Glycogen synthase kinase 3β mediates high glucose-induced ubiquitination and proteasome degradation of insulin receptor substrate 1

Journal of Endocrinology

Volumn 206, Issue 2, 2010, Pages 171-181

  Leng, Sanhua ^a,c   Zhang, Wenshuo ^a   Zheng, Yanbin ^a   Liberman, Ziva ^b   Rhodes, Christopher J ^a   Eldar Finkelman, Hagit ^b   Sun, Xiao Jian ^a  

^a UNIVERSITY OF CHICAGO   (United States)

^b TEL AVIV UNIVERSITY   (Israel)

^c New York Coll Wholistic Hlth E   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GLUCOSE; GLYCOGEN SYNTHASE KINASE 3BETA; INSULIN; INSULIN RECEPTOR SUBSTRATE 1; INSULIN RECEPTOR SUBSTRATE 2; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEASOME; GLYCOGEN SYNTHASE KINASE 3; GLYCOGEN SYNTHASE KINASE 3 BETA; INSULIN RECEPTOR SUBSTRATE;

ANIMAL CELL; ARTICLE; ENZYME ACTIVATION; ENZYME ACTIVITY; INSULIN DEPENDENT DIABETES MELLITUS; INSULIN RESISTANCE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; UBIQUITINATION; ANIMAL; CHO CELL; CRICETULUS; HAMSTER; IMMUNOBLOTTING; LIVER CELL; METABOLISM;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ANIMALS; CHO CELLS; CRICETINAE; CRICETULUS; GLUCOSE; GLYCOGEN SYNTHASE KINASE 3; HEPATOCYTES; IMMUNOBLOTTING; INSULIN RECEPTOR SUBSTRATE PROTEINS; INSULIN RESISTANCE; PROTEASOME ENDOPEPTIDASE COMPLEX; SIGNAL TRANSDUCTION; UBIQUITINATION;

EID: 77955067063     PISSN: 00220795     EISSN: 14796805     Source Type: Journal    
DOI: 10.1677/JOE-09-0456     Document Type: Article

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