Identification of the degradation determinants of insulin receptor substrate 1 for signaling Cullin-RING E3 ubiquitin ligase 7-mediated ubiquitination

Journal of Biological Chemistry

Volumn 287, Issue 48, 2012, Pages 40758-40766

  Xu, Xinsong ^a   Keshwani, Malik ^b   Meyer, Kathleen ^c   Sarikas, Antonio ^c   Taylor, Susan ^b   Pan, Zhen Qiang ^a  

^a MOUNT SINAI SCHOOL OF MEDICINE   (United States)

^b HOWARD HUGHES MEDICAL INSTITUTE   (United States)

^c TECHNICAL UNIVERSITY OF MUNICH   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACID RESIDUES; CELL-BASED; COMPLEX 1; FEEDBACK INHIBITION; FORCED DEGRADATION; HYPERACTIVATION; HYPERPHOSPHORYLATED; IN-VITRO; INSECT CELLS; INSULIN RECEPTOR SUBSTRATE-1; LOW LEVEL; MOLECULAR FEATURE; MULTI-SITE; N-TERMINALS; S6 KINASE 1; SIGNAL SEQUENCE; SUBSTANTIAL REDUCTION; TARGET OF RAPAMYCIN; TYPE II; UBIQUITIN LIGASES; UBIQUITINATION;

AMINO ACIDS; ENZYMES; INSULIN;

PHOSPHORYLATION;

CULLIN RING E3 UBIQUITIN LIGASE 7; INSECT PROTEIN; INSULIN RECEPTOR SUBSTRATE 1; MECHANISTIC TARGET OF RAPAMYCIN COMPLEX 1; S6 KINASE 1; SERINE; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; AMINO TERMINAL SEQUENCE; ANIMAL CELL; ARTICLE; CONSENSUS SEQUENCE; ENZYME ACTIVATION; HUMAN; HUMAN CELL; IN VITRO STUDY; INSECT CELL; NEGATIVE FEEDBACK; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN ISOLATION; PROTEIN LOCALIZATION; PROTEIN METABOLISM; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; SEQUENCE ANALYSIS; SIGNAL TRANSDUCTION; UBIQUITINATION;

HUMANS; INSULIN; INSULIN RECEPTOR SUBSTRATE PROTEINS; PHOSPHORYLATION; PROTEOLYSIS; SIGNAL TRANSDUCTION; UBIQUITIN-PROTEIN LIGASES; UBIQUITINATION;

HEXAPODA;

EID: 84870040172     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M112.405209     Document Type: Article

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