-
1
-
-
60449094498
-
Heart disease and stroke statistics-2009 update: A report from the American Heart Association Statistics Committee and Stroke Statistics Subcommittee
-
Lloyd-Jones, D. et al. Heart disease and stroke statistics-2009 update: a report from the American Heart Association Statistics Committee and Stroke Statistics Subcommittee. Circulation 119, e21-e181 (2009)
-
(2009)
Circulation
, vol.119
-
-
Lloyd-Jones, D.1
-
2
-
-
80455128548
-
Insulin resistance, hyperglycemia, and atherosclerosis
-
Bornfeldt, K.E. & Tabas, I. Insulin resistance, hyperglycemia, and atherosclerosis. Cell Metab. 14, 575-585 (2011)
-
(2011)
Cell Metab.
, vol.14
, pp. 575-585
-
-
Bornfeldt, K.E.1
Tabas, I.2
-
3
-
-
77952887766
-
The predicted effects of chronic obesity in middle age on medicare costs and mortality
-
Cai, L., Lubitz, J., Flegal, K.M. & Pamuk, E.R. The predicted effects of chronic obesity in middle age on medicare costs and mortality. Med. Care 48, 510-517 (2010)
-
(2010)
Med. Care
, vol.48
, pp. 510-517
-
-
Cai, L.1
Lubitz, J.2
Flegal, K.M.3
Pamuk, E.R.4
-
4
-
-
77956261805
-
The economic impact of obesity in the United States
-
Hammond, R.A. & Levine, R. The economic impact of obesity in the United States. Diabetes Metab. Syndr. Obes. 3, 285-295 (2010)
-
(2010)
Diabetes Metab. Syndr. Obes.
, vol.3
, pp. 285-295
-
-
Hammond, R.A.1
Levine, R.2
-
5
-
-
20144363712
-
A potential decline in life expectancy in the United States in the 21st century
-
Olshansky, S.J. et al. A potential decline in life expectancy in the United States in the 21st century. N. Engl. J. Med. 352, 1138-1145 (2005)
-
(2005)
N. Engl. J. Med.
, vol.352
, pp. 1138-1145
-
-
Olshansky, S.J.1
-
6
-
-
84874376872
-
Uncoupling protein 1 of brown adipocytes, the only uncoupler: A historical perspective
-
Ricquier, D. Uncoupling protein 1 of brown adipocytes, the only uncoupler: a historical perspective. Front. Endocrinol. (Lausanne) 2, 85 (2012)
-
(2012)
Front. Endocrinol. (Lausanne)
, vol.2
, pp. 85
-
-
Ricquier, D.1
-
7
-
-
84859410604
-
The adipose organ of obesity-prone C57BL/6J mice is composed of mixed white and brown adipocytes
-
Vitali, A. et al. The adipose organ of obesity-prone C57BL/6J mice is composed of mixed white and brown adipocytes. J. Lipid Res. 53, 619-629 (2012)
-
(2012)
J. Lipid Res.
, vol.53
, pp. 619-629
-
-
Vitali, A.1
-
8
-
-
50049122271
-
PRDM16 controls a brown fat/skeletal muscle switch
-
Seale, P. et al. PRDM16 controls a brown fat/skeletal muscle switch. Nature 454, 961-967 (2008)
-
(2008)
Nature
, vol.454
, pp. 961-967
-
-
Seale, P.1
-
9
-
-
33845977987
-
Genetic variability affects the development of brown adipocytes in white fat but not in interscapular brown fat
-
Xue, B. et al. Genetic variability affects the development of brown adipocytes in white fat but not in interscapular brown fat. J. Lipid Res. 48, 41-51 (2007)
-
(2007)
J. Lipid Res.
, vol.48
, pp. 41-51
-
-
Xue, B.1
-
10
-
-
84864287504
-
Beige adipocytes are a distinct type of thermogenic fat cell in mouse and human
-
Wu, J. et al. Beige adipocytes are a distinct type of thermogenic fat cell in mouse and human. Cell 150, 366-376 (2012)
-
(2012)
Cell
, vol.150
, pp. 366-376
-
-
Wu, J.1
-
11
-
-
84869233588
-
Human BAT possesses molecular signatures that resemble beige/brite cells
-
Sharp, L.Z. et al. Human BAT possesses molecular signatures that resemble beige/brite cells. PLoS ONE 7, e49452 (2012)
-
(2012)
PLoS ONE
, vol.7
-
-
Sharp, L.Z.1
-
12
-
-
77950226740
-
Chronic peroxisome proliferator-activated receptor γ (PPARγ) activation of epididymally derived white adipocyte cultures reveals a population of thermogenically competent, UCP1-containing adipocytes molecularly distinct from classic brown adipocytes
-
Petrovic, N. et al. Chronic peroxisome proliferator-activated receptor γ (PPARγ) activation of epididymally derived white adipocyte cultures reveals a population of thermogenically competent, UCP1-containing adipocytes molecularly distinct from classic brown adipocytes. J. Biol. Chem. 285, 7153-7164 (2010)
-
(2010)
J. Biol. Chem.
, vol.285
, pp. 7153-7164
-
-
Petrovic, N.1
-
13
-
-
84873518501
-
Adaptive thermogenesis in adipocytes: Is beige the new brown?
-
Wu, J., Cohen, P. & Spiegelman, B.M. Adaptive thermogenesis in adipocytes: is beige the new brown? Genes Dev. 27, 234-250 (2013)
-
(2013)
Genes Dev.
, vol.27
, pp. 234-250
-
-
Wu, J.1
Cohen, P.2
Spiegelman, B.M.3
-
14
-
-
0029143743
-
Functional assessment of white and brown adipocyte development and energy metabolism in cell culture. Dissociation of terminal differentiation and thermogenesis in brown adipocytes
-
Klaus, S., Ely, M., Encke, D. & Heldmaier, G. Functional assessment of white and brown adipocyte development and energy metabolism in cell culture. Dissociation of terminal differentiation and thermogenesis in brown adipocytes. J. Cell Sci. 108, 3171-3180 (1995)
-
(1995)
J. Cell Sci.
, vol.108
, pp. 3171-3180
-
-
Klaus, S.1
Ely, M.2
Encke, D.3
Heldmaier, G.4
-
15
-
-
17944377509
-
FOXC2 is a winged helix gene that counteracts obesity, hypertriglyceridemia, and diet-induced insulin resistance
-
Cederberg, A. et al. FOXC2 is a winged helix gene that counteracts obesity, hypertriglyceridemia, and diet-induced insulin resistance. Cell 106, 563-573 (2001)
-
(2001)
Cell
, vol.106
, pp. 563-573
-
-
Cederberg, A.1
-
16
-
-
78650945931
-
Prdm16 determines the thermogenic program of subcutaneous white adipose tissue in mice
-
Seale, P. et al. Prdm16 determines the thermogenic program of subcutaneous white adipose tissue in mice. J. Clin. Invest. 121, 96-105 (2011)
-
(2011)
J. Clin. Invest.
, vol.121
, pp. 96-105
-
-
Seale, P.1
-
17
-
-
0028865142
-
Expression of the mitochondrial uncoupling protein gene from the aP2 gene promoter prevents genetic obesity
-
Kopecky, J., Clarke, G., Enerback, S., Spiegelman, B. & Kozak, L.P. Expression of the mitochondrial uncoupling protein gene from the aP2 gene promoter prevents genetic obesity. J. Clin. Invest. 96, 2914-2923 (1995)
-
(1995)
J. Clin. Invest.
, vol.96
, pp. 2914-2923
-
-
Kopecky, J.1
Clarke, G.2
Enerback, S.3
Spiegelman, B.4
Kozak, L.P.5
-
18
-
-
64349105205
-
Identification and importance of brown adipose tissue in adult humans
-
Cypess, A.M. et al. Identification and importance of brown adipose tissue in adult humans. N. Engl. J. Med. 360, 1509-1517 (2009)
-
(2009)
N. Engl. J. Med.
, vol.360
, pp. 1509-1517
-
-
Cypess, A.M.1
-
20
-
-
67650242165
-
High incidence of metabolically active brown adipose tissue in healthy adult humans: Effects of cold exposure and adiposity
-
Saito, M. et al. High incidence of metabolically active brown adipose tissue in healthy adult humans: effects of cold exposure and adiposity. Diabetes 58, 1526-1531 (2009)
-
(2009)
Diabetes
, vol.58
, pp. 1526-1531
-
-
Saito, M.1
-
21
-
-
64349095231
-
Cold-activated brown adipose tissue in healthy men
-
van Marken Lichtenbelt, W.D. et al. Cold-activated brown adipose tissue in healthy men. N. Engl. J. Med. 360, 1500-1508 (2009)
-
(2009)
N. Engl. J. Med.
, vol.360
, pp. 1500-1508
-
-
Van Marken Lichtenbelt, W.D.1
-
22
-
-
64349123664
-
Functional brown adipose tissue in healthy adults
-
Virtanen, K.A. et al. Functional brown adipose tissue in healthy adults. N. Engl. J. Med. 360, 1518-1525 (2009)
-
(2009)
N. Engl. J. Med.
, vol.360
, pp. 1518-1525
-
-
Virtanen, K.A.1
-
23
-
-
0035502402
-
Mitochondrial uncoupling as a target for drug development for the treatment of obesity
-
Harper, J.A., Dickinson, K. & Brand, M.D. Mitochondrial uncoupling as a target for drug development for the treatment of obesity. Obes. Rev. 2, 255-265 (2001)
-
(2001)
Obes. Rev.
, vol.2
, pp. 255-265
-
-
Harper, J.A.1
Dickinson, K.2
Brand, M.D.3
-
24
-
-
0015332110
-
The distribution of brown adipose tissue in the human
-
Heaton, J.M. The distribution of brown adipose tissue in the human. J. Anat. 112, 35-39 (1972)
-
(1972)
J. Anat.
, vol.112
, pp. 35-39
-
-
Heaton, J.M.1
-
25
-
-
84877340732
-
Evidence for two types of brown adipose tissue in humans
-
Lidell, M.E. et al. Evidence for two types of brown adipose tissue in humans. Nat. Med. b, 631-634 (2013)
-
(2013)
Nat. Med. B
, pp. 631-634
-
-
Lidell, M.E.1
-
26
-
-
84865792944
-
PTEN loss in the Myf5 lineage redistributes body fat and reveals subsets of white adipocytes that arise from Myf5 precursors
-
Sanchez-Gurmaches, J. et al. PTEN loss in the Myf5 lineage redistributes body fat and reveals subsets of white adipocytes that arise from Myf5 precursors. Cell Metab. 16, 348-362 (2012)
-
(2012)
Cell Metab.
