Multiplex gene editing by CRISPR-Cpf1 using a single crRNA array

Nature Biotechnology

Volumn 35, Issue 1, 2017, Pages 31-34

  Zetsche, Bernd ^a,b,c,d,e   Heidenreich, Matthias ^a,b,c,d   Mohanraju, Prarthana ^f   Fedorova, Iana ^a,b,c,d,g,h   Kneppers, Jeroen ^a,f   Degennaro, Ellen M ^a,c   Winblad, Nerges ^a,b,c,d   Choudhury, Sourav R ^a,b,c,d   Abudayyeh, Omar O ^a,b,c,d   Gootenberg, Jonathan S ^a,b,c,d,i   Wu, Wen Y ^f   Scott, David A ^a,b   Severinov, Konstantin ^g,j,k   Van Der Oost, John ^f   Zhang, Feng ^a,b,c,d  

^a BROAD INSTITUTE OF MIT AND HARVARD   (United States)

^b MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

^c MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

^d Massachusetts Institute of Technology Cambridge   (United States)

^e UNIVERSITY HOSPITAL BONN   (Germany)

^f WAGENINGEN UNIVERSITY   (Netherlands)

^g SKOLKOVO INSTITUTE OF SCIENCE AND TECHNOLOGY   (Russian Federation)

^h PETER THE GREAT ST PETERSBURG POLYTECHNIC UNIVERSITY   (Russian Federation)

ⁱ HARVARD MEDICAL SCHOOL   (United States)

^j RUTGERS UNIVERSITY   (United States)

^k INSTITUTE OF MOLECULAR GENETICS   (Russian Federation)

more..

Author keywords

[No Author keywords available]

Indexed keywords

MAMMALS; MULTIPLEXING;

EXPRESSION CONSTRUCTS; GENOMIC LOCUS; MAMMALIAN CELLS; MOUSE BRAIN;

GENES;

AMINO ACID; CLUSTERED REGULARLY INTERSPACED SHORT PALINDROMIC REPEAT RNA; DNA METHYLTRANSFERASE 1; NUCLEOTIDE; PROTEIN; PROTEIN CPF1; RNA; UNCLASSIFIED DRUG; BACTERIAL PROTEIN; BACTERIAL RNA; CRISPR ASSOCIATED PROTEIN;

CHEMICAL ANALYSIS; CONTROLLED STUDY; CRISPR CAS SYSTEM; CRYSTAL STRUCTURE; ENZYME ACTIVITY; FREQUENCY; GENE EDITING; GENE EXPRESSION; GENE LOCUS; HUMAN; HUMAN CELL; PRIORITY JOURNAL; REVIEW; ANIMAL; GENETICS; MOUSE; PROCEDURES; SEQUENCE ANALYSIS;

ANIMALS; BACTERIAL PROTEINS; CRISPR-ASSOCIATED PROTEINS; CRISPR-CAS SYSTEMS; GENE EDITING; MICE; RNA, BACTERIAL; SEQUENCE ANALYSIS, RNA;

EID: 85011072174     PISSN: 10870156     EISSN: 15461696     Source Type: Journal    
DOI: 10.1038/nbt.3737     Document Type: Review

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