Divergent Roles of IRS (Insulin Receptor Substrate) 1 and 2 in Liver and Skeletal Muscle

Current Medicinal Chemistry

Volumn 24, Issue 17, 2017, Pages 1827-1852

  Eckstein, Sabine Sarah ^a   Weigert, Cora ^a,b,c   Lehmann, Rainer ^a,b,c  

^a UNIVERSITY HOSPITAL TÜBINGEN   (Germany)

^b UNIVERSITY OF TÜBINGEN   (Germany)

^c GERMAN CENTER FOR DIABETES RESEARCH DZD   (Germany)

Author keywords

Degradation; Insulin receptor substrate; Insulin resistance; Liver; Metabolism; Phosphorylation; Skeletal muscle

Indexed keywords

AKT1 PROTEIN; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN BINDING PROTEIN; GLIBENCLAMIDE; GLUCOSE TRANSPORTER 4; GLYCOGEN SYNTHASE KINASE 3; INSULIN; INSULIN RECEPTOR SUBSTRATE 1; INSULIN RECEPTOR SUBSTRATE 2; MAMMALIAN TARGET OF RAPAMYCIN COMPLEX 2; MITOGEN ACTIVATED PROTEIN KINASE P38; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR; PROTEIN; PROTEIN KINASE B BETA; RETINOBLASTOMA PROTEIN; RETINOID X RECEPTOR; SMALL INTERFERING RNA; STEROL REGULATORY ELEMENT BINDING PROTEIN 1C; TRANSCRIPTION FACTOR FKHR; UNCLASSIFIED DRUG; GLUCOSE; INSULIN RECEPTOR SUBSTRATE;

CARBOHYDRATE METABOLISM; CELL CULTURE; CELL DIFFERENTIATION; DIFFERENTIATION; ENDURANCE TRAINING; FATTY ACID OXIDATION; FIBROBLAST; FOOD INTAKE; GASTROCNEMIUS MUSCLE; GENE EXPRESSION; GLUCOSE METABOLISM; GLUCOSE TRANSPORT; GLYCOGEN SYNTHESIS; GROWTH; HUMAN; INSULIN METABOLISM; INSULIN RESISTANCE; INSULIN SENSITIVITY; LIPID METABOLISM; LIVER; LIVER LOBULE; MUSCLE ATROPHY; MUSCLE DEVELOPMENT; MUSCLE MASS; MYOBLAST; MYOTUBE; NEGATIVE FEEDBACK; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; OBESITY; PATHOGENESIS; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; PROTEIN PROCESSING; QUADRICEPS FEMORIS MUSCLE; REVIEW; SEQUENCE HOMOLOGY; SIGNAL TRANSDUCTION; SKELETAL MUSCLE; SKELETAL MUSCLE CELL; SOLEUS MUSCLE; UPREGULATION; WILD TYPE; ANIMAL; EXERCISE; METABOLISM; PATHOLOGY;

ANIMALS; DIABETES MELLITUS, TYPE 2; EXERCISE; GLUCOSE; HUMANS; INSULIN; INSULIN RECEPTOR SUBSTRATE PROTEINS; LIPID METABOLISM; LIVER; MUSCLE, SKELETAL; SIGNAL TRANSDUCTION;

EID: 85026736546     PISSN: 09298673     EISSN: 1875533X     Source Type: Journal    
DOI: 10.2174/0929867324666170426142826     Document Type: Review

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