Two distinct RNase activities of CRISPR-C2c2 enable guide-RNA processing and RNA detection

Nature

Volumn 538, Issue 7624, 2016, Pages 270-273

  East Seletsky, Alexandra ^a   O'Connell, Mitchell R ^a   Knight, Spencer C ^a   Burstein, David ^a   Cate, Jamie H D ^a,b   Tjian, Robert ^a,c,d   Doudna, Jennifer A ^a,b,d  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b LAWRENCE BERKELEY NATIONAL LABORATORY   (United States)

^c HOWARD HUGHES MEDICAL INSTITUTE   (United States)

^d HOWARD HUGHES MEDICAL INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIAL PROTEIN; C2C2 PROTEIN; CPF1 PROTEIN; CRISPR ASSOCIATED PROTEIN; GUIDE RNA; RIBONUCLEASE; SINGLE STRANDED RNA; TRANSFER RNA; UNCLASSIFIED DRUG; BACTERIAL RNA;

BACTERIUM; ENZYME ACTIVITY; GENE EXPRESSION; GENETIC ANALYSIS; IMMUNE SYSTEM; NUCLEIC ACID; PROTEIN;

ADAPTIVE IMMUNITY; ARTICLE; CLUSTERED REGULARLY INTERSPACED SHORT PALINDROMIC REPEAT; ENZYME ACTIVITY; IMMUNOSURVEILLANCE; NONHUMAN; PRIORITY JOURNAL; RNA DEGRADATION; RNA PROCESSING; CHEMISTRY; CRISPR CAS SYSTEM; ENZYMOLOGY; GENETICS; LEPTOTRICHIA; METABOLISM; NUCLEOTIDE SEQUENCE; RNA CLEAVAGE;

BACTERIA (MICROORGANISMS); PROKARYOTA;

BASE SEQUENCE; CLUSTERED REGULARLY INTERSPACED SHORT PALINDROMIC REPEATS; CRISPR-ASSOCIATED PROTEINS; CRISPR-CAS SYSTEMS; LEPTOTRICHIA; RIBONUCLEASES; RNA CLEAVAGE; RNA, BACTERIAL; RNA, GUIDE;

EID: 84991728709     PISSN: 00280836     EISSN: 14764687     Source Type: Journal    
DOI: 10.1038/nature19802     Document Type: Article

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