Grp78 heterozygosity promotes adaptive unfolded protein response and attenuates diet-induced obesity and insulin resistance

Diabetes

Volumn 59, Issue 1, 2010, Pages 6-16

  Ye, Risheng ^a   Jung, Dae Young ^b,c   Jun, John Y ^b   Li, Jianze ^a   Luo, Shengzhan ^a   Ko, Hwi Jin ^b,c   Kim, Jason K ^b,c   Lee, Amy S ^a,d  

^a UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

^b PENN STATE COLLEGE OF MEDICINE   (United States)

^c UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL   (United States)

^d STANFORD UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVATING TRANSCRIPTION FACTOR 6; ALPHA MANNOSIDASE; ENDOPLASMIC RETICULUM GOLGI INTERMEDIATE COMPARTMENT PROTEIN 53; GLUCOSE REGULATED PROTEIN 78; HEAT SHOCK PROTEIN; INSULIN; MOLECULAR CHAPERONE GRP78;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; ENDOPLASMIC RETICULUM STRESS; ENERGY BALANCE; ENERGY EXPENDITURE; FATTY LIVER; GLUCOSE METABOLISM; HETEROZYGOSITY; HYPERGLYCEMIA; HYPERINSULINEMIA; IMMUNOBLOTTING; INFLAMMATION; INSULIN RESISTANCE; INSULIN SENSITIVITY; LIPID DIET; MALE; MOUSE; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; OBESITY; PATHOGENESIS; PHENOTYPE; PHYSICAL ACTIVITY; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FOLDING; PROTEIN FUNCTION; TISSUE CULTURE; WHITE ADIPOSE TISSUE; ANIMAL; BLOOD; C57BL MOUSE; CHEMICALLY INDUCED DISORDER; CROSS BREEDING; DIET; ENERGY METABOLISM; FAT INTAKE; GENETIC TRANSFECTION; GENETICS; GLUCOSE BLOOD LEVEL; HETEROZYGOTE; METABOLISM; MOUSE MUTANT; PROTEIN DENATURATION; UNFOLDED PROTEIN RESPONSE;

ANIMALS; BLOOD GLUCOSE; CROSSES, GENETIC; DIABETES MELLITUS, TYPE 2; DIET; DIETARY FATS; ENERGY METABOLISM; HEAT-SHOCK PROTEINS; HETEROZYGOTE; IMMUNOBLOTTING; INSULIN; INSULIN RESISTANCE; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; OBESITY; PROTEIN DENATURATION; TRANSFECTION; UNFOLDED PROTEIN RESPONSE;

EID: 77449096697     PISSN: 00121797     EISSN: 1939327X     Source Type: Journal    
DOI: 10.2337/db09-0755     Document Type: Article

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