-
3
-
-
38849133044
-
A calculated response: Control of inflammation by the innate immune system
-
Barton, G. M. A calculated response: control of inflammation by the innate immune system. J. Clin. Invest. 118, 413-420 (2008).
-
(2008)
J. Clin. Invest
, vol.118
, pp. 413-420
-
-
Barton, G.M.1
-
4
-
-
34748914299
-
Evolving functions of endothelial cells in inflammation
-
Pober, J. S. & Sessa, W. C. Evolving functions of endothelial cells in inflammation. Nature Rev. Immunol. 7, 803-815 (2007).
-
(2007)
Nature Rev. Immunol
, vol.7
, pp. 803-815
-
-
Pober, J.S.1
Sessa, W.C.2
-
5
-
-
33344468233
-
Neutrophils and immunity: Challenges and opportunities
-
Nathan, C. Neutrophils and immunity: challenges and opportunities. Nature Rev. Immunol. 6, 173-182 (2006).
-
(2006)
Nature Rev. Immunol
, vol.6
, pp. 173-182
-
-
Nathan, C.1
-
6
-
-
0037180812
-
Points of control in inflammation
-
Nathan, C. Points of control in inflammation. Nature 420, 846-852 (2002).
-
(2002)
Nature
, vol.420
, pp. 846-852
-
-
Nathan, C.1
-
7
-
-
30044449982
-
Resolution of inflammation: The beginning programs the end
-
Serhan, C. N. & Savill, J. Resolution of inflammation: the beginning programs the end. Nature Immunol. 6, 1191-1197 (2005).
-
(2005)
Nature Immunol
, vol.6
, pp. 1191-1197
-
-
Serhan, C.N.1
Savill, J.2
-
8
-
-
34247847681
-
Resolution phase of inflammation: Novel endogenous anti-inflammatory and proresolving lipid mediators and pathways
-
Serhan, C. N. Resolution phase of inflammation: novel endogenous anti-inflammatory and proresolving lipid mediators and pathways. Annu. Rev. Immunol. 25, 101-137 (2007).
-
(2007)
Annu. Rev. Immunol
, vol.25
, pp. 101-137
-
-
Serhan, C.N.1
-
9
-
-
33645106845
-
Lymphoid organ development: From ontogeny to neogenesis
-
Drayton, D. L., Liao, S., Mounzer, R. H. & Ruddle, N. H. Lymphoid organ development: from ontogeny to neogenesis. Nature Immunol. 7, 344-353 (2006).
-
(2006)
Nature Immunol
, vol.7
, pp. 344-353
-
-
Drayton, D.L.1
Liao, S.2
Mounzer, R.H.3
Ruddle, N.H.4
-
10
-
-
0030666222
-
-
Medzhitov, R. & Janeway, C. A. Jr Innate immunity: the virtues of a nonclonal system of recognition. Cell 91, 295-298 (1997).
-
Medzhitov, R. & Janeway, C. A. Jr Innate immunity: the virtues of a nonclonal system of recognition. Cell 91, 295-298 (1997).
-
-
-
-
11
-
-
32944470765
-
Cryopyrin activates the inflammasome in response to toxins and ATP
-
This study shows that pore-forming exotoxins activate the NALP3 inflammasome
-
Mariathasan, S. et al. Cryopyrin activates the inflammasome in response to toxins and ATP. Nature 440, 228-232 (2006). This study shows that pore-forming exotoxins activate the NALP3 inflammasome.
-
(2006)
Nature
, vol.440
, pp. 228-232
-
-
Mariathasan, S.1
-
12
-
-
39449133957
-
A mechanism for the initiation of allergen-induced T helper type 2 responses
-
Sokol, C. L., Barton, G. M., Farr, A. G. & Medzhitov, R. A mechanism for the initiation of allergen-induced T helper type 2 responses. Nature Immunol. 9, 310-318 (2008).
