Competition of nuclear factor-erythroid 2 factors related transcription factor isoforms, Nrf1 and Nrf2, in antioxidant enzyme inductio

Redox Biology

Volumn 1, Issue 1, 2013, Pages 183-189

  Chepelev, Nikolai L ^a   Zhang, Hongqiao ^b   Liu, Honglei ^b   McBride, Skye ^a   Seal, Andrew J ^a   Morgan, Todd E ^b   Finch, Caleb E ^b,c   Willmore, William G ^a   Davies, Kelvin J A ^b,c   Forman, Henry Jay ^b,d  

^a CARLETON UNIVERSITY   (Canada)

^b UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

^c UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

^d UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Air pollution; Electrophile response element; Glutamate cysteine ligase; Nrf1; Nrf2; Phase II genes

Indexed keywords

GLUTAMATE CYSTEINE LIGASE; LUCIFERASE; SYNAPTOTAGMIN I; TRANSCRIPTION FACTOR NRF1; TRANSCRIPTION FACTOR NRF2; ANTIOXIDANT; ISOPROTEIN; NUCLEAR RESPIRATORY FACTOR 1; PARTICULATE MATTER; TRANSCRIPTION FACTOR NF E2 P45 SUBUNIT; PROTEIN P120;

ANIMAL TISSUE; ARTICLE; BINDING AFFINITY; CATALYSIS; CELL PROTECTION; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME INDUCTION; GENE; GENE CONTROL; GENE EXPRESSION REGULATION; GENE OVEREXPRESSION; GENE SILENCING; GLYCOSYLATION; HUMAN; HUMAN CELL; IN VITRO STUDY; MALE; MOUSE; NONHUMAN; NRF1 GENE; NRF2 GENE; NUCLEOTIDE SEQUENCE; PARTICULATE MATTER; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN BINDING; PROTEIN DEGRADATION; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; RNA INTERFERENCE; AGING; ANIMAL; BRONCHUS; C57BL MOUSE; CELL LINE; CYTOLOGY; DNA RESPONSIVE ELEMENT; EPITHELIUM CELL; GENE INACTIVATION; GENETICS; HEK293 CELL LINE; LUNG; METABOLISM; PHARMACOLOGY; AIRBORNE PARTICLE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIOXIDANT ACTIVITY; ANTIOXIDANT RESPONSIVE ELEMENT; BIOSYNTHESIS; BRONCHIAL EPITHELIAL CELL; BRONCHUS MUCOSA; DETOXIFICATION; ELECTROPHILE RESPONSIVE ELEMENT; ENVIRONMENTAL EXPOSURE; GENE FUNCTION; GENE IDENTIFICATION; PARTICLE SIZE; SIGNAL TRANSDUCTION;

ANIMALIA; MUS;

AGING; ANIMALS; ANTIOXIDANTS; BRONCHI; CELL LINE; EPITHELIAL CELLS; GENE EXPRESSION REGULATION; GENE KNOCKOUT TECHNIQUES; GLUTAMATE-CYSTEINE LIGASE; HEK293 CELLS; HUMANS; LUNG; MALE; MICE; MICE, INBRED C57BL; NF-E2 TRANSCRIPTION FACTOR, P45 SUBUNIT; NUCLEAR RESPIRATORY FACTOR 1; PARTICULATE MATTER; PROTEIN ISOFORMS; RESPONSE ELEMENTS;

EID: 84878981709     PISSN: 22132317     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.redox.2013.01.005     Document Type: Article

References (27)

