메뉴 건너뛰기




Volumn 1, Issue 1, 2013, Pages 45-49

The Keap1-Nrf2 pathway: Mechanisms of activation and dysregulation in cancer

Author keywords

Antioxidant response element; Cancer; Gene therapy; Keap 1; Nrf2

Indexed keywords

BRUSATOL; CISPLATIN; DOXORUBICIN; GANCICLOVIR; KELCH LIKE ECH ASSOCIATED PROTEIN 1; LENTIVIRUS VECTOR; PHOSPHATIDYLINOSITOL 3 KINASE INHIBITOR; SMALL INTERFERING RNA; THYMIDINE KINASE; TRANSCRIPTION FACTOR NRF2; CYTOSKELETON PROTEIN; SIGNAL PEPTIDE;

EID: 84878785993     PISSN: 22132317     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.redox.2012.10.001     Document Type: Review
Times cited : (1077)

References (17)
  • 1
    • 84857233782 scopus 로고    scopus 로고
    • Activation of stress signaling pathways by electrophilic oxidized and nitrated lipids
    • E. Kansanen, H.-K. Jyrkkänen, A.-L. Levonen, Activation of stress signaling pathways by electrophilic oxidized and nitrated lipids, Free Radical Biology and Medicine 52 (2012) 973-982.
    • (2012) Free Radical Biology and Medicine , vol.52 , pp. 973-982
    • Kansanen, E.1    Jyrkkänen, H.-K.2    Levonen, A.-L.3
  • 2
    • 70349801984 scopus 로고    scopus 로고
    • Regulation of Nrf2-dependent gene expression by 15-deoxy-Delta12,14-prostaglandin J2
    • E. Kansanen, A.M. Kivelä, A.-L. Levonen, Regulation of Nrf2-dependent gene expression by 15-deoxy-Delta12,14-prostaglandin J2, Free Radical Biology and Medicine 47 (2009) 1310-1317.
    • (2009) Free Radical Biology and Medicine , vol.47 , pp. 1310-1317
    • Kansanen, E.1    Kivelä, A.M.2    Levonen, A.-L.3
  • 3
    • 78751703950 scopus 로고    scopus 로고
    • Molecular mechanisms of the Keap1-Nrf2 pathway in stress response and cancer evolution
    • K. Taguchi, H. Motohashi, M. Yamamoto, Molecular mechanisms of the Keap1-Nrf2 pathway in stress response and cancer evolution, Genes Cells 16 (2011) 123-140.
    • (2011) Genes Cells , vol.16 , pp. 123-140
    • Taguchi, K.1    Motohashi, H.2    Yamamoto, M.3
  • 4
    • 84864348569 scopus 로고    scopus 로고
    • NRF2 and cancer: the good, the bad and the importance of context
    • M.B. Sporn, K.T. Liby, NRF2 and cancer: the good, the bad and the importance of context, Nature Reviews Cancer 12 (2012) 564-571.
    • (2012) Nature Reviews Cancer , vol.12 , pp. 564-571
    • Sporn, M.B.1    Liby, K.T.2
  • 7
    • 76649089973 scopus 로고    scopus 로고
    • Loss of Kelch-like ECH-associated protein 1 function in prostate cancer cells causes chemoresistance and radioresis-tance and promotes tumor growth
    • P. Zhang, A. Singh, S. Yegnasubramanian, D. Esopi, P. Kombairaju, M. Bodas, H. Wu, S.G. Bova, S. Biswal, Loss of Kelch-like ECH-associated protein 1 function in prostate cancer cells causes chemoresistance and radioresis-tance and promotes tumor growth, Molecular Cancer Therapeutics 9 (2010) 336-346.
    • (2010) Molecular Cancer Therapeutics , vol.9 , pp. 336-346
    • Zhang, P.1    Singh, A.2    Yegnasubramanian, S.3    Esopi, D.4    Kombairaju, P.5    Bodas, M.6    Wu, H.7    Bova, S.G.8    Biswal, S.9
  • 10
    • 84867041441 scopus 로고    scopus 로고
    • Molecular basis of electrophilic and oxidative defense: promises and perils of nrf2
    • Q. Ma, X. He, Molecular basis of electrophilic and oxidative defense: promises and perils of nrf2, Pharmacological Reviews 64 (2012) 1055-1081.
    • (2012) Pharmacological Reviews , vol.64 , pp. 1055-1081
    • Ma, Q.1    He, X.2
  • 13
    • 84881481449 scopus 로고    scopus 로고
    • Nrf2 is controlled by two distinct b-TrCP recognition motifs in its Neh6 domain, one of which can be modulated by GSK-3 activity
    • S. Chowdhry, Y. Zhang, M. McMahon, C. Sutherland, A. Cuadrado, J.D. Hayes, Nrf2 is controlled by two distinct b-TrCP recognition motifs in its Neh6 domain, one of which can be modulated by GSK-3 activity, Oncogene (2012).
    • (2012) Oncogene
    • Chowdhry, S.1    Zhang, Y.2    McMahon, M.3    Sutherland, C.4    Cuadrado, A.5    Hayes, J.D.6
  • 17
    • 0022485359 scopus 로고
    • Tumor chemosensitivity conferred by inserted herpes thymi-dine kinase genes: paradigm for a prospective cancer control strategy
    • F.L. Moolten, Tumor chemosensitivity conferred by inserted herpes thymi-dine kinase genes: paradigm for a prospective cancer control strategy, Cancer Research 46 (1986) 5276-5281.
    • (1986) Cancer Research , vol.46 , pp. 5276-5281
    • Moolten, F.L.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.