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Volumn 29, Issue 5, 2010, Pages 625-634

Defining the role of hypoxia-inducible factor 1 in cancer biology and therapeutics

Author keywords

Angiogenesis; Chemotherapy; Metabolism; Oxygen; Radiation therapy; Transcription

Indexed keywords

1 BENZYL 3 (5 HYDROXYMETHYL 2 FURYL)INDAZOLE; 17 DEMETHOXY 17 (2 DIMETHYLAMINOETHYLAMINO)GELDANAMYCIN; BORTEZOMIB; CETUXIMAB; DIGOXIN; DNA TOPOISOMERASE INHIBITOR; DOCETAXEL; DOXORUBICIN; ECHINOMYCIN; ERLOTINIB; EVEROLIMUS; GEFITINIB; GELDANAMYCIN; HEAT SHOCK PROTEIN 90; HEAT SHOCK PROTEIN 90 INHIBITOR; HISTONE DEACETYLASE INHIBITOR; HYPOXIA INDUCIBLE FACTOR 1; HYPOXIA INDUCIBLE FACTOR 1 INHIBITOR; HYPOXIA INDUCIBLE FACTOR 1ALPHA; HYPOXIA INDUCIBLE FACTOR 1BETA; IMATINIB; OXYGEN; PROTEIN INHIBITOR; RAPAMYCIN; TANESPIMYCIN; TEMSIROLIMUS; TOPOTECAN; TRASTUZUMAB; TRICHOSTATIN A; UNCLASSIFIED DRUG; UNINDEXED DRUG; VASCULOTROPIN;

EID: 76349095132     PISSN: 09509232     EISSN: 14765594     Source Type: Journal    
DOI: 10.1038/onc.2009.441     Document Type: Review
Times cited : (1463)

References (130)
  • 1
    • 0035300410 scopus 로고    scopus 로고
    • Expression of hypoxia-inducible factor-1a: A novel predictive and prognostic parameter in the radiotherapy of oropharyngeal cancer
    • Aebersold DM, Burri P, Beer KT, Laissue J, Djonov V, Greiner RH, et al. (2001). Expression of hypoxia-inducible factor-1a: a novel predictive and prognostic parameter in the radiotherapy of oropharyngeal cancer. Cancer Res 61: 2911-2916.
    • (2001) Cancer Res , vol.61 , pp. 2911-2916
    • Aebersold, D.M.1    Burri, P.2    Beer, K.T.3    Laissue, J.4    Djonov, V.5    Greiner, R.H.6
  • 2
    • 0035418621 scopus 로고    scopus 로고
    • Constitutive expression of hypoxia-inducible factor-1a renders pancreatic cancer cells resistant to apoptosis induced by hypoxia and nutrient deprivation
    • Akakura N, Kobayashi M, Horiuchi I, Suzuki A, Wang J, Chen J, et al. (2001). Constitutive expression of hypoxia-inducible factor-1a renders pancreatic cancer cells resistant to apoptosis induced by hypoxia and nutrient deprivation. Cancer Res 61: 6548-6554.
    • (2001) Cancer Res , vol.61 , pp. 6548-6554
    • Akakura, N.1    Kobayashi, M.2    Horiuchi, I.3    Suzuki, A.4    Wang, J.5    Chen, J.6
  • 3
    • 0037500967 scopus 로고    scopus 로고
    • Overexpression of hypoxia-inducible factor 1a indicates diminished response to radiotherapy and unfavorable prognosis in patients receiving radical radiotherapy for cervical cancer
    • Bachtiary B, Schindl M, Potter R, Dreier B, Knocke TH, Hainfellner JA, et al. (2003). Overexpression of hypoxia-inducible factor 1a indicates diminished response to radiotherapy and unfavorable prognosis in patients receiving radical radiotherapy for cervical cancer. Clin Cancer Res 9: 2234-2240.
    • (2003) Clin Cancer Res , vol.9 , pp. 2234-2240
    • Bachtiary, B.1    Schindl, M.2    Potter, R.3    Dreier, B.4    Knocke, T.H.5    Hainfellner, J.A.6
  • 5
    • 66149108432 scopus 로고    scopus 로고
    • Heterozygosity for hypoxia inducible factor 1a decreases the incidence of thymic lymphomas in a p53 mutant mouse model
    • Bertout JA, Patel SA, Fryer BH, Durham AC, Covello KL, Olive KP, et al. (2009). Heterozygosity for hypoxia inducible factor 1a decreases the incidence of thymic lymphomas in a p53 mutant mouse model. Cancer Res 69: 3213-3220.
    • (2009) Cancer Res , vol.69 , pp. 3213-3220
    • Bertout, J.A.1    Patel, S.A.2    Fryer, B.H.3    Durham, A.C.4    Covello, K.L.5    Olive, K.P.6
  • 7
    • 0035395098 scopus 로고    scopus 로고
    • Expression of hypoxia-inducible factor-1α in oligodendrogliomas: Its impact on prognosis and on neoangiogenesis
    • DOI 10.1002/1097-0142(20010701)92:1<165::AID-CNCR1305>3.0.CO;2-F
    • Birner P, Gatterbauer B, Oberhuber G, Schindl M, Rossler K, Prodinger A, et al. (2001a). Expression of hypoxia-inducible factor-1a in oligodendrogliomas: its impact on prognosis and on neoangiogenesis. Cancer 92: 165-171. (Pubitemid 32623053)
    • (2001) Cancer , vol.92 , Issue.1 , pp. 165-171
    • Birner, P.1    Gatterbauer, B.2    Oberhuber, G.3    Schindl, M.4    Rossler, K.5    Prodinger, A.6    Budka, H.7    Hainfellner, J.A.8
  • 8
    • 0034896068 scopus 로고    scopus 로고
    • Expression of hypoxia-inducible factor 1a in epithelial ovarian tumors: Its impact on prognosis and on response to chemotherapy
    • Birner P, Schindl M, Obermair A, Breitenecker G, Oberhuber G. (2001b). Expression of hypoxia-inducible factor 1a in epithelial ovarian tumors: its impact on prognosis and on response to chemotherapy. Clin Cancer Res 7: 1661-1668.
    • (2001) Clin Cancer Res , vol.7 , pp. 1661-1668
    • Birner, P.1    Schindl, M.2    Obermair, A.3    Breitenecker, G.4    Oberhuber, G.5
  • 9
    • 0034282518 scopus 로고    scopus 로고
    • Overexpression of hypoxia-inducible factor 1a is a marker for an unfavorable prognosis in early-stage invasive cervical cancer
    • Birner P, Schindl M, Obermair A, Plank C, Breitenecker G, Oberhuber G. (2000). Overexpression of hypoxia-inducible factor 1a is a marker for an unfavorable prognosis in early-stage invasive cervical cancer. Cancer Res 60: 4693-4696.
    • (2000) Cancer Res , vol.60 , pp. 4693-4696
    • Birner, P.1    Schindl, M.2    Obermair, A.3    Plank, C.4    Breitenecker, G.5    Oberhuber, G.6
  • 10
    • 0037443587 scopus 로고    scopus 로고
    • Levels of hypoxia-inducible factor-1a independently predict prognosis in patients with lymph node negative breast carcinoma
    • Bos R, van der Groep P, Greijer AE, Shvarts A, Meijer S, Pinedo HM, et al. (2003). Levels of hypoxia-inducible factor-1a independently predict prognosis in patients with lymph node negative breast carcinoma. Cancer 97: 1573-1581.
    • (2003) Cancer , vol.97 , pp. 1573-1581
    • Bos, R.1    Van Der Groep, P.2    Greijer, A.E.3    Shvarts, A.4    Meijer, S.5    Pinedo, H.M.6
  • 13
    • 0038300418 scopus 로고    scopus 로고
    • Significant correlation of hypoxia-inducible factor-1a with treatment outcome in cervical cancer treated with radical radiotherapy
    • Burri P, Djonov V, Aebersold DM, Lindel K, Studer U, Altermatt HJ, et al. (2003). Significant correlation of hypoxia-inducible factor-1a with treatment outcome in cervical cancer treated with radical radiotherapy. Int J Radiat Oncol Biol Phys 56: 494-501.
    • (2003) Int J Radiat Oncol Biol Phys , vol.56 , pp. 494-501
    • Burri, P.1    Djonov, V.2    Aebersold, D.M.3    Lindel, K.4    Studer, U.5    Altermatt, H.J.6
  • 14
    • 34648833286 scopus 로고    scopus 로고
    • A potential a-helix motif in the amino terminus of LANA encoded by Kaposi's sarcoma-associated herpesvirus is critical for nuclear accumulation of HIF-1a in normoxia
    • Cai Q, Murakami M, Si H, Robertson ES. (2007). A potential a-helix motif in the amino terminus of LANA encoded by Kaposi's sarcoma-associated herpesvirus is critical for nuclear accumulation of HIF-1a in normoxia. J Virol 81: 10413-10423.
    • (2007) J Virol , vol.81 , pp. 10413-10423
    • Cai, Q.1    Murakami, M.2    Si, H.3    Robertson, E.S.4
  • 15
    • 33750464049 scopus 로고    scopus 로고
    • EC5S ubiquitin complex is recruited by KSHV latent antigen LANA for degradation of the VHL and p53 tumor suppressors
    • Cai QL, Knight JS, Verma SC, Zald P, Robertson ES. (2006). EC5S ubiquitin complex is recruited by KSHV latent antigen LANA for degradation of the VHL and p53 tumor suppressors. PLoS Pathog 2: e116.
