Osmotic stress signaling and osmoadaptation in yeasts

Microbiology and Molecular Biology Reviews

Volumn 66, Issue 2, 2002, Pages 300-372

  Hohmann, Stefan ^a  

^a UNIVERSITY OF GOTHENBURG   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

AQUAPORIN; CALCINEURIN; CYCLIC AMP DEPENDENT PROTEIN KINASE; GLYCEROL; GLYCOGEN; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE KINASE KINASE; PROTEIN ACR1P; PROTEIN FPS1P; PROTEIN HOT1P; PROTEIN MIP; PROTEIN MSN1P; PROTEIN MSN2P; PROTEIN SGD1P; PROTEIN SHO1; PROTEIN SIN1; PROTEIN SKN7P; PROTEIN SKO1; PROTEIN STY1; TRANSCRIPTION FACTOR; TREHALOSE; UNCLASSIFIED DRUG;

ADAPTATION; CALCIUM SIGNALING; CELL GROWTH; CELL PROLIFERATION; CELL STRUCTURE; CELL SURFACE; CELL VACUOLE; CELL WALL; CELLULAR DISTRIBUTION; DIFFUSION; FEEDBACK SYSTEM; GENE EXPRESSION; GENE OVEREXPRESSION; ION TRANSPORT; MOLECULAR BIOLOGY; MOLECULAR DYNAMICS; MOLECULAR MODEL; MORPHOGENESIS; OSMOLARITY; OSMOSIS; OSMOTIC STRESS; OXIDATION REDUCTION REACTION; OXIDATIVE STRESS; PROTEIN DOMAIN; PROTEIN PHOSPHORYLATION; PROTEIN SYNTHESIS; REVIEW; SACCHAROMYCES CEREVISIAE; SEQUENCE ANALYSIS; SIGNAL TRANSDUCTION; STRESS; TRANSCRIPTION REGULATION; YEAST;

ADAPTATION, PHYSIOLOGICAL; AMINO ACID SEQUENCE; CYCLIC AMP-DEPENDENT PROTEIN KINASES; FEEDBACK; FUNGAL PROTEINS; GENES, FUNGAL; GLYCEROL; MITOGEN-ACTIVATED PROTEIN KINASES; MODELS, BIOLOGICAL; MOLECULAR SEQUENCE DATA; OSMOTIC PRESSURE; PROTEIN KINASES; SACCHAROMYCES CEREVISIAE PROTEINS; SIGNAL TRANSDUCTION; TRANSCRIPTION FACTORS; YEASTS;

EUKARYOTA; SACCHAROMYCES; SACCHAROMYCES CEREVISIAE;

EID: 0036282743     PISSN: 10922172     EISSN: None     Source Type: Journal    
DOI: 10.1128/MMBR.66.2.300-372.2002     Document Type: Review

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255. + gene include two redundant Tuplp-like corepressors and the CCAAT binding factor activation complex
256. Mutations in the SAM domain of STE50 differentially influence the MAP kinase-mediated pathways for mating, filamentous growth and osmotolerance in Saccharomyces cerevisiae
257. Mother cell-specific HO expression in budding yeast depends on the unconventional myosin myo4p and other cytoplasmic proteins
258. The complete set of genes encoding major intrinsic proteins in Arabidopsis provides a framework for a new nomenclature for major intrinsic proteins in plants
259. The role of aquaporins in cellular and whole plant water balance
260. Cdc42: An essential rho-type GTPase controlling eukaryotic cell polarity
261. Molecular dissection of gating in the CIC-2 chloride channel
262. Trehalases and trehalose hydrolysis in fungi
263. The essential protein fap7 is involved in the oxidative stress response of Saccharomyces cerevisiae
264. Purification, reconstitution, and characterization of KdpD, the turgor sensor of Escherichia coli
265. + and ionic strength directly influence the autophosphorylation activity of the putative turgor sensor KdpD of Escherichia coli
266. Genome-wide analysis of gene expression regulated by the yeast cell wall integrity signalling pathway
267. Analysis of the otsBA operon for osmoregulatory trehalose synthesis in Escherichia coli and homology of the OtsA and OtsB proteins to the yeast trehalose-6-phosphate synthase/phosphatase complex
268. The protein kinase C-activated MAP kinase pathway of Saccharomyces cerevisiae mediates a novel aspect of the heat shock response
269. Activation of yeast protein kinase C by Rhol GTPase
270. 1 arrest and gene expression under nitrogen starvation
271. Molecular identification of a eukaryotic, stretch-activated nonselective cation channel
272. Low external pH induces HOG1-dependent changes in the organization of the Saccharomyces cerevisiae cell wall
273. Reference deleted
274. Stress signal, mediated by a Hogl-like MAP kinase, controls sexual development in fission yeast
275. Fission yeast torl functions in response to various stresses including nitrogen starvation, high osmolarity, and high temperature
276. Conservation and release of osmolytes by yeasts during hypo-osmotic stress
277. Uptake and synthesis of compatible solutes as microbial stress responses to high-osmolality environments
278. Yeast Skn7p activity is modulated by the Sln1p-Ypd1p osmosensor and contributes to regulation of the HOG pathway
279. Saccharomyces cerevisiae Mid2p is a potential cell wall stress sensor and upstream activator of the PKC1MPK1 cell integrity pathway
280. Protein phosphatases and the regulation of mitogenactivated protein kinase signalling
281. Disruption of the yeast ATHI gene confers better survival after dehydration, freezing, and ethanol shock: Potential commercial applications
282. The Zygosaccharomyces rouxii strain CBS732 contains only one copy of the HOG1 and the SOD2 genes
283. Functional study of the Saccharomyces cerevisiae Nhalp C terminus
284. Signaling to rho GTPases
285. Review: Cell wall assembly in yeast
286. + transporters in Saccharomyces cerevisiae
287. Evidence for a heat shock transcription factor-independent mechanism for heat shock induction of transcription in Saccharomyces cerevisiae
288. Identification of cis and trans components of a novel heat shock stress regulatory pathway in Saccharomyces cerevisiae
