C2c1-sgRNA Complex Structure Reveals RNA-Guided DNA Cleavage Mechanism

Molecular Cell

Volumn 65, Issue 2, 2017, Pages 310-322

  Liu, Liang ^a   Chen, Peng ^a,b   Wang, Min ^a   Li, Xueyan ^a,b   Wang, Jiuyu ^a   Yin, Maolu ^a,b   Wang, Yanli ^a,b,c  

^a INSTITUTE OF BIOPHYSICS   (China)

^b UNIVERSITY OF CHINESE ACADEMY OF SCIENCES   (China)

^c FUDAN UNIVERSITY   (China)

Author keywords

C2c1; CRISPR Cas system; crystal structure; DNA endonuclease; genome editing

Indexed keywords

AMINO ACID; C2C1 PROTEIN; CAS 9 PROTEIN; CELLULAR APOPTOSIS SUSCEPTIBILITY PROTEIN; CPF1 PROTEIN; DEOXYRIBONUCLEASE; DOUBLE STRANDED DNA; GUIDE RNA; NUC PROTEIN; NUCLEOTIDE; PROTEIN; REC PROTEIN; TRACRRNA; UNCLASSIFIED DRUG; BACTERIAL DNA; BACTERIAL PROTEIN; BACTERIAL RNA; CRISPR ASSOCIATED PROTEIN; HETERODUPLEX; PROTEIN BINDING;

ALICYCLOBACILLUS; ALICYCLOBACILLUS ACIDOTERRESTRIS; ARTICLE; BINDING AFFINITY; CRISPR CAS SYSTEM; CRYSTAL STRUCTURE; DNA CLEAVAGE; DNA HELIX; DNA RNA HYBRIDIZATION; GENE EDITING; NONHUMAN; PROTEIN ANALYSIS; PROTEIN INTERACTION; PROTEIN SECONDARY STRUCTURE; PROTOSPACER ADJACENT MOTIF; RNA STRUCTURE; SINGLE NUCLEOTIDE POLYMORPHISM; SURFACE PROPERTY; CHEMISTRY; CLUSTERED REGULARLY INTERSPACED SHORT PALINDROMIC REPEAT; CONFORMATION; DOUBLE STRANDED DNA BREAK; ENZYMOLOGY; GENETICS; METABOLISM; MOLECULAR MODEL; PROTEIN DOMAIN; STRUCTURE ACTIVITY RELATION;

ALICYCLOBACILLUS; BACTERIAL PROTEINS; CLUSTERED REGULARLY INTERSPACED SHORT PALINDROMIC REPEATS; CRISPR-ASSOCIATED PROTEINS; CRISPR-CAS SYSTEMS; DNA BREAKS, DOUBLE-STRANDED; DNA, BACTERIAL; ENDODEOXYRIBONUCLEASES; MODELS, MOLECULAR; NUCLEIC ACID CONFORMATION; NUCLEIC ACID HETERODUPLEXES; PROTEIN BINDING; PROTEIN INTERACTION DOMAINS AND MOTIFS; RNA, BACTERIAL; RNA, GUIDE; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 85008512771     PISSN: 10972765     EISSN: 10974164     Source Type: Journal    
DOI: 10.1016/j.molcel.2016.11.040     Document Type: Article

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