    • (2006) PLoS Pathog , vol.2
    • Cai, Q.L.1    Knight, J.S.2    Verma, S.C.3    Zald, P.4    Robertson, E.S.5
  • 16
    • 1042267263 scopus 로고    scopus 로고
    • Cell adhesion and signalling by cadherins and Ig-CAMs in cancer
    • Cavallaro U, Christofori G. (2004). Cell adhesion and signalling by cadherins and Ig-CAMs in cancer. Nat Rev Cancer 4: 118-132.
    • (2004) Nat Rev Cancer , vol.4 , pp. 118-132
    • Cavallaro, U.1    Christofori, G.2
  • 17
    • 34547125574 scopus 로고    scopus 로고
    • Hypoxia, gene expression, and metastasis
    • Chan DA, Giaccia AJ. (2007). Hypoxia, gene expression, and metastasis. Cancer Metastasis Rev 26: 333-339.
    • (2007) Cancer Metastasis Rev , vol.26 , pp. 333-339
    • Chan, D.A.1    Giaccia, A.J.2
  • 18
    • 33646707041 scopus 로고    scopus 로고
    • Effect of antisense hypoxia-inducible factor 1a on progression, metastasis, and chemosensitivity of pancreatic cancer
    • Chang Q, Qin R, Huang T, Gao J, Feng Y. (2006). Effect of antisense hypoxia-inducible factor 1a on progression, metastasis, and chemosensitivity of pancreatic cancer. Pancreas 32: 297-305.
    • (2006) Pancreas , vol.32 , pp. 297-305
    • Chang, Q.1    Qin, R.2    Huang, T.3    Gao, J.4    Feng, Y.5
  • 19
    • 0344608877 scopus 로고    scopus 로고
    • Dominant-negative hypoxia-inducible factor-1a reduces tumori-genicity of pancreatic cancer cells through the suppression of glucose metabolism
    • Chen J, Zhao S, Nakada K, Kuge Y, Tamaki N, Okada F, et al. (2003). Dominant-negative hypoxia-inducible factor-1a reduces tumori-genicity of pancreatic cancer cells through the suppression of glucose metabolism. Am J Pathol 162: 1283-1291.
    • (2003) Am J Pathol , vol.162 , pp. 1283-1291
    • Chen, J.1    Zhao, S.2    Nakada, K.3    Kuge, Y.4    Tamaki, N.5    Okada, F.6
  • 20
    • 58249094845 scopus 로고    scopus 로고
    • Hypoxia-inducible carbonic anhydrase IX and XII promote tumor cell growth by counteracting acidosis through the regulation of the intracellular pH
    • Chiche J, Ilc K, Laferriere J, Trottier E, Dayan F, Mazure NM, et al. (2009). Hypoxia-inducible carbonic anhydrase IX and XII promote tumor cell growth by counteracting acidosis through the regulation of the intracellular pH. Cancer Res 69: 358-368.
    • (2009) Cancer Res , vol.69 , pp. 358-368
    • Chiche, J.1    Ilc, K.2    Laferriere, J.3    Trottier, E.4    Dayan, F.5    Mazure, N.M.6
  • 21
    • 34249815207 scopus 로고    scopus 로고
    • Stromal expression of hypoxia regulated proteins is an adverse prognostic factor in colorectal carcinomas
    • Cleven AH, van Engeland M, Wouters BG, de Bruine AP. (2007). Stromal expression of hypoxia regulated proteins is an adverse prognostic factor in colorectal carcinomas. Cell Oncol 29: 229-240.
    • (2007) Cell Oncol , vol.29 , pp. 229-240
    • Cleven, A.H.1    Van Engeland, M.2    Wouters, B.G.3    De Bruine, A.P.4
  • 22
    • 23244463512 scopus 로고    scopus 로고
    • Overexpression of hypoxia-inducible factor HIF-1a predicts early relapse in breast cancer: Retrospective study in a series of 745 patients
    • Dales JP, Garcia S, Meunier-Carpentier S, Andrac-Meyer L, Haddad O, Lavaut MN, et al. (2005). Overexpression of hypoxia-inducible factor HIF-1a predicts early relapse in breast cancer: retrospective study in a series of 745 patients. Int J Cancer 116: 734-739.
    • (2005) Int J Cancer , vol.116 , pp. 734-739
    • Dales, J.P.1    Garcia, S.2    Meunier-Carpentier, S.3    Andrac-Meyer, L.4    Haddad, O.5    Lavaut, M.N.6
  • 23
    • 62349084794 scopus 로고    scopus 로고
    • Prognostic significance of hypoxia-inducible factor 1a (HIF-1a) expression in serous ovarian cancer: An immunohisto-chemical study
    • Daponte A, Ioannou M, Mylonis I, Simos G, Minas M, Messinis IE, et al. (2008). Prognostic significance of hypoxia-inducible factor 1a (HIF-1a) expression in serous ovarian cancer: an immunohisto-chemical study. BMC Cancer 8: 335.
    • (2008) BMC Cancer , vol.8 , pp. 335
    • Daponte, A.1    Ioannou, M.2    Mylonis, I.3    Simos, G.4    Minas, M.5    Messinis, I.E.6
  • 24
    • 44349157832 scopus 로고    scopus 로고
    • Cycling hypoxia and free radicals regulate angiogenesis and radiotherapy response
    • Dewhirst MW, Cao Y, Moeller B. (2008). Cycling hypoxia and free radicals regulate angiogenesis and radiotherapy response. Nat Rev Cancer 8: 425-437.
    • (2008) Nat Rev Cancer , vol.8 , pp. 425-437
    • Dewhirst, M.W.1    Cao, Y.2    Moeller, B.3
  • 25
    • 25444465116 scopus 로고    scopus 로고
    • Both microtubule-stabilizing and microtubule-destabilizing drugs inhibit hypoxia-inducible factor-1a accumulation and activity by disrupting micro-tubule function
    • Escuin D, Kline ER, Giannakakou P. (2005). Both microtubule-stabilizing and microtubule-destabilizing drugs inhibit hypoxia-inducible factor-1a accumulation and activity by disrupting micro-tubule function. Cancer Res 65: 9021-9028.
    • (2005) Cancer Res , vol.65 , pp. 9021-9028
    • Escuin, D.1    Kline, E.R.2    Giannakakou, P.3
  • 26
    • 33744963443 scopus 로고    scopus 로고
    • Histone deacetylase inhibitors repress the transactivation potential of hypoxia-inducible factors independently of direct acetylation of HIF-a
    • Fath DM, Kong X, Liang D, Lin Z, Chou A, Jiang Y, et al. (2006). Histone deacetylase inhibitors repress the transactivation potential of hypoxia-inducible factors independently of direct acetylation of HIF-a. J Biol Chem 281: 13612-13619.
    • (2006) J Biol Chem , vol.281 , pp. 13612-13619
    • Fath, D.M.1    Kong, X.2    Liang, D.3    Lin, Z.4    Chou, A.5    Jiang, Y.6
  • 27
    • 34548257176 scopus 로고    scopus 로고
    • HIF-dependent antitumorigenic effect of antioxidants in vivo
    • Gao P, Zhang H, Dinavahi R, Li F, Xiang Y, Raman V, et al. (2007). HIF-dependent antitumorigenic effect of antioxidants in vivo. Cancer Cell 12: 230-238.
    • (2007) Cancer Cell , vol.12 , pp. 230-238
    • Gao, P.1    Zhang, H.2    Dinavahi, R.3    Li, F.4    Xiang, Y.5    Raman, V.6
  • 29
    • 37549013776 scopus 로고    scopus 로고
    • A microenvironmental model of carcinogenesis
    • Gatenby RA, Gillies RJ. (2008). A microenvironmental model of carcinogenesis. Nat Rev Cancer 8: 56-61.
    • (2008) Nat Rev Cancer , vol.8 , pp. 56-61
    • Gatenby, R.A.1    Gillies, R.J.2
  • 30
    • 33748037026 scopus 로고    scopus 로고
    • Hypoxia-inducible factor-1a expression predicts a poor response to primary chemoendocrine therapy and disease-free survival in primary human breast cancer
    • Generali D, Berruti A, Brizzi MP, Campo L, Bonardi S, Wigfield S, et al. (2006). Hypoxia-inducible factor-1a expression predicts a poor response to primary chemoendocrine therapy and disease-free survival in primary human breast cancer. Clin Cancer Res 12: 4562-4568.
    • (2006) Clin Cancer Res , vol.12 , pp. 4562-4568
    • Generali, D.1    Berruti, A.2    Brizzi, M.P.3    Campo, L.4    Bonardi, S.5    Wigfield, S.6
  • 32
    • 0035860147 scopus 로고    scopus 로고
    • Relation of hypoxia inducible factor 1a and 2a in operable non-small cell lung cancer to angiogenic/molecular profile of tumors and survival
    • Giatromanolaki A, Koukourakis MI, Sivridis E, Turley H, Talks K, Pezzella F, et al. (2001). Relation of hypoxia inducible factor 1a and 2a in operable non-small cell lung cancer to angiogenic/molecular profile of tumors and survival. Br J Cancer 85: 881-890.
    • (2001) Br J Cancer , vol.85 , pp. 881-890
    • Giatromanolaki, A.1    Koukourakis, M.I.2    Sivridis, E.3    Turley, H.4    Talks, K.5    Pezzella, F.6
  • 33
    • 0142120661 scopus 로고    scopus 로고
    • Hypoxia-inducible factors 1a and 2a are related to vascular endothelial growth factor expression and a poorer prognosis in nodular malignant melanomas of the skin
    • Giatromanolaki A, Sivridis E, Kouskoukis C, Gatter KC, Harris AL, Koukourakis MI. (2003). Hypoxia-inducible factors 1a and 2a are related to vascular endothelial growth factor expression and a poorer prognosis in nodular malignant melanomas of the skin. Melanoma Res 13: 493-501.
