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Volumn 16, Issue 6, 1996, Pages 3074-3084

Insulin signalling and insulin actions in the muscles and livers of insulin-resistant, insulin receptor substrate 1-deficient mice

Author keywords

[No Author keywords available]

Indexed keywords

GLUCOSE; INSULIN; INSULIN RECEPTOR KINASE; INSULIN RECEPTOR SUBSTRATE 1; MITOGEN ACTIVATED PROTEIN KINASE; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHOTYROSINE; WORTMANNIN;

EID: 0029897280     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.16.6.3074     Document Type: Article
Times cited : (253)

References (50)
  • 3
    • 0028308412 scopus 로고
    • Phosphatidylinositol 3-kinase activation is required for insulin stimulation of pp70 S6 kinase, DNA synthesis, and glucose transporter translocation
    • Cheatham, B., C. J. Vlahos, L. Cheatham, L. Wang, J. Blenis, and C. R. Kahn. 1994. Phosphatidylinositol 3-kinase activation is required for insulin stimulation of pp70 S6 kinase, DNA synthesis, and glucose transporter translocation. Mol. Cell. Biol. 14:4902-4911.
    • (1994) Mol. Cell. Biol. , vol.14 , pp. 4902-4911
    • Cheatham, B.1    Vlahos, C.J.2    Cheatham, L.3    Wang, L.4    Blenis, J.5    Kahn, C.R.6
  • 4
    • 0029157595 scopus 로고
    • Insulin receptor substrate 1 rescues insulin action in CHO cells expressing mutant insulin receptors that lack a juxtamembrane NPXY motif
    • Chen, D., D. J. Van Horn, M. F. White, and J. M. Backer. 1995. Insulin receptor substrate 1 rescues insulin action in CHO cells expressing mutant insulin receptors that lack a juxtamembrane NPXY motif. Mol. Cell. Biol. 15:4711-4717.
    • (1995) Mol. Cell. Biol. , vol.15 , pp. 4711-4717
    • Chen, D.1    Van Horn, D.J.2    White, M.F.3    Backer, J.M.4
  • 6
    • 0026659046 scopus 로고
    • Rapamycin-FKBP specifically blocks growth-dependent activation of and signaling by the 70 kd S6 protein kinases
    • Chung, J., C. J. Kuo, G. R. Crabtree, and J. Blenis. 1992. Rapamycin-FKBP specifically blocks growth-dependent activation of and signaling by the 70 kd S6 protein kinases. Cell 69:1227-1236.
    • (1992) Cell , vol.69 , pp. 1227-1236
    • Chung, J.1    Kuo, C.J.2    Crabtree, G.R.3    Blenis, J.4
  • 7
    • 0027536041 scopus 로고
    • Dissociation of pp70 ribosomal protein S6 kinase from insulin-stimulated glucose transport in 3T3-LI adipocytes
    • Fingar, D. C., S. F. Havsdorff, J. Blenis, and M. J. Birnbaum. 1993. Dissociation of pp70 ribosomal protein S6 kinase from insulin-stimulated glucose transport in 3T3-LI adipocytes. J. Biol. Chem. 268:3005-3008.
    • (1993) J. Biol. Chem. , vol.268 , pp. 3005-3008
    • Fingar, D.C.1    Havsdorff, S.F.2    Blenis, J.3    Birnbaum, M.J.4
  • 8
    • 0018571702 scopus 로고
    • Regulation of protein metabolism by a physiological concentration of insulin in mouse soleus and extensor digilorum longus muscles
    • Frayn, K. N., and P. F. Maycock. 1979. Regulation of protein metabolism by a physiological concentration of insulin in mouse soleus and extensor digilorum longus muscles. Biochem. J. 184:323-330.
    • (1979) Biochem. J. , vol.184 , pp. 323-330
    • Frayn, K.N.1    Maycock, P.F.2
  • 9
    • 0029120591 scopus 로고
    • AMP- And rapamycin-sensitive regulation of the association of eukaryotic initiation factor 4E and the translational regulator PHAS-I in aortic smooth muscle cells
    • Graves, L. M., K. E. Bornfeldt, G. M. Argast, E. G. Krebs, X. Kong, T. A. Lin, and J. C. J. Lawrence. 1995. cAMP- and rapamycin-sensitive regulation of the association of eukaryotic initiation factor 4E and the translational regulator PHAS-I in aortic smooth muscle cells. Proc. Natl. Acad. Sci. USA 92:7222-7226.