289. Bni1p implicated in cytoskeletal control is a putative target of Rholp small GTP binding protein in Saccharomyces cerevisiae
290. Growth-related expression of ribosomal protein genes in Saccharomyces cerevisiae
291. Effect of xylitol and trehalose on dry resistance of yeasts
292. Reference deleted
293. Mutants of Saccharomyces cerevisiae sensitive to oxidative and osmotic stress
294. The response regulatorlike protein Pos9/Skn7 of Saccharomyces cerevisiae is involved in oxidative stress resistance
295. A regulatory shortcut between the Snfl protein kinase and RNA polymerase II holoenzyme
296. Cyclin-dependent protein kinase and cyclin homologs SSN3 and SSN8 contribute to transcriptional control in yeast
297. A novel nuclear export signal sensitive to oxidative stress in the fission yeast transcription factor Pap1
298. YAP1 dependent activation of TRX2 is essential for the response of Saccharomyces cerevisiae to oxidative stress by hydroperoxides
299. Regulation of yAP-1 nuclear localization in response to oxidative stress
300. Global and specific translational regulation in the genomic response of Saccharomyces cerevisiae to a rapid transfer from a fermentable to a nonfermentable carbon source
301. Evolution of osmotic stress signaling via MAP kinase cascades
302. cDNA cloning of a calcineurin B homolog in Saccharomyces cerevisiae
303. Cell volume regulated transporters of compatible solutes
304. Mammalian mitogen-activated protein kinase signal transduction pathways activated by stress and inflammation
305. Contribution to the physiological characterization of glycerol active uptake in Saccharomyces cerevisiae
306. Active glycerol uptake is a mechanism underlying halotolerance in yeasts: A study of 42 species
307. Polymorphism of Saccharomyces cerevisiae aquaporins
308. Muc1, a mucin-like protein that is regulated by Mss10, is critical for pseudohyphal differentiation in yeast
309. A multicopy suppressor gene, MSSIO, restores STA2 expression in Saccharomyces cerevisiae strains containing the STAT10 repressor gene
310. Functional significance of cell volume regulatory mechanisms
311. Osmoregulation in Escherichia coli by accumulation of organic osmolytes: Betaines, glutamic acid, and trehalose
312. Glycerol production in relation to the ATP pool and heat production rate of the yeast Debaryomyces hansenii and Saccharomyces cerevisiae during salt stress
313. The importance of the glycerol 3-phosphate shuttle during aerobic growth of Saccharomyces cerevisiae
314. +) complements an osmosensitive mutant of Saccharomyces cerevisiae
315. Evidence for a dual osmoregulatory mechanism in the yeast Saccharomyces cerevisiae
316. Isolation and characterization of osmosensitive vacuolar mutants of Saccharomyces cerevisiae
317. The protein kinase homologue Ste20p is required to link the yeast pheromone response G-protein beta gamma subunits to downstream signalling components
318. Functional characterization of the Cdc42p binding domain of yeast Ste20p protein kinase
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320. Yap1 and Skn7 control two specialized oxidative stress response regulons in yeast
321. A new antioxidant with alkyl hydroperoxide defense properties in yeast
322. A pair of functionally redundant yeast genes (PPZ1 and PPZ2) encoding type 1-related protein phosphatases function within the PKC1-mediated pathway
323. A yeast mitogen-activated protein kinase homolog (Mpk1p) mediates signaling by protein kinase C
324. Dominant mutations in a gene encoding a putative protein kinase (BCK1) bypass the requirement for a Saccharomyces cerevisiae protein kinase C homolog
325. Signal transduction cascades regulating fungal development and virulence
326. Trehalose lowers membrane phase transitions in dry yeast cells
327. Mutants in the S. cerevisiae PKC1 gene display a cell cycle-specific osmotic stability defect
328. Dissecting the protein kinase C/MAP kinase signalling pathway of Saccharomyces cerevisiae
329. A candidate protein kinase C gene, PKC1, is required for the S. cerevisiae cell cycle
330. Protection of Escherichia coli cells against extreme turgor by activation of MscS and MscL mechanosensitive channels: Identification of genes required for MscS activity
331. Induction of heat, freezing and salt tolerance by heat and salt shock in Saccharomyces cerevisiae
332. Mechanical stress-initiated signal transductions in vascular smooth muscle cells
333. The yeast histidine protein kinase, Sln1p, mediates phosphotransfer to two response regulators, Ssk1p and Skn7p
334. The eukaryotic two-component histidine kinase Sln1p regulates OCH1 via the transcription factor, Skn7p
335. Mitogen-activated protein [MAP] kinase pathways in plants: Versatile signaling tools
336. Evolution of cyclin-dependent kinases (CDKs) and CDK-activating kinases (CAKs): Differential conservation of CAKs in yeast and metazoa
337. The Saccharomyces cerevisiae genes (CMP1 and CMP2) encoding calmodulin-binding proteins homologous to the catalytic subunit of mammalian protein phosphatase 2B
338. The cell surface flocculin Flo11 is required for pseudohyphae formation and invasion by Saccharomyces cerevisiae