    • (2003) Melanoma Res , vol.13 , pp. 493-501
    • Giatromanolaki, A.1    Sivridis, E.2    Kouskoukis, C.3    Gatter, K.C.4    Harris, A.L.5    Koukourakis, M.I.6
  • 34
    • 34547124566 scopus 로고    scopus 로고
    • Hypoxia and adaptive landscapes in the evolution of carcinogenesis
    • Gillies RJ, Gatenby RA. (2007). Hypoxia and adaptive landscapes in the evolution of carcinogenesis. Cancer Metastasis Rev 26: 311-317.
    • (2007) Cancer Metastasis Rev , vol.26 , pp. 311-317
    • Gillies, R.J.1    Gatenby, R.A.2
  • 35
    • 84960987950 scopus 로고
    • The concentration of oxygen dissolved in tissues at the time of irradiation as a factor in radiotherapy
    • Gray LH, Conger AO, Ebert M, Hornsey S, Scott OCA. (1953). The concentration of oxygen dissolved in tissues at the time of irradiation as a factor in radiotherapy. Br J Radiol 26: 638-648.
    • (1953) Br J Radiol , vol.26 , pp. 638-648
    • Gray, L.H.1    Conger, A.O.2    Ebert, M.3    Hornsey, S.4    Scott, O.C.A.5
  • 36
    • 33846189403 scopus 로고    scopus 로고
    • Hypoxia-inducible factor-1a expression in the gastric carcinogenesis sequence and its prognostic role in gastric and gastro-oesophageal adenocarcinomas
    • Griffiths EA, Pritchard SA, Valentine HR, Whitchelo N, Bishop PW, Ebert MP, et al. (2007). Hypoxia-inducible factor-1a expression in the gastric carcinogenesis sequence and its prognostic role in gastric and gastro-oesophageal adenocarcinomas. Br J Cancer 96: 95-103.
    • (2007) Br J Cancer , vol.96 , pp. 95-103
    • Griffiths, E.A.1    Pritchard, S.A.2    Valentine, H.R.3    Whitchelo, N.4    Bishop, P.W.5    Ebert, M.P.6
  • 37
    • 0037458325 scopus 로고    scopus 로고
    • Minimizing long-term tumor burden: The logic for metronomic chemotherapeutic dosing and its antiangiogenic basis
    • Hahnfeldt P, Folkman J, Hlatky L. (2003). Minimizing long-term tumor burden: the logic for metronomic chemotherapeutic dosing and its antiangiogenic basis. J Theor Biol 220: 545-554.
    • (2003) J Theor Biol , vol.220 , pp. 545-554
    • Hahnfeldt, P.1    Folkman, J.2    Hlatky, L.3
  • 38
    • 0036359548 scopus 로고    scopus 로고
    • Hypoxia\-a key regulatory factor in tumor growth
    • Harris AL. (2002). Hypoxia\-a key regulatory factor in tumor growth. Nat Rev Cancer 2: 38-47.
    • (2002) Nat Rev Cancer , vol.2 , pp. 38-47
    • Harris, A.L.1
  • 39
    • 34249340478 scopus 로고    scopus 로고
    • Hypoxia and hypoxia-inducible factor-1 expression enhance osteolytic bone metastases of breast cancer
    • Hiraga T, Kizaka-Kondoh S, Hirota K, Hiraoka M, Yoneda T. (2007). Hypoxia and hypoxia-inducible factor-1 expression enhance osteolytic bone metastases of breast cancer. Cancer Res 67: 4157-4163.
    • (2007) Cancer Res , vol.67 , pp. 4157-4163
    • Hiraga, T.1    Kizaka-Kondoh, S.2    Hirota, K.3    Hiraoka, M.4    Yoneda, T.5
  • 41
    • 0037119415 scopus 로고    scopus 로고
    • Hsp90 regulates a von Hippel Lindau-independent hypoxia-inducible factor-1a-degradative pathway
    • Isaacs JS, Jung YJ, Mimnaugh EG, Martinez A, Cuttitta F, Neckers LM. (2002). Hsp90 regulates a von Hippel Lindau-independent hypoxia-inducible factor-1a-degradative pathway. J Biol Chem 277: 29936-29944.
    • (2002) J Biol Chem , vol.277 , pp. 29936-29944
    • Isaacs, J.S.1    Jung, Y.J.2    Mimnaugh, E.G.3    Martinez, A.4    Cuttitta, F.5    Neckers, L.M.6
  • 42
    • 23644448721 scopus 로고    scopus 로고
    • HIF overexpression correlates with biallelic loss of fumarate hydratase in renal cancer: Novel role of fumarate in regulation of HIF stability
    • Isaacs JS, Jung YJ, Mole DR, Lee S, Torres-Cabala C, Chung YL, et al. (2005). HIF overexpression correlates with biallelic loss of fumarate hydratase in renal cancer: novel role of fumarate in regulation of HIF stability. Cancer Cell 8: 143-153.
    • (2005) Cancer Cell , vol.8 , pp. 143-153
    • Isaacs, J.S.1    Jung, Y.J.2    Mole, D.R.3    Lee, S.4    Torres-Cabala, C.5    Chung, Y.L.6
  • 43
    • 0030659531 scopus 로고    scopus 로고
    • V-SRC induces expression of hypoxia-inducible factor 1 (HIF-1) and transcription of genes encoding vascular endothelial growth factor and enolase 1: Involvement of HIF-1 in tumor progression
    • Jiang BH, Agani F, Passaniti A, Semenza GL. (1997). V-SRC induces expression of hypoxia-inducible factor 1 (HIF-1) and transcription of genes encoding vascular endothelial growth factor and enolase 1: involvement of HIF-1 in tumor progression. Cancer Res 57: 5328-5335.
    • (1997) Cancer Res , vol.57 , pp. 5328-5335
    • Jiang, B.H.1    Agani, F.2    Passaniti, A.3    Semenza, G.L.4
  • 44
    • 43649093915 scopus 로고    scopus 로고
    • Oxygen sensing by metazoans: The central role of the HIF hydroxylase pathway
    • Kaelin Jr WG, Ratcliffe PJ. (2008). Oxygen sensing by metazoans: the central role of the HIF hydroxylase pathway. Mol Cell 30: 393-402.
    • (2008) Mol Cell , vol.30 , pp. 393-402
    • Kaelin Jr, W.G.1    Ratcliffe, P.J.2
  • 45
    • 33746496671 scopus 로고    scopus 로고
    • Proteasomal inhibition attenuates transcriptional activity of hypoxia-inducible factor 1 (HIF-1) via specific effect on the HIF-1a C-terminal activation domain
    • Kaluz S, Kaluzov M, Stanbridge EJ. (2006). Proteasomal inhibition attenuates transcriptional activity of hypoxia-inducible factor 1 (HIF-1) via specific effect on the HIF-1a C-terminal activation domain. Mol Cell Biol 26: 5895-5907.
    • (2006) Mol Cell Biol , vol.26 , pp. 5895-5907
    • Kaluz, S.1    Kaluzov, M.2    Stanbridge, E.J.3
  • 46
    • 46749104161 scopus 로고    scopus 로고
    • Comment on the role of FIH in the inhibitory effect of bortezomib on hypoxia-inducible factor-1
    • Kaluz S, Kaluzov M, Stanbridge EJ. (2008). Comment on the role of FIH in the inhibitory effect of bortezomib on hypoxia-inducible factor-1. Blood 111: 5258-5259.
    • (2008) Blood , vol.111 , pp. 5258-5259
    • Kaluz, S.1    Kaluzov, M.2    Stanbridge, E.J.3
  • 47
    • 2942615257 scopus 로고    scopus 로고
    • The anti-angiogenic basis of metronomic chemotherapy
    • Kerbel RS, Kamen BA. (2004). The anti-angiogenic basis of metronomic chemotherapy. Nat Rev Cancer 4: 423-436.
    • (2004) Nat Rev Cancer , vol.4 , pp. 423-436
    • Kerbel, R.S.1    Kamen, B.A.2
  • 48
    • 2342597973 scopus 로고    scopus 로고
    • Inhibition of HIF-2a is sufficient to suppress pVHL-defective tumor growth
    • Kondo K, Kim WY, Lechpammer M, Kaelin Jr WG. (2003). Inhibition of HIF-2a is sufficient to suppress pVHL-defective tumor growth. PLoS Biol 1: e83.
    • (2003) PLoS Biol , vol.1
    • Kondo, K.1    Kim, W.Y.2    Lechpammer, M.3    Kaelin Jr, W.G.4
  • 49
    • 33750537081 scopus 로고    scopus 로고
    • EBV latent membrane protein 1 up-regulates hypoxia-inducible factor 1a through Siah1-mediated down-regulation of prolyl hydroxylases 1 and 3 in nasopharyngeal epithelial cells
    • Kondo S, Seo SY, Yoshizaki T, Wakisaka N, Furukawa M, Joab I, et al. (2006). EBV latent membrane protein 1 up-regulates hypoxia-inducible factor 1a through Siah1-mediated down-regulation of prolyl hydroxylases 1 and 3 in nasopharyngeal epithelial cells. Cancer Res 66: 9870-9877.
    • (2006) Cancer Res , vol.66 , pp. 9870-9877
    • Kondo, S.1    Seo, S.Y.2    Yoshizaki, T.3    Wakisaka, N.4    Furukawa, M.5    Joab, I.6
  • 50
    • 25444523184 scopus 로고    scopus 로고
    • Echinomycin, a small-molecule inhibitor of hypoxia-inducible factor-1 DNA-binding activity
    • Kong D, Park EJ, Stephen AG, Calvani M, Cardellina JH, Monks A, et al. (2005). Echinomycin, a small-molecule inhibitor of hypoxia-inducible factor-1 DNA-binding activity. Cancer Res 65: 9047-9055.