, vol.16
, pp. 348-363
-
-
Sanchez-Gurmaches, J.1
-
27
-
-
77954741222
-
Inducible lineage tracing of Pax7-descendant cells reveals embryonic origin of adult satellite cells
-
Lepper, C. & Fan, C.M. Inducible lineage tracing of Pax7-descendant cells reveals embryonic origin of adult satellite cells. Genesis 48, 424-436 (2010)
-
(2010)
Genesis
, vol.48
, pp. 424-436
-
-
Lepper, C.1
Fan, C.M.2
-
28
-
-
34248372084
-
Myogenic gene expression signature establishes that brown and white adipocytes originate from distinct cell lineages
-
Timmons, J.A. et al. Myogenic gene expression signature establishes that brown and white adipocytes originate from distinct cell lineages. Proc. Natl. Acad. Sci. USA 104, 4401-4406 (2007)
-
(2007)
Proc. Natl. Acad. Sci. USA
, vol.104
, pp. 4401-4406
-
-
Timmons, J.A.1
-
29
-
-
70349490370
-
Proteome differences between brown and white fat mitochondria reveal specialized metabolic functions
-
Forner, F. et al. Proteome differences between brown and white fat mitochondria reveal specialized metabolic functions. Cell Metab. 10, 324-335 (2009)
-
(2009)
Cell Metab.
, vol.10
, pp. 324-335
-
-
Forner, F.1
-
30
-
-
0033825933
-
Multilocular fat cells in WAT of CL-316243-treated rats derive directly from white adipocytes
-
Himms-Hagen, J. et al. Multilocular fat cells in WAT of CL-316243-treated rats derive directly from white adipocytes. Am. J. Physiol. Cell Physiol. 279, C670-C681 (2000)
-
(2000)
Am. J. Physiol. Cell Physiol.
, vol.279
-
-
Himms-Hagen, J.1
-
31
-
-
84887502374
-
Tracking adipogenesis during white adipose tissue development, expansion and regeneration
-
doi:10.1038/nm.3324 (1 September
-
Wang, Q.A., Tao, C., Gupta, R.K. & Scherer, P.E. Tracking adipogenesis during white adipose tissue development, expansion and regeneration. Nat. Med. advance online publication, doi:10.1038/nm.3324 (1 September 2013)
-
(2013)
Nat. Med. Advance Online Publication
-
-
Wang, Q.A.1
Tao, C.2
Gupta, R.K.3
Scherer, P.E.4
-
32
-
-
84878525220
-
Bi-directional interconversion of brite and white adipocytes
-
Rosenwald, M., Perdikari, A., Rulicke, T. & Wolfrum, C. Bi-directional interconversion of brite and white adipocytes. Nat. Cell Biol. 15, 659-667 (2013)
-
(2013)
Nat. Cell Biol.
, vol.15
, pp. 659-667
-
-
Rosenwald, M.1
Perdikari, A.2
Rulicke, T.3
Wolfrum, C.4
-
33
-
-
77952623888
-
The emergence of cold-induced brown adipocytes in mouse white fat depots is determined predominantly by white to brown adipocyte transdifferentiation
-
Barbatelli, G. et al. The emergence of cold-induced brown adipocytes in mouse white fat depots is determined predominantly by white to brown adipocyte transdifferentiation. Am. J. Physiol. Endocrinol. Metab. 298, E1244-E1253 (2010)
-
(2010)
Am. J. Physiol. Endocrinol. Metab.
, vol.298
-
-
Barbatelli, G.1
-
34
-
-
84859465056
-
In vivo identification of bipotential adipocyte progenitors recruited by β3-adrenoceptor activation and high-fat feeding
-
Lee, Y.H., Petkova, A.P., Mottillo, E.P. & Granneman, J.G. In vivo identification of bipotential adipocyte progenitors recruited by β3-adrenoceptor activation and high-fat feeding. Cell Metab. 15, 480-491 (2012)
-
(2012)
Cell Metab.
, vol.15
, pp. 480-491
-
-
Lee, Y.H.1
Petkova, A.P.2
Mottillo, E.P.3
Granneman, J.G.4
-
35
-
-
84874657953
-
Characterization of the adipocyte cellular lineage in vivo
-
Berry, R. & Rodeheffer, M.S. Characterization of the adipocyte cellular lineage in vivo. Nat. Cell Biol. 15, 302-308 (2013)
-
(2013)
Nat. Cell Biol.
, vol.15
, pp. 302-308
-
-
Berry, R.1
Rodeheffer, M.S.2
-
36
-
-
70350434580
-
Human multipotent adipose-derived stem cells differentiate into functional brown adipocytes
-
Elabd, C. et al. Human multipotent adipose-derived stem cells differentiate into functional brown adipocytes. Stem Cells 27, 2753-2760 (2009)
-
(2009)
Stem Cells
, vol.27
, pp. 2753-2760
-
-
Elabd, C.1
-
37
-
-
84877263632
-
A classical brown adipose tissue mRNA signature partly overlaps with brite in the supraclavicular region of adult humans
-
Jespersen, N.Z. et al. A classical brown adipose tissue mRNA signature partly overlaps with brite in the supraclavicular region of adult humans. Cell Metab. 17, 798-805 (2013)
-
(2013)
Cell Metab.
, vol.17
, pp. 798-805
-
-
Jespersen, N.Z.1
-
38
-
-
84877331455
-
Anatomical localization, gene expression profiling and functional characterization of adult human neck brown fat
-
Cypess, A.M. et al. Anatomical localization, gene expression profiling and functional characterization of adult human neck brown fat. Nat. Med. 19, 635-639 (2013)
-
(2013)
Nat. Med.
, vol.19
, pp. 635-639
-
-
Cypess, A.M.1
-
39
-
-
34347326271
-
Transcriptional control of brown fat determination by PRDM16
-
Seale, P. et al. Transcriptional control of brown fat determination by PRDM16. Cell Metab. 6, 38-54 (2007)
-
(2007)
Cell Metab.
, vol.6
, pp. 38-54
-
-
Seale, P.1
-
40
-
-
79961233289
-
High prevalence of brown adipose tissue in adult humans
-
Lee, P. et al. High prevalence of brown adipose tissue in adult humans. J. Clin. Endocrinol. Metab. 96, 2450-2455 (2011)
-
(2011)
J. Clin. Endocrinol. Metab.
, vol.96
, pp. 2450-2455
-
-
Lee, P.1
-
41
-
-
83355163350
-
Peroxisome proliferator-activated receptor α (PPARα) induces PPARγ coactivator 1α (PGC-1α) gene expression and contributes to thermogenic activation of brown fat: Involvement of PRDM16
-
Hondares, E. et al. Peroxisome proliferator-activated receptor α (PPARα) induces PPARγ coactivator 1α (PGC-1α) gene expression and contributes to thermogenic activation of brown fat: involvement of PRDM16. J. Biol. Chem. 286, 43112-43122 (2011)
-
(2011)
J. Biol. Chem.
, vol.286
, pp. 43112-43122
-
-
Hondares, E.1
-
42
-
-
69349088117
-
Initiation of myoblast to brown fat switch by a PRDM16-C/EBP-β transcriptional complex
-
Kajimura, S. et al. Initiation of myoblast to brown fat switch by a PRDM16-C/EBP-β transcriptional complex. Nature 460, 1154-1158 (2009)
-
(2009)
Nature
, vol.460
, pp. 1154-1158
-
-
Kajimura, S.1
-
43
-
-
84858039282
-
PPARγ agonists induce a white-to-brown fat conversion through stabilization of PRDM16 protein
-
Ohno, H., Shinoda, K., Spiegelman, B.M. & Kajimura, S. PPARγ agonists induce a white-to-brown fat conversion through stabilization of PRDM16 protein. Cell Metab. 15, 395-404 (2012)
-
(2012)
Cell Metab.
, vol.15
, pp. 395-404
-
-
Ohno, H.1
Shinoda, K.2
Spiegelman, B.M.3
Kajimura, S.4
-
44
-
-
50049127055
-
New role of bone morphogenetic protein 7 in brown adipogenesis and energy expenditure
-
Tseng, Y.H. et al. New role of bone morphogenetic protein 7 in brown adipogenesis and energy expenditure. Nature 454, 1000-1004 (2008)
-
(2008)
Nature
, vol.454
, pp. 1000-1004
-
-
Tseng, Y.H.1
-
45
-
-
78651094465
-
Identification of inducible brown adipocyte progenitors residing in skeletal muscle and white fat
-
Schulz, T.J. et al. Identification of inducible brown adipocyte progenitors residing in skeletal muscle and white fat. Proc. Natl. Acad. Sci. USA 108, 143-148 (2011)
-
(2011)
Proc. Natl. Acad. Sci. USA
, vol.108
, pp. 143-148
-
-
Schulz, T.J.1
-
46
-
-
84875367849
-
Brown-fat paucity due to impaired BMP signalling induces compensatory browning of white fat
-
Schulz, T.J. et al. Brown-fat paucity due to impaired BMP signalling induces compensatory browning of white fat. Nature 495, 379-383 (2013)
-
(2013)
Nature
, vol.495
, pp. 379-383
-
-
Schulz, T.J.1
-
47
-
-
84864615516
-
Brown remodeling of white adipose tissue by SirT1-dependent deacetylation of Pparγ
-
Qiang, L. et al. Brown remodeling of white adipose tissue by SirT1-dependent deacetylation of Pparγ. Cell 150, 620-632 (2012)
-
(2012)
Cell
, vol.150
, pp. 620-632
-
-
Qiang, L.1
-
48
-
-
84870595878
-
MyomiR-133 regulates brown fat differentiation through Prdm16
-
Trajkovski, M., Ahmed, K., Esau, C.C. & Stoffel, M. MyomiR-133 regulates brown fat differentiation through Prdm16. Nat. Cell Biol. 14, 1330-1335 (2012)
-
(2012)
Nat. Cell Biol.
, vol.14
, pp. 1330-1335
-
-
Trajkovski, M.1
Ahmed, K.2
Esau, C.C.3
Stoffel, M.4
-
49
-
-
84880812042
-
MiR-133a regulates adipocyte browning in vivo
-
Liu, W. et al. miR-133a regulates adipocyte browning in vivo. PLoS Genet. 9, e1003626 (2013)
-
(2013)
PLoS Genet.
, vol.9
-
-
Liu, W.1
-
50
-
-
84873327762
-
MicroRNA-133 controls brown adipose determination in skeletal muscle satellite cells by targeting Prdm16
-
Yin, H. et al. MicroRNA-133 controls brown adipose determination in skeletal muscle satellite cells by targeting Prdm16. Cell Metab. 17, 210-224 (2013)
-
(2013)
Cell Metab.