339. 2- in yeast
340. Characterization of the Wscl protein, a putative receptor in the stress response of Saccharomyces cerevisiae
341. Trehalose-6-phosphate synthase/phosphatase complex from bakers' yeast: Purification of a proteolytically activated form
342. Purification of trehalose synthase from baker's yeast. Its temperature-dependent activation by fructose 6-phosphate and inhibition by phosphate
343. Understanding the growth phenotype of the yeast gcr1 mutant in terms of global genomic expression patterns
344. The MEP2 ammonium permease regulates pseudohyphal differentiation in Saccharomyces cerevisiae
345. Regulators of pseudohyphal differentiation in Saccharomyces cerevisiae identified through multicopy suppressor analysis in ammonium permease mutant strains
346. Large scale identification of genes involved in cell surface biosynthesis and architecture in Saccharomyces cerevisiae
347. Fps1, a yeast member of the MIP family of channel proteins, is a facilitator for glycerol uptake and efflux and is inactive under osmotic stress
348. Characterization of two members of the rho gene family from the yeast Saccharomyces cerevisiae
349. SBF cell cycle regulator as a target of the yeast PKC-MAP kinase pathway
350. MAP kinases with distinct inhibitory functions impart signaling specificity during yeast differentiation
351. Activation of yeast PBS2 MAPKK by MAPKKKs or by binding of an SH3-containing osmosensor
352. Mutations in a protein tyrosine phosphatase gene (PTP2) and a protein serine/threonine phosphatase gene (PTC1) cause a synthetic growth defect in Saccharomyces cerevisiae
353. A two-component system that regulates an osmosensing MAP kinase cascade in yeast
354. Stress-induced transcriptional activation
355. Coordinate expression of ribosomal protein genes in yeast as a function of cellular growth rate
356. Osmostress response of the yeast Saccharomyces
357. The rho-GEF Rom2p localizes to sites of polarized cell growth and participates in cytoskeletal functions in Saccharomyces cerevisiae
358. A Saccharomyces cerevisiae UAS element controlled by protein kinase A activates transcription in response to a variety of stress conditions
359. A pathway in the yeast cell division cycle linking protein kinase C (Pkc1) to activation of Cdc28 at START
360. The Ssn6-Tup1 repressor complex of Saccharomyces cerevisiae is involved in the osmotic induction of HOG-dependent and -independent genes
361. Multiple transduction pathways regulate the sodium-extrusion gene PMR2/ENA1 during salt stress in yeast
362. Activity of the yeast MAP kinase homologue Slt2 is critically required for cell integrity at 37 degrees C
363. Molecular and functional characterization of a mutant allele of the mitogen-activated protein-kinase gene SLT2 (MPK1) rescued from yeast autolytic mutants
364. Characterization of SKMI, a Saccharomyces cerevisiae gene encoding a novel Ste20/PAK-like protein kinase
365. Regulatory mechanisms for modulation of signaling through the cell integrity Slt2-mediated pathway in Saccharomyces cerevisiae
366. The Saccharomyces cerevisiae zinc finger proteins Msn2p and Msn4p are required for transcriptional induction through the stress-response element (STRE)
367. Tcn1p/Crz1p, a calcineurin-dependent transcription factor that differentially regulates gene expression in Saccharomyces cerevisiae
368. Two protein tyrosine phosphatases, Ptp2 and Ptp3, modulate the subcellular localization of the Hogl MAP kinase in yeast
369. Differential regulation of the cell wall integrity mitogen-activated protein kinase pathway in budding yeast by the protein tyrosine phosphatases Ptp2 and Ptp3
370. Aquaporins. A molecular entry into plant water relations
371. In vitro activity of 1,3-β-D-glucan synthase requires the GTP-binding protein Rhol
372. Differential expression and function of two homologous subunits of yeast 1,3-β-D-glucan synthase
373. The SLT2 (MPKI) MAP kinase homolog is involved in polarized cell growth in Saccharomyces cerevisiae
374. Identification and characterization of the CLK1 gene product, a novel CaM kinase-like protein kinase from the yeast Saccharomyces cerevisiae
375. The extended protein kinase C super-family
376. Regulation of Cdc28 cyclin-dependent protein kinase activity during the cell cycle of the yeast Saccharomyces cerevisiae
377. The protein phosphatase calcineurin is essential for NaCl tolerance of Saccharomyces cerevisiae
378. Existence of a tightly regulated water channel in Saccharomyces cerevisiae
379. Stress-activated MAP kinase (mitogen-activated protein kinase) pathways of budding and fission yeasts
380. Pyp1 and Pyp2 PTPases dephosphorylate an osmosensing MAP kinase controlling cell size at division in fission yeast
381. Negative regulation of mitosis by two functionally overlapping PTPases in fission yeast
382. His-Asp phosphotransfer signal transduction
383. cdc2 and the regulation of mitosis: Six interacting mcs genes
384. Protein chaperones and the heat shock response in Saccharomyces cerevisiae
385. The Skn7 response regulator controls gene expression in the oxidative stress response of the budding yeast Saccharomyces cerevisiae