    • (2005) Cancer Res , vol.65 , pp. 9047-9055
    • Kong, D.1    Park, E.J.2    Stephen, A.G.3    Calvani, M.4    Cardellina, J.H.5    Monks, A.6
  • 51
    • 33644780111 scopus 로고    scopus 로고
    • Histone deacetylase inhibitors induce VHL and ubiquitin-independent proteasomal degradation of hypoxia-inducible factor 1a
    • Kong X, Lin Z, Liang D, Fath D, Sang N, Caro J. (2006). Histone deacetylase inhibitors induce VHL and ubiquitin-independent proteasomal degradation of hypoxia-inducible factor 1a. Mol Cell Biol 26: 2019-2028.
    • (2006) Mol Cell Biol , vol.26 , pp. 2019-2028
    • Kong, X.1    Lin, Z.2    Liang, D.3    Fath, D.4    Sang, N.5    Caro, J.6
  • 52
    • 2942707871 scopus 로고    scopus 로고
    • Hypoxia-inducible factor 1a/ vascular endothelial growth factor axis in astrocytomas
    • Associations with microvessel morphometry, proliferation and prognosis
    • Korkolopoulou P, Patsouris E, Konstantinidou AE, Pavlopoulos PM, Kavantzas N, Boviatsis E, et al. (2004). Hypoxia-inducible factor 1a/ vascular endothelial growth factor axis in astrocytomas. Associations with microvessel morphometry, proliferation and prognosis. Neuropathol Appl Neurobiol 30: 267-278.
    • (2004) Neuropathol Appl Neurobiol , vol.30 , pp. 267-278
    • Korkolopoulou, P.1    Patsouris, E.2    Konstantinidou, A.E.3    Pavlopoulos, P.M.4    Kavantzas, N.5    Boviatsis, E.6
  • 53
    • 15244344206 scopus 로고    scopus 로고
    • HIF-1a induces genetic instability by transcriptionally downregulating MutSa expression
    • Koshiji M, To KK, Hammer S, Kumamoto K, Harris AL, Modrich P, et al. (2005). HIF-1a induces genetic instability by transcriptionally downregulating MutSa expression. Mol Cell 17: 793-803.
    • (2005) Mol Cell , vol.17 , pp. 793-803
    • Koshiji, M.1    To, K.K.2    Hammer, S.3    Kumamoto, K.4    Harris, A.L.5    Modrich, P.6
  • 54
    • 0036680153 scopus 로고    scopus 로고
    • Hypoxia-inducible factor (HIF1A and HIF2A), angiogenesis, and chemoradiotherapy outcome of squamous cell head-and-neck cancer
    • Koukourakis MI, Giatromanolaki A, Sivridis E, Simopoulos C, Turley H, Talks K, et al. (2002). Hypoxia-inducible factor (HIF1A and HIF2A), angiogenesis, and chemoradiotherapy outcome of squamous cell head-and-neck cancer. Int J Radiat Oncol Biol Phys 53: 1192-1202.
    • (2002) Int J Radiat Oncol Biol Phys , vol.53 , pp. 1192-1202
    • Koukourakis, M.I.1    Giatromanolaki, A.2    Sivridis, E.3    Simopoulos, C.4    Turley, H.5    Talks, K.6
  • 55
    • 33645090169 scopus 로고    scopus 로고
    • Hypoxia-inducible factor-1-dependent repression of E-cadherin in von Hippel-Lindau tumor suppressor-null renal cell carcinoma mediated by TCF3, ZFHX1A, and ZFHX1B
    • Krishnamachary B, Zagzag D, Nagasawa H, Rainey K, Okuyama H, Baek JH, et al. (2006). Hypoxia-inducible factor-1-dependent repression of E-cadherin in von Hippel-Lindau tumor suppressor-null renal cell carcinoma mediated by TCF3, ZFHX1A, and ZFHX1B. Cancer Res 66: 2725-2731.
    • (2006) Cancer Res , vol.66 , pp. 2725-2731
    • Krishnamachary, B.1    Zagzag, D.2    Nagasawa, H.3    Rainey, K.4    Okuyama, H.5    Baek, J.H.6
  • 56
    • 33646423829 scopus 로고    scopus 로고
    • Hypoxia inducible factor-1a is a prognostic marker in premenopausal patients with intermediate to highly differentiated breast cancer but not a predictive marker for tamoxifen response
    • Kronblad A, Jirstrom K, Ryden L, Nordenskjold B, Landberg G. (2006). Hypoxia inducible factor-1a is a prognostic marker in premenopausal patients with intermediate to highly differentiated breast cancer but not a predictive marker for tamoxifen response. Int J Cancer 118: 2609-2616.
    • (2006) Int J Cancer , vol.118 , pp. 2609-2616
    • Kronblad, A.1    Jirstrom, K.2    Ryden, L.3    Nordenskjold, B.4    Landberg, G.5
  • 57
    • 0034529914 scopus 로고    scopus 로고
    • Suppression of tumor growth through disruption of hypoxia-inducible transcription
    • Kung AL, Wang S, Klco JM, Kaelin WG, Livingston DM. (2000). Suppression of tumor growth through disruption of hypoxia-inducible transcription. Nat Med 6: 1335-1340.
    • (2000) Nat Med , vol.6 , pp. 1335-1340
    • Kung, A.L.1    Wang, S.2    Klco, J.M.3    Kaelin, W.G.4    Livingston, D.M.5
  • 58
    • 0037097861 scopus 로고    scopus 로고
    • FIH-1 is an asparaginyl hydroxylase enzyme that regulates the transcriptional activity of hypoxia-inducible factor
    • Lando D, Peet DJ, Gorman JJ, Whelan DA, Whitelaw ML, Bruick RK. (2002). FIH-1 is an asparaginyl hydroxylase enzyme that regulates the transcriptional activity of hypoxia-inducible factor. Genes Dev 16: 1466-1471.
    • (2002) Genes Dev , vol.16 , pp. 1466-1471
    • Lando, D.1    Peet, D.J.2    Gorman, J.J.3    Whelan, D.A.4    Whitelaw, M.L.5    Bruick, R.K.6
  • 59
    • 34247219188 scopus 로고    scopus 로고
    • Target gene selectivity of hypoxia-inducible factor-a in renal cancer cells is conveyed by post-DNA-binding mechanisms
    • Lau KW, Tian YM, Raval RR, Ratcliffe PJ, Pugh CW. (2007). Target gene selectivity of hypoxia-inducible factor-a in renal cancer cells is conveyed by post-DNA-binding mechanisms. Br J Cancer 96: 1284-1292.
    • (2007) Br J Cancer , vol.96 , pp. 1284-1292
    • Lau, K.W.1    Tian, Y.M.2    Raval, R.R.3    Ratcliffe, P.J.4    Pugh, C.W.5
  • 60
    • 0035012605 scopus 로고    scopus 로고
    • HER2 (neu) signaling increases the rate of hypoxia-inducible factor 1a (HIF-1a) synthesis: Novel mechanism for HIF-1-mediated vascular endothelial growth factor expression
    • Laughner E, Taghavi P, Chiles K, Mahon PC, Semenza GL. (2001). HER2 (neu) signaling increases the rate of hypoxia-inducible factor 1a (HIF-1a) synthesis: novel mechanism for HIF-1-mediated vascular endothelial growth factor expression. Mol Cell Biol 21: 3995-4004.
    • (2001) Mol Cell Biol , vol.21 , pp. 3995-4004
    • Laughner, E.1    Taghavi, P.2    Chiles, K.3    Mahon, P.C.4    Semenza, G.L.5
  • 61
    • 60549092506 scopus 로고    scopus 로고
    • Anthracycline chemotherapy inhibits HIF-1 transcriptional activity and tumor-induced mobilization of circulating angiogenic cells
    • Lee K, Qian DZ, Rey S, Wei H, Liu JO, Semenza GL. (2009). Anthracycline chemotherapy inhibits HIF-1 transcriptional activity and tumor-induced mobilization of circulating angiogenic cells. Proc Natl Acad Sci USA 106: 2353-2358.
    • (2009) Proc Natl Acad Sci USA , vol.106 , pp. 2353-2358
    • Lee, K.1    Qian, D.Z.2    Rey, S.3    Wei, H.4    Liu, J.O.5    Semenza, G.L.6
  • 63
    • 23844461100 scopus 로고    scopus 로고
    • Evaluating hypoxia-inducible factor-1a as a cancer therapeutic target via inducible RNA interference in vivo
    • Li L, Lin X, Staver M, Shoemaker A, Semizarov D, Fesik SW, et al. (2005). Evaluating hypoxia-inducible factor-1a as a cancer therapeutic target via inducible RNA interference in vivo. Cancer Res 65: 7249-7258.
    • (2005) Cancer Res , vol.65 , pp. 7249-7258
    • Li, L.1    Lin, X.2    Staver, M.3    Shoemaker, A.4    Semizarov, D.5    Fesik, S.W.6
  • 64
    • 33846652552 scopus 로고    scopus 로고
    • Hypoxia-inducible factor-1a is a key regulator of metastasis in a transgenic model of cancer initiation and progression
    • Liao D, Corle C, Seagroves TN, Johnson RS. (2007). Hypoxia-inducible factor-1a is a key regulator of metastasis in a transgenic model of cancer initiation and progression. Cancer Res 67: 563-572.