    • (1995) Proc. Natl. Acad. Sci. USA , vol.92 , pp. 7222-7226
    • Graves, L.M.1    Bornfeldt, K.E.2    Argast, G.M.3    Krebs, E.G.4    Kong, X.5    Lin, T.A.6    Lawrence, J.C.J.7
  • 10
    • 0028329843 scopus 로고
    • Suitability of 2-deoxyglucose for in vitro measurement of glucose transport activity in skeletal muscle
    • Hansen, P. A., E. A. Gulve, and J. O. Holloszy. 1994. Suitability of 2-deoxyglucose for in vitro measurement of glucose transport activity in skeletal muscle. J. Appl. Physiol. 76:979-985.
    • (1994) J. Appl. Physiol. , vol.76 , pp. 979-985
    • Hansen, P.A.1    Gulve, E.A.2    Holloszy, J.O.3
  • 13
    • 0028207001 scopus 로고
    • Rapamycin selectively represses translation of the "polypyrimidine tract" mRNA
    • Jeffries, H. B. J., C. Reinhard, S. C. Kozma, and G. Thomas. 1994. Rapamycin selectively represses translation of the "polypyrimidine tract" mRNA. Proc. Natl. Acad. Sci. USA 91:4441-4445.
    • (1994) Proc. Natl. Acad. Sci. USA , vol.91 , pp. 4441-4445
    • Jeffries, H.B.J.1    Reinhard, C.2    Kozma, S.C.3    Thomas, G.4
  • 16
    • 0023192181 scopus 로고
    • Tyrosine phosphorylation of common and specific sets of cellular proteins rapidly induced by insulin, insulin-like growth factor I, and epidermal growth factor in an intact cell
    • Kadowaki, T., S. Koyasu, E. Nishida, K. Tobe, T. Izumi, F. Takaku, H. Sakai, I. Yahara, and M. Kasuga. 1987. Tyrosine phosphorylation of common and specific sets of cellular proteins rapidly induced by insulin, insulin-like growth factor I, and epidermal growth factor in an intact cell. J. Biol. Chem. 262:7342-7350.
    • (1987) J. Biol. Chem. , vol.262 , pp. 7342-7350
    • Kadowaki, T.1    Koyasu, S.2    Nishida, E.3    Tobe, K.4    Izumi, T.5    Takaku, F.6    Sakai, H.7    Yahara, I.8    Kasuga, M.9
  • 17
    • 0001489445 scopus 로고
    • Tyrosine-specific protein kinase activity is associated with the purified insulin receptor
    • Kasuga, M., Y. Fujita-Yamaguchi, D. L. Blithe, and C. R. Kahn. 1983. Tyrosine-specific protein kinase activity is associated with the purified insulin receptor. Proc. Natl. Acad. Sci. USA 80:2137-2141.
    • (1983) Proc. Natl. Acad. Sci. USA , vol.80 , pp. 2137-2141
    • Kasuga, M.1    Fujita-Yamaguchi, Y.2    Blithe, D.L.3    Kahn, C.R.4
  • 19
    • 0026705268 scopus 로고
    • A fraction of the mRNA 5′ cap-binding protein, eukaryotic initiation factor 4E, localizes to the nucleus
    • Lejbkowicz, F., C. Goyer, A. Darveau, S. Nerson, R. Lemieux, and N. Sonenberg. 1092. A fraction of the mRNA 5′ cap-binding protein, eukaryotic initiation factor 4E, localizes to the nucleus. Proc. Natl. Acad. Sci. USA 89:9612-9616.
    • (1092) Proc. Natl. Acad. Sci. USA , vol.89 , pp. 9612-9616
    • Lejbkowicz, F.1    Goyer, C.2    Darveau, A.3    Nerson, S.4    Lemieux, R.5    Sonenberg, N.6
  • 23
    • 0027217074 scopus 로고
    • Ash/Grb-2, a SH2/SH3-containing protein, couples to signaling' for mitogenesis and cytoskeletal reorganization by EOF and PDGF
    • Matsuoka, K., F. Shibasaki, M. Shibata, and T. Tatenawa. 1993. Ash/Grb-2, a SH2/SH3-containing protein, couples to signaling' for mitogenesis and cytoskeletal reorganization by EOF and PDGF. EMBO J. 12:3467-3473.
    • (1993) EMBO J. , vol.12 , pp. 3467-3473
    • Matsuoka, K.1    Shibasaki, F.2    Shibata, M.3    Tatenawa, T.4
  • 25
    • 0029130717 scopus 로고
    • Shc isoform-specific tyrosine phosphorylation by the insulin and epidermal growth factor receptors
    • Okada, S., K. Yamauchi, and J. E. Pessin. 1995. Shc isoform-specific tyrosine phosphorylation by the insulin and epidermal growth factor receptors. J. Biol. Chem. 270:20737-20741.
    • (1995) J. Biol. Chem. , vol.270 , pp. 20737-20741
    • Okada, S.1    Yamauchi, K.2    Pessin, J.E.3
