Health effects of intermittent fasting: Hormesis or harm? A systematic review

American Journal of Clinical Nutrition

Volumn 102, Issue 2, 2015, Pages 464-470

  Horne, Benjamin D ^a,b   Muhlestein, Joseph B ^a,b   Anderson, Jeffrey L ^a,b  

^a INTERMOUNTAIN MEDICAL CENTER   (United States)

^b UNIVERSITY OF UTAH SCHOOL OF MEDICINE   (United States)

Author keywords

Alternate day fasting; Caloric restriction; Cognitive performance; Coronary artery disease; Diabetes; Energy restriction; Intermittent fasting; Obesity; Time restricted feeding; Total caloric desistance

Indexed keywords

ADVERSE OUTCOME; BODY WEIGHT; CARDIOVASCULAR DISEASE; CLINICAL TRIAL (TOPIC); DIABETES MELLITUS; DIET; DIET RESTRICTION; HORMESIS; HUMAN; META ANALYSIS (TOPIC); NONHUMAN; RANDOMIZED CONTROLLED TRIAL (TOPIC); REVIEW; SMOKING; SYSTEMATIC REVIEW; ADULT; ADVERSE EFFECTS; ALTERNATIVE MEDICINE; ANIMAL; CALORIC RESTRICTION; CORONARY ARTERY DISEASE; DIABETES MELLITUS, TYPE 2; DIET THERAPY; EVIDENCE BASED MEDICINE; HEALTH STATUS; HYPERCHOLESTEROLEMIA; LOW CALORY DIET; META ANALYSIS; MILD COGNITIVE IMPAIRMENT; OBESITY; OBSERVATIONAL STUDY; OVERWEIGHT; PATHOPHYSIOLOGY; RISK FACTOR;

ANIMALIA;

ADULT; ANIMALS; CALORIC RESTRICTION; CORONARY ARTERY DISEASE; DIABETES MELLITUS, TYPE 2; DIET FADS; DIET, REDUCING; EVIDENCE-BASED MEDICINE; FASTING; HEALTH STATUS; HORMESIS; HUMANS; HYPERCHOLESTEROLEMIA; MILD COGNITIVE IMPAIRMENT; OBESITY; OBSERVATIONAL STUDY AS TOPIC; OVERWEIGHT; RANDOMIZED CONTROLLED TRIALS AS TOPIC; RISK FACTORS;

EID: 84938723264     PISSN: 00029165     EISSN: 19383207     Source Type: Journal    
DOI: 10.3945/ajcn.115.109553     Document Type: Review

References (57)

