Proteotoxic stress and inducible chaperone networks in neurodegenerative disease and aging

Genes and Development

Volumn 22, Issue 11, 2008, Pages 1427-1438

  Morimoto, Richard I ^a  

^a NORTHWESTERN UNIVERSITY   (United States)

Author keywords

Molecular chaperones; Protein misfolding; Stress responses

Indexed keywords

BAG PROTEIN; BENZYLOXYCARBONYLLEUCYLLEUCYLLEUCINAL; CELASTROL; CHAPERONE; GELDANAMYCIN; HEAT SHOCK ELEMENT; HEAT SHOCK PROTEIN 104; HEAT SHOCK PROTEIN 40; HEAT SHOCK PROTEIN 60; HEAT SHOCK PROTEIN 70; HEAT SHOCK PROTEIN 90; HEAT SHOCK PROTEIN 90 INHIBITOR; HIP PROTEIN; INDOMETACIN; LACTACYSTIN; NONSTEROID ANTIINFLAMMATORY AGENT; PROTEASOME INHIBITOR; PROTEIN; PROTEIN HSF1; PROTEIN HSF2; PROTEIN HSF4; PROTEINASE INHIBITOR; PROTEOME; RADICICOL; SALICYLATE SODIUM; SERINE PROTEINASE INHIBITOR; TANESPIMYCIN; TRIPTOLIDE; TRITERPENOID; UNINDEXED DRUG;

ADAPTATION; AGING; ALZHEIMER DISEASE; AMYOTROPHIC LATERAL SCLEROSIS; CAENORHABDITIS ELEGANS; CELL DAMAGE; CELL STRESS; CELL SURVIVAL; CHRONIC STRESS; DEGENERATIVE DISEASE; DROSOPHILA; DRUG MECHANISM; ENVIRONMENTAL STRESS; EXPERIMENTAL MODEL; GENE FUNCTION; HOMEOSTASIS; HUMAN; HUNTINGTON CHOREA; KENNEDY DISEASE; LIFESPAN; METABOLIC DISORDER; MOLECULAR INTERACTION; NEOPLASM; NONHUMAN; PARKINSON DISEASE; PATHOPHYSIOLOGY; PRION DISEASE; PRIORITY JOURNAL; PROTEIN AGGREGATION; PROTEIN ASSEMBLY; PROTEIN CONFORMATION; PROTEIN DEGRADATION; PROTEIN DNA BINDING; PROTEIN DOMAIN; PROTEIN FOLDING; PROTEIN SYNTHESIS; PROTEIN TRANSPORT; REVIEW; SIGNAL TRANSDUCTION; SPINOCEREBELLAR DEGENERATION;

AGING; ANIMALS; FORECASTING; HEAT-SHOCK PROTEINS; HUMANS; MODELS, BIOLOGICAL; MOLECULAR CHAPERONES; NEURODEGENERATIVE DISEASES; PROTEIN CONFORMATION; PROTEIN FOLDING; PROTEOMICS;

EID: 44849094781     PISSN: 08909369     EISSN: 15495477     Source Type: Journal    
DOI: 10.1101/gad.1657108     Document Type: Review

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