-
(2008)
Nature Immunol
, vol.9
, pp. 310-318
-
-
Sokol, C.L.1
Barton, G.M.2
Farr, A.G.3
Medzhitov, R.4
-
13
-
-
3242664636
-
Recognition of commensal microflora by Toll-like receptors is required for intestinal homeostasis
-
Rakoff-Nahoum, S., Paglino, J., Eslami-Varzaneh, F., Edberg, S. & Medzhitov, R. Recognition of commensal microflora by Toll-like receptors is required for intestinal homeostasis. Cell 118, 229-241 (2004).
-
(2004)
Cell
, vol.118
, pp. 229-241
-
-
Rakoff-Nahoum, S.1
Paglino, J.2
Eslami-Varzaneh, F.3
Edberg, S.4
Medzhitov, R.5
-
14
-
-
39549107115
-
Homeostatic MyD88-dependent signals cause lethal inflammation in the absence of A20
-
This paper shows that the activation of TLRs by commensal microorganisms can result in lethal inflammation in the absence of a negative regulator of TLR signalling
-
Turer, E. E. et al. Homeostatic MyD88-dependent signals cause lethal inflammation in the absence of A20. J. Exp. Med. 205, 451-464 (2008). This paper shows that the activation of TLRs by commensal microorganisms can result in lethal inflammation in the absence of a negative regulator of TLR signalling.
-
(2008)
J. Exp. Med
, vol.205
, pp. 451-464
-
-
Turer, E.E.1
-
15
-
-
0026734517
-
Lamellocyte differentiation in Drosophila larvae parasitized by Leptopilina
-
Rizki, T. M. & Rizki, R. M. Lamellocyte differentiation in Drosophila larvae parasitized by Leptopilina. Dev. Comp. Immunol. 16, 103-110 (1992).
-
(1992)
Dev. Comp. Immunol
, vol.16
, pp. 103-110
-
-
Rizki, T.M.1
Rizki, R.M.2
-
16
-
-
43249125839
-
Innate immune activation through Nalp3 inflammasome sensing of asbestos and silica
-
This study shows that environmental particles can trigger inflammation through the NALP3 inflammasome
-
Dostert, C. et al. Innate immune activation through Nalp3 inflammasome sensing of asbestos and silica. Science 320, 674-677 (2008). This study shows that environmental particles can trigger inflammation through the NALP3 inflammasome.
-
(2008)
Science
, vol.320
, pp. 674-677
-
-
Dostert, C.1
-
17
-
-
41749104586
-
The inflammatory response to cell death
-
Rock, K. L. & Kono, H. The inflammatory response to cell death. Annu. Rev. Pathol. 3, 99-126 (2008).
-
(2008)
Annu. Rev. Pathol
, vol.3
, pp. 99-126
-
-
Rock, K.L.1
Kono, H.2
-
18
-
-
33845951211
-
-
Bianchi, M. E. DAMPs, PAMPs and alarmins: all we need to know about danger. J. Leukoc. Biol. 81, 1-5 (2007).
-
Bianchi, M. E. DAMPs, PAMPs and alarmins: all we need to know about danger. J. Leukoc. Biol. 81, 1-5 (2007).
-
-
-
-
19
-
-
0035855860
-
Molecular mechanisms of nociception
-
Julius, D. & Basbaum, A. I. Molecular mechanisms of nociception. Nature 413, 203-210 (2001).
-
(2001)
Nature
, vol.413
, pp. 203-210
-
-
Julius, D.1
Basbaum, A.I.2
-
20
-
-
33645461206
-
High mobility group box 1 protein interacts with multiple Toll-like receptors
-
Park, J. S. et al. High mobility group box 1 protein interacts with multiple Toll-like receptors. Am. J. Physiol. Cell Physiol. 290, C917-C924 (2006).
-
(2006)
Am. J. Physiol. Cell Physiol
, vol.290
-
-
Park, J.S.1
-
21
-
-
0033603241
-
RAGE mediates a novel proinflammatory axis: A central cell surface receptor for S100/calgranulin polypeptides
-
Hofmann, M. A. et al. RAGE mediates a novel proinflammatory axis: a central cell surface receptor for S100/calgranulin polypeptides. Cell 97, 889-901 (1999).