386. Two-component signal-transduction systems in budding yeast MAP a different pathway?
387. A yeast transcription factor bypassing the requirement for SBF and DSC1/MBF in budding yeast has homology to bacterial signal transduction proteins
388. +-ATPase
389. Latrunculin alters the actin-monomer subunit interface to prevent polymerization
390. Dissection of filamentous growth by transposon mutagenesis in Saccharomyces cerevisiae
391. 2+-calmodulin-dependent protein kinase
392. Stress factors acting at the level of the plasma membrane induce transcription via the stress response element (STRE) of the yeast Saccharomyces cerevisiae
393. A search in the genome of Saccharomyces cerevisiae for genes regulated via stress response elements
394. The hbrm and BRG-1 proteins, components of the human SNF/SW1 complex, are phosphorylated and excluded from the condensed chromosomes during mitosis
395. Ultrastructure of the yeast actin cytoskeleton and its association with the plasma membrane
396. Trehalose and trehalase in Arabidopsis
397. Structural determinants of water permeation through aquaporin-1
398. Isolation of CaSLN1 and CaNIK1, the genes for osmosensing histidine kinase homologues, from the pathogenic fungus Candida albicans
399. Identification of the catalase gene promoter region involved in superinduction in Schizosaccharomyces pombe caused by cycloheximide and hydrogen peroxide
400. Role of Atf1 and Pap1 in the induction of the catalase gene of fission yeast Schizosaccharomyces pombe
401. +]ATPase in secretory vesicles. A new strategy for directed mutagenesis
402. Protein phosphatase type 2B (calcineurin)-mediated, FK506-sensitive regulation of intracellular ions in yeast is an important determinant for adaptation to high salt stress conditions
403. Perturbation of the nucleus: A novel Hog1p-independent, Pkc1p-dependent consequence of hypertonic shock in yeast
404. +-ATPase. Insights into mechanisms of sodium tolerance
405. + exchanger in a late endosomal compartment of yeast. Implications for vacuole biogenesis
406. + exchanger, Nhx1, confers osmotolerance following acute hypertonic shock
407. Protein kinase A and mitogen-activated protein kinase pathways antagonistically regulate fission yeast fbp1 transcription by employing different modes of action at two upstream activation sites
408. Yeast SKO1 gene encodes a bZIP protein that binds to the CRE motif and acts as a repressor of transcription
409. Yeast MIG1 repressor is related to the mammalian early growth response and Wilms' tumour finger proteins
410. On the mechanism by which a heat shock induces trehalose accumulation in Saccharomyces cerevisiae
411. Osmoregulation and glycerol metabolism in the yeast Saccharomyces cerevisiae
412. Multistep phosphorelay proteins transmit oxidative stress signals to the fission yeast stress-activated protein kinase
413. Heat-shock-induced activation of stress MAP kinase is regulated by threonine- and tyrosine-specific phosphatases
414. BRO1, a novel gene that interacts with components of the Pkc1p-mitogen-activated protein kinase pathway in Saccharomyces cerevisiae
415. Physiology and pathophysiology of renal aquaporins
416. Expression of a cytoplasmic transhydrogenase in Saccharomyces cerevisiae results in formation of 2-oxoglutarate due to depletion of the NADPH pool
417. A downstream target of RHOI small GTP-binding protein is PKC1, a homolog of protein kinase C, which leads to activation of the MAP kinase cascade in Saccharomyces cerevisiae
418. Amino acid uptake is strongly affected during exponential growth of Saccharomyces cerevisiae in 0.7 M NaCl medium
419. The level of cAMP-dependent protein kinase A activity strongly affects osmotolerance and osmo-instigated gene expression changes in Saccharomyces cerevisiae
420. Metabolic and regulatory changes associated with growth of Saccharomyces cerevisiae in 1.4 M NaCl. Evidence for osmotic induction of glycerol dissimilation via the dihydroxyacetone pathway
421. Protein expression during exponential growth in 0.7 M NaCl medium of Saccharomyces cerevisiae
422. Purification and characterization of two isoenzymes of DL-glycerol-3-phosphatase from Saccharomyces cerevisiae. Identification of the corresponding GPP1 and GPP2 genes and evidence for osmotic regulation of Gpp2p expression by the osmosensing mitogen-activated protein kinase signal transduction pathway
423. Phenotypic analysis of temperaturesensitive yeast actin mutants
424. Molecular biology of trehalose and the trehalases in the yeast Saccharomyces cerevisiae
425. Expression and function of the trehalase genes NTH1 and YBR0106 in Saccharomyces cerevisiae
426. Phenotypic features of trehalase mutants in Saccharomyces cerevisiae
427. Deletion of the ATH1 gene in Saccharomyces cerevisiae prevents growth on trehalose
428. A lecithin cholesterol acyltransferase-like gene mediates diacylglycerol esterification in yeast
429. +) that encodes a response regulator implicated in oxidative stress response
430. + and for sexual development in fission yeast
431. Nuclear protein import, but not mRNA export, is defective in all Saccharomyces cerevisiae mutants that produce temperature-sensitive forms of the Ran GTPase homologue Gsp1p
432. Energy flow and osmoregulation of Saccharomyces cerevisiae grown in a chemostat under NaCl stress
433. 2+-binding domain and shows mating pheromone-stimulated expression in Saccharomyces cerevisiae
434. The Hog1 MAP kinase prevents cross talk between the HOG and pheromone response MAP kinase pathways in Saccharomyces cerevisiae
435. The extracellular domain of the Saccharomyces cerevisiae Sln1p membrane osmolarity sensor is necessary for kinase activity
436. A gene encoding a putative tyrosine phosphatase suppresses lethality of an N-end rule-dependent mutant
437. A yeast protein similar to bacterial two-component regulators
438. 2+ encode protein tyrosine phosphatases that negatively regulate mitosis
439. Rom1p and Rom2p are GDP/GTP exchange proteins (GEPs) for the Rho1p small GTP binding protein in Saccharomyces cerevisiae
440. Dynamic localization and function of Bni1p at the sites of directed growth in Saccharomyces cerevisiae