  • 26
    • 0028124189 scopus 로고
    • Essential role of phosphatidylinositol 3-kinase in insulin-induced glucose transport and antilipolysis in rat adipocytes
    • Okada, T., Y. Kawano, T. Sakakibara, O. Hazeki, and M. Ui. 1994. Essential role of phosphatidylinositol 3-kinase in insulin-induced glucose transport and antilipolysis in rat adipocytes. J. Biol. Chem. 269:3568-3573.
    • (1994) J. Biol. Chem. , vol.269 , pp. 3568-3573
    • Okada, T.1    Kawano, Y.2    Sakakibara, T.3    Hazeki, O.4    Ui, M.5
  • 27
    • 0028810236 scopus 로고
    • 4PS/insulin receptor subsrate (IRS)-2 is the alternative substrate of the insulin receptor in IRS-1-deficient mice
    • Patti, M. E., X. J. Sun, J. C. Bruening, E. Araki M. A. Lipes, M. F. White, and C. R. Kahn. 1995. 4PS/insulin receptor subsrate (IRS)-2 is the alternative substrate of the insulin receptor in IRS-1-deficient mice. J. Biol. Chem. 270:24670-24673.
    • (1995) J. Biol. Chem. , vol.270 , pp. 24670-24673
    • Patti, M.E.1    Sun, X.J.2    Bruening, J.C.3    Araki, E.4    Lipes, M.A.5    White, M.F.6    Kahn, C.R.7
  • 28
    • 0028034233 scopus 로고
    • Insulin-dependent stimulation of protein synthesis by phosphorylation of a regulator of 5′-cap function
    • Pause, A., G. J. Belsham, A. C. Gingras, O. Donze, T. A. Lin, J. C. J. Lawrence, and N. Sonenberg. 1994. Insulin-dependent stimulation of protein synthesis by phosphorylation of a regulator of 5′-cap function. Nature (London) 371:762-767.
    • (1994) Nature (London) , vol.371 , pp. 762-767
    • Pause, A.1    Belsham, G.J.2    Gingras, A.C.3    Donze, O.4    Lin, T.A.5    Lawrence, J.C.J.6    Sonenberg, N.7
  • 30
    • 0026759874 scopus 로고
    • Rapamycin-induced inhibition of the 70-kilodalton S6 protein kinase
    • Price, D. J., J. R. Grove, V. Calvo, J. Avruch, and B. E. Bierer. 1992. Rapamycin-induced inhibition of the 70-kilodalton S6 protein kinase. Science 257:973-977.
    • (1992) Science , vol.257 , pp. 973-977
    • Price, D.J.1    Grove, J.R.2    Calvo, V.3    Avruch, J.4    Bierer, B.E.5
  • 31
    • 0028809279 scopus 로고
    • Association between Grb2/Sos and insulin receptor substrate 1 is not sufficient for activation of extracellular signal-regulated kinases by interleukin-4: Implications for Ras activation by insulin
    • Pruett, W., Y. Yuan, E. Rose, A. G. Batzer, N. Harada, and E. Y. Skolnik. 1995. Association between Grb2/Sos and insulin receptor substrate 1 is not sufficient for activation of extracellular signal-regulated kinases by interleukin-4: implications for Ras activation by insulin. Mol. Cell. Biol. 15:1778-1785.
    • (1995) Mol. Cell. Biol. , vol.15 , pp. 1778-1785
    • Pruett, W.1    Yuan, Y.2    Rose, E.3    Batzer, A.G.4    Harada, N.5    Skolnik, E.Y.6
  • 38
    • 0026348652 scopus 로고
    • Insulin and 12-O-tetradecanoylphorbol-13-acetatc activation of two immunologically distinct myelin basic protein/microtubule-associated protein 2 (MBP/MAP2) kinases via de novo phosphorylation of threonine and tyrosine residues
    • Tobe, K., T. Kadowaki, H. Tantemolo, K. Ueki, K. Hara, O. Koshio, K. Momomura, Y. Gotoh, E. Nishida, Y. Akanuma, Y. Yazaki, and M. Kasuga. 1991. Insulin and 12-O-tetradecanoylphorbol-13-acetatc activation of two immunologically distinct myelin basic protein/microtubule-associated protein 2 (MBP/MAP2) kinases via de novo phosphorylation of threonine and tyrosine residues. J. Biol. Chem. 266:24793-24803.
    • (1991) J. Biol. Chem. , vol.266 , pp. 24793-24803
    • Tobe, K.1    Kadowaki, T.2    Tantemolo, H.3    Ueki, K.4    Hara, K.5    Koshio, O.6    Momomura, K.7    Gotoh, Y.8    Nishida, E.9    Akanuma, Y.10    Yazaki, Y.11    Kasuga, M.12
  • 39
    • 0025299090 scopus 로고
