Cas13b Is a Type VI-B CRISPR-Associated RNA-Guided RNase Differentially Regulated by Accessory Proteins Csx27 and Csx28

Molecular Cell

Volumn 65, Issue 4, 2017, Pages 618-630.e7

  Smargon, Aaron A ^a,b,c,d   Cox, David B T ^a,b,c,e   Pyzocha, Neena K ^a,b,c   Zheng, Kaijie ^a,b,c   Slaymaker, Ian M ^a,b,c   Gootenberg, Jonathan S ^a,b,c,f   Abudayyeh, Omar A ^a,b,c,e   Essletzbichler, Patrick ^a,b,c   Shmakov, Sergey ^g,h   Makarova, Kira S ^h   Koonin, Eugene V ^h   Zhang, Feng ^a,b,c,d  

^a BROAD INSTITUTE OF MIT AND HARVARD   (United States)

^b MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

^c MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

^d Department of Electrical Engineering and Computer Science   (United States)

^e HARVARD MIT DIVISION OF HEALTH SCIENCES AND TECHNOLOGY   (United States)

^f HARVARD MEDICAL SCHOOL   (United States)

^g SKOLKOVO INSTITUTE OF SCIENCE AND TECHNOLOGY   (Russian Federation)

^h NATIONAL INSTITUTES OF HEALTH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CAS13B PROTEIN; CRISPR ASSOCIATED PROTEIN; CSX27 PROTEIN; CSX28 PROTEIN; PROTEIN VARIANT; RIBONUCLEASE; SINGLE STRANDED RNA; UNCLASSIFIED DRUG; BACTERIAL PROTEIN; BACTERIAL RNA; GUIDE RNA;

ARTICLE; CRISPR CAS SYSTEM; DNA FLANKING REGION; ESCHERICHIA COLI; ESSENTIAL GENE; PROTEIN EXPRESSION; PROTEIN SECONDARY STRUCTURE; REGULATORY MECHANISM; RNA CLEAVAGE; RNA INTERFERENCE; BIOLOGY; DATA MINING; ENZYMOLOGY; GENE EDITING; GENE EXPRESSION REGULATION; GENETIC DATABASE; GENETICS; METABOLISM; PROCEDURES;

BACTERIAL PROTEINS; COMPUTATIONAL BIOLOGY; CRISPR-ASSOCIATED PROTEINS; CRISPR-CAS SYSTEMS; DATA MINING; DATABASES, GENETIC; ESCHERICHIA COLI; GENE EDITING; GENE EXPRESSION REGULATION, BACTERIAL; RIBONUCLEASES; RNA INTERFERENCE; RNA, BACTERIAL; RNA, GUIDE;

EID: 85008425651     PISSN: 10972765     EISSN: 10974164     Source Type: Journal    
DOI: 10.1016/j.molcel.2016.12.023     Document Type: Article

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