-
1
-
-
84971006562
-
Programmable editing of a target base in genomic DNA without double-stranded DNA cleavage
-
Komor, A.C., Kim, Y.B., Packer, M.S., Zuris, J.A. & Liu, D.R. Programmable editing of a target base in genomic DNA without double-stranded DNA cleavage. Nature 533, 420-424 (2016).
-
(2016)
Nature
, vol.533
, pp. 420-424
-
-
Komor, A.C.1
Kim, Y.B.2
Packer, M.S.3
Zuris, J.A.4
Liu, D.R.5
-
2
-
-
84981516964
-
Targeted nucleotide editing using hybrid prokaryotic and vertebrate adaptive immune systems
-
Nishida, K. et al. Targeted nucleotide editing using hybrid prokaryotic and vertebrate adaptive immune systems. Science 353, 1248-1257 (2016).
-
(2016)
Science
, vol.353
, pp. 1248-1257
-
-
Nishida, K.1
-
3
-
-
84990898361
-
Targeted AID-mediated mutagenesis (TAM) enables efficient genomic diversification in mammalian cells
-
Ma, Y. et al. Targeted AID-mediated mutagenesis (TAM) enables efficient genomic diversification in mammalian cells. Nat. Methods 13, 1029-1035 (2016).
-
(2016)
Nat. Methods
, vol.13
, pp. 1029-1035
-
-
Ma, Y.1
-
4
-
-
84992745786
-
Directed evolution using dCas9-targeted somatic hypermutation in mammalian cells
-
Hess, G.T. et al. Directed evolution using dCas9-targeted somatic hypermutation in mammalian cells. Nat. Methods 13, 1036-1042 (2016).
-
(2016)
Nat. Methods
, vol.13
, pp. 1036-1042
-
-
Hess, G.T.1
-
5
-
-
84994320280
-
Engineering and optimising deaminase fusions for genome editing
-
Yang, L. et al. Engineering and optimising deaminase fusions for genome editing. Nat. Commun. 7, 13330 (2016).
-
(2016)
Nat. Commun.
, vol.7
, pp. 13330
-
-
Yang, L.1
-
6
-
-
84898778301
-
A guide to genome engineering with programmable nucleases
-
Kim, H. & Kim, J.S. A guide to genome engineering with programmable nucleases. Nat. Rev. Genet. 15, 321-334 (2014).
-
(2014)
Nat. Rev. Genet.
, vol.15
, pp. 321-334
-
-
Kim, H.1
Kim, J.S.2
-
7
-
-
84923266604
-
GUIDE-seq enables genome-wide profiling of off-target cleavage by CRISPR-Cas nucleases
-
Tsai, S.Q. et al. GUIDE-seq enables genome-wide profiling of off-target cleavage by CRISPR-Cas nucleases. Nat. Biotechnol. 33, 187-197 (2015).
-
(2015)
Nat. Biotechnol.
, vol.33
, pp. 187-197
-
-
Tsai, S.Q.1
-
8
-
-
84923275611
-
Genome-wide detection of DNA double-stranded breaks induced by engineered nucleases
-
Frock, R.L. et al. Genome-wide detection of DNA double-stranded breaks induced by engineered nucleases. Nat. Biotechnol. 33, 179-186 (2015).
-
(2015)
Nat. Biotechnol.
, vol.33
, pp. 179-186
-
-
Frock, R.L.1
-
9
-
-
84927514894
-
In vivo genome editing using Staphylococcus aureus Cas9
-
Ran, F.A. et al. In vivo genome editing using Staphylococcus aureus Cas9. Nature 520, 186-191 (2015).
-
(2015)
Nature
, vol.520
, pp. 186-191
-
-
Ran, F.A.1
-
10
-
-
84875754465
-
Nucleotide-resolution DNA double-strand break mapping by next-generation sequencing
-
Crosetto, N. et al. Nucleotide-resolution DNA double-strand break mapping by next-generation sequencing. Nat. Methods 10, 361-365 (2013).
-
(2013)
Nat. Methods
, vol.10
, pp. 361-365
-
-
Crosetto, N.1
-
11
-
-
84923221641
-
Unbiased detection of off-target cleavage by CRISPR-Cas9 and TALENs using integrase-defective lentiviral vectors
-
Wang, X. et al. Unbiased detection of off-target cleavage by CRISPR-Cas9 and TALENs using integrase-defective lentiviral vectors. Nat. Biotechnol. 33, 175-178 (2015).
-
(2015)
Nat. Biotechnol.
, vol.33
, pp. 175-178
-
-
Wang, X.1
-
12
-
-
80052766645
-
An unbiased genome-wide analysis of zinc-finger nuclease specificity
-
Gabriel, R. et al. An unbiased genome-wide analysis of zinc-finger nuclease specificity. Nat. Biotechnol. 29, 816-823 (2011).
-
(2011)
Nat. Biotechnol.
, vol.29
, pp. 816-823
-
-
Gabriel, R.1
-
13
-
-
84923846574
-
Digenome-seq: Genome-wide profiling of CRISPR-Cas9 off-target effects in human cells
-
Kim, D. et al. Digenome-seq: genome-wide profiling of CRISPR-Cas9 off-target effects in human cells. Nat. Methods 12, 237-243 (2015).
