High-Throughput Approaches to Pinpoint Function within the Noncoding Genome

Molecular Cell

Volumn 68, Issue 1, 2017, Pages 44-59

  Montalbano, Antonino ^a,b   Canver, Matthew C ^c   Sanjana, Neville E ^a,b  

^a NEW YORK GENOME CENTER   (United States)

^b NEW YORK UNIVERSITY   (United States)

^c HARVARD MEDICAL SCHOOL   (United States)

Author keywords

Cas9; conservation; CRISPR; enhancers; functional genomics; gene editing; gene expression; mutagenesis; noncoding genome; pooled screens

Indexed keywords

DNA; NONCODING DNA; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG; ENDONUCLEASE; GUIDE RNA; SPACER DNA;

BINDING SITE; CLUSTERED REGULARLY INTERSPACED SHORT PALINDROMIC REPEAT; CRISPR CAS SYSTEM; FUNCTIONAL GENOMICS; GENE EDITING; HIGH THROUGHPUT SCREENING; HUMAN; MUTAGENESIS; NONHUMAN; REVIEW; ANIMAL; CYTOLOGY; EUKARYOTIC CELL; GENE LIBRARY; GENETIC ENGINEERING; GENETICS; GENOME; METABOLISM; PROCEDURES;

ANIMALS; CLUSTERED REGULARLY INTERSPACED SHORT PALINDROMIC REPEATS; CRISPR-CAS SYSTEMS; DNA, INTERGENIC; ENDONUCLEASES; EUKARYOTIC CELLS; GENE EDITING; GENETIC ENGINEERING; GENOME; GENOMIC LIBRARY; HIGH-THROUGHPUT SCREENING ASSAYS; HUMANS; RNA, GUIDE;

EID: 85030700465     PISSN: 10972765     EISSN: 10974164     Source Type: Journal    
DOI: 10.1016/j.molcel.2017.09.017     Document Type: Review

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