Organic extracts from African dust storms stimulate oxidative stress and induce inflammatory responses in human lung cells through Nrf2 but not NF-κB

Environmental Toxicology and Pharmacology

Volumn 39, Issue 2, 2015, Pages 845-856

  Rodríguez Cotto, Rosa I ^a,b   Ortiz Martínez, Mario G ^a,b   Jiménez Vélez, Braulio D ^a,b  

^a UNIVERSITY OF PUERTO RICO   (Puerto Rico)

^b Center for Environmental and Toxicological Research   (Puerto Rico)

Author keywords

African dust; Metals; Nrf2; Oxidative stress; Particulate matter; ROS

Indexed keywords

ACETYLCYSTEINE; ALUMINUM; CADMIUM; COPPER; DEFEROXAMINE MESYLATE; GLUTATHIONE TRANSFERASE P1; HEME OXYGENASE 1; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 6; INTERLEUKIN 8; IRON; LEAD; REACTIVE OXYGEN METABOLITE; TRANSCRIPTION FACTOR NRF2; VANADIUM; AIR POLLUTANT; DEFEROXAMINE; DUST; GSTP1 PROTEIN, HUMAN; HMOX1 PROTEIN, HUMAN; IL6 PROTEIN, HUMAN; IL8 PROTEIN, HUMAN; MESSENGER RNA; NFE2L2 PROTEIN, HUMAN;

AFRICA; AIR SAMPLING; ANTIOXIDANT ASSAY; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; CORRELATIONAL STUDY; DUST; GENE EXPRESSION; GSTP1 GENE; HMOX1 GENE; HUMAN; HUMAN CELL; IL 6 GENE; IL 8 GENE; IN VITRO STUDY; INFLAMMATION; LUNG ALVEOLUS CELL; OXIDATIVE STRESS; PARTICULATE MATTER; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; SIGNAL TRANSDUCTION; AIR; AIR POLLUTANT; CELL LINE; CYTOLOGY; DRUG EFFECTS; GENETICS; LUNG; METABOLISM; PUERTO RICO; TOXICITY;

ACETYLCYSTEINE; AFRICA; AIR MOVEMENTS; AIR POLLUTANTS; CELL LINE; DEFEROXAMINE; DUST; GLUTATHIONE S-TRANSFERASE PI; HEME OXYGENASE-1; HUMANS; INFLAMMATION; INTERLEUKIN-6; INTERLEUKIN-8; LUNG; NF-E2-RELATED FACTOR 2; NF-KAPPA B; OXIDATIVE STRESS; PUERTO RICO; REACTIVE OXYGEN SPECIES; RNA, MESSENGER;

EID: 84924705776     PISSN: 13826689     EISSN: 18727077     Source Type: Journal    
DOI: 10.1016/j.etap.2015.02.015     Document Type: Article

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