Muscle wasting in aged, sarcopenic rats is associated with enhanced activity of the ubiquitin proteasome pathway

Journal of Biological Chemistry

Volumn 285, Issue 51, 2010, Pages 39597-39608

  Altun, Mikael ^a,b   Besche, Henrike C ^c   Overkleeft, Herman S ^d   Piccirillo, Rosanna ^c   Edelmann, Mariola J ^b   Kessler, Benedikt M ^b   Goldberg, Alfred L ^c   Ulfhake, Brun ^a  

^a KAROLINSKA INSTITUTE   (Sweden)

^b UNIVERSITY OF OXFORD   (United Kingdom)

^c HARVARD MEDICAL SCHOOL   (United States)

^d LEIDEN UNIVERSITY   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

ADULT ANIMALS; AGE-RELATED CHANGES; GLUCOCORTICOIDS; HIND LIMBS; MISFOLDED PROTEINS; MUSCLE MASS; MUSCLE WASTING; MYOFIBRILLAR PROTEINS; PROTEASOMES; SARCOPENIA; SKELETAL MUSCLE; UBIQUITIN; UBIQUITIN LIGASES; UBIQUITIN-PROTEASOME SYSTEM;

ANIMALS; ENZYMES; RATS; SUBSTRATES;

MUSCLE;

ATROGIN 1; GLUCOCORTICOID; MESSENGER RNA; MUSCLE PROTEIN; MUSCLE RING FINGER 1 PROTEIN; PROTEASOME; PROTEASOME 26S; PROTEIN CHIP; UBIQUITIN; UBIQUITIN PROTEIN LIGASE; UNCLASSIFIED DRUG;

AGED; AGING; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DIET RESTRICTION; ENZYME ACTIVITY; HINDLIMB; MALE; MUSCLE ATROPHY; MUSCLE MASS; NONHUMAN; PATHOPHYSIOLOGY; PRIORITY JOURNAL; PROTEIN CONTENT; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN FOLDING; RAT; SIGNAL TRANSDUCTION; THERAPY EFFECT; UBIQUITINATION;

AGING; ANIMALS; MALE; MUSCLE PROTEINS; MUSCLE, SKELETAL; PROTEASOME ENDOPEPTIDASE COMPLEX; RATS; RATS, SPRAGUE-DAWLEY; SKP CULLIN F-BOX PROTEIN LIGASES; UBIQUITIN; UBIQUITIN-PROTEIN LIGASES; UBIQUITINATION;

ANIMALIA; RATTUS;

EID: 78650046347     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M110.129718     Document Type: Article

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