1734–R1741.
    • (1997) Am J Physiol Regul Integr Comp Physiol , vol.273 , pp. R1734-R1741
    • Xia, Y.1    Warshaw, J.B.2    Haddad, G.G.3
  • 401
    • 67650757278 scopus 로고    scopus 로고
    • Expression of hsp22 and hsp70 transgenes is partially predictive of drosophila survival under normal and stress conditions
    • Yang J & Tower J (2009). Expression of hsp22 and hsp70 transgenes is partially predictive of drosophila survival under normal and stress conditions. J Gerontol A Biol Sci Med Sci 64, 828–838.
    • (2009) J Gerontol A Biol Sci Med Sci , vol.64 , pp. 828-838
    • Yang, J.1    Tower, J.2
  • 402
    • 77449096697 scopus 로고    scopus 로고
    • Grp78 heterozygosity promotes adaptive unfolded protein response and attenuates diet-induced obesity and insulin resistance
    • Ye R, Jung DY, Jun JY, Li J, Luo S, Ko HJ, Kim JK & Lee AS (2010). Grp78 heterozygosity promotes adaptive unfolded protein response and attenuates diet-induced obesity and insulin resistance. Diabetes 59, 6–16.
    • (2010) Diabetes , vol.59 , pp. 6-16
    • Ye, R.1    Jung, D.Y.2    Jun, J.Y.3    Li, J.4    Luo, S.5    Ko, H.J.6    Kim, J.K.7    Lee, A.S.8
  • 405
    • 80053920774 scopus 로고    scopus 로고
    • + intermediate, treats the pathophysiology of diet-and age-induced diabetes in mice
    • + intermediate, treats the pathophysiology of diet-and age-induced diabetes in mice. Cell Metab 14, 528–536.
    • (2011) Cell Metab , vol.14 , pp. 528-536
    • Yoshino, J.1    Mills, K.F.2    Yoon, M.J.3    Imai, S.-I.4
  • 406
    • 0242580049 scopus 로고    scopus 로고
    • Distinct cysteine residues in Keap1 are required for Keap1-dependent ubiquitination of Nrf2 and for stabilization of Nrf2 by chemopreventive agents and oxidative stress
    • Zhang DD & Hannink M (2003). Distinct cysteine residues in Keap1 are required for Keap1-dependent ubiquitination of Nrf2 and for stabilization of Nrf2 by chemopreventive agents and oxidative stress. Mol Cell Biol 23, 8137–8151.
    • (2003) Mol Cell Biol , vol.23 , pp. 8137-8151
    • Zhang, D.D.1    Hannink, M.2
  • 407
    • 84860471609 scopus 로고    scopus 로고
    • Nrf2-regulated phase II enzymes are induced by chronic ambient nanoparticle exposure in young mice with age-related impairments
    • Zhang H, Liu H, Davies KJA, Sioutas C, Finch CE, Morgan TE & Forman HJ (2012). Nrf2-regulated phase II enzymes are induced by chronic ambient nanoparticle exposure in young mice with age-related impairments. Free Radic Biol Med 52, 2038–2046.
    • (2012) Free Radic Biol Med , vol.52 , pp. 2038-2046
    • Zhang, H.1    Liu, H.2    Davies, K.J.A.3    Sioutas, C.4    Finch, C.E.5    Morgan, T.E.6    Forman, H.J.7
  • 409
    • 76649089973 scopus 로고    scopus 로고
    • Loss of Kelch-like ECH-associated protein 1 function in prostate cancer cells causes chemoresistance and radioresistance and promotes tumor growth
    • Zhang P, Singh A, Yegnasubramanian S, Esopi D, Kombairaju P, Bodas M, Wu H, Bova SG & Biswal S (2010). Loss of Kelch-like ECH-associated protein 1 function in prostate cancer cells causes chemoresistance and radioresistance and promotes tumor growth. Mol Cancer Ther 9, 336–346.
    • (2010) Mol Cancer Ther , vol.9 , pp. 336-346
    • Zhang, P.1    Singh, A.2    Yegnasubramanian, S.3    Esopi, D.4    Kombairaju, P.5    Bodas, M.6    Wu, H.7    Bova, S.G.8    Biswal, S.9
  • 410
    • 84925662746 scopus 로고    scopus 로고
    • Role of the unfolded protein response, GRP78 and GRP94 in organ homeostasis
    • Zhu G & Lee AS (2015). Role of the unfolded protein response, GRP78 and GRP94 in organ homeostasis. J Cell Physiol 230, 1413–1420.
    • (2015) J Cell Physiol , vol.230 , pp. 1413-1420
    • Zhu, G.1    Lee, A.S.2
  • 412
    • 84928730718 scopus 로고    scopus 로고
    • Exercise training increases anabolic and attenuates catabolic and apoptotic processes in aged skeletal muscle of male rats
    • Ziaaldini MM, Koltai E, Csende Z, Goto S, Boldogh I, Taylor AW & Radak Z (2015). Exercise training increases anabolic and attenuates catabolic and apoptotic processes in aged skeletal muscle of male rats. Exp Gerontol 67, 9–14.
    • (2015) Exp Gerontol , vol.67 , pp. 9-14
    • Ziaaldini, M.M.1    Koltai, E.2    Csende, Z.3    Goto, S.4    Boldogh, I.5    Taylor, A.W.6    Radak, Z.7
  • 413
    • 8844256241 scopus 로고    scopus 로고
    • Skeletal muscle fiber type: influence on contractile and metabolic properties
    • Zierath JR & Hawley JA (2004). Skeletal muscle fiber type: influence on contractile and metabolic properties. PLoS Biol 2, e348.
    • (2004) PLoS Biol , vol.2
    • Zierath, J.R.1    Hawley, J.A.2
  • 414
    • 84877654967 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor (PPAR) γ and PPARα agonists modulate mitochondrial fusion-fission dynamics: relevance to reactive oxygen species (ROS)-related neurodegenerative disorders
    • Zolezzi JM, Silva-Alvarez C, Ordenes D, Godoy JA, Carvajal FJ, Santos MJ & Inestrosa NC (2013). Peroxisome proliferator-activated receptor (PPAR) γ and PPARα agonists modulate mitochondrial fusion-fission dynamics: relevance to reactive oxygen species (ROS)-related neurodegenerative disorders? PLoS One 8, e64019.
    • (2013) PLoS One , vol.8
    • Zolezzi, J.M.1    Silva-Alvarez, C.2    Ordenes, D.3    Godoy, J.A.4    Carvajal, F.J.5    Santos, M.J.6    Inestrosa, N.C.7


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