Multiplexed activation of endogenous genes by CRISPR-on, an RNA-guided transcriptional activator system

Cell Research

Volumn 23, Issue 10, 2013, Pages 1163-1171

  Cheng, Albert W ^a,b   Wang, Haoyi ^a   Yang, Hui ^a   Shi, Linyu ^a   Katz, Yarden ^a,b   Theunissen, Thorold W ^a   Rangarajan, Sudharshan ^a   Shivalila, Chikdu S ^a,b   Dadon, Daniel B ^a,b   Jaenisch, Rudolf ^a,b  

^a WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH   (United States)

^b MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

Author keywords

artificial transcription factor; CRISPR; gene expression; synthetic biology; transcription factor

Indexed keywords

DEOXYRIBONUCLEASE I; GUIDE RNA; HYBRID PROTEIN; TRANSCRIPTION FACTOR;

ANIMAL; ARTICLE; C57BL MOUSE; CELL STRAIN 3T3; CELL STRAIN HEK293; CLUSTERED REGULARLY INTERSPACED SHORT PALINDROMIC REPEAT; FEMALE; GENETICS; HELA CELL; HUMAN; MOLECULAR CLONING; MOUSE; PROMOTER REGION; TRANSCRIPTION INITIATION; TRANSGENE;

ANIMALS; CLONING, MOLECULAR; CLUSTERED REGULARLY INTERSPACED SHORT PALINDROMIC REPEATS; DEOXYRIBONUCLEASE I; FEMALE; HEK293 CELLS; HELA CELLS; HUMANS; MICE; MICE, INBRED C57BL; NIH 3T3 CELLS; PROMOTER REGIONS, GENETIC; RECOMBINANT FUSION PROTEINS; RNA, GUIDE; TRANSCRIPTION FACTORS; TRANSCRIPTIONAL ACTIVATION; TRANSGENES;

EID: 84885180675     PISSN: 10010602     EISSN: 17487838     Source Type: Journal    
DOI: 10.1038/cr.2013.122     Document Type: Article

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