Gene expression changes in response to aging compared to heat stress, oxidative stress and ionizing radiation in Drosophila melanogaster

Aging

Volumn 4, Issue 11, 2012, Pages 768-789

  Landis, Gary ^a   Shen, Jie ^a   Tower, John ^a  

^a UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

Author keywords

GST; Mitochondria; Nrf2; Oxidative stress; ROS

Indexed keywords

EID: 84872530990     PISSN: 19454589     EISSN: None     Source Type: Journal    
DOI: 10.18632/aging.100499     Document Type: Article

References (71)

1. Voellmy R and Boellmann F. Chaperone regulation of the heat shock protein response. Adv Exp Med Biol. 2007; 594:89-99.
2. Tower J. Hsps and aging. Trends Endocrinol Metab. 2009; 20:216-222.
3. Wheeler JC, Bieschke ET and Tower J. Muscle-specific expression of Drosophila hsp70 in response to aging and oxidative stress. Proc Natl Acad Sci U S A. 1995; 92:10408-10412.
4. Wheeler JC, King V and Tower J. Sequence requirements for upregulated expression of Drosophila hsp70 transgenes during aging. Neurobiol Aging. 1999; 20:545-553.
5. King V and Tower J. Aging-specific expression of Drosophila hsp22. Dev Biol. 1999; 207:107-118.
6. Landis GN, Abdueva D, Skvortsov D, Yang J, Rabin BE, Carrick J, Tavaré S and Tower J. Similar gene expression patterns characterize aging and oxidative stress in Drosophila melanogaster. Proc Natl Acad Sci U S A. 2004; 101:7663-7668.
7. Zou S, Meadows S, Sharp L, Jan LY and Jan YN. Genome-wide study of aging and oxidative stress response in Drosophila melanogaster. Proc Natl Acad Sci U S A. 2000; 97:13726-13731.
8. Pletcher SD, Macdonald SJ, Marguerie R, Certa U, Stearns SC, Goldstein DB and Partridge L. Genome-wide transcript profiles in aging and calorically restricted Drosophila melanogaster. Curr Biol. 2002; 12:712-723.
9. Zahn JM, Sonu R, Vogel H, Crane E, Mazan-Mamczarz K, Rabkin R, Davis RW, Becker KG, Owen AB and Kim SK. Transcriptional profiling of aging in human muscle reveals a common aging signature. PLoS Genet. 2006; 2:e115.
10. Mccarroll SA, Murphy CT, Zou S, Pletcher SD, Chin CS, Jan YN, Kenyon C, Bargmann CI and Li H. Comparing genomic expression patterns across species identifies shared transcriptional profile in aging. Nat Genet. 2004; 36:197-204.
11. Yang J and Tower J. Expression of hsp22 and hsp70 transgenes is partially predictive of drosophila survival under normal and stress conditions. J Gerontol A Biol Sci Med Sci. 2009; 64:828-838.
12. Rea SL, Wu D, Cypser JR, Vaupel JW and Johnson TE. A stresssensitive reporter predicts longevity in isogenic populations of Caenorhabditis elegans. Nat Genet. 2005; 37:894-898.
13. Ren C, Webster P, Finkel SE and Tower J. Increased internal and external bacterial load during Drosophila aging without lifespan trade-off. Cell Metab. 2007; 6:144-152.
14. Ling D and Salvaterra PM. Robust RT-qPCR data normalization: validation and selection of internal reference genes during post-experimental data analysis. PLoS One. 2011; 6:e17762.
15. Sykiotis GP and Bohmann D. Keap1/Nrf2 signaling regulates oxidative stress tolerance and lifespan in Drosophila. Dev Cell. 2008; 14:76-85.
16. Wang MC, Bohmann D and Jasper H. JNK Signaling Confers Tolerance to Oxidative Stress and Extends Lifespan in Drosophila. Dev Cell. 2003; 5:811-816.
17. Karpac J, Hull-Thompson J, Falleur M and Jasper H. JNK signaling in insulin-producing cells is required for adaptive responses to stress in Drosophila. Aging Cell. 2009; 8:288-295.
18. Hochmuth CE, Biteau B, Bohmann D and Jasper H. Redox regulation by Keap1 and Nrf2 controls intestinal stem cell proliferation in Drosophila. Cell Stem Cell. 2011; 8:188-199.
19. Okamura T, Shimizu H, Nagao T, Ueda R and Ishii S. ATF-2 regulates fat metabolism in Drosophila. Mol Biol Cell. 2007; 18:1519-1529.
20. Hanson RW and Hakimi P. Born to run; the story of the PEPCK-Cmus mouse. Biochimie. 2008; 90:838-842.
21. Arndt V, Dick N, Tawo R, Dreiseidler M, Wenzel D, Hesse M, Furst DO, Saftig P, Saint R, Fleischmann BK, Hoch M and Hohfeld J. Chaperone-assisted selective autophagy is essential for muscle maintenance. Curr Biol. 2010; 20:143-148.
22. Morimoto RI. Proteotoxic stress and inducible chaperone networks in neurodegenerative disease and aging. Genes Dev. 2008; 22:1427-1438.
