Optimizing sgRNA position markedly improves the efficiency of CRISPR/dCas9-mediated transcriptional repression

Nucleic Acids Research

Volumn 44, Issue 18, 2016, Pages

  Radzisheuskaya, Aliaksandra ^a,b,c   Shlyueva, Daria ^a,b,c   Müller, Iris ^a,b,c   Helin, Kristian ^a,b,c  

^a UNIVERSITY OF COPENHAGEN   (Denmark)

^b UNIVERSITY OF COPENHAGEN   (Denmark)

^c University of Copenhagen   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

RNA; SINGLE GUIDE RNA; UNCLASSIFIED DRUG; CHROMATIN; GUIDE RNA;

ARTICLE; CELL PROLIFERATION; CHROMATIN; CONTROLLED STUDY; CRISPR CAS SYSTEM; CRISPR INTERFERENCE; GENE SILENCING; GENE TARGETING; HETEROCHROMATIN; HOUSEKEEPING GENE; HUMAN; HUMAN CELL; LEUKEMIA CELL LINE; PHENOTYPE; PLASMID; PRIORITY JOURNAL; PROMOTER REGION; TRANSCRIPTION INITIATION SITE; GENETIC TRANSCRIPTION; GENETICS; GENOME; HEK293 CELL LINE; K-562 CELL LINE; METABOLISM; NUCLEOTIDE SEQUENCE;

BASE SEQUENCE; CHROMATIN; CRISPR-CAS SYSTEMS; GENE KNOCKDOWN TECHNIQUES; GENOME; HEK293 CELLS; HUMANS; K562 CELLS; PROMOTER REGIONS, GENETIC; RNA, GUIDE; TRANSCRIPTION INITIATION SITE; TRANSCRIPTION, GENETIC;

EID: 84992189595     PISSN: 03051048     EISSN: 13624962     Source Type: Journal    
DOI: 10.1093/nar/gkw583     Document Type: Article

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