Tensional homeostasis and the malignant phenotype

Cancer Cell

Volumn 8, Issue 3, 2005, Pages 241-254

  Paszek, Matthew J ^a,b   Zahir, Nastaran ^a,b   Johnson, Kandice R ^a,b   Lakins, Johnathon N ^b   Rozenberg, Gabriela I ^b   Gefen, Amit ^c   Reinhart King, Cynthia A ^a   Margulies, Susan S ^a   Dembo, Micah ^d   Boettiger, David ^b   Hammer, Daniel A ^a   Weaver, Valerie M ^b  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b UNIVERSITY OF PENNSYLVANIA   (United States)

^c TEL AVIV UNIVERSITY   (Israel)

^d Boston University   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EPIDERMAL GROWTH FACTOR; INTEGRIN; MITOGEN ACTIVATED PROTEIN KINASE; RHO FACTOR;

ANIMAL CELL; ARTICLE; CELL ADHESION; CELL DISRUPTION; CELL GROWTH; CELL JUNCTION; CELL PROLIFERATION; CELL TRANSFORMATION; CONTROLLED STUDY; CYTOSKELETON; EMBRYO; ENZYME ACTIVATION; ENZYME ACTIVITY; EPITHELIUM CELL; EXTRACELLULAR MATRIX; GENE EXPRESSION; HOMEOSTASIS; HUMAN; HUMAN CELL; MALIGNANT NEOPLASTIC DISEASE; MORPHOGENESIS; MOUSE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; STROMA; TENSION;

EID: 24944547482     PISSN: 15356108     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ccr.2005.08.010     Document Type: Article

References (52)

