Knockdown of PRAS40 inhibits insulin action via proteasome-mediated degradation of IRS1 in primary human skeletal muscle cells

Diabetologia

Volumn 56, Issue 5, 2013, Pages 1118-1128

  Wiza, C ^a   Herzfeld De Wiza, D ^a   Nascimento, E B M ^b   Lehr, S ^a   Al Hasani, H ^a   Ouwens, D M ^a,c  

^a LEIBNIZ CENTER FOR DIABETES RESEARCH AT HEINRICH HEINE UNIVERSITY DÜSSELDORF   (Germany)

^b KAROLINSKA INSTITUTE   (Sweden)

^c GHENT UNIVERSITY HOSPITAL   (Belgium)

Author keywords

Chemokines; Insulin resistance; IRS1; mTOR; PRAS40; Skeletal muscle

Indexed keywords

ATROGIN 1; CHEMOKINE; GLUCOSE; GLYCOGEN SYNTHASE KINASE 3; GROWTH FACTOR RECEPTOR; INITIATION FACTOR 4E BINDING PROTEIN 1; INSULIN; MAMMALIAN TARGET OF RAPAMYCIN; MONOCYTE CHEMOTACTIC PROTEIN 1; MUSCLE RING FINGER 1 PROTEIN; PRAS40 PROTEIN; PROLINE RICH PROTEIN; PROTEASOME; SMALL INTERFERING RNA; TUBERIN; UBIQUITIN PROTEIN LIGASE E3; UNCLASSIFIED DRUG;

ADULT; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; DRUG MECHANISM; FEMALE; GENE EXPRESSION; GENETIC CODE; GLUCOSE TRANSPORT; HUMAN; HUMAN CELL; INSULIN RESISTANCE; MALE; MUSCLE CELL; MYOTUBE; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; SKELETAL MUSCLE;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; CELLS, CULTURED; CHEMOKINE CCL2; CHEMOKINES; DOWN-REGULATION; FEMALE; GENE SILENCING; HUMANS; HYPOGLYCEMIC AGENTS; INSULIN RECEPTOR SUBSTRATE PROTEINS; INSULIN RESISTANCE; INSULIN, REGULAR, PORK; MALE; MUSCLE, SKELETAL; PHOSPHORYLATION; PROTEASOME ENDOPEPTIDASE COMPLEX; PROTEIN PROCESSING, POST-TRANSLATIONAL; PROTEOLYSIS; PROTO-ONCOGENE PROTEINS C-AKT; RECOMBINANT PROTEINS; RNA, SMALL INTERFERING; UP-REGULATION;

EID: 84876467214     PISSN: 0012186X     EISSN: 14320428     Source Type: Journal    
DOI: 10.1007/s00125-013-2861-9     Document Type: Article

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