    • (2007) Cancer Res , vol.67 , pp. 563-572
    • Liao, D.1    Corle, C.2    Seagroves, T.N.3    Johnson, R.S.4
  • 65
    • 34547124062 scopus 로고    scopus 로고
    • Hypoxia: A key regulator of angiogenesis in cancer
    • Liao D, Johnson RS. (2007). Hypoxia: a key regulator of angiogenesis in cancer. Cancer Metastasis Rev 26: 281-290.
    • (2007) Cancer Metastasis Rev , vol.26 , pp. 281-290
    • Liao, D.1    Johnson, R.S.2
  • 66
    • 63649108348 scopus 로고    scopus 로고
    • Targeting hypoxia-inducible factor-1a with Tf-PEI-shRNA complex via transferrin receptor-mediated endocytosis inhibits melanoma growth
    • Liu Y, Tao J, Li Y, Yang J, Yu Y, Wang M, et al. (2009). Targeting hypoxia-inducible factor-1a with Tf-PEI-shRNA complex via transferrin receptor-mediated endocytosis inhibits melanoma growth. Mol Ther 17: 269-277.
    • (2009) Mol Ther , vol.17 , pp. 269-277
    • Liu, Y.1    Tao, J.2    Li, Y.3    Yang, J.4    Yu, Y.5    Wang, M.6
  • 68
    • 34547120458 scopus 로고    scopus 로고
    • Hypoxia-dependent anti-inflammatory pathways in protection of cancerous tissues
    • Lukashev D, Ohta A, Sitkovsky M. (2007). Hypoxia-dependent anti-inflammatory pathways in protection of cancerous tissues. Cancer Metastasis Rev 26: 273-279.
    • (2007) Cancer Metastasis Rev , vol.26 , pp. 273-279
    • Lukashev, D.1    Ohta, A.2    Sitkovsky, M.3
  • 69
    • 21744454494 scopus 로고    scopus 로고
    • The antiepidermal growth factor receptor monoclonal antibody cetux-imab/C225 reduces hypoxia-inducible factor-1a, leading to tran-scriptional inhibition of vascular endothelial growth factor expression
    • Luwor RB, Lu Y, Li X, Mendelsohn J, Fan Z. (2005). The antiepidermal growth factor receptor monoclonal antibody cetux-imab/C225 reduces hypoxia-inducible factor-1a, leading to tran-scriptional inhibition of vascular endothelial growth factor expression. Oncogene 24: 4433-4441.
    • (2005) Oncogene , vol.24 , pp. 4433-4441
    • Luwor, R.B.1    Lu, Y.2    Li, X.3    Mendelsohn, J.4    Fan, Z.5
  • 70
    • 2942724235 scopus 로고    scopus 로고
    • MTOR inhibition reverses Akt-dependent prostate intra-epithelial neoplasia through regulation of apoptotic and HIF-1-dependent pathways
    • Majumder PK, Yeh JJ, George DJ, Febbo PG, Kum J, Xue Q, et al. (2004). mTOR inhibition reverses Akt-dependent prostate intra-epithelial neoplasia through regulation of apoptotic and HIF-1-dependent pathways. Nat Med 10: 594-601.
    • (2004) Nat Med , vol.10 , pp. 594-601
    • Majumder, P.K.1    Yeh, J.J.2    George, D.J.3    Febbo, P.G.4    Kum, J.5    Xue, Q.6
  • 71
    • 34347265260 scopus 로고    scopus 로고
    • Transcriptional up-regulation of inhibitory PAS domain protein gene expression by hypoxia-inducible factor 1 (HIF-1): A negative feedback regulatory circuit in HIF-1-mediated signaling in hypoxic cells
    • Makino Y, Uenishi R, Okamoto K, Isoe T, Hosono O, Tanaka H, et al. (2007). Transcriptional up-regulation of inhibitory PAS domain protein gene expression by hypoxia-inducible factor 1 (HIF-1): a negative feedback regulatory circuit in HIF-1-mediated signaling in hypoxic cells. J Biol Chem 282: 14073-14082.
    • (2007) J Biol Chem , vol.282 , pp. 14073-14082
    • Makino, Y.1    Uenishi, R.2    Okamoto, K.3    Isoe, T.4    Hosono, O.5    Tanaka, H.6
  • 72
    • 11244315697 scopus 로고    scopus 로고
    • Transcriptional regulation of vascular endothelial cell responses to hypoxia by HIF-1
    • Manalo DJ, Rowan A, Lavoie T, Natarajan L, Kelly BD, Ye SQ, et al. (2005). Transcriptional regulation of vascular endothelial cell responses to hypoxia by HIF-1. Blood 105: 659-669.
    • (2005) Blood , vol.105 , pp. 659-669
    • Manalo, D.J.1    Rowan, A.2    Lavoie, T.3    Natarajan, L.4    Kelly, B.D.5    Ye, S.Q.6
  • 73
    • 0030816109 scopus 로고    scopus 로고
    • Hypoxia-inducible factor-1 modulates gene expression in solid tumors and influences both angiogenesis and tumor growth
    • Maxwell PH, Dachs GU, Gleadle JM, Nicholls LG, Harris AL, Stratford IJ, et al. (1997). Hypoxia-inducible factor-1 modulates gene expression in solid tumors and influences both angiogenesis and tumor growth. Proc Natl Acad Sci USA 94: 8104-8109.
    • (1997) Proc Natl Acad Sci USA , vol.94 , pp. 8104-8109
    • Maxwell, P.H.1    Dachs, G.U.2    Gleadle, J.M.3    Nicholls, L.G.4    Harris, A.L.5    Stratford, I.J.6
  • 74
    • 0033587146 scopus 로고    scopus 로고
    • The tumor suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis
    • Maxwell PH, Wiesener MS, Chang GW, Clifford SC, Vaux EC, Cockman ME, et al. (1999). The tumor suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis. Nature 399: 271-275.
    • (1999) Nature , vol.399 , pp. 271-275
    • Maxwell, P.H.1    Wiesener, M.S.2    Chang, G.W.3    Clifford, S.C.4    Vaux, E.C.5    Cockman, M.E.6
  • 75
    • 0037111665 scopus 로고    scopus 로고
    • BCR/ABL induces expression of vascular endothelial growth factor and its transcriptional activator, hypoxia inducible factor-1a, through a pathway involving phosphoinositide 3-kinase and the mammalian target of rapamycin
    • Mayerhofer M, Valent P, Sperr WR, Griffin JD, Sillaber C. (2002). BCR/ABL induces expression of vascular endothelial growth factor and its transcriptional activator, hypoxia inducible factor-1a, through a pathway involving phosphoinositide 3-kinase and the mammalian target of rapamycin. Blood 100: 3767-3775.
    • (2002) Blood , vol.100 , pp. 3767-3775
    • Mayerhofer, M.1    Valent, P.2    Sperr, W.R.3    Griffin, J.D.4    Sillaber, C.5
  • 76
    • 34547098129 scopus 로고    scopus 로고
    • Targeting hypoxia cell signaling for cancer therapy
    • Melillo G. (2007). Targeting hypoxia cell signaling for cancer therapy. Cancer Metastasis Rev 26: 341-352.
    • (2007) Cancer Metastasis Rev , vol.26 , pp. 341-352
    • Melillo, G.1
  • 77
    • 2342611976 scopus 로고    scopus 로고
    • Radiation activates HIF-1 to regulate vascular radiosensitivity in tumors: Role of reoxygenation, free radicals, and stress granules
    • Moeller BJ, Cao Y, Li CY, Dewhirst MW. (2004). Radiation activates HIF-1 to regulate vascular radiosensitivity in tumors: role of reoxygenation, free radicals, and stress granules. Cancer Cell 5: 429-441.
    • (2004) Cancer Cell , vol.5 , pp. 429-441
    • Moeller, B.J.1    Cao, Y.2    Li, C.Y.3    Dewhirst, M.W.4
  • 78
    • 34547103992 scopus 로고    scopus 로고
    • Hypoxia and radiotherapy: Opportunities for improved outcomes in cancer treatment
    • Moeller BJ, Richardson RA, Dewhirst MW. (2007). Hypoxia and radiotherapy: opportunities for improved outcomes in cancer treatment. Cancer Metastasis Rev 26: 241-248.
    • (2007) Cancer Metastasis Rev , vol.26 , pp. 241-248
    • Moeller, B.J.1    Richardson, R.A.2    Dewhirst, M.W.3
  • 79
    • 67650531089 scopus 로고    scopus 로고
    • Genome-wide association of hypoxia-inducible factor (HIF)-1a and HIF-2a DNA binding with expression profiling of hypoxia-inducible transcripts
    • Mole DR, Blancher C, Copley RR, Pollard PJ, Gleadle JM, Ragoussis J, et al. (2009). Genome-wide association of hypoxia-inducible factor (HIF)-1a and HIF-2a DNA binding with expression profiling of hypoxia-inducible transcripts. J Biol Chem 284: 16767-16775.
    • (2009) J Biol Chem , vol.284 , pp. 16767-16775
    • Mole, D.R.1    Blancher, C.2    Copley, R.R.3    Pollard, P.J.4    Gleadle, J.M.5    Ragoussis, J.6
  • 81
    • 66449130218 scopus 로고    scopus 로고
    • Endothelial NOS, estrogen receptor beta, and HIFs cooperate in the activation of a prognostic transcriptional pattern in aggressive human prostate cancer
    • Nanni S, Benvenuti V, Grasselli A, Priolo C, Aiello A, Mattiussi S, et al. (2009). Endothelial NOS, estrogen receptor beta, and HIFs cooperate in the activation of a prognostic transcriptional pattern in aggressive human prostate cancer. J Clin Invest 119: 1093-1108.
