메뉴 건너뛰기




Volumn 107, Issue 2, 2001, Pages 181-189

Insulin/IGF-1 and TNF-α stimulate phosphorylation of IRS-1 at inhibitory Ser307 via distinct pathways

Author keywords

[No Author keywords available]

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; 2 MORPHOLINO 8 PHENYLCHROMONE; INSULIN; INSULIN RECEPTOR SUBSTRATE 1; POLYCLONAL ANTIBODY; SERINE; SOMATOMEDIN C; STRESS ACTIVATED PROTEIN KINASE; THREONINE; TUMOR NECROSIS FACTOR ALPHA; WORTMANNIN;

EID: 0035144307     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI10934     Document Type: Article
Times cited : (508)

References (36)
  • 2
    • 0030724591 scopus 로고    scopus 로고
    • Pathogenesis of type 2 diabetes: Metabolic and molecular implications for identifying diabetes genes
    • (1997) Diabetes Review , vol.5 , pp. 177-269
    • DeFronzo, R.A.1
  • 5
    • 0033524937 scopus 로고    scopus 로고
    • Tissue-specific knockout of the insulin receptor in pancreatic β cells creates an insulin secretory defect similar to that in type 2 diabetes
    • (1999) Cell , vol.96 , pp. 329-339
    • Kulkarni, R.N.1
  • 6
    • 0032567937 scopus 로고    scopus 로고
    • Disruption of IRS-2 causes type 2 diabetes in mice
    • (1998) Nature , vol.391 , pp. 900-904
    • Withers, D.J.1
  • 8
    • 0027008081 scopus 로고
    • Interaction between the p21rasGTPase activating protein and the insulin receptor
    • (1993) J. Biol. Chem. , vol.267 , pp. 24058-24063
    • Pronk, G.J.1
  • 12
    • 0001035842 scopus 로고    scopus 로고
    • PI 3-kinase but not map kinase signaling is insulin resistant in obesity and niddm
    • Abstr.
    • (1998) Diabetes. , vol.47
    • Maezono, K.1
  • 14
    • 0031022434 scopus 로고    scopus 로고
    • Tumor necrosis factor-α-induced insulin resistance in 3T3-L1 adipocytes is accompanied by a loss of insulin receptor substrate-1 and GLUT4 expression without a loss of insulin receptor-mediated signal transduction
    • (1997) J. Biol. Chem. , vol.272 , pp. 971-976
    • Stephens, J.M.1    Lee, J.2    Pilch, P.F.3
  • 15
    • 0034455290 scopus 로고    scopus 로고
    • Persistent activation of phosphatidylinositol 3-kinase causes insulin resistance due to accelerated insulin-induced insulin receptor substrate-1 degradation in 3T3-L1 adipocytes
    • (2000) Endocrinology , vol.141 , pp. 1930-1935
    • Egawa, K.1
  • 16
    • 0033525870 scopus 로고    scopus 로고
    • Increased insulin sensitivity and obesity resistance in mice lacking the protein tyrosine phosphatase-1B gene
    • (1999) Science , vol.283 , pp. 1544-1548
    • Elchebly, M.1
  • 21
    • 0030061922 scopus 로고    scopus 로고
    • IRS-1-mediated inhibition of insulin receptor tyrosine kinase activity in TNF-α- and obesity-induced insulin resistance
    • (1996) Science , vol.271 , pp. 665-668
    • Hotamisligil, G.S.1
  • 23
    • 0030669392 scopus 로고    scopus 로고
    • A molecular basis for insulin resistance. Elevated serine/threonine phosphorylation of IRS-1 and IRS-2 inhibits their binding to the juxtamembrane region of the insulin receptor and impairs their ability to undergo insulin-induced tyrosine phosphorylation
    • (1997) J. Biol. Chem. , vol.272 , pp. 29911-29918
    • Paz, K.1
  • 25
    • 15844389443 scopus 로고    scopus 로고
    • Phosphorylation of insulin receptor substrate-1 on multiple serine residues, 612, 632, 662, and 731, modulates insulin action
    • (1996) J. Biol. Chem. , vol.271 , pp. 11222-11227
    • Mothe, I.1    Van Obberghen, E.2
  • 30
    • 0003100113 scopus 로고
    • Insulin resistance and hyperinsulinemia: The link between NIDDM, CAD, hypertension and dyslipidemia
    • New horizons in diabetes mellitus and cardiovascular disease. C.J. Schwartz and G.V.R. Born, editors. Science Press. London, United Kingdom
    • (1995) , pp. 11-27
    • DeFronzo, R.A.1
  • 31
    • 0025813375 scopus 로고
    • The structure of the insulin receptor substrate IRS-1 defines a unique signal transduction protein
    • (1991) Nature , vol.352 , pp. 73-77
    • Sun, X.J.1
  • 32
    • 0031465447 scopus 로고    scopus 로고
    • Modulation of insulin receptor substrate-1 tyrosine phosphorylation and function by mitogen-activated protein kinase
    • (1997) J. Biol. Chem. , vol.272 , pp. 31400-31406
    • De Fea, K.1    Roth, R.A.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.