23. Kurapati R, Passananti HB, Rose MR and Tower J. Increased hsp22 RNA levels in Drosophila lines genetically selected for increased longevity. J Gerontol A Biol Sci Med Sci. 2000; 55:B552-559.
24. Tower J. Heat shock proteins and Drosophila aging. Exp Gerontol. 2011; 46:355-362.
25. Wang HD, Kazemi-Esfarjani P and Benzer S. Multiple-stress analysis for isolation of Drosophila longevity genes. Proc Natl Acad Sci U S A. 2004; 101:12610-12615.
26. Gough DR and Cotter TG. Hydrogen peroxide: a Jekyll and Hyde signalling molecule. Cell death & disease. 2011; 2:e213.
27. Rice ME. H2O2: a dynamic neuromodulator. The Neuroscientist a review journal bringing neurobiology, neurology and psychiatry. 2011; 17:389-406.
28. Lee J, Giordano S and Zhang J. Autophagy, mitochondria and oxidative stress: cross-talk and redox signalling. Biochem J. 2012; 441:523-540.
29. Rhee SG, Woo HA, Kil IS and Bae SH. Peroxiredoxin functions as a peroxidase and a regulator and sensor of local peroxides. J Biol Chem. 2012; 287:4403-4410.
30. Owusu-Ansah E and Banerjee U. Reactive oxygen species prime Drosophila haematopoietic progenitors for differentiation. Nature. 2009; 461:537-541.
31. Deocaris CC, Kaul SC and Wadhwa R. On the brotherhood of the mitochondrial chaperones mortalin and heat shock protein 60. Cell stress & chaperones. 2006; 11:116-128.
32. Ramaekers CH and Wouters BG. Regulatory functions of ubiquitin in diverse DNA damage responses. Current molecular medicine. 2011; 11:152-169.
33. Salmon AB, Richardson A and Perez VI. Update on the oxidative stress theory of aging: does oxidative stress play a role in aging or healthy aging? Free Radic Biol Med. 2010; 48:642-655.
34. Ito M, Imai M, Muraki M, Miyado K, Qin J, Kyuwa S, Yoshikawa Y, Hosoi Y, Saito H and Takahashi Y. GSTT1 is upregulated by oxidative stress through p38-MK2 signaling pathway in human granulosa cells: possible association with mitochondrial activity. Aging. 2011; 3:1213-1223.
35. Sun J, Folk D, Bradley TJ and Tower J. Induced overexpression of mitochondrial Mn-superoxide dismutase extends the life span of adult Drosophila melanogaster. Genetics. 2002; 161:661-672.
36. Curtis C, Landis GN, Folk D, Wehr NB, Hoe N, Waskar M, Abdueva D, Skvortsov D, Ford D, Luu A, Badrinath A, Levine RL, Bradley TJ, et al. Transcriptional profiling of MnSOD-mediated lifespan extension in Drosophila reveals a species-general network of aging and metabolic genes. Genome Biol. 2007; 8:R262.
37. Cabreiro F, Ackerman D, Doonan R, Araiz C, Back P, Papp D, Braeckman BP and Gems D. Increased life span from overexpression of superoxide dismutase in Caenorhabditis elegans is not caused by decreased oxidative damage. Free Radic Biol Med. 2011; 51:1575-1582.
38. Libert S, Zwiener J, Chu X, Vanvoorhies W, Roman G and Pletcher SD. Regulation of Drosophila life span by olfaction and food-derived odors. Science. 2007; 315:1133-1137.
39. Girardot F, Lasbleiz C, Monnier V and Tricoire H. Specific agerelated signatures in Drosophila body parts transcriptome. BMC Genomics. 2006; 7:69.
40. Zhang Q, Raoof M, Chen Y, Sumi Y, Sursal T, Junger W, Brohi K, Itagaki K and Hauser CJ. Circulating mitochondrial DAMPs cause inflammatory responses to injury. Nature. 2010; 464:104-107.
41. Fleming JE, Miquel J and Bensch KG. Age dependent changes in mitochondria. Basic Life Sci. 1985; 35:143-156.
42. Miquel J, Lundgren PR, Bensch KG and Atlan H. Effects of temperature on the life span, vitality and fine structure of Drosophila melanogaster. Mech Ageing Dev. 1976; 5:347-370.
43. Takahashi A, Philpott DE and Miquel J. Electron microscope studies on aging Drosophila melanogaster. II. Intramitochondrial crystalloid in fat body cells. J Gerontol. 1970; 25:218-221.
44. Walker DW and Benzer S. Mitochondrial "swirls" induced by oxygen stress and in the Drosophila mutant hyperswirl. Proc Natl Acad Sci U S A. 2004; 101:10290-10295.
45. Calleja M, Pena P, Ugalde C, Ferreiro C, Marco R and Garesse R. Mitochondrial DNA remains intact during Drosophila aging, but the levels of mitochondrial transcripts are significantly reduced. J Biol Chem. 1993; 268:18891-18897.
