piggyBac mediates efficient in vivo CRISPR library screening for tumorigenesis in mice

Proceedings of the National Academy of Sciences of the United States of America

Volumn 114, Issue 4, 2017, Pages 722-727

  Xu, Chunlong ^a   Qi, Xiaolan ^a   Du, Xuguang ^a   Zou, Huiying ^a   Gao, Fei ^a   Feng, Tao ^a   Lu, Hengxing ^a   Li, Shenglan ^b,c   An, Xiaomeng ^a   Zhang, Lijun ^a   Wu, Yuanyuan ^d   Liu, Ying ^b,c   Li, Ning ^a   Capecchi, Mario R ^d   Wu, Sen ^a  

^a CHINA AGRICULTURAL UNIVERSITY   (China)

^b UNIVERSITY OF TEXAS MEDICAL SCHOOL   (United States)

^c UNIVERSITY OF TEXAS   (United States)

^d UNIVERSITY OF UTAH SCHOOL OF MEDICINE   (United States)

Author keywords

CRISPR Cas9; Liver cancer; piggyBac transposon; Screening; Tumorigenesis

Indexed keywords

CRISPR ASSOCIATED PROTEIN; GUIDE RNA; LENTIVIRUS VECTOR; PROTEIN CAS9; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CLUSTERED REGULARLY INTERSPACED SHORT PALINDROMIC REPEAT; CONTROLLED STUDY; CRISPR CAS9 SYSTEM; GENE; GENE EDITING; GENE LIBRARY; GENETIC SCREENING; GENOME; HISTOLOGY; IMMUNOHISTOCHEMISTRY; IN VIVO STUDY; LIVER CARCINOGENESIS; MOUSE; NONHUMAN; PIGGYBAC GENE; PRIORITY JOURNAL; TRANSPOSON; TUMOR GENE; TUMOR SUPPRESSOR GENE; ANIMAL; CARCINOGENESIS; CRISPR CAS SYSTEM; GENETIC ENGINEERING; GENETICS; LIVER; LIVER TUMOR; PATHOLOGY; PHYSIOLOGY; PROCEDURES;

ANIMALS; CARCINOGENESIS; CRISPR-CAS SYSTEMS; DNA TRANSPOSABLE ELEMENTS; GENE LIBRARY; GENES, TUMOR SUPPRESSOR; GENETIC ENGINEERING; GENOME; LIVER; LIVER NEOPLASMS; MICE; RNA, GUIDE;

EID: 85010635827     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1615735114     Document Type: Article

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