Systematic mapping of functional enhancer-promoter connections with CRISPR interference

Science

Volumn 354, Issue 6313, 2016, Pages 769-773

  Fulco, Charles P ^a,b   Munschauer, Mathias ^a   Anyoha, Rockwell ^a   Munson, Glen ^a   Grossman, Sharon R ^a,c   Perez, Elizabeth M ^a   Kane, Michael ^a   Cleary, Brian ^a,c   Lander, Eric S ^a,b,c   Engreitz, Jesse M ^a  

^a BROAD INSTITUTE OF MIT AND HARVARD   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

^c MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

HISTONE DEACETYLASE 6; MYC PROTEIN; TRANSCRIPTION FACTOR GATA 1; GATA1 PROTEIN, HUMAN; MYC PROTEIN, HUMAN;

CHROMOSOME; DISEASE INCIDENCE; GENE EXPRESSION; GENETIC VARIATION; MAMMAL; PHYSIOLOGY; PROTEIN;

ARTICLE; CELL PROLIFERATION; CHROMATIN; CHROMOSOME; CLUSTERED REGULARLY INTERSPACED SHORT PALINDROMIC REPEAT; CLUSTERED REGULARLY INTERSPACED SHORT PALINDROMIC REPEAT INTERFERENCE; CONTROLLED STUDY; DNA RESPONSIVE ELEMENT; ENHANCER REGION; GENE EXPRESSION REGULATION; GENE REGULATORY NETWORK; GENETIC REGULATION; HIGH THROUGHPUT SEQUENCING; HISTONE MODIFICATION; HUMAN; HUMAN CELL; POLYMERASE CHAIN REACTION; PREDICTION; PRIORITY JOURNAL; PROMOTER REGION; QUANTITATIVE ANALYSIS; CHROMOSOMAL MAPPING; CRISPR CAS SYSTEM; DISEASES; GENETICS; K-562 CELL LINE; PHYSIOLOGY; PROCEDURES; REAL TIME POLYMERASE CHAIN REACTION;

MAMMALIA;

CELL PROLIFERATION; CHROMOSOME MAPPING; CLUSTERED REGULARLY INTERSPACED SHORT PALINDROMIC REPEATS; CRISPR-CAS SYSTEMS; DISEASE; ENHANCER ELEMENTS, GENETIC; GATA1 TRANSCRIPTION FACTOR; GENE EXPRESSION REGULATION; HIGH-THROUGHPUT NUCLEOTIDE SEQUENCING; HUMANS; K562 CELLS; PROMOTER REGIONS, GENETIC; PROTO-ONCOGENE PROTEINS C-MYC; REAL-TIME POLYMERASE CHAIN REACTION;

EID: 84990852918     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.aag2445     Document Type: Article

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