, vol.17
, pp. 210-224
-
-
Yin, H.1
-
51
-
-
0018646453
-
A role for brown adipose tissue in diet-induced thermogenesis
-
Rothwell, N.J. & Stock, M.J. A role for brown adipose tissue in diet-induced thermogenesis. Nature 281, 31-35 (1979)
-
(1979)
Nature
, vol.281
, pp. 31-35
-
-
Rothwell, N.J.1
Stock, M.J.2
-
52
-
-
0027731309
-
Development of obesity in transgenic mice after genetic ablation of brown adipose tissue
-
Lowell, B.B. et al. Development of obesity in transgenic mice after genetic ablation of brown adipose tissue. Nature 366, 740-742 (1993)
-
(1993)
Nature
, vol.366
, pp. 740-742
-
-
Lowell, B.B.1
-
53
-
-
1842409029
-
Mice lacking mitochondrial uncoupling protein are cold-sensitive but not obese
-
Enerbäck, S. et al. Mice lacking mitochondrial uncoupling protein are cold-sensitive but not obese. Nature 387, 90-94 (1997)
-
(1997)
Nature
, vol.387
, pp. 90-94
-
-
Enerbäck, S.1
-
54
-
-
58749091645
-
UCP1 ablation induces obesity and abolishes diet-induced thermogenesis in mice exempt from thermal stress by living at thermoneutrality
-
Feldmann, H.M., Golozoubova, V., Cannon, B. & Nedergaard, J. UCP1 ablation induces obesity and abolishes diet-induced thermogenesis in mice exempt from thermal stress by living at thermoneutrality. Cell Metab. 9, 203-209 (2009)
-
(2009)
Cell Metab.
, vol.9
, pp. 203-209
-
-
Feldmann, H.M.1
Golozoubova, V.2
Cannon, B.3
Nedergaard, J.4
-
55
-
-
79953173286
-
Inactivation of the mitochondrial carrier SLC25A25 (ATP-Mg2+/Pi transporter) reduces physical endurance and metabolic efficiency in mice
-
Anunciado-Koza, R.P. et al. Inactivation of the mitochondrial carrier SLC25A25 (ATP-Mg2+/Pi transporter) reduces physical endurance and metabolic efficiency in mice. J. Biol. Chem. 286, 11659-11671 (2011)
-
(2011)
J. Biol. Chem.
, vol.286
, pp. 11659-11671
-
-
Anunciado-Koza, R.P.1
-
56
-
-
84870265848
-
Sarcolipin is a newly identified regulator of muscle-based thermogenesis in mammals
-
Bal, N.C. et al. Sarcolipin is a newly identified regulator of muscle-based thermogenesis in mammals. Nat. Med. 18, 1575-1579 (2012)
-
(2012)
Nat. Med.
, vol.18
, pp. 1575-1579
-
-
Bal, N.C.1
-
57
-
-
23844474515
-
UCP1 deficiency increases susceptibility to diet-induced obesity with age
-
Kontani, Y. et al. UCP1 deficiency increases susceptibility to diet-induced obesity with age. Aging Cell 4, 147-155 (2005)
-
(2005)
Aging Cell
, vol.4
, pp. 147-155
-
-
Kontani, Y.1
-
58
-
-
0024205125
-
Absence of increased oxygen consumption in brown adipose tissue of rats exhibiting "cafeteria" diet-induced thermogenesis
-
Ma, S.W., Foster, D.O., Nadeau, B.E. & Triandafillou, J. Absence of increased oxygen consumption in brown adipose tissue of rats exhibiting "cafeteria" diet-induced thermogenesis. Can. J. Physiol. Pharmacol. 66, 1347-1354 (1988)
-
(1988)
Can. J. Physiol. Pharmacol.
, vol.66
, pp. 1347-1354
-
-
Ma, S.W.1
Foster, D.O.2
Nadeau, B.E.3
Triandafillou, J.4
-
60
-
-
84862776702
-
A PGC1-α-dependent myokine that drives brown-fat-like development of white fat and thermogenesis
-
Bostr?m, P. et al. A PGC1-α-dependent myokine that drives brown-fat-like development of white fat and thermogenesis. Nature 481, 463-468 (2012)
-
(2012)
Nature
, vol.481
, pp. 463-468
-
-
Boström, P.1
-
61
-
-
0031025546
-
Strain-specific response to β3-adrenergic receptor agonist treatment of diet-induced obesity in mice
-
Collins, S., Daniel, K.W., Petro, A.E. & Surwit, R.S. Strain-specific response to β3-adrenergic receptor agonist treatment of diet-induced obesity in mice. Endocrinology 138, 405-413 (1997)
-
(1997)
Endocrinology
, vol.138
, pp. 405-413
-
-
Collins, S.1
Daniel, K.W.2
Petro, A.E.3
Surwit, R.S.4
-
62
-
-
0032528169
-
Emergence of brown adipocytes in white fat in mice is under genetic control. Effects on body weight and adiposity
-
Guerra, C., Koza, R.A., Yamashita, H., Walsh, K. & Kozak, L.P. Emergence of brown adipocytes in white fat in mice is under genetic control. Effects on body weight and adiposity. J. Clin. Invest. 102, 412-420 (1998)
-
(1998)
J. Clin. Invest.
, vol.102
, pp. 412-420
-
-
Guerra, C.1
Koza, R.A.2
Yamashita, H.3
Walsh, K.4
Kozak, L.P.5
-
63
-
-
84873854027
-
Brown adipose tissue regulates glucose homeostasis and insulin sensitivity
-
Stanford, K.I. et al. Brown adipose tissue regulates glucose homeostasis and insulin sensitivity. J. Clin. Invest. 123, 215-223 (2013)
-
(2013)
J. Clin. Invest.
, vol.123
, pp. 215-223
-
-
Stanford, K.I.1
-
64
-
-
84863229962
-
Cardiac natriuretic peptides act via p38 MAPK to induce the brown fat thermogenic program in mouse and human adipocytes
-
Bordicchia, M. et al. Cardiac natriuretic peptides act via p38 MAPK to induce the brown fat thermogenic program in mouse and human adipocytes. J. Clin. Invest. 122, 1022-1036 (2012)
-
(2012)
J. Clin. Invest.
, vol.122
, pp. 1022-1036
-
-
Bordicchia, M.1
-
65
-
-
79751503329
-
Brown adipose tissue activity controls triglyceride clearance
-
Bartelt, A. et al. Brown adipose tissue activity controls triglyceride clearance. Nat. Med. 17, 200-205 (2011)
-
(2011)
Nat. Med.
, vol.17
, pp. 200-205
-
-
Bartelt, A.1
-
66
-
-
84865489581
-
Loss of perivascular adipose tissue on peroxisome proliferator-activated receptor-γ deletion in smooth muscle cells impairs intravascular thermoregulation and enhances atherosclerosis
-
Chang, L. et al. Loss of perivascular adipose tissue on peroxisome proliferator-activated receptor-γ deletion in smooth muscle cells impairs intravascular thermoregulation and enhances atherosclerosis. Circulation 126, 1067-1078 (2012)
-
(2012)
Circulation
, vol.126
, pp. 1067-1078
-
-
Chang, L.1
-
67
-
-
84873038752
-
Central control of brown adipose tissue thermogenesis
-
Morrison, S.F., Madden, C.J. & Tupone, D. Central control of brown adipose tissue thermogenesis. Front. Endocrinol. (Lausanne) 3, 5 (2012)
-
(2012)
Front. Endocrinol. (Lausanne)
, vol.3
, pp. 5
-
-
Morrison, S.F.1
Madden, C.J.2
Tupone, D.3
-
68
-
-
82555186955
-
Alternatively activated macrophages produce catecholamines to sustain adaptive thermogenesis
-
Nguyen, K.D. et al. Alternatively activated macrophages produce catecholamines to sustain adaptive thermogenesis. Nature 480, 104-108 (2011)
-
(2011)
Nature
, vol.480
, pp. 104-108
-
-
Nguyen, K.D.1
-
69
-
-
84874413612
-
β-adrenoceptor signaling networks in adipocytes for recruiting stored fat and energy expenditure
-
Collins, S. β-adrenoceptor signaling networks in adipocytes for recruiting stored fat and energy expenditure. Front. Endocrinol. (Lausanne) 2, 102 (2012)
-
(2012)
Front. Endocrinol. (Lausanne)
, vol.2
, pp. 102
-
-
Collins, S.1
-
70
-
-
0000143140
-
Brown adipose tissue hyperplasia: A fundamental mechanism of adaptation to cold and hyperphagia
-
Bukowiecki, L., Collet, A.J., Follea, N., Guay, G. & Jahjah, L. Brown adipose tissue hyperplasia: a fundamental mechanism of adaptation to cold and hyperphagia. Am. J. Physiol. 242, E353-E359 (1982)
-
(1982)
Am. J. Physiol.
, vol.242
-
-
Bukowiecki, L.1
Collet, A.J.2
Follea, N.3
Guay, G.4
Jahjah, L.5
-
71
-
-
0022970811
-
Selective loss of uncoupling protein from mitochondria of surgically denervated brown adipose tissue of cold-acclimated mice
-
Desautels, M., Dulos, R.A. & Mozaffari, B. Selective loss of uncoupling protein from mitochondria of surgically denervated brown adipose tissue of cold-acclimated mice. Biochem. Cell Biol. 64, 1125-1134 (1986)
-
(1986)
Biochem. Cell Biol.
, vol.64
, pp. 1125-1134
-
-
Desautels, M.1
Dulos, R.A.2
Mozaffari, B.3
-
72
-
-
0347989317
-
Brown adipose tissue: Function and physiological significance
-
Cannon, B. & Nedergaard, J. Brown adipose tissue: function and physiological significance. Physiol. Rev. 84, 277-359 (2004)
-
(2004)
Physiol. Rev.