    • Immunological detection of phosphotyrosine-containing proteins in rat livers after insulin injection
    • Tobe, K., O. Koshio, Y. Tashiro-Hashimoto, F. Takaku, Y. Akanuma, and M. Kasuga. 1990. Immunological detection of phosphotyrosine-containing proteins in rat livers after insulin injection. Diabetes 39:528-533.
    • (1990) Diabetes , vol.39 , pp. 528-533
    • Tobe, K.1    Koshio, O.2    Tashiro-Hashimoto, Y.3    Takaku, F.4    Akanuma, Y.5    Kasuga, M.6
  • 41
    • 0028957037 scopus 로고
    • Identification of a 190-kDa protein as a novel substrate for the insulin receptor kinase functionally similar to insulin receptor substrate-1
    • Tobe, K., H. Tamemoto, T. Yamauchi, S. Aizawa, Y. Yazaki, and T. Kadowaki. 1995. Identification of a 190-kDa protein as a novel substrate for the insulin receptor kinase functionally similar to insulin receptor substrate-1. J. Biol. Chem. 270:5698-5701.
    • (1995) J. Biol. Chem. , vol.270 , pp. 5698-5701
    • Tobe, K.1    Tamemoto, H.2    Yamauchi, T.3    Aizawa, S.4    Yazaki, Y.5    Kadowaki, T.6
  • 42
    • 0028176732 scopus 로고
    • Feedback regulation of mitogen-activated protein kinase kinase kinase activity of c-Raf-1 by insulin and phorbol ester stimulation
    • Ueki, K., S. Matsuda, K. Tobe, Y. Gotoh, H. Tamemoto, M. Yachi, Y. Akanuma, Y. Yazaki, E. Nishida, and T. Kadowaki. 1994. Feedback regulation of mitogen-activated protein kinase kinase kinase activity of c-Raf-1 by insulin and phorbol ester stimulation. J. Biol. Chem. 269:15756-15761.
    • (1994) J. Biol. Chem. , vol.269 , pp. 15756-15761
    • Ueki, K.1    Matsuda, S.2    Tobe, K.3    Gotoh, Y.4    Tamemoto, H.5    Yachi, M.6    Akanuma, Y.7    Yazaki, Y.8    Nishida, E.9    Kadowaki, T.10
  • 44
    • 0027507755 scopus 로고
    • IRS-1: Essential for insulin- And IL-4-stimulated mitogenesis in hematopoietic cells
    • Wang, L.-M., M. G. Myers, Jr., X.-J. Sun, S. A. Aaronson, M. F. White, and J. H. Pierce. 1993. IRS-1: essential for insulin- and IL-4-stimulated mitogenesis in hematopoietic cells. Science 261:1591-1594.
    • (1993) Science , vol.261 , pp. 1591-1594
    • Wang, L.-M.1    Myers Jr., M.G.2    Sun, X.-J.3    Aaronson, S.A.4    White, M.F.5    Pierce, J.H.6
  • 45
    • 0028085078 scopus 로고
    • The insulin signaling system
    • White, M. F., and C. R. Kahn. 1994. The insulin signaling system. J. Biol. Chem. 268:1-4.
    • (1994) J. Biol. Chem. , vol.268 , pp. 1-4
    • White, M.F.1    Kahn, C.R.2
  • 46
    • 0022347547 scopus 로고
    • Insulin rapidly stimulates tyrosine phosphorylation of a Mr-185,000 protein in intact cells
    • White, M. F., R. Maron, and C. R. Kahn. 1985. Insulin rapidly stimulates tyrosine phosphorylation of a Mr-185,000 protein in intact cells. Nature (London) 318:183-186.
    • (1985) Nature (London) , vol.318 , pp. 183-186
    • White, M.F.1    Maron, R.2    Kahn, C.R.3
  • 47
    • 0028036724 scopus 로고
    • Insulin substrate-1 (IRS-I) and Shc compete for a limited pool of Grb2 in mediating insulin downstream signaling
    • Yamauchi, K., and J. E. Pessin. 1994. Insulin substrate-1 (IRS-I) and Shc compete for a limited pool of Grb2 in mediating insulin downstream signaling. J. Biol. Chem. 269:31107-31114.
    • (1994) J. Biol. Chem. , vol.269 , pp. 31107-31114
    • Yamauchi, K.1    Pessin, J.E.2
  • 48
    • 0028947991 scopus 로고
    • The effects of wortmannin on rat skeletal muscle
    • Yeh, J. I., E. A. Gulve, L. Rameh, and M. J. Birnbaum. 1995. The effects of wortmannin on rat skeletal muscle. J. Biol. Chem. 270:2107-2111.
    • (1995) J. Biol. Chem. , vol.270 , pp. 2107-2111
    • Yeh, J.I.1    Gulve, E.A.2    Rameh, L.3    Birnbaum, M.J.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.