Insulin down-regulates insulin receptor substrate-2 expression through the phosphatidylinositol 3-kinase/Akt pathway

Journal of Endocrinology

Volumn 179, Issue 2, 2003, Pages 253-266

  Hirashima, Y ^b   Tsuruzoe, K ^a   Kodama, S ^b   Igata, M ^b   Toyonaga, T ^b   Ueki, K ^a   Kahn, C R ^a   Araki, E ^b  

^a HARVARD MEDICAL SCHOOL   (United States)

^b KUMAMOTO UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; 2 MORPHOLINO 8 PHENYLCHROMONE; CELL DNA; INSULIN; INSULIN RECEPTOR SUBSTRATE 1; INSULIN RECEPTOR SUBSTRATE 2; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE INHIBITOR; NUCLEAR PROTEIN; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3 KINASE INHIBITOR; PROTEASOME; PROTEIN KINASE B;

ANIMAL CELL; ARTICLE; CANCER CELL CULTURE; CONTROLLED STUDY; DNA RESPONSIVE ELEMENT; DNA SEQUENCE; ENZYME ACTIVATION; ENZYME DEGRADATION; ENZYME INHIBITION; GENE ACTIVITY; GENE EXPRESSION REGULATION; GENE OVEREXPRESSION; GENE REPRESSION; HEPATOMA CELL; HORMONAL REGULATION; HUMAN; IN VITRO STUDY; INSULIN RESPONSE; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN BINDING; PROTEIN EXPRESSION; RAT; RECEPTOR DOWN REGULATION; REGULATORY MECHANISM; REPORTER GENE;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ANIMALS; CARCINOMA, HEPATOCELLULAR; CELL LINE; CHROMONES; CYCLOHEXIMIDE; DEPRESSION, CHEMICAL; ENZYME INHIBITORS; FLAVONOIDS; HUMANS; INSULIN; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; LIVER; MICE; MORPHOLINES; PHOSPHOPROTEINS; PROMOTER REGIONS (GENETICS); PROTEIN SYNTHESIS INHIBITORS; PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-AKT; RATS; RNA, MESSENGER; SEQUENCE ALIGNMENT; SIGNAL TRANSDUCTION;

EID: 0344035946     PISSN: 00220795     EISSN: None     Source Type: Journal    
DOI: 10.1677/joe.0.1790253     Document Type: Article

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