, vol.84
, pp. 277-359
-
-
Cannon, B.1
Nedergaard, J.2
-
73
-
-
33745615380
-
The physiological regulation of uncoupling proteins
-
Nicholls, D.G. The physiological regulation of uncoupling proteins. Biochim. Biophys. Acta 1757, 459-466 (2006)
-
(2006)
Biochim. Biophys. Acta
, vol.1757
, pp. 459-466
-
-
Nicholls, D.G.1
-
74
-
-
84867564026
-
Mechanism of fatty-acid-dependent UCP1 uncoupling in brown fat mitochondria
-
Fedorenko, A., Lishko, P.V. & Kirichok, Y. Mechanism of fatty-acid-dependent UCP1 uncoupling in brown fat mitochondria. Cell 151, 400-413 (2012)
-
(2012)
Cell
, vol.151
, pp. 400-413
-
-
Fedorenko, A.1
Lishko, P.V.2
Kirichok, Y.3
-
75
-
-
84862329994
-
Functional characterization of UCP1 in mammalian HEK293 cells excludes mitochondrial uncoupling artefacts and reveals no contribution to basal proton leak
-
Jastroch, M., Hirschberg, V. & Klingenspor, M. Functional characterization of UCP1 in mammalian HEK293 cells excludes mitochondrial uncoupling artefacts and reveals no contribution to basal proton leak. Biochim. Biophys. Acta 1817, 1660-1670 (2012)
-
(2012)
Biochim. Biophys. Acta
, vol.1817
, pp. 1660-1670
-
-
Jastroch, M.1
Hirschberg, V.2
Klingenspor, M.3
-
76
-
-
77953812880
-
Uncoupling protein-1 is not leaky
-
Shabalina, I.G. et al. Uncoupling protein-1 is not leaky. Biochim. Biophys. Acta 1797, 773-784 (2010)
-
(2010)
Biochim. Biophys. Acta
, vol.1797
, pp. 773-784
-
-
Shabalina, I.G.1
-
77
-
-
77952623888
-
The emergence of cold-induced brown adipocytes in mouse white fat depots is predominantly determined by white to brown adipocyte transdifferentiation
-
Barbatelli, G. et al. The emergence of cold-induced brown adipocytes in mouse white fat depots is predominantly determined by white to brown adipocyte transdifferentiation. Am. J. Physiol. Endocrinol. Metab. 298, E1244-E1253 (2010)
-
(2010)
Am. J. Physiol. Endocrinol. Metab.
, vol.298
-
-
Barbatelli, G.1
-
78
-
-
0027051199
-
Occurrence of brown adipocytes in rat white adipose tissue: Molecular and morphological characterization
-
Cousin, B. et al. Occurrence of brown adipocytes in rat white adipose tissue: molecular and morphological characterization. J. Cell Sci. 103, 931-942 (1992)
-
(1992)
J. Cell Sci.
, vol.103
, pp. 931-942
-
-
Cousin, B.1
-
79
-
-
0019518677
-
The occurrence of brown adipose tissue in outdoor workers
-
Huttunen, P., Hirvonen, J. & Kinnula, V. The occurrence of brown adipose tissue in outdoor workers. Eur. J. Appl. Physiol. Occup. Physiol. 46, 339-345 (1981)
-
(1981)
Eur. J. Appl. Physiol. Occup. Physiol.
, vol.46
, pp. 339-345
-
-
Huttunen, P.1
Hirvonen, J.2
Kinnula, V.3
-
80
-
-
0021319695
-
Brown adipose tissue in the parametrial fat pad of the mouse
-
Young, P., Arch, J.R. & Ashwell, M. Brown adipose tissue in the parametrial fat pad of the mouse. FEBS Lett. 167, 10-14 (1984)
-
(1984)
FEBS Lett.
, vol.167
, pp. 10-14
-
-
Young, P.1
Arch, J.R.2
Ashwell, M.3
-
81
-
-
58149337340
-
Noradrenergic parenchymal nerve fiber branching after cold acclimatisation correlates with brown adipocyte density in mouse adipose organ
-
Murano, I., Barbatelli, G., Giordano, A. & Cinti, S. Noradrenergic parenchymal nerve fiber branching after cold acclimatisation correlates with brown adipocyte density in mouse adipose organ. J. Anat. 214, 171-178 (2009)
-
(2009)
J. Anat.
, vol.214
, pp. 171-178
-
-
Murano, I.1
Barbatelli, G.2
Giordano, A.3
Cinti, S.4
-
82
-
-
20044386339
-
Adipocyte-specific overexpression of FOXC2 prevents diet-induced increases in intramuscular fatty acyl CoA and insulin resistance
-
Kim, J.K. et al. Adipocyte-specific overexpression of FOXC2 prevents diet-induced increases in intramuscular fatty acyl CoA and insulin resistance. Diabetes 54, 1657-1663 (2005)
-
(2005)
Diabetes
, vol.54
, pp. 1657-1663
-
-
Kim, J.K.1
-
83
-
-
48249143579
-
FOXC2 controls Ang-2 expression and modulates angiogenesis, vascular patterning, remodeling, and functions in adipose tissue
-
Xue, Y. et al. FOXC2 controls Ang-2 expression and modulates angiogenesis, vascular patterning, remodeling, and functions in adipose tissue. Proc. Natl. Acad. Sci. USA 105, 10167-10172 (2008)
-
(2008)
Proc. Natl. Acad. Sci. USA
, vol.105
, pp. 10167-10172
-
-
Xue, Y.1
-
84
-
-
79551610057
-
The adipocyte-expressed forkhead transcription factor Foxc2 regulates metabolism through altered mitochondrial function
-
Lidell, M.E. et al. The adipocyte-expressed forkhead transcription factor Foxc2 regulates metabolism through altered mitochondrial function. Diabetes 60, 427-435 (2011)
-
(2011)
Diabetes
, vol.60
, pp. 427-435
-
-
Lidell, M.E.1
-
85
-
-
0037151047
-
Mechanisms of FOXC2- and FOXD1-mediated regulation of the RIα subunit of cAMP-dependent protein kinase include release of transcriptional repression and activation by protein kinase Bα and cAMP
-
Dahle, M.K. et al. Mechanisms of FOXC2- and FOXD1-mediated regulation of the RIα subunit of cAMP-dependent protein kinase include release of transcriptional repression and activation by protein kinase Bα and cAMP. J. Biol. Chem. 277, 22902-22908 (2002)
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 22902-22908
-
-
Dahle, M.K.1
-
86
-
-
0033653610
-
Effects of the two β3-agonists, ZD7114 and ZD2079 on 24 hour energy expenditure and respiratory quotient in obese subjects
-
Buemann, B., Toubro, S. & Astrup, A. Effects of the two β3-agonists, ZD7114 and ZD2079 on 24 hour energy expenditure and respiratory quotient in obese subjects. Int. J. Obes. Relat. Metab. Disord. 24, 1553-1560 (2000)
-
(2000)
Int. J. Obes. Relat. Metab. Disord.
, vol.24
, pp. 1553-1560
-
-
Buemann, B.1
Toubro, S.2
Astrup, A.3
-
87
-
-
0037066575
-
β3-adrenoceptor agonists: Potential, pitfalls and progress
-
Arch, J.R. β3-adrenoceptor agonists: potential, pitfalls and progress. Eur. J. Pharmacol. 440, 99-107 (2002)
-
(2002)
Eur. J. Pharmacol.
, vol.440
, pp. 99-107
-
-
Arch, J.R.1
-
88
-
-
0017872806
-
Nonshivering thermogenesis in the rat. II. Measurements of blood flow with microspheres point to brown adipose tissue as the dominant site of the calorigenesis induced by noradrenaline
-
Foster, D.O. & Frydman, M.L. Nonshivering thermogenesis in the rat. II. Measurements of blood flow with microspheres point to brown adipose tissue as the dominant site of the calorigenesis induced by noradrenaline. Can. J. Physiol. Pharmacol. 56, 110-122 (1978)
-
(1978)
Can. J. Physiol. Pharmacol.
, vol.56
, pp. 110-122
-
-
Foster, D.O.1
Frydman, M.L.2
-
89
-
-
57849153917
-
Hypoxia-independent angiogenesis in adipose tissues during cold acclimation
-
Xue, Y. et al. Hypoxia-independent angiogenesis in adipose tissues during cold acclimation. Cell Metab. 9, 99-109 (2009)
-
(2009)
Cell Metab.
, vol.9
, pp. 99-109
-
-
Xue, Y.1
-
90
-
-
0030726356
-
Adrenergic activation of vascular endothelial growth factor mRNA expression in rat brown adipose tissue: Implication in cold-induced angiogenesis
-
Asano, A., Morimatsu, M., Nikami, H., Yoshida, T. & Saito, M. Adrenergic activation of vascular endothelial growth factor mRNA expression in rat brown adipose tissue: implication in cold-induced angiogenesis. Biochem. J. 328, 179-183 (1997)
-
(1997)
Biochem. J.
, vol.328
, pp. 179-183
-
-
Asano, A.1
Morimatsu, M.2
Nikami, H.3
Yoshida, T.4
Saito, M.5
-
91
-
-
0032932827
-
Role of sympathetic activity in controlling the expression of vascular endothelial growth factor in brown fat cells of lean and genetically obese rats
-
Tonello, C. et al. Role of sympathetic activity in controlling the expression of vascular endothelial growth factor in brown fat cells of lean and genetically obese rats. FEBS Lett. 442, 167-172 (1999)
-
(1999)
FEBS Lett.
, vol.442
, pp. 167-172
-
-
Tonello, C.1
-
92
-
-
84881186105
-
Vascular endothelial growth factor is important for brown adipose tissue development and maintenance
-
Bagchi, M. et al. Vascular endothelial growth factor is important for brown adipose tissue development and maintenance. FASEB J. 27, 3257-3271 (2013)
-
(2013)
FASEB J.
, vol.27
, pp. 3257-3171
-
-
Bagchi, M.1
-
93
-
-
84863198909
-
Adipose tissue overexpression of vascular endothelial growth factor protects against diet-induced obesity and insulin resistance
-
Elias, I. et al. Adipose tissue overexpression of vascular endothelial growth factor protects against diet-induced obesity and insulin resistance. Diabetes 61, 1801-1813 (2012)
-
(2012)
Diabetes
, vol.61
, pp. 1801-1813
-
-
Elias, I.1
-
94
-
-
84859615812
-
Dichotomous effects of VEGF-A on adipose tissue dysfunction
-
Sun, K. et al. Dichotomous effects of VEGF-A on adipose tissue dysfunction. Proc. Natl. Acad. Sci. USA 109, 5874-5879 (2012)
-
(2012)
Proc. Natl. Acad. Sci. USA
, vol.109
, pp. 5874-5879
-
-
Sun, K.1
-
95
-
-
84862740201
-
Resistance to obesity by repression of VEGF gene expression through induction of brown-like adipocyte differentiation
-
Lu, X. et al. Resistance to obesity by repression of VEGF gene expression through induction of brown-like adipocyte differentiation. Endocrinology 153, 3123-3132 (2012)
-
(2012)
Endocrinology
, vol.153
, pp. 3123-3132
-
-
Lu, X.1
-
96
-
-
0032549811
-
A cold-inducible coactivator of nuclear receptors linked to adaptive thermogenesis
-
Puigserver, P. et al. A cold-inducible coactivator of nuclear receptors linked to adaptive thermogenesis. Cell 92, 829-839 (1998)
-
(1998)
Cell
, vol.92
, pp. 829-839
-
-
Puigserver, P.1
-
97
-
-
0042357130
-
Acquirement of brown fat cell features by human white adipocytes
-
Tiraby, C. et al. Acquirement of brown fat cell features by human white adipocytes. J. Biol. Chem. 278, 33370-33376 (2003)
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 33370-33376
-
-
Tiraby, C.1
-
98
-
-
5344252327
-
Defects in adaptive energy metabolism with CNS-linked hyperactivity in PGC-1α null mice
-
Lin, J. et al. Defects in adaptive energy metabolism with CNS-linked hyperactivity in PGC-1α null mice. Cell 119, 121-135 (2004)
-
(2004)
Cell
, vol.119
, pp. 121-135
-
-
Lin, J.1
-
99
-
-
21144446106
-
PGC-1α deficiency causes multi-system energy metabolic derangements: Muscle dysfunction, abnormal weight control and hepatic steatosis
-
Leone, T.C. et al. PGC-1α deficiency causes multi-system energy metabolic derangements: muscle dysfunction, abnormal weight control and hepatic steatosis. PLoS Biol. 3, e101 (2005)
-
(2005)
PLoS Biol.