-
(1999)
Cell
, vol.97
, pp. 889-901
-
-
Hofmann, M.A.1
-
22
-
-
34948900275
-
Mrp8 and Mrp14 are endogenous activators of Toll-like receptor 4, promoting lethal, endotoxin-induced shock
-
Vogl, T. et al. Mrp8 and Mrp14 are endogenous activators of Toll-like receptor 4, promoting lethal, endotoxin-induced shock. Nature Med. 13, 1042-1049 (2007).
-
(2007)
Nature Med
, vol.13
, pp. 1042-1049
-
-
Vogl, T.1
-
23
-
-
39749084641
-
Active caspase-1 is a regulator of unconventional protein secretion
-
This study shows that caspase 1 regulates the secretion of many cytosolic proteins by a non-canonical (ER-Golgi-independent) mechanism
-
Keller, M., Ruegg, A., Werner, S. & Beer, H. D. Active caspase-1 is a regulator of unconventional protein secretion. Cell 132, 818-831 (2008). This study shows that caspase 1 regulates the secretion of many cytosolic proteins by a non-canonical (ER-Golgi-independent) mechanism.
-
(2008)
Cell
, vol.132
, pp. 818-831
-
-
Keller, M.1
Ruegg, A.2
Werner, S.3
Beer, H.D.4
-
24
-
-
7744222474
-
Bacterial endotoxin stimulates macrophages to release HMGB1 partly through CD14- and TNF-dependent mechanisms
-
Chen, G. et al. Bacterial endotoxin stimulates macrophages to release HMGB1 partly through CD14- and TNF-dependent mechanisms. J. Leukoc. Biol. 76, 994-1001 (2004).
-
(2004)
J. Leukoc. Biol
, vol.76
, pp. 994-1001
-
-
Chen, G.1
-
25
-
-
11844279745
-
Activated macrophages are an adaptive element of the colonic epithelial progenitor niche necessary for regenerative responses to injury
-
Pull, S. L., Doherty, J. M., Mills, J. C., Gordon, J. I. & Stappenbeck, T. S. Activated macrophages are an adaptive element of the colonic epithelial progenitor niche necessary for regenerative responses to injury. Proc. Natl Acad. Sci. USA 102, 99-104 (2005).
-
(2005)
Proc. Natl Acad. Sci. USA
, vol.102
, pp. 99-104
-
-
Pull, S.L.1
Doherty, J.M.2
Mills, J.C.3
Gordon, J.I.4
Stappenbeck, T.S.5
-
26
-
-
0037456842
-
Segregation of receptor and ligand regulates activation of epithelial growth factor receptor
-
Vermeer, P. D. et al. Segregation of receptor and ligand regulates activation of epithelial growth factor receptor. Nature 422, 322-326 (2003).
-
(2003)
Nature
, vol.422
, pp. 322-326
-
-
Vermeer, P.D.1
-
27
-
-
32944468985
-
Gout-associated uric acid crystals activate the NALP3 inflammasome
-
This study shows that uric acid (urate) crystals induce inflammation by activating the NALP3 inflammasome
-
Martinon, F., Petrilli, V., Mayor, A., Tardivel, A. & Tschopp, J. Gout-associated uric acid crystals activate the NALP3 inflammasome. Nature 440, 237-241 (2006). This study shows that uric acid (urate) crystals induce inflammation by activating the NALP3 inflammasome.
-
(2006)
Nature
, vol.440
, pp. 237-241
-
-
Martinon, F.1
Petrilli, V.2
Mayor, A.3
Tardivel, A.4
Tschopp, J.5
-
28
-
-
0023950461
-
Advanced glycosylation end products in tissue and the biochemical basis of diabetic complications
-
This paper describes AGEs and their role in inflammation
-
Brownlee, M., Cerami, A. & Vlassara, H. Advanced glycosylation end products in tissue and the biochemical basis of diabetic complications. N. Engl. J. Med. 318, 1315-1321 (1988). This paper describes AGEs and their role in inflammation.