    • (2009) J Clin Invest , vol.119 , pp. 1093-1108
    • Nanni, S.1    Benvenuti, V.2    Grasselli, A.3    Priolo, C.4    Aiello, A.5    Mattiussi, S.6
  • 82
    • 12344287138 scopus 로고    scopus 로고
    • Transcriptional regulation of the vascular endothelial growth factor gene\-a concert of activating factors
    • Pages G, Pouyssegur J. (2005). Transcriptional regulation of the vascular endothelial growth factor gene\-a concert of activating factors. Cardiovasc Res 65: 564-573.
    • (2005) Cardiovasc Res , vol.65 , pp. 564-573
    • Pages, G.1    Pouyssegur, J.2
  • 83
    • 33645499486 scopus 로고    scopus 로고
    • EGFR tyrosine kinase inhibitors decrease VEGF expression by both hypoxia-inducible factor (HIF)-1-independent and HIF-1-dependent mechanisms
    • Pore N, Jiang Z, Gupta A, Cerniglia G, Kao GD, Maity A. (2006). EGFR tyrosine kinase inhibitors decrease VEGF expression by both hypoxia-inducible factor (HIF)-1-independent and HIF-1-dependent mechanisms. Cancer Res 66: 3197-3204.
    • (2006) Cancer Res , vol.66 , pp. 3197-3204
    • Pore, N.1    Jiang, Z.2    Gupta, A.3    Cerniglia, G.4    Kao, G.D.5    Maity, A.6
  • 84
    • 33749006252 scopus 로고    scopus 로고
    • Class II histone deacetylases are associated with VHL-independent regulation of hypoxia-inducible factor 1a
    • Qian DZ, Kachhap SK, Collis SJ, Verheul HM, Carducci MA, Atadja P, et al. (2006). Class II histone deacetylases are associated with VHL-independent regulation of hypoxia-inducible factor 1a. Cancer Res 66: 8814-8821.
    • (2006) Cancer Res , vol.66 , pp. 8814-8821
    • Qian, D.Z.1    Kachhap, S.K.2    Collis, S.J.3    Verheul, H.M.4    Carducci, M.A.5    Atadja, P.6
  • 85
    • 31544473721 scopus 로고    scopus 로고
    • Nitric oxide is a factor in the stabilization of hypoxia-inducible factor-1a in cancer: Role of free radical formation
    • Quintero M, Brennan PA, Thomas GJ, Moncada S. (2006). Nitric oxide is a factor in the stabilization of hypoxia-inducible factor-1a in cancer: role of free radical formation. Cancer Res 66: 770-774.
    • (2006) Cancer Res , vol.66 , pp. 770-774
    • Quintero, M.1    Brennan, P.A.2    Thomas, G.J.3    Moncada, S.4
  • 87
    • 0036682284 scopus 로고    scopus 로고
    • Identification of small molecule inhibitors of hypoxia-inducible factor 1 transcriptional activation pathway
    • Rapisarda A, Uranchimeg B, Scudiero DA, Selby M, Sausville EA, Shoemaker RH, et al. (2002). Identification of small molecule inhibitors of hypoxia-inducible factor 1 transcriptional activation pathway. Cancer Res 62: 4316-4324.
    • (2002) Cancer Res , vol.62 , pp. 4316-4324
    • Rapisarda, A.1    Uranchimeg, B.2    Scudiero, D.A.3    Selby, M.4    Sausville, E.A.5    Shoemaker, R.H.6
  • 88
    • 66149119317 scopus 로고    scopus 로고
    • Hypoxia-inducible factor-1a and-2a are expressed in most rectal cancers but only hypoxia-inducible factor-1a is associated with prognosis
    • Rasheed S, Harris AL, Tekkis PP, Turley H, Silver A, McDonald PJ, et al. (2009). Hypoxia-inducible factor-1a and-2a are expressed in most rectal cancers but only hypoxia-inducible factor-1a is associated with prognosis. Br J Cancer 100: 1666-1673.
    • (2009) Br J Cancer , vol.100 , pp. 1666-1673
    • Rasheed, S.1    Harris, A.L.2    Tekkis, P.P.3    Turley, H.4    Silver, A.5    McDonald, P.J.6
  • 89
    • 20744445650 scopus 로고    scopus 로고
    • Contrasting properties of hypoxia-inducible factor 1 (HIF-1) and HIF-2 in von Hippel-Lindau-associated renal cell carcinoma
    • Raval RR, Lau KW, Tran MG, Sowter HM, Mandriota SJ, LI J-L, et al. (2005). Contrasting properties of hypoxia-inducible factor 1 (HIF-1) and HIF-2 in von Hippel-Lindau-associated renal cell carcinoma. Mol Cell Biol 25: 5675-5686.
    • (2005) Mol Cell Biol , vol.25 , pp. 5675-5686
    • Raval, R.R.1    Lau, K.W.2    Tran, M.G.3    Sowter, H.M.4    Mandriota, S.J.5
  • 90
    • 0033954247 scopus 로고    scopus 로고
    • Regulation of tumor angiogenesis by p53-induced degradation of hypoxia-inducible factor 1a
    • Ravi R, Mookerjee B, Bhujwalla ZM, Sutter CH, Artemov D, Zeng Q, et al. (2000). Regulation of tumor angiogenesis by p53-induced degradation of hypoxia-inducible factor 1a. Genes Dev 14: 34-44.
    • (2000) Genes Dev , vol.14 , pp. 34-44
    • Ravi, R.1    Mookerjee, B.2    Bhujwalla, Z.M.3    Sutter, C.H.4    Artemov, D.5    Zeng, Q.6
  • 91
    • 0036278899 scopus 로고    scopus 로고
    • Overexpression of hypoxia-inducible factor 1a is associated with an unfavorable prognosis in lymph node-positive breast cancer
    • Schindl M, Schoppmann SF, Samonigg H, Hausmaninger H, Kwasny W, Gnant M, et al. (2002). Overexpression of hypoxia-inducible factor 1a is associated with an unfavorable prognosis in lymph node-positive breast cancer. Clin Cancer Res 8: 1831-1837.
    • (2002) Clin Cancer Res , vol.8 , pp. 1831-1837
    • Schindl, M.1    Schoppmann, S.F.2    Samonigg, H.3    Hausmaninger, H.4    Kwasny, W.5    Gnant, M.6
  • 92
    • 70350020416 scopus 로고    scopus 로고
    • Combined analysis of hypoxia-inducible factor 1a and metallothionein indicates an aggressive subtype of colorectal carcinoma
    • Schmitz KJ, Muller CI, Reis H, Alakus H, Winde G, Baba HA, et al. (2009). Combined analysis of hypoxia-inducible factor 1a and metallothionein indicates an aggressive subtype of colorectal carcinoma. Int J Colorectal Dis 24: 1287-1296.
    • (2009) Int J Colorectal Dis , vol.24 , pp. 1287-1296
    • Schmitz, K.J.1    Muller, C.I.2    Reis, H.3    Alakus, H.4    Winde, G.5    Baba, H.A.6
  • 93
    • 49549103347 scopus 로고    scopus 로고
    • Overexpression of intrinsic hypoxia markers HIF-1a and CA-IX predict for local recurrence in stage T1-T2 glottic laryngeal carcinoma treated with radiotherapy
    • Schrijvers ML, van der Laan BF, de Bock GH, Pattje WJ, Mastik MF, Menkema L, et al. (2008). Overexpression of intrinsic hypoxia markers HIF-1a and CA-IX predict for local recurrence in stage T1-T2 glottic laryngeal carcinoma treated with radiotherapy. Int J Radiat Oncol Biol Phys 72: 161-169.
    • (2008) Int J Radiat Oncol Biol Phys , vol.72 , pp. 161-169
    • Schrijvers, M.L.1    Van Der Laan, B.F.2    De Bock, G.H.3    Pattje, W.J.4    Mastik, M.F.5    Menkema, L.6
  • 94
    • 66449118481 scopus 로고    scopus 로고
    • The selective hypoxia inducible factor-1 inhibitor PX-478 provides in vivo radiosensitization through tumor stromal effects
    • Schwartz DL, Powis G, Thitai-Kumar A, He Y, Bankson J, Williams R, et al. (2009). The selective hypoxia inducible factor-1 inhibitor PX-478 provides in vivo radiosensitization through tumor stromal effects. Mol Cancer Ther 8: 947-958.
    • (2009) Mol Cancer Ther , vol.8 , pp. 947-958
    • Schwartz, D.L.1    Powis, G.2    Thitai-Kumar, A.3    He, Y.4    Bankson, J.5    Williams, R.6
  • 96
    • 0034021690 scopus 로고    scopus 로고
    • Hypoxia, clonal selection, and the role of HIF-1 in tumor progression
    • Semenza GL. (2000). Hypoxia, clonal selection, and the role of HIF-1 in tumor progression. Crit Rev Biochem Mol Biol 35: 71-103.
    • (2000) Crit Rev Biochem Mol Biol , vol.35 , pp. 71-103
    • Semenza, G.L.1
  • 97
    • 60549083256 scopus 로고    scopus 로고
    • Oxygen homeostasis
    • Systems Biol Med (doi:10.1002/wsbm.69). Semenza GL. (2009b)Regulation of cancer cell metabolism by hypoxia-inducible factor 1
    • Semenza GL. (2009a). Oxygen homeostasis. Systems Biol Med (doi:10.1002/wsbm.69). Semenza GL. (2009b). Regulation of cancer cell metabolism by hypoxia-inducible factor 1. Semin Cancer Biol 19: 12-16.