, vol.3
-
-
Leone, T.C.1
-
100
-
-
33646124709
-
Complementary action of the PGC-1 coactivators in mitochondrial biogenesis and brown fat differentiation
-
Uldry, M. et al. Complementary action of the PGC-1 coactivators in mitochondrial biogenesis and brown fat differentiation. Cell Metab. 3, 333-341 (2006)
-
(2006)
Cell Metab.
, vol.3
, pp. 333-341
-
-
Uldry, M.1
-
101
-
-
84862162100
-
Development of insulin resistance in mice lacking PGC-1α in adipose tissues
-
Kleiner, S. et al. Development of insulin resistance in mice lacking PGC-1α in adipose tissues. Proc. Natl. Acad. Sci. USA 109, 9635-9640 (2012)
-
(2012)
Proc. Natl. Acad. Sci. USA
, vol.109
, pp. 9635-9640
-
-
Kleiner, S.1
-
102
-
-
1642293248
-
P38 mitogen-activated protein kinase is the central regulator of cyclic AMP-dependent transcription of the brown fat uncoupling protein 1 gene
-
Cao, W. et al. p38 mitogen-activated protein kinase is the central regulator of cyclic AMP-dependent transcription of the brown fat uncoupling protein 1 gene. Mol. Cell Biol. 24, 3057-3067 (2004)
-
(2004)
Mol. Cell Biol.
, vol.24
, pp. 3057-3067
-
-
Cao, W.1
-
103
-
-
0035920122
-
β-adrenergic activation of p38 MAP kinase in adipocytes: CAMP induction of the uncoupling protein 1 (UCP1) gene requires p38 MAP kinase
-
Cao, W., Medvedev, A.V., Daniel, K.W. & Collins, S. β-adrenergic activation of p38 MAP kinase in adipocytes: cAMP induction of the uncoupling protein 1 (UCP1) gene requires p38 MAP kinase. J. Biol. Chem. 276, 27077-27082 (2001)
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 27077-27082
-
-
Cao, W.1
Medvedev, A.V.2
Daniel, K.W.3
Collins, S.4
-
104
-
-
43749088035
-
T3-mediated expression of PGC-1α via a far upstream located thyroid hormone response element
-
Wulf, A. et al. T3-mediated expression of PGC-1α via a far upstream located thyroid hormone response element. Mol. Cell Endocrinol. 287, 90-95 (2008)
-
(2008)
Mol. Cell Endocrinol.
, vol.287
, pp. 90-95
-
-
Wulf, A.1
-
105
-
-
33646782581
-
Thiazolidinediones and rexinoids induce peroxisome proliferator-activated receptor-coactivator (PGC)-1α gene transcription: An autoregulatory loop controls PGC-1α expression in adipocytes via peroxisome proliferator-activated receptor-γ coactivation
-
Hondares, E. et al. Thiazolidinediones and rexinoids induce peroxisome proliferator-activated receptor-coactivator (PGC)-1α gene transcription: an autoregulatory loop controls PGC-1α expression in adipocytes via peroxisome proliferator-activated receptor-γ coactivation. Endocrinology 147, 2829-2838 (2006)
-
(2006)
Endocrinology
, vol.147
, pp. 2829-2838
-
-
Hondares, E.1
-
106
-
-
33645064540
-
Rb and p107 regulate preadipocyte differentiation into white versus brown fat through repression of PGC-1α
-
Scim?, A. et al. Rb and p107 regulate preadipocyte differentiation into white versus brown fat through repression of PGC-1α. Cell Metab. 2, 283-295 (2005)
-
(2005)
Cell Metab.
, vol.2
, pp. 283-295
-
-
Scimè, A.1
-
107
-
-
12144287013
-
Retinoblastoma protein functions as a molecular switch determining white versus brown adipocyte differentiation
-
Hansen, J.B. et al. Retinoblastoma protein functions as a molecular switch determining white versus brown adipocyte differentiation. Proc. Natl. Acad. Sci. USA 101, 4112-4117 (2004)
-
(2004)
Proc. Natl. Acad. Sci. USA
, vol.101
, pp. 4112-4117
-
-
Hansen, J.B.1
-
108
-
-
55849147331
-
A functional interaction between RIP140 and PGC-1α regulates the expression of the lipid droplet protein CIDEA
-
Hallberg, M. et al. A functional interaction between RIP140 and PGC-1α regulates the expression of the lipid droplet protein CIDEA. Mol. Cell Biol. 28, 6785-6795 (2008)
-
(2008)
Mol. Cell Biol.
, vol.28
, pp. 6785-6795
-
-
Hallberg, M.1
-
109
-
-
41149117092
-
Liver X receptor α is a transcriptional repressor of the uncoupling protein 1 gene and the brown fat phenotype
-
Wang, H. et al. Liver X receptor α is a transcriptional repressor of the uncoupling protein 1 gene and the brown fat phenotype. Mol. Cell Biol. 28, 2187-2200 (2008)
-
(2008)
Mol. Cell Biol.
, vol.28
, pp. 2187-2200
-
-
Wang, H.1
-
111
-
-
84860009214
-
Essential role for miR-196a in brown adipogenesis of white fat progenitor cells
-
Mori, M., Nakagami, H., Rodriguez-Araujo, G., Nimura, K. & Kaneda, Y. Essential role for miR-196a in brown adipogenesis of white fat progenitor cells. PLoS Biol. 10, e1001314 (2012)
-
(2012)
PLoS Biol.
, vol.10
-
-
Mori, M.1
Nakagami, H.2
Rodriguez-Araujo, G.3
Nimura, K.4
Kaneda, Y.5
-
112
-
-
22144453196
-
Defective thermoregulation, impaired lipid metabolism, but preserved adrenergic induction of gene expression in brown fat of mice lacking C/EBPβ
-
Carmona, M.C. et al. Defective thermoregulation, impaired lipid metabolism, but preserved adrenergic induction of gene expression in brown fat of mice lacking C/EBPβ. Biochem. J. 389, 47-56 (2005)
-
(2005)
Biochem. J.
, vol.389
, pp. 47-56
-
-
Carmona, M.C.1
-
113
-
-
34548317506
-
C/EBPβ reprograms white 3T3-L1 preadipocytes to a brown adipocyte pattern of gene expression
-
Karamanlidis, G., Karamitri, A., Docherty, K., Hazlerigg, D.G. & Lomax, M.A. C/EBPβ reprograms white 3T3-L1 preadipocytes to a brown adipocyte pattern of gene expression. J. Biol. Chem. 282, 24660-24669 (2007)
-
(2007)
J. Biol. Chem.
, vol.282
, pp. 24660-24669
-
-
Karamanlidis, G.1
Karamitri, A.2
Docherty, K.3
Hazlerigg, D.G.4
Lomax, M.A.5
-
114
-
-
0031435337
-
Defective adipocyte differentiation in mice lacking the C/EBPβ and/or C/EBP? Gene
-
Tanaka, T., Yoshida, N., Kishimoto, T. & Akira, S. Defective adipocyte differentiation in mice lacking the C/EBPβ and/or C/EBP? gene. EMBO J. 16, 7432-7443 (1997)
-
(1997)
EMBO J.
, vol.16
, pp. 7432-7443
-
-
Tanaka, T.1
Yoshida, N.2
Kishimoto, T.3
Akira, S.4
-
115
-
-
10544229796
-
Activation of the nuclear receptor peroxisome proliferator-activated receptor γ promotes brown adipocyte differentiation
-
Tai, T.A. et al. Activation of the nuclear receptor peroxisome proliferator-activated receptor γ promotes brown adipocyte differentiation. J. Biol. Chem. 271, 29909-29914 (1996)
-
(1996)
J. Biol. Chem.
, vol.271
, pp. 29909-29914
-
-
Tai, T.A.1
-
116
-
-
84875900015
-
EBF2 determines and maintains brown adipocyte identity
-
Rajakumari, S. et al. EBF2 determines and maintains brown adipocyte identity. Cell Metab. 17, 562-574 (2013)
-
(2013)
Cell Metab.
, vol.17
, pp. 562-574
-
-
Rajakumari, S.1
-
117
-
-
84866291650
-
Genome-wide profiling of PPARγ in primary epididymal, inguinal, and brown adipocytes reveals depot-selective binding correlated with gene expression
-
Siersbk, M.S. et al. Genome-wide profiling of PPARγ in primary epididymal, inguinal, and brown adipocytes reveals depot-selective binding correlated with gene expression. Mol. Cell Biol. 32, 3452-3463 (2012)
-
(2012)
Mol. Cell Biol.