-
(1988)
N. Engl. J. Med
, vol.318
, pp. 1315-1321
-
-
Brownlee, M.1
Cerami, A.2
Vlassara, H.3
-
29
-
-
34248383624
-
The biology of RAGE and its ligands: Uncovering mechanisms at the heart of diabetes and its complications
-
Yan, S. F. et al. The biology of RAGE and its ligands: uncovering mechanisms at the heart of diabetes and its complications. Curr. Diab. Rep. 7, 146-153 (2007).
-
(2007)
Curr. Diab. Rep
, vol.7
, pp. 146-153
-
-
Yan, S.F.1
-
30
-
-
33748440953
-
Mechanisms of disease: Proatherogenic HDL - an evolving field
-
Navab, M. et al. Mechanisms of disease: proatherogenic HDL - an evolving field. Nature Clin. Pract. Endocrinol. Metab. 2, 504-511 (2006).
-
(2006)
Nature Clin. Pract. Endocrinol. Metab
, vol.2
, pp. 504-511
-
-
Navab, M.1
-
31
-
-
30744462300
-
Regulation of lung injury and repair by Toll-like receptors and hyaluronan
-
This study shows the protective role of TLR-induced tissue repair in sterile tissue injury
-
Jiang, D. et al. Regulation of lung injury and repair by Toll-like receptors and hyaluronan. Nature Med. 11, 1173-1179 (2005). This study shows the protective role of TLR-induced tissue repair in sterile tissue injury.
-
(2005)
Nature Med
, vol.11
, pp. 1173-1179
-
-
Jiang, D.1
-
32
-
-
38049066579
-
Hyaluronan in tissue injury and repair
-
Jiang, D., Liang, J. & Noble, P. W. Hyaluronan in tissue injury and repair. Annu. Rev. Cell Dev. Biol. 23, 435-461 (2007).
-
(2007)
Annu. Rev. Cell Dev. Biol
, vol.23
, pp. 435-461
-
-
Jiang, D.1
Liang, J.2
Noble, P.W.3
-
33
-
-
0021704401
-
Eicosanoids in inflammation
-
Higgs, G. A., Moncada, S. & Vane, J. R. Eicosanoids in inflammation. Ann. Clin. Res. 16, 287-299 (1984).
-
(1984)
Ann. Clin. Res
, vol.16
, pp. 287-299
-
-
Higgs, G.A.1
Moncada, S.2
Vane, J.R.3
-
34
-
-
0032905515
-
Regulation of the hypothalamic-pituitary-adrenal axis by cytokines: Actions and mechanisms of action
-
Turnbull, A. V. & Rivier, C. L. Regulation of the hypothalamic-pituitary-adrenal axis by cytokines: actions and mechanisms of action. Physiol. Rev. 79, 1-71 (1999).
-
(1999)
Physiol. Rev
, vol.79
, pp. 1-71
-
-
Turnbull, A.V.1
Rivier, C.L.2
-
35
-
-
0000733534
-
Organization for physiological homeostasis
-
This classic theoretical paper and review describes the principles of homeostatic control
-
Cannon, W. Organization for physiological homeostasis. Physiol. Rev. 9, 399-431 (1929). This classic theoretical paper and review describes the principles of homeostatic control.
-
(1929)
Physiol. Rev
, vol.9
, pp. 399-431
-
-
Cannon, W.1
-
36
-
-
29944438881
-
Necrotic death as a cell fate
-
Zong, W. X. & Thompson, C. B. Necrotic death as a cell fate. Genes Dev. 20, 1-15 (2006).
-
(2006)
Genes Dev
, vol.20
, pp. 1-15
-
-
Zong, W.X.1
Thompson, C.B.2
-
37
-
-
34548289502
-
Dynamic FoxO transcription factors
-
Huang, H. & Tindall, D. J. Dynamic FoxO transcription factors. J. Cell Sci. 120, 2479-2487 (2007).