441. Identification of ASK10 as a multicopy activator of Skn7p-dependent transcription of a HIS3 reporter gene
442. The yeast glycerol 3-phosphatases Gpp1p and Gpp2p are required for glycerol biosynthesis and differentially involved in the cellular responses to osmotic, anaerobic, and oxidative stress
443. 2+ uptake and exacerbates the cdcl(Ts) growth defect
444. The osmotic integrity of the yeast cell requires a functional PKC1 gene product
445. Protein-protein interactions in the yeast PKC1 pathway: Pkc1p interacts with a component of the MAP kinase cascade
446. The freeze-thaw stress response of the yeast Saccharomyces cerevisiae is growth phase specific and is controlled by nutritional state via the RAS-cyclic AMP signal transduction pathway
447. STRE- and cAMP-independent transcriptional induction of Saccharomyces cerevisiae GSY2 encoding glycogen synthase during diauxic growth on glucose
448. Effects of various types of stress on the metabolism of reserve carbohydrates in Saccharomyces cerevisiae: Genetic evidence for a stress-induced recycling of glycogen and trehalose
449. Multiple levels of control regulate the yeast cAMP-response element-binding protein repressor Sko1p in response to stress
450. The Sko1p repressor and Gcn4p activator antagonistically modulate stress-regulated transcription in Saccharomyces cerevisiae
451. The glycerol kinase (GUT1) gene of Saccharomyces cerevisiae: Cloning and characterization
452. Signaling through scaffold, anchoring, and adaptor proteins
453. Saccharomyces cerevisiae Ras/cAMP pathway controls postdiauxic shift element-dependent transcription through the zinc finger protein Gisl
454. Glucose-triggered signalling in Saccharomyces cerevisiae: Different requirements for sugar phosphorylation between cells grown on glucose and those grown on non-fermentable carbon sources
455. Functional analysis of the interaction between the small GTP binding protein Cdc42 and the Ste20 protein kinase in yeast
456. Interactions between the bud emergence proteins Bem1p and Bem2p and rho-type GTPases in yeast
457. Wscl and Mid2 are cell surface sensors for cell wall integrity signaling that act through Rom2, a guanine nucleotide exchange factor for Rhol
458. Osmotic balance regulates cell fusion during mating in Saccharomyces cerevisiae
459. Differential role of Hsps and trehalose in stress tolerance
460. The heat shock and ethanol stress responses of yeast exhibit extensive similarity and functional overlap
461. Global regulators of ribosome biosynthesis in yeast
462. AGT1, encoding an alpha-glucoside transporter involved in uptake and intracellular accumulation of trehalose in Saccharomyces cerevisiae
463. The PPZ protein phosphatases are important determinants of salt tolerance in yeast cells
464. The PPZ protein phosphatases are involved in the maintenance of osmotic stability of yeast cells
465. The transcriptional response of yeast to saline stress
466. Activation of the yeast SSK2 MAPKKK by the SSK1 two-component response regulator
467. Osmotic activation of the HOG MAP kinase pathway via Ste11p MAPKKK: Scaffold role of Pbs2p MAPKK
468. Signal transduction by MAP kinase cascades in budding yeast
469. Requirement of STE50 for osmostress-induced activation of the STE11 mitogen-activated protein kinase kinase kinase in the high-osmolarity glycerol response pathway
470. Yeast HOG1 MAP kinase cascade is regulated by a multistep phosphorelay mechanism in the SLN1-YPD1-SSK1 "two-component" osmosensor
471. The isolation of FOS-1, a gene encoding a putative two-component histidine kinase from Aspergillus fumigatus
472. Tailoring wine yeast for the new millennium: Novel approaches to the ancient art of winemaking
473. Anatomy of a transcription factor important for the start of the cell cycle in Saccharomyces cerevisiae
474. Regulation of the Skol transcriptional repressor by the Hogl MAP kinase in response to osmotic stress
475. Repressors and upstream repressing sequences of the stress-regulated ENA1 gene in Saccharomyces cerevisiae: bZIP protein Sko1p confers HOG-dependent osmotic regulation
476. Polarization of cell growth in yeast. I. Establishment and maintenance of polarity states
477. Polarization of cell growth in yeast. II. The role of the cortical actin cytoskeleton
478. Conditional lethality of a yeast strain expressing human RHOA in place of RHO1
479. Identification of yeast Rho1p GTPase as a regulatory subunit of 1,3-β-glucan synthase
480. The Skn7 response regulator of Saccharomyces cerevisiae interacts with Hsf1 in vivo and is required for the induction of heat shock genes by oxidative stress
481. Yeast Cdc42 GTPase and Ste20 PAK-like kinase regulate Shol-dependent activation of the Hog1 MAP kinase pathway
482. Mid2 is a putative sensor for cell integrity signaling in Saccharomyces cerevisiae
483. The protein kinases Rck1 and Rck2 inhibit meiosis in budding yeast
484. Engineering baker's yeast: Room for improvement
485. The target of rapamycin (TOR) proteins
486. Kinetic characterization of individual hexose transporters of Saccharomyces cerevisiae and their relation to the triggering mechanisms of glucose repression
487. Identification of novel HXT genes in Saccharomyces cerevisiae reveals the impact of individual hexose transporters on glycolytic flux
488. Structural analysis of the subunits of the trehalose-6-phosphate synthase/phosphatase complex in Saccharomyces cerevisiae and their function during heat shock
489. Nucleocytoplasmic traffic of MAP kinases
490. Kinase activity-dependent nuclear export opposes stress-induced nuclear accumulation and retention of Hog1 mitogen-activated protein kinase in the budding yeast Saccharomyces cerevisiae
491. Polarized localization of yeast Pbs2 depends on osmostress, the membrane protein Sho1 and Cdc42
492. Glycerol export and glycerol-3-phosphate dehydrogenase, but not glycerol phosphatases, are rate limiting for glycerol production in Saccharomyces cerevisiae
493. Genome-wide location and function of DNA-binding proteins
494. Different signalling pathways contribute to the control of GPD1 expression by osmotic stress in Saccharomyces cerevisiae
