Saturated fatty acids inhibit induction of insulin gene transcription by JNK-mediated phosphorylation of insulin-receptor substrates

Proceedings of the National Academy of Sciences of the United States of America

Volumn 103, Issue 44, 2006, Pages 16454-16459

  Solinas, Giovanni ^a   Naugler, Willscott ^a   Galimi, Francesco ^b   Lee, Myung Shik ^c   Karin, Michael ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF SASSARI   (Italy)

^c Samsung Medical Center   (South Korea)

Author keywords

Diabetes; Insulin gene expression; Lipotoxicity; Obesity

Indexed keywords

GLUCOSE; INSULIN; INSULIN RECEPTOR; INSULIN RECEPTOR SUBSTRATE 1; INSULIN RECEPTOR SUBSTRATE 2; PALMITIC ACID; SATURATED FATTY ACID; STRESS ACTIVATED PROTEIN KINASE; STRESS ACTIVATED PROTEIN KINASE INHIBITOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AUTOCRINE EFFECT; BINDING SITE; CONTROLLED STUDY; DIET; DRUG TARGETING; EMBRYO; ENZYME ACTIVATION; ENZYME ACTIVITY; GENE EXPRESSION; GENETIC MODEL; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; INSULIN RESISTANCE; INSULIN SENSITIVITY; LIVER CELL; MALE; MOUSE; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; OBESITY; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION;

AMINO ACID SEQUENCE; ANIMALS; BLOOD GLUCOSE; CELLS, CULTURED; ENZYME ACTIVATION; FATTY ACIDS; GENE EXPRESSION REGULATION; HEPATOCYTES; HUMANS; INSULIN; INSULIN RESISTANCE; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MALE; MICE; MITOGEN-ACTIVATED PROTEIN KINASE 8; OBESITY; PALMITIC ACID; PHOSPHOPROTEINS; PHOSPHORYLATION; RATS; SUBSTRATE SPECIFICITY; TRANSCRIPTION, GENETIC;

EID: 33750823407     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.0607626103     Document Type: Article

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