-
(2007)
J. Cell Sci
, vol.120
, pp. 2479-2487
-
-
Huang, H.1
Tindall, D.J.2
-
38
-
-
0036234459
-
Missing pieces in the NF-κB puzzle
-
Ghosh, S. & Karin, M. Missing pieces in the NF-κB puzzle. Cell 109, S81-S96 (2002).
-
(2002)
Cell
, vol.109
-
-
Ghosh, S.1
Karin, M.2
-
39
-
-
2642536197
-
Alkylating DNA damage stimulates a regulated form of necrotic cell death
-
Zong, W. X., Ditsworth, D., Bauer, D. E., Wang, Z. Q. & Thompson, C. B. Alkylating DNA damage stimulates a regulated form of necrotic cell death. Genes Dev. 18, 1272-1282 (2004).
-
(2004)
Genes Dev
, vol.18
, pp. 1272-1282
-
-
Zong, W.X.1
Ditsworth, D.2
Bauer, D.E.3
Wang, Z.Q.4
Thompson, C.B.5
-
40
-
-
28544446111
-
Monocyte and macrophage heterogeneity
-
Gordon, S. & Taylor, P. R. Monocyte and macrophage heterogeneity. Nature Rev. Immunol. 5, 953-964 (2005).
-
(2005)
Nature Rev. Immunol
, vol.5
, pp. 953-964
-
-
Gordon, S.1
Taylor, P.R.2
-
41
-
-
30044434256
-
The mononuclear phagocyte system
-
Hume, D. A. The mononuclear phagocyte system. Curr. Opin. Immunol. 18, 49-53 (2006).
-
(2006)
Curr. Opin. Immunol
, vol.18
, pp. 49-53
-
-
Hume, D.A.1
-
42
-
-
33745216724
-
MCP-1 contributes to macrophage infiltration into adipose tissue, insulin resistance, and hepatic steatosis in obesity
-
Kanda, H. et al. MCP-1 contributes to macrophage infiltration into adipose tissue, insulin resistance, and hepatic steatosis in obesity. J. Clin. Invest. 116, 1494-1505 (2006).
-
(2006)
J. Clin. Invest
, vol.116
, pp. 1494-1505
-
-
Kanda, H.1
-
43
-
-
18844406447
-
Homing to hypoxia: HIF-1 as a mediator of progenitor cell recruitment to injured tissue
-
Ceradini, D. J. & Gurtner, G. C. Homing to hypoxia: HIF-1 as a mediator of progenitor cell recruitment to injured tissue. Trends Cardiovasc. Med. 15, 57-63 (2005).
-
(2005)
Trends Cardiovasc. Med
, vol.15
, pp. 57-63
-
-
Ceradini, D.J.1
Gurtner, G.C.2
-
44
-
-
7644231561
-
The chemokine system in diverse forms of macrophage activation and polarization
-
Mantovani, A. et al. The chemokine system in diverse forms of macrophage activation and polarization. Trends Immunol. 25, 677-686 (2004).
-
(2004)
Trends Immunol
, vol.25
, pp. 677-686
-
-
Mantovani, A.1
-
45
-
-
0037265240
-
Alternative activation of macrophages
-
Gordon, S. Alternative activation of macrophages. Nature Rev. Immunol. 3, 23-35 (2003).
-
(2003)
Nature Rev. Immunol
, vol.3
, pp. 23-35
-
-
Gordon, S.1
-
46
-
-
31044433663
-
Macrophages: Obligate partners for tumor cell migration, invasion, and metastasis
-
Condeelis, J. & Pollard, J. W. Macrophages: obligate partners for tumor cell migration, invasion, and metastasis. Cell 124, 263-236 (2006).
-
(2006)
Cell
, vol.124
, pp. 263-236
-
-
Condeelis, J.1
Pollard, J.W.2
-
47
-
-
0028891783
-
Apoptosis, oncosis, and necrosis. An overview of cell death
-
Majno, G. & Joris, I. Apoptosis, oncosis, and necrosis. An overview of cell death. Am. J. Pathol. 146, 3-15 (1995).
