Nucleosomes impede cas9 access to DNA in vivo and in vitro

eLife

Volumn 5, Issue MARCH2016, 2016, Pages

  Horlbeck, Max A ^a,b   Witkowsky, Lea B ^c   Guglielmi, Benjamin ^c   Replogle, Joseph M ^a,b   Gilbert, Luke A ^a,b   Villalta, Jacqueline E ^a,b   Torigoe, Sharon E ^c   Tjian, Robert ^c   Weissman, Jonathan S ^a,b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CAS9 PROTEIN; CRISPR ASSOCIATED PROTEIN; NAKED DNA; OLIGONUCLEOTIDE; UNCLASSIFIED DRUG; BACTERIAL PROTEIN; CAS9 ENDONUCLEASE STREPTOCOCCUS PYOGENES; DNA; ENDONUCLEASE; NUCLEOSOME;

ARTICLE; CHROMATIN ASSEMBLY AND DISASSEMBLY; CONTROLLED STUDY; CRYSTAL STRUCTURE; DNA CLEAVAGE; ENZYME ACTIVITY; GEL MOBILITY SHIFT ASSAY; GENE EXPRESSION; GENE SEQUENCE; NUCLEOSOME; NUCLEOTIDE BINDING SITE; PHENOTYPE; POLYMERASE CHAIN REACTION; PREDICTION; PROTEIN PURIFICATION; RESTRICTION MAPPING; SCORING SYSTEM; TRANSCRIPTION INITIATION SITE; ANTAGONISTS AND INHIBITORS; CELL LINE; GENE TARGETING; HUMAN; METABOLISM; PROCEDURES;

BACTERIAL PROTEINS; CELL LINE; DNA; ENDONUCLEASES; GENE TARGETING; HUMANS; NUCLEOSOMES;

EID: 84969195094     PISSN: None     EISSN: 2050084X     Source Type: Journal    
DOI: 10.7554/eLife.12677     Document Type: Article

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