Keap1-null mutation leads to postnatal lethality due to constitutive Nrf2 activation

Nature Genetics

Volumn 35, Issue 3, 2003, Pages 238-245

  Wakabayashi, Nobunao ^a   Itoh, Ken ^a   Wakabayashi, Junko ^a   Motohashi, Hozumi ^a   Noda, Shuhei ^a   Takahashi, Satoru ^a   Imakado, Sumihisa ^a   Kotsuji, Tomoe ^a   Otsuka, Fujio ^a   Roop, Dennis R ^b   Harada, Takanori ^c   Engel, James Douglas ^d   Yamamoto, Masayuki ^a  

^a UNIVERSITY OF TSUKUBA   (Japan)

^b BAYLOR COLLEGE OF MEDICINE   (United States)

^c INSTITUTE OF ENVIRONMENTAL TOXICOLOGY   (Japan)

^d UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR NRF2; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL PROTECTION; CONTROLLED STUDY; EFFECTOR CELL; EMBRYO; GENE; GENE ACTIVATION; GENE REPRESSION; GENE TARGETING; HYPERKERATOSIS; KEAP 1 GENE; LETHALITY; MALNUTRITION; MECHANICAL STRESS; MOUSE; NEWBORN; NONHUMAN; NULL ALLELE; OXIDATIVE STRESS; POSTNATAL DEVELOPMENT; PRIORITY JOURNAL; SQUAMOUS EPITHELIUM; TRANSCRIPTION REGULATION; XENOBIOTIC METABOLISM;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ANIMALS; CARRIER PROTEINS; CYTOSKELETAL PROTEINS; DNA-BINDING PROTEINS; ESOPHAGEAL DISEASES; GENES, LETHAL; KERATINS; MEMBRANE PROTEINS; MICE; MICE, KNOCKOUT; MUTATION; NF-E2-RELATED FACTOR 2; STOMACH DISEASES; TRANS-ACTIVATORS; WEANING;

ANIMALIA;

EID: 0242329881     PISSN: 10614036     EISSN: None     Source Type: Journal    
DOI: 10.1038/ng1248     Document Type: Article

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