    • (2009) Semin Cancer Biol , vol.19 , pp. 12-16
    • Semenza, G.L.1
  • 98
    • 67650480092 scopus 로고    scopus 로고
    • MTOR and HIF-1a-mediated tumor metabolism in an LKB1 mouse model of Peutz-Jeghers syndrome
    • Shackelford DB, Vasquez DS, Corbeil J, Wu S, Leblanc M, Wu CL, et al. (2009). mTOR and HIF-1a-mediated tumor metabolism in an LKB1 mouse model of Peutz-Jeghers syndrome. Proc Natl Acad Sci USA 106: 11137-11142.
    • (2009) Proc Natl Acad Sci USA , vol.106 , pp. 11137-11142
    • Shackelford, D.B.1    Vasquez, D.S.2    Corbeil, J.3    Wu, S.4    Leblanc, M.5    Wu, C.L.6
  • 99
    • 42449130564 scopus 로고    scopus 로고
    • Bortezomib inhibits tumor adaptation to hypoxia by stimulating the FIH-mediated repression of hypoxia-inducible factor-1
    • Shin DH, Chun YS, Lee DS, Huang LE, Park JW. (2008). Bortezomib inhibits tumor adaptation to hypoxia by stimulating the FIH-mediated repression of hypoxia-inducible factor-1. Blood 111: 3131-3136.
    • (2008) Blood , vol.111 , pp. 3131-3136
    • Shin, D.H.1    Chun, Y.S.2    Lee, D.S.3    Huang, L.E.4    Park, J.W.5
  • 100
    • 40949131915 scopus 로고    scopus 로고
    • Kaposi's sarcoma-associated herpesvirus viral IFN regulatory factor 3 stabilizes hypoxia-inducible factor-1a to induce vascular endothelial growth factor expression
    • Shin YC, Joo CH, Gack MU, Lee HR, Jung JU. (2008). Kaposi's sarcoma-associated herpesvirus viral IFN regulatory factor 3 stabilizes hypoxia-inducible factor-1a to induce vascular endothelial growth factor expression. Cancer Res 68: 1751-1759.
    • (2008) Cancer Res , vol.68 , pp. 1751-1759
    • Shin, Y.C.1    Joo, C.H.2    Gack, M.U.3    Lee, H.R.4    Jung, J.U.5
  • 101
    • 0036721256 scopus 로고    scopus 로고
    • Association of hypoxia-inducible factors 1a and 2a with activated angiogenic pathways and prognosis in patients with endometrial carcinoma
    • Sivridis E, Giatromanolaki A, Gatter KC, Harris AL, Koukourakis MI. (2002). Association of hypoxia-inducible factors 1a and 2a with activated angiogenic pathways and prognosis in patients with endometrial carcinoma. Cancer 95: 1055-1063.
    • (2002) Cancer , vol.95 , pp. 1055-1063
    • Sivridis, E.1    Giatromanolaki, A.2    Gatter, K.C.3    Harris, A.L.4    Koukourakis, M.I.5
  • 102
    • 0034282553 scopus 로고    scopus 로고
    • The Kaposi's sarcoma-associated herpes virus G protein-coupled receptor up-regulates vascular endothelial growth factor expression and secretion through mitogen-activated protein kinase and p38 pathways acting on hypoxia-inducible factor 1a
    • Sodhi A, Montaner S, Patel V, Zohar M, Bais C, Mesri EA, et al. (2000). The Kaposi's sarcoma-associated herpes virus G protein-coupled receptor up-regulates vascular endothelial growth factor expression and secretion through mitogen-activated protein kinase and p38 pathways acting on hypoxia-inducible factor 1a. Cancer Res 60: 4873-4880.
    • (2000) Cancer Res , vol.60 , pp. 4873-4880
    • Sodhi, A.1    Montaner, S.2    Patel, V.3    Zohar, M.4    Bais, C.5    Mesri, E.A.6
  • 103
    • 2942685341 scopus 로고    scopus 로고
    • Role of hypoxia-inducible factor 1a in gastric cancer cell growth, angiogenesis, and vessel maturation
    • Stoeltzing O, McCarty MF, Wey JS, Fan F, Liu W, Belcheva A, et al. (2004). Role of hypoxia-inducible factor 1a in gastric cancer cell growth, angiogenesis, and vessel maturation. J Natl Cancer Inst 96: 946-956.
    • (2004) J Natl Cancer Inst , vol.96 , pp. 946-956
    • Stoeltzing, O.1    McCarty, M.F.2    Wey, J.S.3    Fan, F.4    Liu, W.5    Belcheva, A.6
  • 104
    • 34547107592 scopus 로고    scopus 로고
    • Hypoxia-driven selection of the metastatic phenotype
    • Sullivan R, Graham CH. (2007). Hypoxia-driven selection of the metastatic phenotype. Cancer Metastasis Rev 26: 319-331.
    • (2007) Cancer Metastasis Rev , vol.26 , pp. 319-331
    • Sullivan, R.1    Graham, C.H.2
  • 105
    • 34447266708 scopus 로고    scopus 로고
    • Expression of hypoxia-inducible factor-1a and associated proteins in pancreatic ductal adenocarcinoma and their impact on prognosis
    • Sun HC, Qiu ZJ, Liu J, Sun J, Jiang T, Huang KJ, et al. (2007). Expression of hypoxia-inducible factor-1a and associated proteins in pancreatic ductal adenocarcinoma and their impact on prognosis. Int J Oncol 30: 1359-1367.
    • (2007) Int J Oncol , vol.30 , pp. 1359-1367
    • Sun, H.C.1    Qiu, Z.J.2    Liu, J.3    Sun, J.4    Jiang, T.5    Huang, K.J.6
  • 107
    • 3042816190 scopus 로고    scopus 로고
    • Hypoxia-inducible factor-1a in non small cell lung cancer: Relation to growth factor, protease and apoptosis pathways
    • Swinson DE, Jones JL, Cox G, Richardson D, Harris AL, O'Byrne KJ. (2004). Hypoxia-inducible factor-1a in non small cell lung cancer: relation to growth factor, protease and apoptosis pathways. Int J Cancer 111: 43-50.
    • (2004) Int J Cancer , vol.111 , pp. 43-50
    • Swinson, D.E.1    Jones, J.L.2    Cox, G.3    Richardson, D.4    Harris, A.L.5    O'Byrne, K.J.6
  • 108
    • 0033870281 scopus 로고    scopus 로고
    • The expression and distribution of the hypoxia-inducible factors HIF-1a and HIF-2a in normal human tissues, cancers, and tumor-associated macrophages
    • Talks KL, Turley H, Gatter KC, Maxwell PH, Pugh CW, Ratcliffe PJ, et al. (2000). The expression and distribution of the hypoxia-inducible factors HIF-1a and HIF-2a in normal human tissues, cancers, and tumor-associated macrophages. Am J Pathol 157: 411-421.
    • (2000) Am J Pathol , vol.157 , pp. 411-421
    • Talks, K.L.1    Turley, H.2    Gatter, K.C.3    Maxwell, P.H.4    Pugh, C.W.5    Ratcliffe, P.J.6
  • 109
    • 7944224442 scopus 로고    scopus 로고
    • Loss of HIF-1a in endothelial cells disrupts a hypoxia-driven VEGF autocrine loop necessary for tumorigenesis
    • Tang N, Wang L, Esko J, Giordano FJ, Huang Y, Gerber HP, et al. (2004). Loss of HIF-1a in endothelial cells disrupts a hypoxia-driven VEGF autocrine loop necessary for tumorigenesis. Cancer Cell 6: 485-495.
    • (2004) Cancer Cell , vol.6 , pp. 485-495
    • Tang, N.1    Wang, L.2    Esko, J.3    Giordano, F.J.4    Huang, Y.5    Gerber, H.P.6
  • 110
    • 0142175222 scopus 로고    scopus 로고
    • Hypoxia-inducible factor-1a expression and angiogenesis in gastrointestinal stromal tumor of the stomach
    • Takahashi R, Tanaka S, Hiyama T, Ito M, Kitadai Y, Sumii M, et al. (2003). Hypoxia-inducible factor-1a expression and angiogenesis in gastrointestinal stromal tumor of the stomach. Oncol Rep 10: 797-802.
    • (2003) Oncol Rep , vol.10 , pp. 797-802
    • Takahashi, R.1    Tanaka, S.2    Hiyama, T.3    Ito, M.4    Kitadai, Y.5    Sumii, M.6
  • 111
    • 14144250813 scopus 로고    scopus 로고
    • Evaluation of hypoxia-inducible factor 1a overexpression as a predictor of tumor recurrence and progression in superficial urothelial bladder carcinoma
    • Theodoropoulos VE, Lazaris AC, Kastriotis I, Spiliadi C, Theodor-opoulos GE, Tsoukala V, et al. (2005). Evaluation of hypoxia-inducible factor 1a overexpression as a predictor of tumor recurrence and progression in superficial urothelial bladder carcinoma. BJU Int 95: 425-431.
    • (2005) BJU Int , vol.95 , pp. 425-431
    • Theodoropoulos, V.E.1    Lazaris, A.C.2    Kastriotis, I.3    Spiliadi, C.4    Theodor-Opoulos, G.E.5    Tsoukala, V.6
  • 112
    • 3142534607 scopus 로고    scopus 로고
    • Hypoxia-inducible factor 1a expression correlates with angiogenesis and unfavorable prognosis in bladder cancer
    • Theodoropoulos VE, Lazaris AC, Sofras F, Gerzelis I, Tsoukala V, Ghikonti I, et al. (2004). Hypoxia-inducible factor 1a expression correlates with angiogenesis and unfavorable prognosis in bladder cancer. Eur Urol 46: 200-208.