-
(2015)
Nat. Methods
, vol.12
, pp. 237-243
-
-
Kim, D.1
-
14
-
-
84960392032
-
Genome-wide target specificities of CRISPR-Cas9 nucleases revealed by multiplex Digenome-seq
-
Kim, D., Kim, S., Kim, S., Park, J. & Kim, J.S. Genome-wide target specificities of CRISPR-Cas9 nucleases revealed by multiplex Digenome-seq. Genome Res. 26, 406-415 (2016).
-
(2016)
Genome Res.
, vol.26
, pp. 406-415
-
-
Kim, D.1
Kim, S.2
Kim, S.3
Park, J.4
Kim, J.S.5
-
15
-
-
84981318543
-
Genome-wide analysis reveals specificities of Cpf1 endonucleases in human cells
-
Kim, D. et al. Genome-wide analysis reveals specificities of Cpf1 endonucleases in human cells. Nat. Biotechnol. 34, 863-868 (2016).
-
(2016)
Nat. Biotechnol.
, vol.34
, pp. 863-868
-
-
Kim, D.1
-
16
-
-
84903138336
-
CRISPR/Cas9 systems have off-target activity with insertions or deletions between target DNA and guide RNA sequences
-
Lin, Y. et al. CRISPR/Cas9 systems have off-target activity with insertions or deletions between target DNA and guide RNA sequences. Nucleic Acids Res. 42, 7473-7485 (2014).
-
(2014)
Nucleic Acids Res.
, vol.42
, pp. 7473-7485
-
-
Lin, Y.1
-
17
-
-
84896308706
-
Cas-OFFinder: A fast and versatile algorithm that searches for potential off-target sites of Cas9 RNA-guided endonucleases
-
Bae, S., Park, J. & Kim, J.S. Cas-OFFinder: a fast and versatile algorithm that searches for potential off-target sites of Cas9 RNA-guided endonucleases. Bioinformatics 30, 1473-1475 (2014).
-
(2014)
Bioinformatics
, vol.30
, pp. 1473-1475
-
-
Bae, S.1
Park, J.2
Kim, J.S.3
-
18
-
-
85018918215
-
Highly efficient RNA-guided base editing in mouse embryos
-
Kyoungmi Kim, K. et al. Highly efficient RNA-guided base editing in mouse embryos. Nat. Biotechnol. http://dx.doi.org/10.1038/nbt.3816 (2017).
-
(2017)
Nat. Biotechnol.
-
-
Kyoungmi Kim, K.1
-
19
-
-
84896929630
-
Improving CRISPR-Cas nuclease specificity using truncated guide RNAs
-
Fu, Y., Sander, J.D., Reyon, D., Cascio, V.M. & Joung, J.K. Improving CRISPR-Cas nuclease specificity using truncated guide RNAs. Nat. Biotechnol. 32, 279-284 (2014).
-
(2014)
Nat. Biotechnol.
, vol.32
, pp. 279-284
-
-
Fu, Y.1
Sander, J.D.2
Reyon, D.3
Cascio, V.M.4
Joung, J.K.5
-
20
-
-
84891710947
-
Analysis of off-target effects of CRISPR/Cas-derived RNA-guided endonucleases and nickases
-
Cho, S.W. et al. Analysis of off-target effects of CRISPR/Cas-derived RNA-guided endonucleases and nickases. Genome Res. 24, 132-141 (2014).
-
(2014)
Genome Res.
, vol.24
, pp. 132-141
-
-
Cho, S.W.1
-
21
-
-
84952943845
-
Rationally engineered Cas9 nucleases with improved specificity
-
Slaymaker, I.M. et al. Rationally engineered Cas9 nucleases with improved specificity. Science 351, 84-88 (2016).
-
(2016)
Science
, vol.351
, pp. 84-88
-
-
Slaymaker, I.M.1
-
22
-
-
84963941043
-
High-fidelity CRISPR-Cas9 nucleases with no detectable genome-wide off-target effects
-
Kleinstiver, B.P. et al. High-fidelity CRISPR-Cas9 nucleases with no detectable genome-wide off-target effects. Nature 529, 490-495 (2016).
-
(2016)
Nature
, vol.529
, pp. 490-495
-
-
Kleinstiver, B.P.1
-
23
-
-
84884911076
-
Heritable gene knockout in Caenorhabditis elegans by direct injection of Cas9-sgRNA ribonucleoproteins
-
Cho, S.W., Lee, J., Carroll, D., Kim, J.S. & Lee, J. Heritable gene knockout in Caenorhabditis elegans by direct injection of Cas9-sgRNA ribonucleoproteins. Genetics 195, 1177-1180 (2013).
-
(2013)
Genetics
, vol.195
, pp. 1177-1180
-
-
Cho, S.W.1
Lee, J.2
Carroll, D.3
Kim, J.S.4
Lee, J.5
-
24
-
-
84901834420
-
Highly efficient RNA-guided genome editing in human cells via delivery of purified Cas9 ribonucleoproteins
-
Kim, S., Kim, D., Cho, S.W., Kim, J. & Kim, J.S. Highly efficient RNA-guided genome editing in human cells via delivery of purified Cas9 ribonucleoproteins. Genome Res. 24, 1012-1019 (2014).
-
(2014)
Genome Res.
, vol.24
, pp. 1012-1019
-
-
Kim, S.1
Kim, D.2
Cho, S.W.3
Kim, J.4
Kim, J.S.5
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