, vol.32
, pp. 3452-3463
-
-
Siersbk, M.S.1
-
118
-
-
0034085884
-
A new thiazolidinedione, NC-2100, which is a weak PPAR-γ activator, exhibits potent antidiabetic effects and induces uncoupling protein 1 in white adipose tissue of KKAy obese mice
-
Fukui, Y., Masui, S., Osada, S., Umesono, K. & Motojima, K. A new thiazolidinedione, NC-2100, which is a weak PPAR-γ activator, exhibits potent antidiabetic effects and induces uncoupling protein 1 in white adipose tissue of KKAy obese mice. Diabetes 49, 759-767 (2000)
-
(2000)
Diabetes
, vol.49
, pp. 759-767
-
-
Fukui, Y.1
Masui, S.2
Osada, S.3
Umesono, K.4
Motojima, K.5
-
119
-
-
34347391646
-
Adipose mitochondrial biogenesis is suppressed in db/db and high-fat diet-fed mice and improved by rosiglitazone
-
Rong, J.X. et al. Adipose mitochondrial biogenesis is suppressed in db/db and high-fat diet-fed mice and improved by rosiglitazone. Diabetes 56, 1751-1760 (2007)
-
(2007)
Diabetes
, vol.56
, pp. 1751-1760
-
-
Rong, J.X.1
-
120
-
-
3843083938
-
Peroxisome proliferator-activated receptor γ agonism increases the capacity for sympathetically mediated thermogenesis in lean and ob/ob mice
-
Sell, H. et al. Peroxisome proliferator-activated receptor γ agonism increases the capacity for sympathetically mediated thermogenesis in lean and ob/ob mice. Endocrinology 145, 3925-3934 (2004)
-
(2004)
Endocrinology
, vol.145
, pp. 3925-3934
-
-
Sell, H.1
-
121
-
-
68849107400
-
C/EBPα and the corepressors CtBP1 and CtBP2 regulate repression of select visceral white adipose genes during induction of the brown phenotype in white adipocytes by peroxisome proliferator-activated receptor γ agonists
-
Vernochet, C. et al. C/EBPα and the corepressors CtBP1 and CtBP2 regulate repression of select visceral white adipose genes during induction of the brown phenotype in white adipocytes by peroxisome proliferator-activated receptor γ agonists. Mol. Cell Biol. 29, 4714-4728 (2009)
-
(2009)
Mol. Cell Biol.
, vol.29
, pp. 4714-4728
-
-
Vernochet, C.1
-
122
-
-
85047689659
-
Mitochondrial remodeling in adipose tissue associated with obesity and treatment with rosiglitazone
-
Wilson-Fritch, L. et al. Mitochondrial remodeling in adipose tissue associated with obesity and treatment with rosiglitazone. J. Clin. Invest. 114, 1281-1289 (2004)
-
(2004)
J. Clin. Invest.
, vol.114
, pp. 1281-1289
-
-
Wilson-Fritch, L.1
-
123
-
-
0031985802
-
Thiazolidinedione exposure increases the expression of uncoupling protein 1 in cultured human preadipocytes
-
Digby, J.E. et al. Thiazolidinedione exposure increases the expression of uncoupling protein 1 in cultured human preadipocytes. Diabetes 47, 138-141 (1998)
-
(1998)
Diabetes
, vol.47
, pp. 138-141
-
-
Digby, J.E.1
-
124
-
-
77954941113
-
Anti-diabetic drugs inhibit obesity-linked phosphorylation of PPARγ by Cdk5
-
Choi, J.H. et al. Anti-diabetic drugs inhibit obesity-linked phosphorylation of PPARγ by Cdk5. Nature 466, 451-456 (2010)
-
(2010)
Nature
, vol.466
, pp. 451-456
-
-
Choi, J.H.1
-
125
-
-
0033656675
-
Thiazolidinediones inhibit the expression of β3-adrenergic receptors at a transcriptional level
-
Bakopanos, E. & Silva, J.E. Thiazolidinediones inhibit the expression of β3-adrenergic receptors at a transcriptional level. Diabetes 49, 2108-2115 (2000)
-
(2000)
Diabetes
, vol.49
, pp. 2108-2115
-
-
Bakopanos, E.1
Silva, J.E.2
-
126
-
-
42449109965
-
Peroxisome proliferator-activated receptor-γ-mediated positive energy balance in the rat is associated with reduced sympathetic drive to adipose tissues and thyroid status
-
Festuccia, W.T. et al. Peroxisome proliferator-activated receptor-γ-mediated positive energy balance in the rat is associated with reduced sympathetic drive to adipose tissues and thyroid status. Endocrinology 149, 2121-2130 (2008)
-
(2008)
Endocrinology
, vol.149
, pp. 2121-2130
-
-
Festuccia, W.T.1
-
127
-
-
84875835392
-
Pharmacological and nutritional agents promoting browning of white adipose tissue
-
Bonet, M.L., Oliver, P. & Palou, A. Pharmacological and nutritional agents promoting browning of white adipose tissue. Biochim. Biophys. Acta 1831, 969-985 (2013)
-
(2013)
Biochim. Biophys. Acta
, vol.1831
, pp. 969-985
-
-
Bonet, M.L.1
Oliver, P.2
Palou, A.3
-
128
-
-
84877585823
-
Beyond the sympathetic tone: The new brown fat activators
-
Villarroya, F. & Vidal-Puig, A. Beyond the sympathetic tone: the new brown fat activators. Cell Metab. 17, 638-643 (2013)
-
(2013)
Cell Metab.
, vol.17
, pp. 638-643
-
-
Villarroya, F.1
Vidal-Puig, A.2
-
129
-
-
77954909425
-
PGC-1α regulation by exercise training and its influences on muscle function and insulin sensitivity
-
Lira, V.A., Benton, C.R., Yan, Z. & Bonen, A. PGC-1α regulation by exercise training and its influences on muscle function and insulin sensitivity. Am. J. Physiol. Endocrinol. Metab. 299, E145-E161 (2010)
-
(2010)
Am. J. Physiol. Endocrinol. Metab.
, vol.299
-
-
Lira, V.A.1
Benton, C.R.2
Yan, Z.3
Bonen, A.4
-
130
-
-
73949099327
-
Increased muscle PGC-1α expression protects from sarcopenia and metabolic disease during aging
-
Wenz, T., Rossi, S.G., Rotundo, R.L., Spiegelman, B.M. & Moraes, C.T. Increased muscle PGC-1α expression protects from sarcopenia and metabolic disease during aging. Proc. Natl. Acad. Sci. USA 106, 20405-20410 (2009)
-
(2009)
Proc. Natl. Acad. Sci. USA
, vol.106
, pp. 20405-20410
-
-
Wenz, T.1
Rossi, S.G.2
Rotundo, R.L.3
Spiegelman, B.M.4
Moraes, C.T.5
-
131
-
-
79960743932
-
Brown adipose tissue responds to cold and adrenergic stimulation by induction of FGF21
-
Chartoumpekis, D.V. et al. Brown adipose tissue responds to cold and adrenergic stimulation by induction of FGF21. Mol. Med. 17, 736-740 (2011)
-
(2011)
Mol. Med.
, vol.17
, pp. 736-740
-
-
Chartoumpekis, D.V.1
-
132
-
-
79953886306
-
Thermogenic activation induces FGF21 expression and release in brown adipose tissue
-
Hondares, E. et al. Thermogenic activation induces FGF21 expression and release in brown adipose tissue. J. Biol. Chem. 286, 12983-12990 (2011)
-
(2011)
J. Biol. Chem.
, vol.286
, pp. 12983-12990
-
-
Hondares, E.1
-
133
-
-
77249099832
-
Hepatic FGF21 expression is induced at birth via PPARα in response to milk intake and contributes to thermogenic activation of neonatal brown fat
-
Hondares, E. et al. Hepatic FGF21 expression is induced at birth via PPARα in response to milk intake and contributes to thermogenic activation of neonatal brown fat. Cell Metab. 11, 206-212 (2010)
-
(2010)
Cell Metab.
, vol.11
, pp. 206-212
-
-
Hondares, E.1
-
134
-
-
57349098220
-
Fibroblast growth factor 21 corrects obesity in mice
-
Coskun, T. et al. Fibroblast growth factor 21 corrects obesity in mice. Endocrinology 149, 6018-6027 (2008)
-
(2008)
Endocrinology
, vol.149
, pp. 6018-6027
-
-
Coskun, T.1
-
135
-
-
84863012022
-
FGF21 regulates PGC-1α and browning of white adipose tissues in adaptive thermogenesis
-
Fisher, F.M. et al. FGF21 regulates PGC-1α and browning of white adipose tissues in adaptive thermogenesis. Genes Dev. 26, 271-281 (2012)
-
(2012)
Genes Dev.
, vol.26
, pp. 271-281
-
-
Fisher, F.M.1
-
136
-
-
20444435873
-
FGF-21 as a novel metabolic regulator
-
Kharitonenkov, A. et al. FGF-21 as a novel metabolic regulator. J. Clin. Invest. 115, 1627-1635 (2005)
-
(2005)
J. Clin. Invest.
, vol.115
, pp. 1627-1635
-
-
Kharitonenkov, A.1
-
137
-
-
61649127208
-
Fibroblast growth factor 21 reverses hepatic steatosis, increases energy expenditure, and improves insulin sensitivity in diet-induced obese mice
-
Xu, J. et al. Fibroblast growth factor 21 reverses hepatic steatosis, increases energy expenditure, and improves insulin sensitivity in diet-induced obese mice. Diabetes 58, 250-259 (2009)
-
(2009)
Diabetes
, vol.58
, pp. 250-259
-
-
Xu, J.1
-
138
-
-
84863116228
-
Fibroblast growth factor 21 promotes bone loss by potentiating the effects of peroxisome proliferator-activated receptor γ
-
Wei, W. et al. Fibroblast growth factor 21 promotes bone loss by potentiating the effects of peroxisome proliferator-activated receptor γ. Proc. Natl. Acad. Sci. USA 109, 3143-3148 (2012)
-
(2012)
Proc. Natl. Acad. Sci. USA
, vol.109
, pp. 3143-3148
-
-
Wei, W.1
-
139
-
-
77952421379
-
Relation of B-type natriuretic peptide levels to body mass index after comprehensive lifestyle changes
-
Chainani-Wu, N. et al. Relation of B-type natriuretic peptide levels to body mass index after comprehensive lifestyle changes. Am. J. Cardiol. 105, 1570-1576 (2010)
-
(2010)
Am. J. Cardiol.
, vol.105
, pp. 1570-1576
-
-
Chainani-Wu, N.1
-
140
-
-
0033936322
-
Natriuretic peptides: A new lipolytic pathway in human adipocytes
-
Sengenès, C., Berlan, M., De Glisezinski, I., Lafontan, M. & Galitzky, J. Natriuretic peptides: a new lipolytic pathway in human adipocytes. FASEB J. 14, 1345-1351 (2000)
-
(2000)
FASEB J.