495. The transcriptional response of Saccharomyces cerevisiae to osmotic shock. Hot1p and Msn2p/Msn4p are required for the induction of subsets of high osmolarity glycerol pathway-dependent genes
496. The Saccharomyces cerevisiae Sko1p transcription factor mediates HOG pathway-dependent osmotic regulation of a set of genes encoding enzymes implicated in protection from oxidative damage
497. Osmotic stress-induced gene expression in Saccharomyces cerevisiae requires Msn1p and the novel nuclear factor Hot1p
498. The high osmolarity glycerol response (HOG) MAP kinase pathway controls localization of a yeast Golgi glycosyltransferase
499. Mechanisms of salt tolerance conferred by overexpression of the HAL1 gene in Saccharomyces cerevisiae
500. Signaling and circuitry of multiple MAP kinase pathways revealed by a matrix of global gene expression profiles
501. Elements of a single MAP kinase cascade in Saccharomyces cerevisiae mediate two developmental programs in the same cell type: Mating and invasive growth
502. The yeast A kinases differentially regulate iron uptake and respiratory function
503. Potassium transport in fungi and plants
504. Characterization of the yeast (1→6)-beta-glucan biosynthetic components. Kre6p and Skn1p, and genetic interactions between the PKC1 pathway and extracellular matrix assembly
505. The TOR kinases link nutrient sensing to cell growth
506. Glucose repression in fungi
507. GUT2, a gene for mitochondrial glycerol 3-phosphate dehydrogenase of Saccharomyces cerevisiae
508. 1 phase cell cycle machinery
509. Thioredoxin peroxidase is required for the transcriptional response to oxidative stress in budding yeast
510. Large-scale analysis of the yeast genome by transposon tagging and gene disruption
511. +
512. Stress signaling in yeast
513. Calcineurin: Form and function
514. Histidine phosphorylation and two-component signaling in eukaryotic cells
515. Multiple modes of activation of the stress-responsive MAP kinase pathway in fission yeast
516. + encodes an MAPKKK that phosphorylates and activates Wis1 MAPKK in response to high osmolarity
517. Hsp104 is required for tolerance to many forms of stress
518. Dimorphism in fungal pathogens: Candida albicans and Ustilago maydis - Similar inputs, different outputs
519. The mitogen-activated protein kinase homolog HOG1 gene controls glycerol accumulation in the pathogenic fungus Candida albicans
520. A dual role for intracellular trehalose in the resistance of yeast cells to water stress
521. The high diversity of aquaporins reveals novel facets of plant membrane functions
522. TOR, a central controller of cell growth
523. The yeast phosphatidylinositol kinase homolog TOR2 activates RHO1 and RHO2 via the exchange factor ROM2
524. Beta-subunits of Snfl kinase are required for kinase function and substrate definition
525. Msn2p, a zinc finger DNA-binding protein, is the transcriptional activator of the multistress response in Saccharomyces cerevisiae
526. The HOG pathway controls osmotic regulation of transcription via the stress response element (STRE) of the Saccharomyces cerevisiae CTT1 gene
527. Molecular analysis of SSN6, a gene functionally related to the SNF1 protein kinase of Saccharomyces cerevisiae
528. The hybrid histidine kinase DokA is part of the osmotic response system of Dictyostelium
529. Yeast genome evolution in the postgenome era
530. Salt tolerance in plants and microorganisms: Toxicity targets and defense responses
531. Crucial factors in salt tolerance
532. A glimpse of the mechanisms of ion homeostasis during salt stress
533. Ion homeostasis during salt stress in plants
534. β-1,6-glucan synthesis in Saccharomyces cerevisiae
535. Partitioning the transcriptional program induced by rapamycin among the effectors of the Tor proteins
536. Roles of sugar alcohols in osmotic stress adaptation. Replacement of glycerol by mannitol and sorbitol in yeast
537. Spa2p interacts with cell polarity proteins and signaling components involved in yeast cell morphogenesis
538. The Mcs4 response regulator coordinately controls the stress-activated Wak1-Wis1-Sty1 MAP kinase pathway and fission yeast cell cycle
539. The Winl mitotic regulator is a component of the fission yeast stress-activated Styl MAP kinase pathway
540. The hypo-osmolarity-sensitire phenotype of the Saccharomyces cerevisiae hpo2 mutant is due to a mutation in PKC1, which regulates expression of β-glucanase
541. Cell cycle control linked to extracellular environment by MAP kinase pathway in fission yeast
542. Cellular function of protein phosphatase 2C in yeast
543. Conjugation, meiosis, and the osmotic stress response are regulated by Spc1 kinase through Atf1 transcription factor in fission yeast
544. Counteractive roles of protein phosphatase 2C (PP2C) and a MAPKK homolog in the osmoregulation of fission yeast
545. Heat stress activates fission yeast Spc1/Stv1 MAP kinase by a MEKK-independent mechanism
546. Mcs4 mitotic catastrophe suppressor regulates the fission yeast cell cycle through the Wik1-Wis1-Spc1 kinase cascade
547. Candidate osmosensors from Candida utilis and Kluyveromyces lactis: Structural and functional homology to the Sho1p putative osmosensor from Saccharomyces cerevisiae
548. The general stress response in search for a common denominator
549. The control of intracellular glycerol in Saccharomyces cerevisiae influences osmotic stress response and resistance to increased temperature
550. 1 phase duration, cyclin expression, and reserve carbohydrate metabolism in Saccharomyces cerevisiae
551. Function of trehalose and glycogen in cell cycle progression and cell viability in Saccharomyces cerevisiae
552. Multiple effects of trehalose on protein folding in vitro and in vivo
553. Thermotolerance in Saccharomyces cerevisiae: The yin and yang of trehalose
554. The Saccharomyces cerevisiae Sln1p-Ssk1p two-component system mediates response to oxidative stress and in an oxidant-specific fashion
555. Yeast PKA represses Msn2p/Msn4p-dependent gene expression to regulate growth, stress response and glycogen accumulation
556. Turning genes off by Ssn6-Tupl: A conserved system of transcriptional repression in eukaryotes