1. Rizza W, Veronese N, Fontana L. What are the roles of calorie restriction and diet quality in promoting health and longevity? Ageing Res Rev 2014;13:38-45.
2. Hietaniemi M, Jokela M, Rantala M, Ukkola O, Vuoristto JT, Ilves M, Rysa J, Kesaniemi Y. The effect of a short-term hypocaloric diet on liver gene expression and metabolic risk factors in obese women. Nutr Metab Cardiovasc Dis 2009;19:177-83.
3. Tapsell L, Batterham M, Huang XF, Tan SY, Teuss G, Charlton K, Oshea J, Warensjo E. Short term effects of energy restriction and dietary fat sub-type on weight loss and disease risk factors. Nutr Metab Cardiovasc Dis 2010;20:317-25.
4. Anson RM, Guo Z, de Cabo R, Iyun T, Rios M, Hagepanos A, Ingram DK, Lane MA, Mattson MP. Intermittent fasting dissociates beneficial effects of dietary restriction on glucose metabolism and neuronal resistance to injury from calorie intake. Proc Natl Acad Sci USA 2003; 100:6216-20.
5. Panowski SH, Wolff S, Aguilaniu H, Durieux J, Dillin A. PHA-4/Foxa mediates diet-restriction-induced longevity of C. elegans. Nature 2007; 447:550-5.
6. Longo VD, Mattson MP. Fasting: molecular mechanisms and clinical applications. Cell Metab 2014;19:181-92.
7. Fontana L, Partridge L, Longo VD. Extending healthy life span-from yeast to humans. Science 2010;328:321-6.
8. Zhang L, Rubins NE, Ahima RS, Greenbaum LE, Kaestner KH. Foxa2 integrates the transcriptional response of the hepatocyte to fasting. Cell Metab 2005;2:141-8.
9. Raffaghello L, Lee C, Safdie FM, Wei M, Madia F, Bianchi G, Longo VD. Starvation-dependent differential stress resistance protects normal but not cancer cells against high-dose chemotherapy. Proc Natl Acad Sci USA 2008;105:8215-20.
10. Wan R, Camandola S, Mattson MP. Intermittent fasting and dietary supplementation with 2-deoxy-D-glucose improve functional and metabolic cardiovascular risk factors in rats. FASEB J 2003;17: 1133-4.
11. Cheng CW, Adams GB, Perin L,Wei M, Zhou X, Lam BS, Da Sacco S, Mirisola M, Quinn DI, Dorff TB, et al. Prolonged fasting reduces IGF-1/PKA to promote hematopoietic-stem-cell-based regeneration and reverse immunosuppression. Cell Stem Cell 2014;14:810-23.
12. Duan W, Guo Z, Jiang H, Ware M, Mattson MP. Reversal of behavioral and metabolic abnormalities, and insulin resistance syndrome, by dietary restriction in mice deficient in brain-derived neurotrophic factor. Endocrinology 2003;144:2446-53.
13. Arumugam TV, Phillips TM, Cheng A, Morrell CH, Mattson MP, Wan R. Age and energy intake interact to modify cell stress pathways and stroke outcomes. Ann Neurol 2010;67:41-52.
14. Fann DYW, Santro T, Manzanero S, Widiapradja A, Cheng YL, Lee SY, Chunduri P, Jo DG, Stranahan AM, Mattson MP, et al. Intermittent fasting attenuates inflammasome activity in ischemic stroke. Exp Neurol 2014;257:114-9.
15. Halagappa VKM, Guo Z, Pearson M, Matsuoka Y, Cutler RG, LaFerla FM, Mattson MP. Intermittent fasting and caloric restriction ameliorate age-related behavioral deficits in the triple-transgenic mouse model of Alzheimer?s disease. Neurobiol Dis 2007;26:212-20.
16. Martin B, Pearson M, Kebejian L, Golden E, Keselman A, Bender M, Carlson O, Egan J, Ladenheim B, Cadet JL, et al. Sex-dependent metabolic, neuroendocrine, and cognitive responses to dietary energy restriction and excess. Endocrinology 2007;148:4318-33.
17. Vasconcelos AR, Yshii LM, Viel TA, Buck HS, Mattson MP, Scavone C, Kawamoto EM. Intermittent fasting attenuates lipopolysaccharideinduced neuroinflammation and memory impairment. J Neuroinflammation 2014;11:85.
18. Wan R, Camandola S, Mattson MP. Intermittent food deprivation improves cardiovascular and neuroendocrine responses to stress in rats. J Nutr 2003;133:1921-9.
19. Mattson MP, Allison DB, Fontana L, Harvie M, Longo VD, Malaisse WJ, Mosley M, Notterpek L, Ravussin E, Scheer FAJL, et al. Meal frequency and timing in health and disease. Proc Natl Acad Sci USA 2014;111:16647-53.
20. Harvie MN, Pegington M, Mattson MP, Frystyk J, Dillon B, Evans G, Cuzick J, Jebb SA, Martin B, Cutler RG, et al. The effects of intermittent or continuous energy restriction on weight loss and metabolic disease risk markers: a randomized trial in young overweight women. Int J Obes (Lond) 2011;35:714-27.
