Activation of proto-oncogenes by disruption of chromosome neighborhoods

Science

Volumn 351, Issue 6280, 2016, Pages 1454-1458

  Hnisz, Denes ^a   Weintrau, Abraham S ^a,b   Day, Daniel S ^a   Valton, Anne Laure ^c   Bak, Rasmus O ^d   Li, Charles H ^a,b   Goldmann, Johanna ^a   Lajoie, Bryan R ^c   Fan, Zi Peng ^a,b   Sigova, Alla A ^a   Reddy, Jessica ^a,b   Borges Rivera, Diego ^a,b   Lee, Tong Ihn ^a   Jaenisch, Rudolf ^a,b   Porteus, Matthew H ^d   Dekker, Job ^c,e   Young, Richard A ^a,b  

^a WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH   (United States)

^b MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

^c UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL   (United States)

^d STANFORD UNIVERSITY   (United States)

^e HOWARD HUGHES MEDICAL INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CANCER; CELLS AND CELL COMPONENTS; CHROMOSOME; GENE FLOW; GENETIC ENGINEERING; GENOME; TRANSLOCATION;

ACUTE LYMPHOBLASTIC LEUKEMIA; ARTICLE; CANCER CELL; CANCER PATIENT; CHROMATIN; CHROMOSOME; CHROMOSOME NEIGHBORHOOD; CHROMOSOME STRUCTURE; CLINICAL ARTICLE; COHORT ANALYSIS; CONTROLLED STUDY; GENE ACTIVATION; GENE DELETION; GENE DISRUPTION; GENE MAPPING; GENOME; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; ONCOGENE; PRIORITY JOURNAL; PROMOTER REGION; PROTO ONCOGENE; SOMATIC MUTATION; TUMOR CELL; CHROMOSOME ABERRATION; CHROMOSOME MAP; GENE EXPRESSION REGULATION; GENE TRANSLOCATION; GENETICS; HEK293 CELL LINE; MUTATION; TRANSCRIPTION INITIATION;

CHROMOSOME ABERRATIONS; CHROMOSOME MAPPING; GENE EXPRESSION REGULATION, LEUKEMIC; HEK293 CELLS; HUMANS; MUTATION; PRECURSOR T-CELL LYMPHOBLASTIC LEUKEMIA-LYMPHOMA; PROTO-ONCOGENES; SEQUENCE DELETION; TRANSCRIPTIONAL ACTIVATION; TRANSLOCATION, GENETIC;

EID: 84960171833     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.aad9024     Document Type: Article

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