, vol.14
, pp. 1345-1351
-
-
Sengenès, C.1
Berlan, M.2
De Glisezinski, I.3
Lafontan, M.4
Galitzky, J.5
-
141
-
-
84860850964
-
BMP8B increases brown adipose tissue thermogenesis through both central and peripheral actions
-
Whittle, A.J. et al. BMP8B increases brown adipose tissue thermogenesis through both central and peripheral actions. Cell 149, 871-885 (2012)
-
(2012)
Cell
, vol.149
, pp. 871-885
-
-
Whittle, A.J.1
-
142
-
-
0035185505
-
The type 2 iodothyronine deiodinase is essential for adaptive thermogenesis in brown adipose tissue
-
de Jesus, L.A. et al. The type 2 iodothyronine deiodinase is essential for adaptive thermogenesis in brown adipose tissue. J. Clin. Invest. 108, 1379-1385 (2001)
-
(2001)
J. Clin. Invest.
, vol.108
, pp. 1379-1385
-
-
De Jesus, L.A.1
-
143
-
-
77956431307
-
Hypothalamic AMPK and fatty acid metabolism mediate thyroid regulation of energy balance
-
López, M. et al. Hypothalamic AMPK and fatty acid metabolism mediate thyroid regulation of energy balance. Nat. Med. 16, 1001-1008 (2010)
-
(2010)
Nat. Med.
, vol.16
, pp. 1001-1008
-
-
López, M.1
-
144
-
-
33645873573
-
Thermogenic mechanisms and their hormonal regulation
-
Silva, J.E. Thermogenic mechanisms and their hormonal regulation. Physiol. Rev. 86, 435-464 (2006)
-
(2006)
Physiol. Rev.
, vol.86
, pp. 435-464
-
-
Silva, J.E.1
-
145
-
-
80053928150
-
Orexin is required for brown adipose tissue development, differentiation and function
-
Sellayah, D., Bharaj, P. & Sikder, D. Orexin is required for brown adipose tissue development, differentiation and function. Cell Metab. 14, 478-490 (2011)
-
(2011)
Cell Metab.
, vol.14
, pp. 478-490
-
-
Sellayah, D.1
Bharaj, P.2
Sikder, D.3
-
146
-
-
78049464825
-
Orexin neurons are indispensable for stress-induced thermogenesis in mice
-
Zhang, W. et al. Orexin neurons are indispensable for stress-induced thermogenesis in mice. J. Physiol. (Lond.) 588, 4117-4129 (2010)
-
(2010)
J. Physiol. (Lond.)
, vol.588
, pp. 4117-4129
-
-
Zhang, W.1
-
147
-
-
77952970098
-
Cyclooxygenase-2 controls energy homeostasis in mice by de novo recruitment of brown adipocytes
-
Vegiopoulos, A. et al. Cyclooxygenase-2 controls energy homeostasis in mice by de novo recruitment of brown adipocytes. Science 328, 1158-1161 (2010)
-
(2010)
Science
, vol.328
, pp. 1158-1161
-
-
Vegiopoulos, A.1
-
148
-
-
84858037735
-
Pten positively regulates brown adipose function, energy expenditure, and longevity
-
Ortega-Molina, A. et al. Pten positively regulates brown adipose function, energy expenditure, and longevity. Cell Metab. 15, 382-394 (2012)
-
(2012)
Cell Metab.
, vol.15
, pp. 382-394
-
-
Ortega-Molina, A.1
-
149
-
-
0031959232
-
Brown fat is essential for cold-induced thermogenesis but not for obesity resistance in aP2-Ucp mice
-
Stefl, B. et al. Brown fat is essential for cold-induced thermogenesis but not for obesity resistance in aP2-Ucp mice. Am. J. Physiol. 274, E527-E533 (1998)
-
(1998)
Am. J. Physiol.
, vol.274
-
-
Stefl, B.1
-
150
-
-
84863992227
-
Blockade of the activin receptor IIb activates functional brown adipogenesis and thermogenesis by inducing mitochondrial oxidative metabolism
-
Fournier, B. et al. Blockade of the activin receptor IIb activates functional brown adipogenesis and thermogenesis by inducing mitochondrial oxidative metabolism. Mol. Cell Biol. 32, 2871-2879 (2012)
-
(2012)
Mol. Cell Biol.
, vol.32
, pp. 2871-2879
-
-
Fournier, B.1
-
151
-
-
84862740881
-
A novel therapeutic approach to treating obesity through modulation of TGFβ signaling
-
Koncarevic, A. et al. A novel therapeutic approach to treating obesity through modulation of TGFβ signaling. Endocrinology 153, 3133-3146 (2012)
-
(2012)
Endocrinology
, vol.153
, pp. 3133-3146
-
-
Koncarevic, A.1
-
152
-
-
84864746050
-
GRK2 contribution to the regulation of energy expenditure and brown fat function
-
Vila-Bedmar, R. et al. GRK2 contribution to the regulation of energy expenditure and brown fat function. FASEB J. 26, 3503-3514 (2012)
-
(2012)
FASEB J.
, vol.26
, pp. 3503-3514
-
-
Vila-Bedmar, R.1
-
153
-
-
84859463290
-
Targeted deletion of thioesterase superfamily member 1 promotes energy expenditure and protects against obesity and insulin resistance
-
Zhang, Y. et al. Targeted deletion of thioesterase superfamily member 1 promotes energy expenditure and protects against obesity and insulin resistance. Proc. Natl. Acad. Sci. USA 109, 5417-5422 (2012)
-
(2012)
Proc. Natl. Acad. Sci. USA
, vol.109
, pp. 5417-5422
-
-
Zhang, Y.1
-
154
-
-
84862000905
-
Retinaldehyde dehydrogenase 1 regulates a thermogenic program in white adipose tissue
-
Kiefer, F.W. et al. Retinaldehyde dehydrogenase 1 regulates a thermogenic program in white adipose tissue. Nat. Med. 18, 918-925 (2012)
-
(2012)
Nat. Med.
, vol.18
, pp. 918-925
-
-
Kiefer, F.W.1
-
155
-
-
80455143723
-
The arrestin domain-containing 3 protein regulates body mass and energy expenditure
-
Patwari, P. et al. The arrestin domain-containing 3 protein regulates body mass and energy expenditure. Cell Metab. 14, 671-683 (2011)
-
(2011)
Cell Metab.
, vol.14
, pp. 671-683
-
-
Patwari, P.1
-
156
-
-
70449448312
-
Autophagy regulates adipose mass and differentiation in mice
-
Singh, R. et al. Autophagy regulates adipose mass and differentiation in mice. J. Clin. Invest. 119, 3329-3339 (2009)
-
(2009)
J. Clin. Invest.
, vol.119
, pp. 3329-3339
-
-
Singh, R.1
-
157
-
-
76449101799
-
ATF4 regulates lipid metabolism and thermogenesis
-
Wang, C. et al. ATF4 regulates lipid metabolism and thermogenesis. Cell Res. 20, 174-184 (2010)
-
(2010)
Cell Res.
, vol.20
, pp. 174-184
-
-
Wang, C.1
-
158
-
-
84055223593
-
Reduction in BACE1 decreases body weight, protects against diet-induced obesity and enhances insulin sensitivity in mice
-
Meakin, P.J. et al. Reduction in BACE1 decreases body weight, protects against diet-induced obesity and enhances insulin sensitivity in mice. Biochem. J. 441, 285-296 (2012)
-
(2012)
Biochem. J.
, vol.441
, pp. 285-296
-
-
Meakin, P.J.1
-
159
-
-
0041353552
-
Cidea-deficient mice have lean phenotype and are resistant to obesity
-
Zhou, Z. et al. Cidea-deficient mice have lean phenotype and are resistant to obesity. Nat. Genet. 35, 49-56 (2003)
-
(2003)
Nat. Genet.
, vol.35
, pp. 49-56
-
-
Zhou, Z.1
-
160
-
-
51449123610
-
Up-regulation of mitochondrial activity and acquirement of brown adipose tissue-like property in the white adipose tissue of fsp27 deficient mice
-
Toh, S.Y. et al. Up-regulation of mitochondrial activity and acquirement of brown adipose tissue-like property in the white adipose tissue of fsp27 deficient mice. PLoS ONE 3, e2890 (2008)
-
(2008)
PLoS ONE
, vol.3
-
-
Toh, S.Y.1
-
161
-
-
73349119690
-
Cannabinoid type 1 receptor blockade induces transdifferentiation towards a brown fat phenotype in white adipocytes
-
Perwitz, N. et al. Cannabinoid type 1 receptor blockade induces transdifferentiation towards a brown fat phenotype in white adipocytes. Diabetes Obes. Metab. 12, 158-166 (2010)
-
(2010)
Diabetes Obes. Metab.
, vol.12
, pp. 158-166
-
-
Perwitz, N.1
-
162
-
-
0037846260
-
Corticotropin-releasing factor receptor-2-deficient mice display abnormal homeostatic responses to challenges of increased dietary fat and cold
-
Bale, T.L. et al. Corticotropin-releasing factor receptor-2-deficient mice display abnormal homeostatic responses to challenges of increased dietary fat and cold. Endocrinology 144, 2580-2587 (2003)
-
(2003)
Endocrinology
, vol.144
, pp. 2580-2587
-
-
Bale, T.L.1
-
163
-
-
84860158411
-
Pref-1 in brown adipose tissue: Specific involvement in brown adipocyte differentiation and regulatory role of C/EBPo
-
Armengol, J. et al. Pref-1 in brown adipose tissue: specific involvement in brown adipocyte differentiation and regulatory role of C/EBP0. Biochem. J. 443, 799-810 (2012)
-
(2012)
Biochem. J.
, vol.443
, pp. 799-810
-
-
Armengol, J.1
-
164
-
-
0034770191
-
Adipose tissue reduction in mice lacking the translational inhibitor 4E-BP1
-
Tsukiyama-Kohara, K. et al. Adipose tissue reduction in mice lacking the translational inhibitor 4E-BP1. Nat. Med. 7, 1128-1132 (2001)
-
(2001)
Nat. Med.
, vol.7
, pp. 1128-1132
-
-
Tsukiyama-Kohara, K.1
-
165
-
-
40449097684
-
Reduced adiposity and improved insulin sensitivity in obese mice with antisense suppression of 4E-BP2 expression
-
Yu, X.X. et al. Reduced adiposity and improved insulin sensitivity in obese mice with antisense suppression of 4E-BP2 expression. Am. J. Physiol. Endocrinol. Metab. 294, E530-E539 (2008)
-
(2008)
Am. J. Physiol. Endocrinol. Metab.
, vol.294
-
-
Yu, X.X.1
-
166
-
-
78650800467
-
Improved glucose control and reduced body fat mass in free fatty acid receptor 2-deficient mice fed a high-fat diet
-
Bjursell, M. et al. Improved glucose control and reduced body fat mass in free fatty acid receptor 2-deficient mice fed a high-fat diet. Am. J. Physiol. Endocrinol. Metab. 300, E211-E220 (2011)
-
(2011)
Am. J. Physiol. Endocrinol. Metab.