557. Cell wall dynamics in yeast
558. The SPA2 protein of yeast localizes to sites of cell growth
559. Characterization of domains in the yeast MAP kinase Slt2 (Mpk1) required for functional activity and in vivo interaction with protein kinases Mkk1 and Mkk2
560. Osmolytes and cell volume regulation: Physiological and evolutionary principles
561. Genomic exploration of the hemiascomycetous yeasts. 1. A set of yeast species for molecular evolution studies
562. Isolation and characterization of Saccharomyces cerevisiae mutants defective in glycerol catabolism
563. Pheromone response and signal transduction during the mating process of Saccharomyces cerevisiae
564. The two-component hybrid kinase regulator CaNIK1 of Candida albicans
565. The aquaporin superfamily: Structure and function
566. Negatively charged phospholipids influence the activity of the sensor kinase KdpD of Escherichia coli
567. Calcineurin acts through the CRZ1/TCN1-encoded transcription factor to regulate gene expression in yeast
568. The role of the YAP1 and YAP2 genes in the regulation of the adaptive oxidative stress responses of Saccharomyces cerevisiae
569. Mutations in SPC110, encoding the yeast spindle pole body calmodulin-binding protein, cause defects in cell integrity as well as spindle formation
570. Two-component signal transduction
571. Osmoregulation in the model organism Escherichia coli: Genes governing the synthesis of glycine betaine and trehalose and their use in metabolic engineering of stress tolerance
572. Trehalose metabolism in Escherichia coli: Stress protection and stress regulation of gene expression
573. Multiple effects of protein phosphatase 2A on nutrient-induced signalling in the yeast Saccharomyces cerevisiae
574. The gating mechanism of the large mechanosensitive channel MscL
575. Mechanosensitive channels of Escherichia coli: The MscL gene, protein, and activities
576. Characteristics of Fpsl-dependent and -independent glycerol transport in Saccharomyces cerevisiae
577. + encodes a transcription factor required for sexual development and entry into stationary phase
578. Fps1p controls the accumulation and release of the compatible solute glycerol in yeast osmoregulation
579. Stimulation of the yeast high osmolarity glycerol (HOG) pathway: Evidence for a signal generated by a change in turgor rather than by water stress
580. NMR structure of the histidine kinase domain of the E. coli osmosensor EnvZ
581. Intracellular glycerol levels modulate the activity of Sln1p, a Saccharomyces cerevisiae two-component regulator
582. Rck2, a member of the calmodulin-protein kinase family, links protein synthesis to high osmolarity MAP kinase signaling in budding yeast
583. Regulation of trehalose mobilization in fungi
584. Signal transduction in yeast
585. Nutrient-induced signal transduction through the protein kinase A pathway and its role in the control of metabolism, stress resistance, and growth in yeast
586. Novel sensing mechanisms and targets for the cAMP-protein kinase A pathway in the yeast Saccharomyces cerevisiae
587. Trehalose synthase, guard to the gate of glycolysis in yeast?
588. TOR signalling and control of cell growth
589. Deletion of SNF1 affects the nutrient response of yeast and resembles mutations which activate the adenylate cyclase pathway
590. Fission yeast pap1-dependent transcription is negatively regulated by an essential nuclear protein, crm1
591. Fission yeast genes that confer resistance to staurosporine encode an AP-1-like transcription factor and a protein kinase related to the mammalian ERK1/MAP2 and budding yeast FUS3 and KSS1 kinases
592. Implications of FPS1 deletion and membrane ergosterol content for glycerol efflux from Saccharomyces cerevisiae
593. Transmembrane signal transduction and osmoregulation in Escherichia coli. Functional importance of the periplasmic domain of the membrane-located protein kinase EnvZ
594. Transmembrane signal transduction and osmoregulation in Escherichia coli: Functional importance of the transmembrane regions of membrane-located protein kinase EnvZ
595. Transmembrane signal transduction by the Escherichia coli osmotic sensor, EnvZ: Intermolecular complementation of transmembrane signalling
596. Transmembrane signal transduction and osmoregulation in Escherichia coli: II. The osmotic sensor, EnvZ, located in the isolated cytoplasmic membrane displays its phosphorylation and dephosphorylation abilities as to the activator protein
597. Solution structure of the homodimeric core domain of Escherichia coli histidine kinase EnvZ
598. Regulation of the fission yeast transcription factor Pap1 by oxidative stress: Requirement for the nuclear export factor Crm1 (exportin) and the stress-activated MAP kinase Sty1/Spc1
599. A protein kinase gene complements the lytic phenotype of Saccharomyces cerevisiae lyt2 mutants
600. Functional analysis of the stress response element and its role in the multistress response of Saccharomyces cerevisiae
601. Transcriptional factor mutations reveal regulatory complexities of heat shock and newly identified stress genes in Saccharomyces cerevisiae
602. Physiological overlap between osmotolerance and thermotolerance in Saccharomyces cerevisiae
603. Cooperative regulation of DOG2, encoding 2-deoxyglucose-6-phosphate phosphatase, by Snf1 kinase and the high-osmolarity glycerol-mitogen-activated protein kinase cascade in stress responses of Saccharomyces cerevisiae
604. Plant aquaporins: Their molecular biology, biophysics and significance for plant water relations
605. Network dynamics and cell physiology
606. Mutations in GCR1, a transcriptional activator of Saccharomyces cerevisiae glycolytic genes, function as suppressors of gcr2 mutations
607. Multidomainial structure of the yeast transcription factor. Gcrl, and its possible mode of DNA-binding
608. Possible His to Asp phosphorelay signaling in an Arabidopsis two-component system
609. A transmembrane hybrid-type histidine kinase in Arabidopsis functions as an osmosensor
610. Two-component systems in plant signal transduction
