CRISPR-Cas9 knockin mice for genome editing and cancer modeling

Cell

Volumn 159, Issue 2, 2014, Pages 440-455

  Platt, Randall J ^a,b,c,d   Chen, Sidi ^c   Zhou, Yang ^b,c   Yim, Michael J ^a,b,c,d   Swiech, Lukasz ^a,b,c,d   Kempton, Hannah R ^a,b,d   Dahlman, James E ^c,d   Parnas, Oren ^a   Eisenhaure, Thomas M ^a,f   Jovanovic, Marko ^a   Graham, Daniel B ^a   Jhunjhunwala, Siddharth ^c   Heidenreich, Matthias ^a,b,c,d   Xavier, Ramnik J ^a   Langer, Robert ^c,d   Anderson, Daniel G ^c,d   Hacohen, Nir ^a,e,f   Regev, Aviv ^a,c,g   Feng, Guoping ^a,b,c   Sharp, Phillip A ^c   Zhang, Feng ^a,b,c,d   more..

^a BROAD INSTITUTE OF MIT AND HARVARD   (United States)

^b MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

^c MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

^d USA   (United States)

^e HARVARD MEDICAL SCHOOL   (United States)

^f MASSACHUSETTS GENERAL HOSPITAL   (United States)

^g HOWARD HUGHES MEDICAL INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CRE RECOMBINASE; GUIDE RNA; K RAS PROTEIN; MYELOID DIFFERENTIATION FACTOR 88; NEURON SPECIFIC NUCLEAR PROTEIN; PROTEIN KINASE LKB1; PROTEIN P53;

ADENO ASSOCIATED VIRUS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; CRISPR CAS SYSTEM; DENDRITIC CELL; ENDOTHELIUM CELL; EX VIVO STUDY; FEMALE; GAIN OF FUNCTION MUTATION; GENE EXPRESSION; GENE MUTATION; GENE SILENCING; GENOME; IMMUNOCOMPETENT CELL; IN VIVO STUDY; LOSS OF FUNCTION MUTATION; LUNG ADENOCARCINOMA; MOLECULAR DYNAMICS; MOUSE; NERVE CELL; NONHUMAN; NONVIRAL GENE DELIVERY SYSTEM; TISSUE SPECIFICITY; TUMOR VOLUME; VIRAL GENE DELIVERY SYSTEM; ADENOCARCINOMA; ANIMAL; CLUSTERED REGULARLY INTERSPACED SHORT PALINDROMIC REPEAT; DISEASE MODEL; GENE TARGETING; GENE VECTOR; GENETIC ENGINEERING; GENETICS; LENTIVIRINAE; LUNG TUMOR; METABOLISM; ONCOGENE; PROCEDURES; TRANSGENIC MOUSE; TUMOR SUPPRESSOR GENE;

ADENO-ASSOCIATED VIRUS; LENTIVIRUS; MUS;

ADENOCARCINOMA; ANIMALS; CLUSTERED REGULARLY INTERSPACED SHORT PALINDROMIC REPEATS; DENDRITIC CELLS; DISEASE MODELS, ANIMAL; GENE KNOCK-IN TECHNIQUES; GENES, TUMOR SUPPRESSOR; GENETIC ENGINEERING; GENETIC VECTORS; LENTIVIRUS; LUNG NEOPLASMS; MICE; MICE, TRANSGENIC; ONCOGENES;

EID: 84912101598     PISSN: 00928674     EISSN: 10974172     Source Type: Journal    
DOI: 10.1016/j.cell.2014.09.014     Document Type: Article

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