Protein oxidation and degradation during cellular senescence of human BJ fibroblasts: Part I - Effects of proliferative senescence

FASEB Journal

Volumn 14, Issue 15, 2000, Pages 2495-2502

  Sitte, N ^a   Merker, K ^a   Von Zglinicki, T ^a   Grune, T ^a   Davies, K J A ^a  

^a UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

Author keywords

Aging; Cross linked proteins; Lysosomes; Proteasome; Protein oxidation; Protein turnover; Proteolysis; Senescence

Indexed keywords

CATHEPSIN; CHYMOTRYPSIN; MESSENGER RNA; PROTEASOME; PROTEIN; PROTEIN SUBUNIT; TRYPSIN;

AGING; ARTICLE; CELL AGING; CELL DEATH; CELL PROLIFERATION; ENZYME ACTIVITY; FIBROBLAST; HUMAN; HUMAN CELL; LYSOSOME; OXIDATION; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN CROSS LINKING; PROTEIN DEGRADATION; SENESCENCE;

EID: 0033673408     PISSN: 08926638     EISSN: None     Source Type: Journal    
DOI: 10.1096/fj.00-0209com     Document Type: Article

References (43)

1. Protein oxidation and degradation during cellular senescence of human BJ fibroblasts: Part II - Aging of nondividing cells
2. Methionine residues as endogenous antioxidants in proteins
3. Modification of protein surface hydrophobicity and methionine oxidation by oxidative systems
4. Exposure of hydrophobic moieties promotes the selective degradation of hydrogen peroxide-modified hemoglobin by the multicatalytic proteinase complex, proteasome
5. Susceptibility of glucose-6-phosphate dehydrogenase modified 4-hydroxynonenal and metal-catalyzed oxidation to proteolysis by multicatalytic protease
6. Protein degradation in cultured liver epithelial cells during oxidative stress
7. Degradation of oxidized proteins in K562 human hematopoietic cells by proteasome
8. Proteasome-dependent degradation of oxidized proteins in MRC-5 fibroblasts
9. Preferential degradation of the oxidatively modified form of glutamine synthetase by intracellular mammalian proteases
10. Purification of a liver alkaline protease which degrades oxidatively modified glutamine synthetase
11. Modification of glucose-6-phosphate dehydrogenase by 4-hydroxynonenal. Formation of cross-linked protein that inhibits the multicatalytic protease
12. Inhibition of the multicatalytic proteinase (proteasome) by 4-hydroxynonenal cross-linked protein
13. Peroxynitrite increases the degradation of aconitase and other cellular proteins by proteasome
14. Hydrophobicity as the signal for selective degradation of hydroxyl radical modified hemoglobin by the multicatalytic proteinase complex, proteasome
15. Degradation of oxidized proteins in mammalian cells
16. Excess brain protein oxidation and enzyme dysfunction in normal aging and in Alzheimer disease
17. Dityrosine, a specific marker of oxidation, is synthesized by the myeloperoxidase-hydrogen peroxide system of human neutrophils and macrophages
18. Protein modification in aging
19. Age-related changes in oxidized proteins
20. Reversal of age-related increase in brain protein oxidation, decrease in enzyme activity, and loss in temporal and spatial memory by chronic administration of the spin-trapping compound N-tert-butyl-alpha-phenylnitrone
21. Aging and protein oxidative damage
22. Biochemical basis of lipofuscin, ceroid, and age pigment-like fluorophores
23. The limited in vitro lifetime of a human diploid cell strains
24. Oxidative DNA damage and senescence of human diploid fibroblast cells
25. Protein degradation in human fibroblasts (WI-38)
26. Catalase turnover in human diploid cell cultures
27. Similar gene expression pattern in senescent and hyperoxic-treated fibroblasts
28. Telomeres: Influencing the rate of aging
29. Attenuated induction of heat shock gene expression in aging diploid fibroblasts
30. Specific assay method fur the activities of cathepsin L-type cysteine proteinases
31. Protein carbonyl measurement by a sensitive ELISA method
32. Lipoperoxides in plasma as measured by liquid-chromatographic separation of malondialdehyde-thiobarbituric acid adduct
33. Formation of 4-hydroxynonenal and further aldehydic mediators of inflammation during bromotrichloromethane treatment of liver cells
34. Lipofuscin accumulation and aging of fibroblasts
35. Cleavage of structural proteins during assembly of the head of bacteriophage T4 Nature (London)
36. Cloning and heterogenous in vivo expression of Tat binding protein-1 (TBP-1) in the mouse
37. Extension of life-span by introduction of telomerase into normal human cells
38. Implication of protein oxidation in protein turnover, aging, and oxygen toxicity
39. Protein oxidation and proteolysis during aging and oxidative stress
40. Protein oxidation and aging
41. Aging and proteolysis of oxidized proteins
42. Comparative resistance of the 20S and 26S proteasome to oxidative stress
43. Labeling of proteins by reductive methylation using sodium cyanoborohydride