Phosphorylation of serine 1137/1138 of mouse Insulin Receptor Substrate (IRS) 2 regulates cAMP-dependent binding to 14-3-3 proteins and IRS2 protein degradation

Journal of Biological Chemistry

Volumn 288, Issue 23, 2013, Pages 16403-16415

  Neukamm, Sabine S ^a,b   Ott, Jennifer ^a   Dammeier, Sascha ^a   Lehmanns, Rainer ^a,b   Har̈ing, Hans Ulrich ^a,b   Schleichers, Erwin ^a,b   Weigert, Cora ^a,b  

^a UNIVERSITY HOSPITAL TÜBINGEN   (Germany)

^b UNIVERSITY OF TÜBINGEN   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

GLUCOSE HOMEOSTASIS; INSULIN RECEPTORS; INSULIN-LIKE GROWTH FACTOR 1; MASS SPECTROMETRIC ANALYSIS; PHOSPHORYLATION SITES; PRIMARY HEPATOCYTES; PROTEIN DEGRADATION; PROTEIN STABILITY;

INSULIN; PHOSPHORYLATION; PROTEINS;

AMINO ACIDS;

CYCLIC AMP; CYCLIC AMP DEPENDENT PROTEIN KINASE; FORSKOLIN; INSULIN RECEPTOR SUBSTRATE 2; PROTEIN 14 3 3; SERINE; SERINE 1137; SERINE 1138; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; BINDING AFFINITY; BINDING SITE; CELL LEVEL; CELL SURVIVAL; CONTROLLED STUDY; GLUCOSE HOMEOSTASIS; LIVER CELL; MALE; MASS SPECTROMETRY; MOLECULAR DYNAMICS; MOUSE; MUTATIONAL ANALYSIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DEGRADATION; PROTEIN DETERMINATION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN MOTIF; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; PROTEIN STABILITY;

14-3-3; CYCLIC AMP (CAMP); INSULIN; IRS2; PHOSPHORYLATION; PROTEIN DEGRADATION; PROTEIN KINASE A (PKA);

14-3-3 PROTEINS; AMINO ACID SUBSTITUTION; ANIMALS; BINDING SITES; CYCLIC AMP; CYCLIC AMP-DEPENDENT PROTEIN KINASES; CYCLOHEXIMIDE; FORSKOLIN; HEK293 CELLS; HUMANS; INSULIN RECEPTOR SUBSTRATE PROTEINS; MICE; MUTATION, MISSENSE; PHOSPHORYLATION; PROTEIN BINDING; PROTEIN STABILITY; PROTEIN SYNTHESIS INHIBITORS; PROTEOLYSIS; SERINE;

EID: 84878747826     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M113.474593     Document Type: Article

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