, vol.300
-
-
Bjursell, M.1
-
167
-
-
40949164735
-
Forkhead transcription factor FoxO1 in adipose tissue regulates energy storage and expenditure
-
Nakae, J. et al. Forkhead transcription factor FoxO1 in adipose tissue regulates energy storage and expenditure. Diabetes 57, 563-576 (2008)
-
(2008)
Diabetes
, vol.57
, pp. 563-576
-
-
Nakae, J.1
-
168
-
-
81155138295
-
Ablation of ghrelin receptor reduces adiposity and improves insulin sensitivity during aging by regulating fat metabolism in white and brown adipose tissues
-
Lin, L. et al. Ablation of ghrelin receptor reduces adiposity and improves insulin sensitivity during aging by regulating fat metabolism in white and brown adipose tissues. Aging Cell 10, 996-1010 (2011)
-
(2011)
Aging Cell
, vol.10
, pp. 996-1010
-
-
Lin, L.1
-
169
-
-
84855414794
-
Ablation of the transcriptional regulator Id1 enhances energy expenditure, increases insulin sensitivity, and protects against age and diet induced insulin resistance, and hepatosteatosis
-
Satyanarayana, A., Klarmann, K.D., Gavrilova, O. & Keller, J.R. Ablation of the transcriptional regulator Id1 enhances energy expenditure, increases insulin sensitivity, and protects against age and diet induced insulin resistance, and hepatosteatosis. FASEB J. 26, 309-323 (2012)
-
(2012)
FASEB J.
, vol.26
, pp. 309-323
-
-
Satyanarayana, A.1
Klarmann, K.D.2
Gavrilova, O.3
Keller, J.R.4
-
170
-
-
69449097633
-
The protein kinase IKK? Regulates energy balance in obese mice
-
Chiang, S.H. et al. The protein kinase IKK? regulates energy balance in obese mice. Cell 138, 961-975 (2009)
-
(2009)
Cell
, vol.138
, pp. 961-975
-
-
Chiang, S.H.1
-
171
-
-
46349105320
-
Attainment of brown adipocyte features in white adipocytes of hormone-sensitive lipase null mice
-
Strom, K. et al. Attainment of brown adipocyte features in white adipocytes of hormone-sensitive lipase null mice. PLoS One 3, e1793 (2008)
-
(2008)
PLoS One
, vol.3
-
-
Strom, K.1
-
172
-
-
84863270429
-
Low density lipoprotein (LDL) receptor-related protein 6 (LRP6) regulates body fat and glucose homeostasis by modulating nutrient sensing pathways and mitochondrial energy expenditure
-
Liu, W. et al. Low density lipoprotein (LDL) receptor-related protein 6 (LRP6) regulates body fat and glucose homeostasis by modulating nutrient sensing pathways and mitochondrial energy expenditure. J. Biol. Chem. 287, 7213-7223 (2012)
-
(2012)
J. Biol. Chem.
, vol.287
, pp. 7213-7223
-
-
Liu, W.1
-
173
-
-
84856725443
-
Inhibition of myostatin protects against diet-induced obesity by enhancing fatty acid oxidation and promoting a brown adipose phenotype in mice
-
Zhang, C. et al. Inhibition of myostatin protects against diet-induced obesity by enhancing fatty acid oxidation and promoting a brown adipose phenotype in mice. Diabetologia 55, 183-193 (2012)
-
(2012)
Diabetologia
, vol.55
, pp. 183-193
-
-
Zhang, C.1
-
174
-
-
0037184960
-
SRC-1 and TIF2 control energy balance between white and brown adipose tissues
-
Picard, F. et al. SRC-1 and TIF2 control energy balance between white and brown adipose tissues. Cell 111, 931-941 (2002)
-
(2002)
Cell
, vol.111
, pp. 931-941
-
-
Picard, F.1
-
175
-
-
27144476457
-
RIP140-targeted repression of gene expression in adipocytes
-
Christian, M. et al. RIP140-targeted repression of gene expression in adipocytes. Mol. Cell Biol. 25, 9383-9391 (2005)
-
(2005)
Mol. Cell Biol.
, vol.25
, pp. 9383-9391
-
-
Christian, M.1
-
176
-
-
2942532305
-
Nuclear receptor corepressor RIP140 regulates fat accumulation
-
Leonardsson, G. et al. Nuclear receptor corepressor RIP140 regulates fat accumulation. Proc. Natl. Acad. Sci. USA 101, 8437-8442 (2004)
-
(2004)
Proc. Natl. Acad. Sci. USA
, vol.101
, pp. 8437-8442
-
-
Leonardsson, G.1
-
177
-
-
31044432605
-
Suppression of oxidative metabolism and mitochondrial biogenesis by the transcriptional corepressor RIP140 in mouse adipocytes
-
Powelka, A.M. et al. Suppression of oxidative metabolism and mitochondrial biogenesis by the transcriptional corepressor RIP140 in mouse adipocytes. J. Clin. Invest. 116, 125-136 (2006)
-
(2006)
J. Clin. Invest.
, vol.116
, pp. 125-136
-
-
Powelka, A.M.1
-
178
-
-
84864779552
-
Mice lacking delta-opioid receptors resist the development of diet-induced obesity
-
Czyzyk, T.A. et al. Mice lacking delta-opioid receptors resist the development of diet-induced obesity. FASEB J. 26, 3482-3492 (2012)
-
(2012)
FASEB J.
, vol.26
, pp. 3482-3492
-
-
Czyzyk, T.A.1
-
179
-
-
70350400603
-
Mice lacking Pctp/StarD2 exhibit increased adaptive thermogenesis and enlarged mitochondria in brown adipose tissue
-
Kang, H.W. et al. Mice lacking Pctp/StarD2 exhibit increased adaptive thermogenesis and enlarged mitochondria in brown adipose tissue. J. Lipid Res. 50, 2212-2221 (2009)
-
(2009)
J. Lipid Res.
, vol.50
, pp. 2212-2221
-
-
Kang, H.W.1
-
180
-
-
0029737861
-
Genetically lean mice result from targeted disruption of the RIIβ subunit of protein kinase A
-
Cummings, D.E. et al. Genetically lean mice result from targeted disruption of the RIIβ subunit of protein kinase A. Nature 382, 622-626 (1996)
-
(1996)
Nature
, vol.382
, pp. 622-626
-
-
Cummings, D.E.1
-
181
-
-
84863278878
-
Protein kinase Cβ deficiency attenuates obesity syndrome of ob/ob mice by promoting white adipose tissue remodeling
-
Huang, W., Bansode, R.R., Bal, N.C., Mehta, M. & Mehta, K.D. Protein kinase Cβ deficiency attenuates obesity syndrome of ob/ob mice by promoting white adipose tissue remodeling. J. Lipid Res. 53, 368-378 (2012)
-
(2012)
J. Lipid Res.
, vol.53
, pp. 368-378
-
-
Huang, W.1
Bansode, R.R.2
Bal, N.C.3
Mehta, M.4
Mehta, K.D.5
-
182
-
-
84865781554
-
Beige differentiation of adipose depots in mice lacking prolactin receptor protects against high-fat-diet-induced obesity
-
Auffret, J. et al. Beige differentiation of adipose depots in mice lacking prolactin receptor protects against high-fat-diet-induced obesity. FASEB J. 26, 3728-3737 (2012)
-
(2012)
FASEB J.
, vol.26
, pp. 3728-3737
-
-
Auffret, J.1
-
183
-
-
67749111842
-
Skin-specific deletion of stearoyl-CoA desaturase-1 alters skin lipid composition and protects mice from high fat diet-induced obesity
-
Sampath, H. et al. Skin-specific deletion of stearoyl-CoA desaturase-1 alters skin lipid composition and protects mice from high fat diet-induced obesity. J. Biol. Chem. 284, 19961-19973 (2009)
-
(2009)
J. Biol. Chem.
, vol.284
, pp. 19961-19973
-
-
Sampath, H.1
-
184
-
-
84863545499
-
Secreted frizzled-related protein 5 suppresses adipocyte mitochondrial metabolism through WNT inhibition
-
Mori, H. et al. Secreted frizzled-related protein 5 suppresses adipocyte mitochondrial metabolism through WNT inhibition. J. Clin. Invest. 122, 2405-2416 (2012)
-
(2012)
J. Clin. Invest.
, vol.122
, pp. 2405-2416
-
-
Mori, H.1
-
185
-
-
79959933148
-
Protection from obesity and diabetes by blockade of TGF-β/Smad3 signaling
-
Yadav, H. et al. Protection from obesity and diabetes by blockade of TGF-β/Smad3 signaling. Cell Metab. 14, 67-79 (2011)
-
(2011)
Cell Metab.
, vol.14
, pp. 67-79
-
-
Yadav, H.1
-
186
-
-
73649094118
-
Deletion of tumor necrosis factor-α receptor 1 (TNFR1) protects against diet-induced obesity by means of increased thermogenesis
-
Romanatto, T. et al. Deletion of tumor necrosis factor-α receptor 1 (TNFR1) protects against diet-induced obesity by means of increased thermogenesis. J. Biol. Chem. 284, 36213-36222 (2009)
-
(2009)
J. Biol. Chem.
, vol.284
, pp. 36213-36222
-
-
Romanatto, T.1
-
187
-
-
84869101137
-
TRPV4 is a regulator of adipose oxidative metabolism, inflammation, and energy homeostasis
-
Ye, L. et al. TRPV4 is a regulator of adipose oxidative metabolism, inflammation, and energy homeostasis. Cell 151, 96-110 (2012)
-
(2012)
Cell
, vol.151
, pp. 96-110
-
-
Ye, L.1
-
188
-
-
63049083171
-
Twist-1 is a PPAR?-inducible, negative-feedback regulator of PGC-1α in brown fat metabolism
-
Pan, D., Fujimoto, M., Lopes, A. & Wang, Y.X. Twist-1 is a PPAR?-inducible, negative-feedback regulator of PGC-1α in brown fat metabolism. Cell 137, 73-86 (2009)
-
(2009)
Cell
, vol.137
, pp. 73-86
-
-
Pan, D.1
Fujimoto, M.2
Lopes, A.3
Wang, Y.X.4
-
189
-
-
73349122261
-
Analysis of knockout mice suggests a role for VGF in the control of fat storage and energy expenditure
-
Watson, E. et al. Analysis of knockout mice suggests a role for VGF in the control of fat storage and energy expenditure. BMC Physiol. 9, 19 (2009)
-
(2009)
BMC Physiol.
, vol.9
, pp. 19
-
-
Watson, E.1
|