Protein turnover by the proteasome in aging and disease

Free Radical Biology and Medicine

Volumn 32, Issue 11, 2002, Pages 1084-1089

  Shringarpure, Reshma ^a   Davies, Kelvin J A ^a,b  

^a UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

^b UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

Author keywords

Aging; Free radicals; Proteasome; Protein oxidation; Proteolysis

Indexed keywords

PROTEASOME; PROTEINASE; REACTIVE OXYGEN METABOLITE; CYSTEINE PROTEINASE; FREE RADICAL; MULTIENZYME COMPLEX; PROTEIN;

AGING; CELL AGING; CROSS LINKING; ENZYME ACTIVITY; ENZYME BINDING; ENZYME INHIBITION; HUMAN; HYDROPHOBICITY; NONHUMAN; OXIDATION; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN FOLDING; PROTEIN METABOLISM; REVIEW; SENESCENCE; ANIMAL; GENERAL ASPECTS OF DISEASE; METABOLISM; OXIDATION REDUCTION REACTION;

AGING; ANIMALS; CYSTEINE ENDOPEPTIDASES; DISEASE; FREE RADICALS; HUMANS; MULTIENZYME COMPLEXES; OXIDATION-REDUCTION; OXIDATIVE STRESS; PROTEASOME ENDOPEPTIDASE COMPLEX; PROTEINS; REACTIVE OXYGEN SPECIES;

EID: 0036591853     PISSN: 08915849     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0891-5849(02)00824-9     Document Type: Article

References (61)

1. Aging: A theory based on free radical and radiation chemistry
2. Aging of C. elegans: Mosaics and mechanisms
3. FLP recombinase-mediated induction of Cu/Zn-superoxide dismutase transgene expression can extend the life span of adult Drosophila melanogaster flies
4. Insulin-like signaling, metabolism, stress resistance and aging in Caenorhabditis elegans
5. Protein damage and degradation by oxygen radicals: I. General aspects
6. Protein damage and degradation by oxygen radicals: III. Modification of secondary and tertiary structure
7. Protein damage and degradation by oxygen radicals: II. Modification of amino acids
8. Protein damage and degradation by oxygen radicals: IV. Degradation of denatured protein
9. Protein oxidation in aging disease and oxidative stress
10. Biochemistry and pathology of radical-mediated protein oxidation
11. Protein oxidation and aging
12. Modification of protein surface hydrophobicity and methionine oxidation by oxidative systems
13. Methionine residues as endogenous antioxidants in proteins
14. Methionine residues may protect proteins from critical oxidative damage
15. Degradation of oxidized proteins in mammalian cells
16. The essential function of protein-disulfide isomerase is to unscramble non-native disulfide bonds
17. 2-induced dityrosine and tyrosine oxidation products in hemoglobin and red blood cells
18. Dityrosine and tyrosine oxidation products are endogenous markers for selective proteolysis of oxidatively modified red blood cell hemoglobin by (the 19S) proteasome
19. Exposure of hydrophobic moieties promotes the selective degradation of hydrogen peroxide-modified hemoglobin by the multicatalytic proteinase complex, proteasome
20. Dityrosine, a specific marker for oxidation, is synthesized by the myeloperoxidase-hydrogen peroxide system of human neutrophiles and macrophages
21. Biochemical basis of lipofuscin, ceroid and AGE pigment-like fluorophores
22. Degradation of oxidized proteins in K562 human hematopoietic cells by proteasome
23. Proteolysis in cultured liver epithelial cells during oxidative stress. Role of the multicatalytic proteinase complex, proteasome
24. Hydrophobicity as the signal for selective degradation of hydroxyl radical-modified hemoglobin by the multicatalytic proteinase complex, proteasome
25. Macroxyproteinase (M.O.P.): A 670 kDa proteinase complex that selectively degrades oxidatively denatured proteins in red blood cells
26. Superoxide dismutase undergoes proteolysis and fragmentation following oxidative modification and inactivation
27. Preferential degradation of the oxidatively modified form of glutamine synthetase by intracellular mammalian proteases
28. Purification of a liver alkaline protease which degrades oxidatively modified glutamine synthetase. Characterization as a high molecular weight cysteine protease
29. Purification of a protease from Escherichia coli with specificity for oxidized glutamine synthetase
30. Proteases and proteolysis in the lysosome
31. Calcium-dependent proteases: An enzyme system active at cellular membranes?
32. Structure and functions of the 20S and 26S proteasomes
33. Degradation of oxidized proteins by the 20S proteasome
34. Modulation of the hydrophobicity of glutamine synthetase by mixed- function oxidation
35. Cation-sensitive neutral endopeptidase: Isolation and specificity of the bovine pituitary enzyme
36. Inhibition of multicatalytic proteinase (proteasome) by 4-hydroxynonenal cross-linked protein
37. 4-Hydroxynonenal-modified amyloid-beta peptide inhibits the proteasome: Possible importance in Alzheimer's disease
38. Proteasome inhibition by lipofuscin/ceroid during postmitotic aging of fibroblasts
39. Protein oxidation and degradation during cellular senescence of human BJ fibroblasts: Part II- aging of nondividing cells
40. Protein oxidation and degradation during cellular senescence of human BJ fibroblasts: Part I-effects of proliferative senescence
41. Inefficient degradation of oxidized regions of protein molecules
42. Hybrid proteasomes. Induction by interferon-gamma and contribution to ATP-dependent proteolysis
43. Subcellular localization of the proteasomes and their regulatory complexes in mammalian cells
44. Distinct 19S and 20S subcomplexes of the 26S proteasome and their distribution in the nucleus and the cytoplasm
45. Regulation of ubiquitin-cojugating enzymes by glutathione following oxidative stress
46. Comparative resistance of the 20S and 26S proteasome to oxidative stress
47. Differential impairment of 20S and 26S proteasome activities in human hematopoietic K562 cells during oxidative stress
48. Activity of ubiquitin-dependent pathway in response to oxidative stress
49. Protein oxidation and 20S proteasome-dependent proteolysis in mammalian cells
50. Ubiquitin may not be required for the degradation of oxidized proteins in vivo
51. Determination of carbonyl content in oxidatively modified proteins
52. Age-related changes in protein oxidation and proteolysis in mammalian cells
53. Reversal of age-related increase in brain protein oxidation, decrease in enzyme activity, and loss in temporal and spatial memory by chronic administration of the spin-trapping compound N-tert-butyl-alpha- phenylnitrone
54. Excess brain protein oxidation and enzyme dysfunction in normal aging and in Alzheimer disease
55. Protein oxidation and enzyme activity decline in old brown Norway rats are reduced by dietary restriction
56. The age-related accumulation of protein carbonyl in rat liver correlates with the age-related decline in liver proteolytic activities
57. Protein oxidation and loss of protease activity may lead to cataract formation in the aged lens
58. Markers of protein oxidation by hydroxyl radical and reactive nitrogen species in tissues of aging rats
59. Increase of oxidatively modified protein is associated with a decrease of proteasome activity and content in aging epidermal cells
60. Mitochondrial oxidative damage, hydrogen peroxide release, and aging
61. Mitochondrial free radical generation, oxidative stress, and aging