    • (2004) Eur Urol , vol.46 , pp. 200-208
    • Theodoropoulos, V.E.1    Lazaris, A.C.2    Sofras, F.3    Gerzelis, I.4    Tsoukala, V.5    Ghikonti, I.6
  • 113
    • 30044432434 scopus 로고    scopus 로고
    • Hypoxia-inducible factor determines sensitivity to inhibitors of mTOR in kidney cancer
    • Thomas GV, Tran C, Mellinghoff IK, Welsbie DS, Chan E, Fueger B, et al. (2006). Hypoxia-inducible factor determines sensitivity to inhibitors of mTOR in kidney cancer. Nat Med 12: 122-127.
    • (2006) Nat Med , vol.12 , pp. 122-127
    • Thomas, G.V.1    Tran, C.2    Mellinghoff, I.K.3    Welsbie, D.S.4    Chan, E.5    Fueger, B.6
  • 114
    • 34548176273 scopus 로고    scopus 로고
    • Activation of hypoxia-inducible factor 1 in human T-cell leukaemia virus type 1-infected cell lines and primary adult T-cell leukaemia cells
    • Tomita M, Semenza GL, Michiels C, Matsuda T, Uchihara JN, Okudaira T, et al. (2007). Activation of hypoxia-inducible factor 1 in human T-cell leukaemia virus type 1-infected cell lines and primary adult T-cell leukaemia cells. Biochem J 406: 317-323.
    • (2007) Biochem J , vol.406 , pp. 317-323
    • Tomita, M.1    Semenza, G.L.2    Michiels, C.3    Matsuda, T.4    Uchihara, J.N.5    Okudaira, T.6
  • 115
    • 33847649279 scopus 로고    scopus 로고
    • HIF-1a and CA IX staining in invasive breast carcinomas: Prognosis and treatment outcome
    • Trastour C, Benizri E, Ettore F, Ramaioli A, Chamorey E, Pouyssegur J, et al. (2007). HIF-1a and CA IX staining in invasive breast carcinomas: prognosis and treatment outcome. Int J Cancer 120: 1443-1450.
    • (2007) Int J Cancer , vol.120 , pp. 1443-1450
    • Trastour, C.1    Benizri, E.2    Ettore, F.3    Ramaioli, A.4    Chamorey, E.5    Pouyssegur, J.6
  • 116
    • 58149385538 scopus 로고    scopus 로고
    • Expression of hypoxia-inducible factor (HIF)-1a and vascular endothelial growth factor (VEGF)-D as outcome predictors in resected esophageal squamous cell carcinoma
    • Tzao C, Lee SC, Tung HJ, Hsu HS, Hsu WH, Sun GH, et al. (2008). Expression of hypoxia-inducible factor (HIF)-1a and vascular endothelial growth factor (VEGF)-D as outcome predictors in resected esophageal squamous cell carcinoma. Dis Markers 25: 141-148.
    • (2008) Dis Markers , vol.25 , pp. 141-148
    • Tzao, C.1    Lee, S.C.2    Tung, H.J.3    Hsu, H.S.4    Hsu, W.H.5    Sun, G.H.6
  • 117
    • 1642565876 scopus 로고    scopus 로고
    • Tumor hypoxia and malignant progression
    • Vaupel P, Mayer A, Hockel M. (2004). Tumor hypoxia and malignant progression. Methods Enzymol 381: 335-354.
    • (2004) Methods Enzymol , vol.381 , pp. 335-354
    • Vaupel, P.1    Mayer, A.2    Hockel, M.3
  • 118
    • 19944434232 scopus 로고    scopus 로고
    • Differential prognostic impact of hypoxia induced and diffuse HIF-1a expression in invasive breast cancer
    • Vleugel MM, Greijer AE, Shvarts A, van der Groep P, van Berkel M, Aarbodem Y, et al. (2005). Differential prognostic impact of hypoxia induced and diffuse HIF-1a expression in invasive breast cancer. J Clin Pathol 58: 172-177.
    • (2005) J Clin Pathol , vol.58 , pp. 172-177
    • Vleugel, M.M.1    Greijer, A.E.2    Shvarts, A.3    Van Der Groep, P.4    Van Berkel, M.5    Aarbodem, Y.6
  • 119
    • 4043181214 scopus 로고    scopus 로고
    • Cancer genes and the pathways they control
    • Vogelstein B, Kinzler KW. (2004). Cancer genes and the pathways they control. Nat Med 10: 789-799.
    • (2004) Nat Med , vol.10 , pp. 789-799
    • Vogelstein, B.1    Kinzler, K.W.2
  • 121
    • 0028816847 scopus 로고
    • Purification and characterization of hypoxia-inducible factor 1
    • Wang GL, Semenza GL. (1995). Purification and characterization of hypoxia-inducible factor 1. J Biol Chem 270: 1230-1237.
    • (1995) J Biol Chem , vol.270 , pp. 1230-1237
    • Wang, G.L.1    Semenza, G.L.2
  • 122
    • 67249148163 scopus 로고    scopus 로고
    • Targeted systemic delivery of a therapeutic siRNA with a multi-functional carrier controls tumor proliferation in mice
    • Wang XL, Xu R, Wu X, Gillespie D, Jensen R, Lu ZR. (2009). Targeted systemic delivery of a therapeutic siRNA with a multi-functional carrier controls tumor proliferation in mice. Mol Pharm 6: 738-746.
    • (2009) Mol Pharm , vol.6 , pp. 738-746
    • Wang, X.L.1    Xu, R.2    Wu, X.3    Gillespie, D.4    Jensen, R.5    Lu, Z.R.6
  • 123
    • 46949094778 scopus 로고    scopus 로고
    • Hypoxia-inducible factor 1a is closely linked to an aggressive phenotype in breast cancer
    • Yamamoto Y, Ibusuki M, Okumura Y, Kawasoe T, Kai K, Iyama K, et al. (2008). Hypoxia-inducible factor 1a is closely linked to an aggressive phenotype in breast cancer. Breast Cancer Res Treat 110: 465-475.
    • (2008) Breast Cancer Res Treat , vol.110 , pp. 465-475
    • Yamamoto, Y.1    Ibusuki, M.2    Okumura, Y.3    Kawasoe, T.4    Kai, K.5    Iyama, K.6
  • 124
    • 7544220200 scopus 로고    scopus 로고
    • The carboxy-terminus of the hepatitis B virus X protein is necessary and sufficient for the activation of hypoxia-inducible factor-1a
    • Yoo YG, Cho S, Park S, Lee MO. (2004). The carboxy-terminus of the hepatitis B virus X protein is necessary and sufficient for the activation of hypoxia-inducible factor-1a. FEBS Lett 577: 121-126.
    • (2004) FEBS Lett , vol.577 , pp. 121-126
    • Yoo, Y.G.1    Cho, S.2    Park, S.3    Lee, M.O.4
  • 126
    • 58149374576 scopus 로고    scopus 로고
    • Digoxin and other cardiac glycosides inhibit HIF-1a synthesis and block tumor growth
    • Zhang H, Qian DZ, Tan YS, Lee K, Gao P, Ren YR, et al. (2008). Digoxin and other cardiac glycosides inhibit HIF-1a synthesis and block tumor growth. Proc Natl Acad Sci USA 105: 19579-19586.
    • (2008) Proc Natl Acad Sci USA , vol.105 , pp. 19579-19586
    • Zhang, H.1    Qian, D.Z.2    Tan, Y.S.3    Lee, K.4    Gao, P.5    Ren, Y.R.6
  • 127
    • 64849098267 scopus 로고    scopus 로고
    • Glioma-derived mutations in IDH1 dominantly inhibit IDH1 catalytic activity and induce HIF-1a
    • Zhao S, Lin Y, Xu W, Jiang W, Zha Z, Wang P, et al. (2009). Glioma-derived mutations in IDH1 dominantly inhibit IDH1 catalytic activity and induce HIF-1a. Science 324: 261-265.
    • (2009) Science , vol.324 , pp. 261-265
    • Zhao, S.1    Lin, Y.2    Xu, W.3    Jiang, W.4    Zha, Z.5    Wang, P.6
  • 128
    • 0034654174 scopus 로고    scopus 로고
    • Modulation of hypoxia-inducible factor 1a expression by the epidermal growth factor/phosphatidylinositol 3-kinase/PTEN/AKT/FRAP pathway in human prostate cancer cells: Implications for tumor angiogenesis and therapeutics
    • Zhong H, Chiles K, Feldser D, Laughner E, Hanrahan C, Georgescu MM, et al. (2000). Modulation of hypoxia-inducible factor 1a expression by the epidermal growth factor/phosphatidylinositol 3-kinase/PTEN/AKT/FRAP pathway in human prostate cancer cells: implications for tumor angiogenesis and therapeutics. Cancer Res 60: 1541-1545.
    • (2000) Cancer Res , vol.60 , pp. 1541-1545
    • Zhong, H.1    Chiles, K.2    Feldser, D.3    Laughner, E.4    Hanrahan, C.5    Georgescu, M.M.6
  • 129
    • 0033571682 scopus 로고    scopus 로고
    • Overexpression of hypoxia-inducible factor 1a in common human cancers and their metastases
    • Zhong H, De Marzo AM, Laughner E, Lim M, Hilton DA, Zagzag D, et al. (1999). Overexpression of hypoxia-inducible factor 1a in common human cancers and their metastases. Cancer Res 59: 5830-5835.
    • (1999) Cancer Res , vol.59 , pp. 5830-5835
    • Zhong, H.1    De Marzo, A.M.2    Laughner, E.3    Lim, M.4    Hilton, D.A.5    Zagzag, D.6


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