Distinct roles of activating transcription factor 6 (ATF6) and double-stranded RNA-activated protein kinase-like endoplasmic reticulum kinase (PERK) in transcription during the mammalian unfolded protein response

Biochemical Journal

Volumn 366, Issue 2, 2002, Pages 585-594

  Okada, Tetsuya ^a   Yoshida, Hiderou ^a   Akazawa, Rieko ^a   Negishi, Manabu ^a   Mori, Kazutoshi ^a  

^a KYOTO UNIVERSITY   (Japan)

Author keywords

Amino acid starvation; Microarray; Protein folding; Translation

Indexed keywords

BIOLOGICAL MEMBRANES; CELLS; GENES; RNA; YEAST;

TRANSCRIPTION FACTORS;

PROTEINS;

ACTIVATING TRANSCRITPION FACTOR 6; CHAPERONE; ENZYME; PHOSPHOTRANSFERASE; PROTEIN; PROTEIN KINASE LIKE ENDOPLASMIC RETICULUM KINASE; RNA; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG;

ARTICLE; CELLULAR PARAMETERS; CONTROLLED STUDY; ENZYME ANALYSIS; EUKARYOTE; FUNGAL CELL; GENETIC CODE; GENOME; HELA CELL; HUMAN; HUMAN CELL; MAMMAL CELL; MEMBRANE BINDING; PRIORITY JOURNAL; PROTEIN FOLDING; SIGNAL TRANSDUCTION;

ACTIVATING TRANSCRIPTION FACTOR 6; AMINO ACIDS; DNA-BINDING PROTEINS; EIF-2 KINASE; GENE EXPRESSION REGULATION, ENZYMOLOGIC; GENES; HELA CELLS; HUMANS; LEUCINE ZIPPERS; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; PROTEIN DENATURATION; PROTEIN FOLDING; RECOMBINANT PROTEINS; TRANSCRIPTION FACTORS; TRANSCRIPTION, GENETIC; TRANSFECTION; TUNICAMYCIN;

EUKARYOTA; MAMMALIA;

EID: 0036713724     PISSN: 02646021     EISSN: None     Source Type: Journal    
DOI: 10.1042/BJ20020391     Document Type: Article

References (57)

