Protection from non-alcoholic steatohepatitis and liver tumourigenesis in high fat-fed insulin receptor substrate-1-knockout mice despite insulin resistance

Diabetologia

Volumn 55, Issue 12, 2012, Pages 3382-3391

  Nakamura, A ^a   Tajima, K ^a   Zolzaya, K ^a   Sato, K ^a   Inoue, R ^a   Yoneda, M ^a   Fujita, K ^a   Nozaki, Y ^a   Kubota, K C ^b   Haga, H ^b   Kubota, N ^c   Nagashima, Y ^a   Nakajima, A ^a   Maeda, S ^a   Kadowaki, T ^c   Terauchi, Y ^a  

^a YOKOHAMA CITY UNIVERSITY   (Japan)

^b HOKKAIDO UNIVERSITY HOSPITAL   (Japan)

^c UNIVERSITY OF TOKYO   (Japan)

Author keywords

High fat diet; Insulin receptor substrate 1; Insulin resistance; Liver tumourigenesis; Non alcoholic steatohepatitis

Indexed keywords

INSULIN RECEPTOR SUBSTRATE 1; MITOGEN ACTIVATED PROTEIN KINASE; PALMITIC ACID; SATURATED FATTY ACID; STEARIC ACID; STRESS ACTIVATED PROTEIN KINASE; UNSATURATED FATTY ACID;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CARCINOGENESIS; CONTROLLED STUDY; DIET THERAPY; FATTY LIVER; FEEDING BEHAVIOR; GLUCOSE BLOOD LEVEL; GLUCOSE TOLERANCE TEST; INSULIN RESISTANCE; INTRAABDOMINAL FAT; LIPID COMPOSITION; LIPID DIET; LIPOGENESIS; LIVER CELL CARCINOMA; MALE; MOUSE; NONALCOHOLIC FATTY LIVER; NONHUMAN; OBESITY; PATHOGENESIS; PRIORITY JOURNAL; WEIGHT GAIN;

ANIMALS; CARCINOMA, HEPATOCELLULAR; DIABETES MELLITUS, EXPERIMENTAL; DIET, HIGH-FAT; DISEASE MODELS, ANIMAL; DISEASE PROGRESSION; FATTY LIVER; GLUCOSE TOLERANCE TEST; INSULIN RECEPTOR SUBSTRATE PROTEINS; INSULIN RESISTANCE; LIVER; LIVER NEOPLASMS; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; OBESITY;

EID: 84868198331     PISSN: 0012186X     EISSN: 14320428     Source Type: Journal    
DOI: 10.1007/s00125-012-2703-1     Document Type: Article

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