46. Schwarze SR, Weindruch R and Aiken JM. Oxidative stress and aging reduce COX I RNA and cytochrome oxidase activity in Drosophila. Free Radic Biol Med. 1998; 25:740-747.
47. Sanz A, Fernandez-Ayala DJ, Stefanatos RK and Jacobs HT. Mitochondrial ROS production correlates with, but does not directly regulate lifespan in Drosophila. Aging (Albany NY). 2010; 2:200-223.
48. Choudhury M, Jonscher KR and Friedman JE. Reduced mitochondrial function in obesity-associated fatty liver: SIRT3 takes on the fat. Aging (Albany NY). 2011; 3:175-178.
49. Cho J, Hur JH and Walker DW. The role of mitochondria in Drosophila aging. Exp Gerontol. 2011; 46:331-334.
50. Rera M, Bahadorani S, Cho J, Koehler CL, Ulgherait M, Hur JH, Ansari WS, Lo T, Jr., Jones DL and Walker DW. Modulation of longevity and tissue homeostasis by the Drosophila PGC-1 homolog. Cell Metab. 2011; 14:623-634.
51. Dillon LM, Rebelo AP and Moraes CT. The role of PGC-1 coactivators in aging skeletal muscle and heart. IUBMB Life. 2012; 64:231-241.
52. Icreverzi A, de la Cruz AF, Van Voorhies WA and Edgar BA. Drosophila cyclin D/Cdk4 regulates mitochondrial biogenesis and aging and sensitizes animals to hypoxic stress. Cell Cycle. 2012; 11:554-568.
53. Choksi KB, Nuss JE, DeFord JH and Papaconstantinou J. Mitochondrial electron transport chain functions in long-lived Ames dwarf mice. Aging (Albany NY). 2011; 3:754-767.
54. Hur JH, Cho J and Walker DW. Aging: Dial M for Mitochondria. Aging. 2010; 2:69-73.
55. Artal-Sanz M and Tavernarakis N. Opposing function of mitochondrial prohibitin in aging. Aging (Albany NY). 2010; 2:1004-1011.
56. Tower J. Sex-specific regulation of aging and apoptosis. Mech Ageing Dev. 2006; 127:705-718.
57. Kirkwood TB. Understanding the odd science of aging. Cell. 2005; 120:437-447.
58. Hur JH and Walker DW. p53, sex, and aging: lessons from the fruit fly. Aging (Albany NY). 2009; 1:881-883.
59. Waskar M, Landis GN, Shen J, Curtis C, Tozer K, Abdueva D, Skvortsov D, Tavare S and Tower J. Drosophila melanogaster p53 has developmental stage-specific and sex-specific effects on adult life span indicative of sexual antagonistic pleiotropy. Aging (Albany NY). 2009; 1:903-936.
60. Shen J, Ford D, Landis GN and Tower J. Identifying sexual differentiation genes that affect Drosophila life span. BMC Geriatr. 2009; 9:56.
61. Tower J. The genetic architecture of aging: sexual antagonistic pleiotropy of p53 and foxo. Cell Cycle. 2010; 9:3840-3841.
62. Ren C, Finkel SE and Tower J. Conditional inhibition of autophagy genes in adult Drosophila impairs immunity without compromising longevity. Exp Gerontol. 2009; 44:228-235.
63. Bieschke ET, Wheeler JC and Tower J. Doxycycline-induced transgene expression during Drosophila development and aging. Mol Gen Genet. 1998; 258:571-579.
64. Shen J and Tower J. Drosophila foxo acts in males to cause sexual-dimorphism in tissue-specific p53 life span effects. Exp Gerontol. 2010; 45:97-105.
65. Ford D, Hoe N, Landis GN, Tozer K, Luu A, Bhole D, Badrinath A and Tower J. Alteration of Drosophila life span using conditional, tissue-specific expression of transgenes triggered by doxycyline or RU486/Mifepristone. Exp Gerontol. 2007; 42:483-497.
66. Abdueva D, Skvortsov D and Tavare S. Non-linear analysis of GeneChip arrays. Nucleic Acids Res. 2006; 34:e105.
67. Smyth GK, Michaud J and Scott HS. Use of within-array replicate spots for assessing differential expression in microarray SUPPLEMENTAL FIGURES experiments. Bioinformatics. 2005; 21:2067-2075.
68. Storey JD and Tibshirani R. Statistical methods for identifying differentially expressed genes in DNA microarrays. Methods Mol Biol. 2003; 224:149-157.
69. Barrett T, Suzek TO, Troup DB, Wilhite SE, Ngau WC, Ledoux P, Rudnev D, Lash AE, Fujibuchi W and Edgar R. NCBI GEO: mining millions of expression profiles-database and tools. Nucleic Acids Res. 2005; 33:D562-566.
70. Lyne R, Smith R, Rutherford K, Wakeling M, Varley A, Guillier F, Janssens H, Ji W, McLaren P, North P, Rana D, Riley T, Sullivan J, et al. FlyMine: an integrated database for Drosophila and Anopheles genomics. Genome Biol. 2007; 8:R129.
71. RDevelopmentCoreTeam. (2009). R: A language and environment for statistical computing. R Foundation for Statistical Computing, Vienna, Austria.