1. G. Akiri, E. Sabo, H. Dafni, Z. Vadasz, Y. Kartvelishvily, N. Gan, O. Kessler, T. Cohen, M. Resnick, M. Neeman, and G. Neufeld Lysyl oxidase-related protein-1 promotes tumor fibrosis and tumor progression in vivo Cancer Res. 63 2003 1657 1666
2. E.G. Arias-Salgado, S. Lizano, S. Sarkar, J.S. Brugge, M.H. Ginsberg, and S.J. Shattil Src kinase activation by direct interaction with the integrin β cytoplasmic domain Proc. Natl. Acad. Sci. USA 100 2003 13298 13302
3. F.S. Azar, D.N. Metaxas, and M.D. Schnall A deformable finite element model of the breast for predicting mechanical deformations under external perturbations Acad. Radiol. 8 2001 965 975
4. M. Beil, A. Micoulet, G. von Wichert, S. Paschke, P. Walther, M.B. Omary, P.P. Van Veldhoven, U. Gern, E. Wolff-Hieber, and J. Eggermann Sphingosylphosphorylcholine regulates keratin network architecture and visco-elastic properties of human cancer cells Nat. Cell Biol. 5 2003 803 811
5. A.D. Bershadsky, N.Q. Balaban, and B. Geiger Adhesion-dependent cell mechanosensitivity Annu. Rev. Cell Dev. Biol. 19 2003 677 695
6. K. Burridge, and K. Wennerberg Rho and Rac take center stage Cell 116 2004 167 179
7. W.D. Callister Fundamentals of Materials Science and Engineering: An Interactive E-Text Fifth Edition 2000 John Wiley & Sons, Inc. Somerset, NJ
8. M. Chrzanowska-Wodnicka, and K. Burridge Rho-stimulated contractility drives the formation of stress fibers and focal adhesions J. Cell Biol. 133 1996 1403 1415
9. C. Colpaert, P. Vermeulen, E. Van Marck, and L. Dirix The presence of a fibrotic focus is an independent predictor of early metastasis in lymph node-negative breast cancer patients Am. J. Surg. Pathol. 25 2001 1557 1558
10. D.R. Croft, E. Sahai, G. Mavria, S. Li, J. Tsai, W.M. Lee, C.J. Marshall, and M.F. Olson Conditional ROCK activation in vivo induces tumor cell dissemination and angiogenesis Cancer Res. 64 2004 8994 9001
11. J. Debnath, S.K. Muthuswamy, and J.S. Brugge Morphogenesis and oncogenesis of MCF-10A mammary epithelial acini grown in three-dimensional basement membrane cultures Methods 30 2003 256 268
12. M. Delcommenne, and C.H. Streuli Control of integrin expression by extracellular matrix J. Biol. Chem. 270 1995 26794 26801
13. A.J. Engler, M.A. Griffin, S. Sen, C.G. Bonnemann, H.L. Sweeney, and D.E. Discher Myotubes differentiate optimally on substrates with tissue-like stiffness: pathological implications for soft or stiff microenvironments J. Cell Biol. 166 2004 877 887
14. G. Fritz, I. Just, and B. Kaina Rho GTPases are over-expressed in human tumors Int. J. Cancer 81 1999 682 687
15. C.G. Galbraith, K.M. Yamada, and M.P. Sheetz The relationship between force and focal complex development J. Cell Biol. 159 2002 695 705
16. A. Gefen, N. Gefen, Q. Zhu, R. Raghupathi, and S.S. Margulies Age-dependent changes in material properties of the brain and braincase of the rat J. Neurotrauma 20 2003 1163 1177
17. W. Guo, and F.G. Giancotti Integrin signalling during tumour progression Nat. Rev. Mol. Cell Biol. 5 2004 816 826
18. H. Huang, R.D. Kamm, and R.T. Lee Cell mechanics and mechanotransduction: pathways, probes, and physiology Am. J. Physiol. Cell Physiol. 287 2004 1 11
19. R. Keller, L.A. Davidson, and D.R. Shook How we are shaped: the biomechanics of gastrulation Differentiation 71 2003 171 205
20. W. Khaled, S. Reichling, O.T. Bruhns, H. Boese, M. Baumann, G. Monkman, S. Egersdoerfer, D. Klein, A. Tunayar, and H. Freimuth Palpation imaging using a haptic system for virtual reality applications in medicine Stud. Health Technol. Inform. 98 2004 147 153
21. Lark, A.L., Livasy, C.A., Dressler, L., Moore, D.T., Millikan, R.C., Geradts, J., Iacocca, M., Cowan, D., Little, D., Craven, R.J., and Cance, W. (2005). High focal adhesion kinase expression in invasive breast carcinomas is associated with an aggressive phenotype. Mod Pathol., in press. Published online April 29, 2005. 10.1038/modpathol.3800424.
22. J.W. Lee, and R. Juliano Mitogenic signal transduction by integrin- and growth factor receptor-mediated pathways Mol. Cells 17 2004 188 202
23. R. Li, N. Mitra, H. Gratkowski, G. Vilaire, R. Litvinov, C. Nagasami, J.W. Weisel, J.D. Lear, W.F. DeGrado, and J.S. Bennett Activation of integrin αIIbβ3 by modulation of transmembrane helix associations Science 300 2003 795 798
24. H. Liu, D.C. Radisky, F. Wang, and M.J. Bissell Polarity and proliferation are controlled by distinct signaling pathways downstream of PI3-kinase in breast epithelial tumor cells J. Cell Biol. 164 2004 603 612
25. C.M. Lo, H.B. Wang, M. Dembo, and Y.L. Wang Cell movement is guided by the rigidity of the substrate Biophys. J. 79 2000 144 152
26. B.H. Luo, J. Takagi, and T.A. Springer Locking the β3 integrin I-like domain into high and low affinity conformations with disulfides J. Biol. Chem. 279 2004 10215 10221
27. B.H. Luo, C.V. Carman, J. Takagi, and T.A. Springer Disrupting integrin transmembrane domain heterodimerization increases ligand binding affinity, not valency or clustering Proc. Natl. Acad. Sci. USA 102 2005 3679 3684