21. Horne BD, Muhlestein JB, Lappé DL, May HT, Carlquist JF, Galenko O, Brunisholz KD, Anderson JL. Randomized cross-over trial of shortterm water-only fasting: metabolic and cardiovascular consequences. Nutr Metab Cardiovasc Dis 2013;23:1050-7.
22. Nørrelund H, Nielsen S, Christiansen JS, Jørgensen JO, Møller N. Modulation of basal glucose metabolism and insulin sensitivity by growth hormone and free fatty acids during short-term fasting. Eur J Endocrinol 2004;150:779-87.
23. Nørrelund H. The metabolic role of growth hormone in humans with particular reference to fasting. Growth Horm IGF Res 2005;15:95-122.
24. Xing C, Cohen JC, Boerwinkle E. A weighted false discovery rate control procedure reveals alleles at FOXA2 that influence fasting glucose levels. Am J Hum Genet 2010;86:440-6.
25. Johnson JB, Summer W, Cutler RG, Martin B, Hyun DH, Dixit VD, Pearson M, Nassar M, Telljohann R, Maudsley S, et al. Alternate day calorie restriction improves clinical findings and reduces markers of oxidative stress and inflammation in overweight adults with moderate asthma. Free Radic Biol Med 2007;42:665-74.
26. Harvie M, Wright C, Pegington M, McMullan D, Mitchell E, Martin B, Cutler RG, Evans G, Whiteside S, Maudsley S, et al. The effect of intermittent energy and carbohydrate restriction v. daily energy restriction on weight loss and metabolic disease risk markers in overweight women. Br J Nutr 2013;110:1534-47.
27. Heilbronn LK, Smith SR, Martin CK, Anton SD, Ravussin E. Alternateday fasting in nonobese subjects: effects on body weight, body composition, and energy metabolism. Am J Clin Nutr 2005;81:69-73.
28. Varady KA, Bhutani S, Church EC, Klempel MC. Short-term modified alternate day fasting: a novel dietary strategy for weight loss and cardio-protection in obese adults. Am J Clin Nutr 2009;90: 1138-43.
29. Klempel MC, Kroeger CM, Bhutani S, Trepanowski JF, Varady KA. Intermittent fasting combined with calorie restriction is effective for weight loss and cardio-protection in obese women. Nutr J 2012; 11:98-106.
30. Kroeger CM, Klempel MC, Bhutani S, Trepanowski JF, Tangney CC, Varady KA. Improvement in coronary heart disease risk factors during an intermittent fasting/calorie restriction regimen: relationship to adipokine modulations. Nutr Metab (Lond) 2012;9:98.
31. Klempel MC, Kroeger CM, Varady KA. Alternate day fasting increases LDL particle size independently of dietary fat content in obese humans. Eur J Clin Nutr 2013;67:783-5.
32. Halberg N, Henriksen M, Söderhamn N, Stallknecht B, Ploug T, Schjerling P, Dela F. Effect of intermittent fasting and refeeding on insulin action in healthy men. J Appl Physiol 2005;99:2128-36.
33. Teng NI, Shahar S, Manaf ZA, Das SK, Taha CS, Ngah WZ. Efficacy of fasting calorie restriction on quality of life among aging men. Physiol Behav 2011;104:1059-64.
34. Hussin NM, Shahar S, Teng NIMF, Ngah WZW, Das SK. Efficacy of fasting and calorie restriction (FCR) on mood and depression among ageing men. J Nutr Health Aging 2013;17:674-80.
35. Teng NI, Shahar S, Rajab NF, Manaf ZA, Johari MH, Ngah WZW. Improvement of metabolic parameters in healthy older adult men following a fasting calorie restriction intervention. Aging Male 2013;16:177-83.
36. Varady KA, Bhutani S, Klempel MC, Kroeger CM, Trepanowski JF, Haus JM, Hoddy KK, Calvo Y. Alternate day fasting for weight loss in normal weight and overweight subjects: a randomized controlled trial. Nutr J 2013;12:146.
37. Horne BD, May HT, Anderson JL, Kfoury AG, Bailey BM, McClure BS, Renlund DG, Lappé DL, Carlquist JF, Fisher PW, et al.; Intermountain Heart Collaborative Study. Usefulness of routine periodic fasting to lower risk of coronary artery disease among patients undergoing coronary angiography. Am J Cardiol 2008;102:814-9.
38. Horne BD, Muhlestein JB, May HT, Carlquist JF, Lappé DL, Bair TL, Anderson JL; Intermountain Heart Collaborative Study Group. Relation of routine, periodic fasting to risk of diabetes mellitus and coronary artery disease among patients undergoing coronary angiography. Am J Cardiol 2012;109:1558-62.
