CRISPRi-based genome-scale identification of functional long noncoding RNA loci in human cells

Science

Volumn 355, Issue 6320, 2017, Pages

  Liu, S John ^a,b   Horlbeck, Max A ^a,b,c   Cho, Seung Woo ^e   Birk, Harjus S ^a,b   Malatesta, Martina ^a,b   He, Daniel ^a,b   Attenello, Frank J ^a,b   Villalta, Jacqueline E ^a,b,c   Cho, Min Y ^a,b,c   Chen, Yuwen ^a,b,c   Mandegar, Mohammad A ^a   Olvera, Michael P ^a   Gilbert, Luke A ^a,b,c   Conklin, Bruce R ^a,d   Chang, Howard Y ^e   Weissman, Jonathan S ^a,b,c   Lim, Daniel A ^a,b,f  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d GLADSTONE INSTITUTE OF CARDIOVASCULAR DISEASE   (United States)

^e STANFORD UNIVERSITY   (United States)

^f SAN FRANCISCO VETERANS AFFAIRS MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GUIDE RNA; LONG UNTRANSLATED RNA; TRANSCRIPTOME;

CELLS AND CELL COMPONENTS; GENE EXPRESSION; GENETIC ANALYSIS; GENOME; IDENTIFICATION METHOD; RNA;

ARTICLE; CELL GROWTH; CLUSTERED REGULARLY INTERSPACED SHORT PALINDROMIC REPEAT; COPY NUMBER VARIATION; DNA STRAND; ENHANCER REGION; GENE FUNCTION; GENE LOCUS; HELA CELL LINE; HUMAN; HUMAN GENOME; INDUCED PLURIPOTENT STEM CELL; K-562 CELL LINE; MACHINE LEARNING; MCF-7 CELL LINE; MDA-MB-231 CELL LINE; NON-TRANSFORMED CELL; PRIORITY JOURNAL; TRANSCRIPTION INITIATION SITE; TRANSFORMED CELL LINE; CELL LINE; GENE REGULATORY NETWORK; GENE SILENCING; GENETIC SCREENING; GENETIC TRANSCRIPTION; GENETICS; RNA INTERFERENCE;

CELL GROWTH PROCESSES; CELL LINE; CLUSTERED REGULARLY INTERSPACED SHORT PALINDROMIC REPEATS; GENE KNOCKDOWN TECHNIQUES; GENE REGULATORY NETWORKS; GENETIC LOCI; GENETIC TESTING; GENOME, HUMAN; HUMANS; INDUCED PLURIPOTENT STEM CELLS; MACHINE LEARNING; RNA INTERFERENCE; RNA, LONG NONCODING; TRANSCRIPTION, GENETIC; TRANSCRIPTOME;

EID: 85008257169     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.aah7111     Document Type: Article

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