28. G.W. McLean, N.H. Komiyama, B. Serrels, H. Asano, L. Reynolds, F. Conti, K. Hodivala-Dilke, D. Metzger, P. Chambon, S.G. Grant, and M.C. Frame Specific deletion of focal adhesion kinase suppresses tumor formation and blocks malignant progression Genes Dev. 18 2004 2998 3003
29. K.A. Moore, S. Huang, Y. Kong, M.E. Sunday, and D.E. Ingber Control of embryonic lung branching morphogenesis by the Rho activator, cytotoxic necrotizing factor 1 J. Surg. Res. 104 2002 95 100
30. P.A. Netti, D.A. Berk, M.A. Swartz, A.J. Grodzinsky, and R.K. Jain Role of extracellular matrix assembly in interstitial transport in solid tumors Cancer Res. 60 2000 2497 2503
31. A. Nicolas, B. Geiger, and S.A. Safran Cell mechanosensitivity controls the anisotropy of focal adhesions Proc. Natl. Acad. Sci. USA 101 2004 12520 12525
32. L.E. O'Brien, T.S. Jou, A.L. Pollack, Q. Zhang, S.H. Hansen, P. Yurchenco, and K.E. Mostov Rac1 orientates epithelial apical polarity through effects on basolateral laminin assembly Nat. Cell Biol. 3 2001 831 838
33. L.E. O'Brien, M.M. Zegers, and K.E. Mostov Opinion: Building epithelial architecture: insights from three-dimensional culture models Nat. Rev. Mol. Cell Biol. 3 2002 531 537
34. T.P. Padera, B.R. Stoll, J.B. Tooredman, D. Capen, E. di Tomaso, and R.K. Jain Pathology: cancer cells compress intratumour vessels Nature 427 2004 695
35. M.J. Paszek, and V.M. Weaver The tension mounts: mechanics meets morphogenesis and malignancy J. Mammary Gland Biol. Neoplasia 9 2004 325 342
36. C.A. Reinhart-King, M. Dembo, and D.A. Hammer Endothelial cell traction forces on RGD-derivatized polyacrylamide substrata Langmuir 19 2003 1573 1579
37. D. Riveline, E. Zamir, N.Q. Balaban, U.S. Schwarz, T. Ishizaki, S. Narumiya, Z. Kam, B. Geiger, and A.D. Bershadsky Focal contacts as mechanosensors: externally applied local mechanical force induces growth of focal contacts by an mDia1-dependent and ROCK-independent mechanism J. Cell Biol. 153 2001 1175 1186
38. K. Roovers, and R.K. Assoian Effects of rho kinase and actin stress fibers on sustained extracellular signal-regulated kinase activity and activation of G(1) phase cyclin-dependent kinases Mol. Cell. Biol. 23 2003 4283 4294
39. E. Sahai, and C.J. Marshall ROCK and Dia have opposing effects on adherens junctions downstream of Rho Nat. Cell Biol. 4 2002 408 415
40. E. Sahai, M.F. Olson, and C.J. Marshall Cross-talk between Ras and Rho signalling pathways in transformation favours proliferation and increased motility EMBO J. 20 2001 755 766
41. Q. Shi, and D. Boettiger A novel mode for integrin-mediated signaling: tethering is required for phosphorylation of FAK Y397 Mol. Biol. Cell 14 2003 4306 4315
42. E. Tzima, M.A. del Pozo, S.J. Shattil, S. Chien, and M.A. Schwartz Activation of integrins in endothelial cells by fluid shear stress mediates Rho-dependent cytoskeletal alignment EMBO J. 20 2001 4639 4647
43. E. Vial, E. Sahai, and C.J. Marshall ERK-MAPK signaling coordinately regulates activity of Rac1 and RhoA for tumor cell motility Cancer Cell 4 2003 67 79
44. F. Wang, V.M. Weaver, O.W. Petersen, C.A. Larabell, S. Dedhar, P. Briand, R. Lupu, and M.J. Bissell Reciprocal interactions between β1-integrin and epidermal growth factor receptor in three-dimensional basement membrane breast cultures: a different perspective in epithelial biology Proc. Natl. Acad. Sci. USA 95 1998 14821 14826
45. H.B. Wang, M. Dembo, and Y.L. Wang Substrate flexibility regulates growth and apoptosis of normal but not transformed cells Am. J. Physiol. Cell Physiol. 279 2000 C1345 C1350
46. V.M. Weaver, S. Lelievre, J.N. Lakins, M.A. Chrenek, J.C. Jones, F. Giancotti, Z. Werb, and M.J. Bissell β4 integrin-dependent formation of polarized three-dimensional architecture confers resistance to apoptosis in normal and malignant mammary epithelium Cancer Cell 2 2002 205 216
47. D.E. White, N.A. Kurpios, D. Zuo, J.A. Hassell, S. Blaess, U. Mueller, and W.J. Muller Targeted disruption of β1-integrin in a transgenic mouse model of human breast cancer reveals an essential role in mammary tumor induction Cancer Cell 6 2004 159 170
48. M.A. Wozniak, R. Desai, P.A. Solski, C.J. Der, and P.J. Keely ROCK-generated contractility regulates breast epithelial cell differentiation in response to the physical properties of a three-dimensional collagen matrix J. Cell Biol. 163 2003 583 595
49. T. Yeung, P.C. Georges, L.A. Flanagan, B. Marg, M. Ortiz, M. Funaki, N. Zahir, W. Ming, V. Weaver, and P.A. Janmey Effects of substrate stiffness on cell morphology, cytoskeletal structure, and adhesion Cell Motil. Cytoskeleton 60 2005 24 34
50. N. Zahir, J.N. Lakins, A. Russell, W. Ming, C. Chatterjee, G.I. Rozenberg, M.P. Marinkovich, and V.M. Weaver Autocrine laminin-5 ligates α6β4 integrin and activates RAC and NFκB to mediate anchorage-independent survival of mammary tumors J. Cell Biol. 163 2003 1397 1407
51. M.B. Zajaczkowski, E. Cukierman, C.G. Galbraith, and K.M. Yamada Cell-matrix adhesions on poly(vinyl alcohol) hydrogels Tissue Eng. 9 2003 525 533
52. C. Zhong, M.S. Kinch, and K. Burridge Rho-stimulated contractility contributes to the fibroblastic phenotype of Ras-transformed epithelial cells Mol. Biol. Cell 8 1997 2329 2344