39. Johnstone AM, Faber P, Gibney ER, Elia M, Horgan G, Golden BE, Stubbs RJ. Effect of an acute fast on energy compensation and feeding behavior in lean men and women. Int J Obes Relat Metab Disord 2002;26:1623-8.
40. Klempel MC, Bhutani S, Fitzgibbon M, Freels S, Varady KA. Dietary and physical activity adaptations to alternate day modified fasting: implications for optimal weight loss. Nutr J 2010;9:35.
41. Horne BD, Muhlestein JB, Butler AR, Brown H, Anderson JL. Effects of water-only fasting among pre-diabetic patients. Diabetes 2014;63 (Suppl 1):A591 (abstr).
42. Horne BD, Muhlestein JB, Anderson JL. Letter by Horne et al regarding article, ?Prognostic value of fasting versus nonfasting lowdensity lipoprotein cholesterol levels on long-term mortality: insight from the National Health and Nutrition Survey III (NHANES-III). Circulation 2015;131:e472.
43. Centers for Disease Control and Prevention. Annual smoking-attributable mortality, years of potential life lost, and economic costs-United States, 1995-1999. MMWR Morb Mortal Wkly Rep 2002;51:300-3.
44. American Heart Association. 2001 Heart and stroke statistical update. Dallas, TX: American Heart Association; 2000.
45. Arnett DK, Goodman RA, Halperin JL, Anderson JL, Parekh AK, Zoghbi WA. AHA/ACC/HHS strategies to enhance application of clinical practice guidelines in patients with cardiovascular disease and comorbid conditions. Circulation 2014;130:1662-7.
46. Anderson JL, Horne BD, Kolek MJ, Muhlestein JB, Mower CP, Park JJ, May HT, Camp NJ, Carlquist JF. Genetic variation at the 9p21 locus predicts angiographic coronary artery disease prevalence but not extent and has clinical utility. Am Heart J 2008;156:1155-62.
47. Smith GCS, Pell JP. Parachute use to prevent death and major trauma related to gravitational challenge: systematic review of randomized controlled trials. BMJ 2003;327:1459-61.
48. McLellan T, Jorde LB, Skolnick MH. Genetic distances between the Utah Mormons and related populations. Am J Hum Genet 1984;36: 836-57.
49. Jorde LB. Inbreeding in the Utah Mormons: an evaluation of estimates based on pedigrees, isonymy, and migration matrices. Ann Hum Genet 1989;53:339-55.
50. Horne BD, May HT, Anderson JL, Kfoury AG, Bailey BM, McClure BS, Renlund DG, Lappé DL, Carlquist JF, Fisher PW, et al. Fasting and other health influences. Am J Cardiol 2009;103:1042.
51. Ahmet I, Wan R, Mattson MP, Lakatta EG, Talan MI. Chronic alternateday fasting results in reduced diastolic compliance and diminished systolic reserve in rats. J Card Fail 2010;16:843-53.
52. Racette SB, Das SK, Bhapkar M, Hadley EC, Roberts SB, Ravussin E, Pieper C, DeLany JP, Kraus WE, Rochon J, et al.; CALERIE Study Group. Approaches for quantifying energy intake and %calorie restriction during calorie restriction interventions in humans: the multicenter CALERIE study. Am J Physiol Endocrinol Metab 2012;302: E441-8.
53. Huffman KM, Redman LM, Landerman LR, Pieper CF, Stevens RD, Muehlbauer MJ, Wenner BR, Bain JR, Kraus VB, Newgard CB, et al. Caloric restriction alters the metabolic response to a mixed-meal: results from a randomized, controlled trial. PLoS ONE 2012;7: e28190.
54. Eckel RH, Jakicic JM, de Jesus JM, Houston Miller N, Hubabrd VS, Lee IM, Lichtenstein AH, Loria CM, Millen BE, Nonas CA, et al. 2013 AHA/ACC guideline on lifestyle management to reduce cardiovascular risk: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines. Circulation 2014;129 (25 Suppl 2):S76-99.
55. Shin JY, Xun P, Nakamura Y, He K. Egg consumption in relation to risk of cardiovascular disease and diabetes: a systematic review and metaanalysis. Am J Clin Nutr 2013;98:146-59.
56. Chowdhury R, Warnajula S, Kunutsor S, Crowe F, Ward HA, Johnson L, Franco OH, Butterworth AS, Forouhi NG, Thompson SG, et al. Association of dietary, circulating, and supplement fatty acids with coronary risk. A systematic review and meta-analysis. Ann Intern Med 2014;160:398-406.
57. US Department of Agriculture [Internet]. Scientific report of the 2015 Dietary Guidelines Advisory Committee [cited 2015 Apr 22]. Available from: http://health.gov/dietaryguidelines/2015-scientific-report/PDFs/Scientific-Report-of-the-2015-Dietary-Guidelines-Advisory-Committee.pdf.