611. A yeast homologue of the bovine lens fibre MIP gene family complements the growth defect of a Saccharomyces cerevisiae mutant on fermentable sugars but not its defect in glucose-induced RAS-mediated cAMP signalling
612. Nucleotide sequence of the Saccharomyces cerevisiae PUT4 proline-permease-encoding gene: Similarities between CAN1, HIP1 and PUT4 permeases
613. Differential importance of trehalose in stress resistance in fermenting and nonfermenting Saccharomyces cerevisiae cells
614. Regulation of trehalase activity during the cell cycle of Saccharomyces cerevisiae
615. Changes in activities of several enzymes involved in carbohydrate metabolism during the cell cycle of Saccharomyces cerevisiae
616. Response of Saccharomyces cerevisiae to severe osmotic stress: Evidence for a novel activation mechanism of the HOG MAP kinase pathway
617. Osmostress-induced changes in yeast gene expression
618. Structure and function of aquaporin water channels
619. A family of genes required for maintenance of cell wall integrity and for the stress response in Saccharomyces cerevisiae
620. A proteome analysis of the cadmium response in Saccharomyces cerevisiae
621. 1 progression
622. ACR1, a yeast ATF/CREB repressor
623. Subeellular localization of the Snf1 kinase is regulated by specific beta subunits and a novel glucose signaling mechanism
624. A novel 'two-component' protein containing histidine kinase and response regulator domains required for sporulation in Aspergillus nidulans
625. Functional analysis of the Neurospora cmssa PZL-1 protein phosphatase by expression in budding and fission yeast
626. Cloning of two related genes encoding the 56-kDa and 123-kDa subunits of trehalose synthase from the yeast Saccharomyces cerevisiae
627. The rho-GAP encoded by BEM2 regulates cytoskeletal structure in budding yeast
628. Five novel elements involved in the regulation of mitosis in fission yeast
629. The wisl protein kinase is a dosage-dependent regulator of mitosis in Schizosaccharomyces pombe
630. Ptc1, a type 2C Ser/Thr phosphatase, inactivates the HOG pathway by dephosphorylating the mitogen-activated protein kinase Hog1
631. Yeast RLM1 encodes a serum response factor-like protein that may function downstream of the Mpk1 (Slt2) mitogen-activated protein kinase pathway
632. Characterization of a serum response factor-like protein in Saccharomyces cerevisiae, Rlm1, which has transcriptional activity regulated by the Mpk1 (Slt2) mitogen-activated protein kinase pathway
633. Opposite roles of trehalase activity in heat-shock recovery and heat-shock survival in Saccharomyces cerevisiae
634. Systematic mutational analysis of the yeast ACT1 gene
635. + pump in the yeast plasma membrane
636. Heat shock factor-independent heat control of transcription of the CTT1 gene encoding the cytosolic catalase T of Saccharomyces cerevisiae
637. The Atf1 transcription factor is a target for the Sty1 stress-activated MAP kinase pathway in fission yeast
638. The eukaryotic response regulator Skn7p regulates calcineurin signaling through stabilization of Crz1p
639. Glucose repression/ derepression in budding yeast: SNF1 protein kinase is activated by phosphorylation under derepressing conditions, and this correlates with a high AMP:ATP ratio
640. Regulation of genes encoding subunits of the trehalose synthase complex in Saccharomyces cerevisiae: Novel variations of STRE-mediated transcription control?
641. Functional characterization of the S. cerevisiae genome by gene deletion and parallel analysis
642. Molecular evidence for an ancient duplication of the entire yeast genome
643. Osmosensing by bacteria: Signals and membrane-based sensors
644. Regulation of the Saccharomyces cerevisiae Hogl mitogen-activated protein kinase by the Ptp2 and Ptp3 protein tyrosine phosphatases
645. The glycerol channel Fps1p mediates the uptake of arsenite and antimonite in Saccharomyces cerevisiae
646. Transcript expression in Saccharomyces cerevisiae at high salinity
647. Roles of three histidine kinase genes in hyphal development and virulence of the pathogenic fungus Candida albicans
648. Regulation of meiosis in fission yeast
649. Growth site localization of Rhol small GTP-binding protein and its involvement in bud formation in Saccharomyces cerevisiae
650. Crm1p mediates regulated nuclear export of a yeast AP-1-like transcription factor
651. Living with water stress: Evolution of osmolyte systems
652. Rapid gating and anion permeability of an intracellular aquaporin
653. Characterization of a staurosporine-sensitive and temperature-sensitive mutant, stt1, of Saccharomyces cerevisiae-STT1 is allelic to PKC1
654. A novel gene STT4, encodes a phosphatidylinositol 4-kinase in the PKC1 protein kinase pathway of Saccharomyces cerevisiae
655. Genetic interactions among genes involved in the STT4-PKC1 pathway of Saccharomyces cerevisiae
656. The essential transcription factor, Mcm1, is a downstream target of Sln1, a yeast "two-component" regulator
657. Genetic analysis of the bipolar pattern of bud site selection in the yeast Saccharomyces cerevisiae
658. Neutral trehalase Nthlp of Saccharomyces cerevisiae encoded by the NTH1 gene is a multiple stress responsive protein
659. Induction of neutral trehalase Nth1 by heat and osmotic stress is controlled by STREs and Msn2/Msn4 transcription factors: Variations of PKA effect during stress and growth
660. The SLT2 (MPK1) MAP kinase is activated during periods of polarized cell growth in yeast
661. How water molecules pass through aquaporins
662. +
663. Differential regulation of FUS3 MAP kinase by tyrosine-specific phosphatases PTP2/PTP3 and dual-specificity phosphatase MSG5 in Saccharomyces cerevisiae
664. A specific protein-protein interaction accounts for the in vivo substrate selectivity of Ptp3 towards the Fus3 MAP kinase
665. Temperature-induced expression of yeast FKS2 is under the dual control of protein kinase C and calcineurin
666. Subcellular localization of Cdc42p, a Saccharomyces cerevisiae GTP-binding protein involved in the control of cell polarity
667. Mutations in WSC genes for putative stress receptors result in sensitivity to multiple stress conditions and impairment of Rlm1-dependent gene expression in Saccharomyces cerevisiae