1. Wild, A. C.; Moinova, H. R.; Mulcahy, R. T. Regulation of gamma-glutamylcysteine synthetase subunit gene expression by the transcription factor Nrf2. Journal of Biological Chemistry 274(47):33627-33636; 1999.
2. Levy, S.; Jaiswal, A. K.; Forman, H. J. The role of c-Jun phosphorylation in EpRE activation of phase II genes. Free Radical Biology and Medicine 47(8):1172-1179; 2009.
3. Katoh, Y.; Itoh, K.; Yoshida, E.; Miyagishi, M.; Fukamizu, A.; Yamamoto, M. Two domains of Nrf2 cooperatively bind CBP, a CREB binding protein, and synergistically activate transcription. Genes Cells 6(10):857-868; 2001.
4. Sun, J.; Brand, M.; Zenke, Y.; Tashiro, S.; Groudine, M.; Igarashi, K. Heme regulates the dynamic exchange of Bach1 and NF-E2-related factors in the Maf transcription factor network. Proceedings of the National Academy of Sciences USA 101(6):1461-1466; 2004.
5. Levy, S.; Forman, H. J. C-Myc is a Nrf2-interacting protein that negatively regulates phase II genes through their electrophile responsive elements. IUBMB Life 62(3):237-246; 2010.
6. Zhang, Y.; Lucocq, J. M.; Yamamoto, M.; Hayes, J. D. The NHB1 (N-terminal homology box 1) sequence in transcription factor Nrf1 is required to anchor it to the endoplasmic reticulum and also to enable its asparagine-glycosylation. Biochemical Journal 408(2):161-172; 2007.
7. Steffen, J.; Seeger, M.; Koch, A.; Kruger, E. Proteasomal degradation is transcriptionally controlled by TCF11 via an ERAD-dependent feedback loop. Molecular Cell 40(1):147-158; 2010.
8. Tsuchiya, Y.; Morita, T.; Kim, M.; Iemura, S.; Natsume, T.; Yamamoto, M., et al. Dual regulation of the transcriptional activity of Nrf1 by beta-TrCP- and Hrd1-dependent degradation mechanisms. Molecular and Cellular Biology 31(22):4500-4512; 2011.
9. Chepelev, N. L.; Bennitz, J. D.; Huang, T.; McBride, S.; Willmore, W. G. The Nrf1 CNC-bZIP protein is regulated by the proteasome and activated by hypoxia. PLoS One 6(12):e29167; 2011.
10. Chan, J. Y.; Han, X. L.; Kan, Y. W. Cloning of Nrf1, an NF-E2-related transcription factor, by genetic selection in yeast. Proceedings of the National Academy of Sciences USA 90(23):11371-11375; 1993.
11. Wang, W.; Kwok, A. M.; Chan, J. Y. The p65 isoform of Nrf1 is a dominant negative inhibitor of ARE-mediated transcription. Journal of Biological Chemistry 282(34):24670-24678; 2007.
12. Ohtsuji, M.; Katsuoka, F.; Kobayashi, A.; Aburatani, H.; Hayes, J. D.; Yama-moto, M. Nrf1and Nrf2 play distinct roles in activation of antioxidant response element-dependent genes. Journal of Biological Chemistry 283(48):33554-33562; 2008.
13. Zhang, H.; Court, N.; Forman, H. J. Submicromolar concentrations of 4-hydroxynonenal induce glutamate cysteine ligase expression in HBE1 cells. Redox Report 12(1):101-106; 2007.
14. Zhang, H.; Liu, H.; Davies, K. J.; Sioutas, C.; Finch, C. E.; Morgan, T. E., et al. Nrf2-regulated phase II enzymes are induced by chronic ambient nanopar-ticle exposure in young mice with age-related impairments. Free Radical Biology and Medicine 52(9):2038-2046; 2012.
15. Furukawa, M.; Xiong, Y. BTB protein Keap1 targets antioxidant transcription factor Nrf2 for ubiquitination by the Cullin 3-Roc1 ligase. Molecular Cell Biology 25(1):162-171; 2005.
16. Mulcahy, R. T.; Wartman, M. A.; Bailey, H. H.; Gipp, J. J. Constitutive and beta-naphthoflavone-induced expression of the human gamma-glutamylcysteine synthetase heavy subunit gene is regulated by a distal antioxidant response element/TRE sequence. Journal of Biological Chemistry 272(11):7445-7454; 1997.
17. Moinova, H. R.; Mulcahy, R. T. An electrophile responsive element (EpRE) regulates beta-naphthoflavone induction of the human gamma-glutamyl-cysteine synthetase regulatory subunit gene. Constitutive expression is mediated by an adjacent AP-1 site. Journal of Biological Chemistry 273(24):14683-14689; 1998.
18. Zhang, H.; Dickinson, D. A.; Liu, R. M.; Forman, H. J. 4-Hydroxynonenal increases gamma-glutamyl transpeptidase gene expression through mitogen-activated protein kinase pathways. Free Radical Biology and Medicine 38(4):463-471; 2005.
19. Zhang, H.; Forman, H. J. Signaling pathways involved in phase II gene induction by alpha, beta-unsaturated aldehydes. Toxicology & Industrial Health 25(4-5):269-278; 2009.
20. Morgan, T. E.; Davis, D. A.; Iwata, N.; Tanner, J. A.; Snyder, D.; Ning, Z., et al. Glutamatergic neurons in rodent models respond to nanoscale particulate urban air pollutants in vivo and in vitro. Environmental Health Perspectives 119(7):1003-1009; 2011.
21. Misra, C.; Kim, S.; Shen, S.; Sioutas, C. A high flow rate, very low pressure drop impactor for inertial separation of ultrafine from accumulation mode particles. Journal of Aerosol Science 33(5):735-752; 2005.
22. Ning, Z.; Geller, M. D.; Moore, K. F.; Sheesley, R.; Schauer, J. J.; Sioutas, C. Daily variation in chemical characteristics of urban ultrafine aerosols and inference of their sources. Environmental Science & Technology 41(17):6000-6006; 2007.
23. Dickinson, D. A.; Iles, K. E.; Zhang, H.; Blank, V.; Forman, H. J. Curcumin alters EpRE and AP-1 binding complexes and elevates glutamate-cysteine ligase gene expression. FASEB Journal 17(3):473-475; 2003.
24. Zhang, Y.; Lucocq, J. M.; Hayes, J. D. The Nrf1 CNC/bZIP protein is a nuclear envelope-bound transcription factor that is activated by t-butyl hydroqui-none but not by endoplasmic reticulum stressors. Biochemical Journal 418(2):293-310; 2009.
25. Sykiotis, G. P.; Bohmann, D. Stress-activated cap'n'collar transcription factors in aging and human disease. Science Signal 3(112); 2010.
26. Kaspar, J. W.; Niture, S. K.; Jaiswal, A. K. Nrf2:INrf2 (Keap1) signaling in oxidative stress. Free Radical Biology and Medicine 47(9):1304-1309; 2009.
27. Zhao, R.; Hou, Y.; Xue, P.; Woods, C. G.; Fu, J.; Feng, B., et al. Long isoforms of NRF1 contribute to arsenic-induced antioxidant response in human kerati-nocytes. Environmental Health Perspectives 119(1):56-62; 2011.