The epigenetic landscape of T cell exhaustion

Science

Volumn 354, Issue 6316, 2016, Pages 1165-1169

  Sen, Debattama R ^a,b   Kaminski, James ^c   Barnitz, R Anthony ^a   Kurachi, Makoto ^d   Gerdemann, Ulrike ^a   Yates, Kathleen B ^a   Tsao, Hsiao Wei ^a   Godec, Jernej ^a,b   LaFleur, Martin W ^a,b   Brown, Flavian D ^a,b   Tonnerre, Pierre ^e   Chung, Raymond T ^e   Tully, Damien C ^f   Allen, Todd M ^f   Frahm, Nicole ^g   Lauer, Georg M ^e   Wherry, E John ^d   Yosef, Nir ^c,f,h   Haining, W Nicholas ^a,i,j  

^a DANA FARBER CANCER INSTITUTE   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d UNIVERSITY OF PENNSYLVANIA   (United States)

^e MASSACHUSETTS GENERAL HOSPITAL   (United States)

^f HARVARD UNIVERSITY   (United States)

^g Fred Hutchinson Cancer Research Center   (United States)

^h UNIVERSITY OF CALIFORNIA   (United States)

ⁱ BOSTON CHILDREN S HOSPITAL   (United States)

^j MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

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Author keywords

[No Author keywords available]

Indexed keywords

GUIDE RNA; PROGRAMMED DEATH 1 RECEPTOR; RETINOIC ACID RECEPTOR; TETRAMER; TRANSCRIPTION FACTOR CTCF; TRANSCRIPTION FACTOR SOX3; TRANSCRIPTION FACTOR T BET; CHROMATIN; PROGRAMMED DEATH 1 LIGAND 1; T BOX TRANSCRIPTION FACTOR; T-BOX TRANSCRIPTION FACTOR TBX21; TRANSCRIPTION FACTOR SOX;

APOPTOSIS; CELLS AND CELL COMPONENTS; GENE; GENE EXPRESSION; GENOME; PROTEIN; RODENT; VIRAL DISEASE;

ANIMAL CELL; ARTICLE; ASSAY; CD8+ T LYMPHOCYTE; CELL DIFFERENTIATION; CELL EXHAUSTION; CELLULAR, SUBCELLULAR AND MOLECULAR BIOLOGICAL PHENOMENA AND FUNCTIONS; CHROMATIN; CHRONIC HEPATITIS C; CLUSTERED REGULARLY INTERSPACED SHORT PALINDROMIC REPEAT; ENHANCER REGION; EPIGENETICS; GENE EXPRESSION; GENE LOCUS; GENOME; HEMATOPOIETIC CELL; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1 INFECTION; LYMPHOCYTIC CHORIOMENINGITIS; MEMORY T LYMPHOCYTE; MOUSE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROMOTER REGION; SINGLE NUCLEOTIDE POLYMORPHISM; TRANSCRIPTION INITIATION SITE; ANIMAL; ANTAGONISTS AND INHIBITORS; C57BL MOUSE; CELL LINEAGE; CHRONIC DISEASE; DISEASE MODEL; GENE EDITING; GENETIC EPIGENESIS; GENETIC TRANSCRIPTION; GENETICS; HEPATITIS C, CHRONIC; HIV INFECTIONS; IMMUNOLOGICAL MEMORY; IMMUNOLOGY; IMMUNOTHERAPY; METABOLISM; TRANSPLANTATION;

ANIMALS; ANTIGENS, CD274; CD8-POSITIVE T-LYMPHOCYTES; CELL LINEAGE; CHROMATIN; CHRONIC DISEASE; DISEASE MODELS, ANIMAL; ENHANCER ELEMENTS, GENETIC; EPIGENESIS, GENETIC; GENE EDITING; HEPATITIS C, CHRONIC; HIV INFECTIONS; HUMANS; IMMUNOLOGIC MEMORY; IMMUNOTHERAPY; LYMPHOCYTIC CHORIOMENINGITIS; MICE; MICE, INBRED C57BL; SOXB1 TRANSCRIPTION FACTORS; T-BOX DOMAIN PROTEINS; TRANSCRIPTION, GENETIC;

EID: 84994335422     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.aae0491     Document Type: Article

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