-
(1995)
Am. J. Pathol
, vol.146
, pp. 3-15
-
-
Majno, G.1
Joris, I.2
-
48
-
-
16244362671
-
Apoptosis, pyroptosis, and necrosis: Mechanistic description of dead and dying eukaryotic cells
-
Fink, S. L. & Cookson, B. T. Apoptosis, pyroptosis, and necrosis: mechanistic description of dead and dying eukaryotic cells. Infect. Immun. 73, 1907-1916 (2005).
-
(2005)
Infect. Immun
, vol.73
, pp. 1907-1916
-
-
Fink, S.L.1
Cookson, B.T.2
-
49
-
-
36849033963
-
TAM receptors are pleiotropic inhibitors of the innate immune response
-
Rothlin, C. V., Ghosh, S., Zuniga, E. I., Oldstone, M. B. & Lemke, G. TAM receptors are pleiotropic inhibitors of the innate immune response. Cell 131, 1124-1136 (2007).
-
(2007)
Cell
, vol.131
, pp. 1124-1136
-
-
Rothlin, C.V.1
Ghosh, S.2
Zuniga, E.I.3
Oldstone, M.B.4
Lemke, G.5
-
50
-
-
33646468643
-
Apoptotic cell removal in development and tissue homeostasis
-
Henson, P. M. & Hume, D. A. Apoptotic cell removal in development and tissue homeostasis. Trends Immunol. 27, 244-250 (2006).
-
(2006)
Trends Immunol
, vol.27
, pp. 244-250
-
-
Henson, P.M.1
Hume, D.A.2
-
51
-
-
36448961645
-
Engulfment of apoptotic cells: Signals for a good meal
-
Ravichandran, K. S. & Lorenz, U. Engulfment of apoptotic cells: signals for a good meal. Nature Rev. Immunol. 7, 964-974 (2007).
-
(2007)
Nature Rev. Immunol
, vol.7
, pp. 964-974
-
-
Ravichandran, K.S.1
Lorenz, U.2
-
52
-
-
0038676258
-
Regulation of wound healing by growth factors and cytokines
-
Werner, S. & Grose, R. Regulation of wound healing by growth factors and cytokines. Physiol. Rev. 83, 835-870 (2003).
-
(2003)
Physiol. Rev
, vol.83
, pp. 835-870
-
-
Werner, S.1
Grose, R.2
-
53
-
-
33645891172
-
Cytokines in atherosclerosis: Pathogenic and regulatory pathways
-
Tedgui, A. & Mallat, Z. Cytokines in atherosclerosis: pathogenic and regulatory pathways. Physiol. Rev. 86, 515-581 (2006).
-
(2006)
Physiol. Rev
, vol.86
, pp. 515-581
-
-
Tedgui, A.1
Mallat, Z.2
-
54
-
-
33845866857
-
Inflammation and metabolic disorders
-
Hotamisligil, G. S. Inflammation and metabolic disorders. Nature 444, 860-867 (2006).
-
(2006)
Nature
, vol.444
, pp. 860-867
-
-
Hotamisligil, G.S.1
-
55
-
-
32944474237
-
Innate immunity gone awry: Linking microbial infections to chronic inflammation and cancer
-
Karin, M., Lawrence, T. & Nizet, V. Innate immunity gone awry: linking microbial infections to chronic inflammation and cancer. Cell 124, 823-835 (2006).
-
(2006)
Cell
, vol.124
, pp. 823-835
-
-
Karin, M.1
Lawrence, T.2
Nizet, V.3
-
57
-
-
0018692402
-
The spandrels of San Marco and the Panglossian paradigm: A critique of the adaptationist programme
-
Gould, S. J. & Lewontin, R. C. The spandrels of San Marco and the Panglossian paradigm: a critique of the adaptationist programme. Proc. R Soc. Lond. B 21, 581-598 (1979).
-
(1979)
Proc. R Soc. Lond. B
, vol.21
, pp. 581-598
-
-
Gould, S.J.1
Lewontin, R.C.2
|