1. Protein folding in the cell
2. The endoplasmic reticulum as a protein folding compartment
3. Stress signaling from the lumen of the endoplasmic reticulum: Coordination of gene transcriptional and translational controls
4. Tripartite management of unfolded proteins in the endoplasmic reticulum
5. IRE1 and efferent signaling from the endoplasmic reticulum
6. Intracellular signaling from the endoplasmic reticulum to the nucleus: The unfolded protein response in yeast and mammals
7. IRE1 encodes a putative protein kinase containing a membrane-spanning domain and is required for inositol phototrophy in Saccharomyces cerevisiae
8. Transcriptional induction of genes encoding endoplasmic reticulum resident proteins requires a transmembrane protein kinase
9. A transmembrane protein with a cdc2 +/CDC28-related kinase activity is required for signaling from the ER to the nucleus
10. Oligomerization and phosphorylation of the Ire1p kinase during intracellular signaling from the endoplasmic reticulum to the nucleus
11. The unfolded protein response pathway in Saccharomyces cerevisiae. Oligomerization and trans-phosphorylation of Ire1p(Ern1p) are required for kinase activation
12. Dynamic interaction of BiP and ER stress transducers in the unfolded-protein response
13. Ligand-independent dimerization activates the stress response kinases IRE1 and PERK in the lumen of the endoplasmic reticulum
14. Dissociation of Kar2p/BiP from an ER sensory molecule, Ire1p, triggers the unfolded protein response in yeast
15. A novel mechanism for regulating activity of a transcription factor that controls the unfolded protein response
16. Signalling from endoplasmic reticulum to nucleus: Transcription factor with a basic-leucine zipper motif is required for the unfolded protein-response pathway
17. Saccharomyces cerevisiae IRE2/HAC1 is involved in IRE1-mediated KAR2 expression
18. A 22 bp cis-acting element is necessary and sufficient for the induction of the yeast KAR2 (BiP) gene by unfolded proteins
19. The promoter region of the yeast KAR2 (BiP) gene contains a regulatory domain that responds to the presence of unfolded proteins in the endoplasmic reticulum
20. Palindrome with spacer of one nucleotide is characteristic of the cis-acting unfolded protein-response element in Saccharomyces cerevisiae
21. The presence of malfolded proteins in the endoplasmic reticulum signals the induction of glucose-regulated proteins
22. The stress response in Chinese hamster ovary cells. Regulation of ERp72 and protein disulfide isomerase expression and secretion
23. The unfolded-protein-response pathway in yeast
24. Functional and genomic analyses reveal an essential coordination between the unfolded protein response and ER-associated degradation
25. The unfolded protein response regulates multiple aspects of secretory and membrane protein biogenesis and endoplasmic reticulum quality control
26. Identification of the cis-acting endoplasmic reticulum stress response element responsible for transcriptional induction of mammalian glucose-regulated proteins. Involvement of basic-leucine zipper transcription factors
27. The mammalian endoplasmic reticulum stress response element consists of an evolutionarily conserved tripartite structure and interacts with a novel stress-inducible complex
28. Mammalian transcription factor ATF6 is synthesized as a transmembrane protein and activated by proteolysis in response to endoplasmic reticulum stress
29. ATF6 activated by proteolysis directly binds in the presence of NF-Y (CBF) to the cis-acting element responsible for the mammalian unfolded protein response
30. Activation of ATF6 and an ATF6 DNA binding site by the endoplasmic reticulum stress response
31. ER stress induces cleavage of membrane-bound ATF6 by the same proteases that process SREBPs
32. Endoplasmic reticulum stress-induced formation of transcription factor complex ERSF including NF-Y (CBF) and activating transcription factors 6α and 6β that activates the mammalian unfolded protein response
33. Identification of the G13 (cAMP-response-element-binding protein-related protein) gene product related to activating transcription factor 6 as a transcriptional activator of the mammalian unfolded protein response
34. The lumenal domain of ATF6 senses ER stress and causes translocation of ATF6 from the ER to the Golgi
35. Regulation of translational initiation during cellular responses to stress
36. Identification and characterization of pancreatic eukaryotic initiation factor 2 α-subunit kinase, PEK, involved in translational control
37. Protein translation and folding are coupled by an endoplasmic-reticulum-resident kinase
38. Complementary signaling pathways regulate the unfolded protein response and are required for C. elegans development
39. Perk is essential for translational regulation and cell survival during the unfolded protein response
40. Diabetes mellitus and exocrine pancreatic dysfunction in Perk-/-mice reveals a role for translational control in secretory cell survival
41. Translational control is required for the unfolded protein response and in vivo glucose homeostasis
42. Regulated translation initiation controls stress-induced gene expression in mammalian cells
43. Amino acid limitation regulates CHOP expression through a specific pathway independent of the unfolded protein response
44. The sarco/endoplasmic reticulum calcium-ATPase 2b is an endoplasmic reticulum stress-inducible protein
45. Sarco/endoplasmic reticulum calcium ATPase-2 expression is regulated by ATF6 during the endoplasmic reticulum stress response. Intracellular signaling of calcium stress in a cardiac myocyte model system
46. PERK mediates cell-cycle exit during the mammalian unfolded protein response
47. Complete sequence analysis of a gene (OS-9) ubiquitously expressed in human tissues and amplified in sarcomas
48. Activation of the unfolded protein response pathway induces human asparagine synthetase gene expression
49. Activation of the human asparagine synthetase gene by the amino acid response and the endoplasmic reticulum stress response pathways occurs by common genomic elements
50. Amino acid regulation of gene expression
51. Amino acids control mammalian gene transcription: Activating transcription factor 2 is essential for the amino acid responsiveness of the CHOP promoter
52. Complexes containing activating transcription factor (ATF)/cAMP-responsive-element-binding protein (CREB) interact with the CCAAT/enhancer-binding protein (C/EBP)-ATF composite site to regulate Gadd153 expression during the stress response
53. S. cerevisiae encodes an essential protein homologous in sequence and function to mammalian BiP
54. XBP1 mRNA is induced by ATF6 and spliced by IRE1 in response to ER stress to produce a highly active transcription factor
55. IRE1 couples endoplasmic reticulum load to secretory capacity by processing the XBP-1 mRNA